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Gene set: MOUSE_DENA_DOWN (C2:MODL:0016)
Standard nameMOUSE_DENA_DOWN
Systematic nameC2:MODL:0016
Brief descriptionGenes down-regulated in hepatoma induced by diethylnitrosamine
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers. 
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

74 genes, 74 accessions (Toggle view)

GeneTitleLinks
MYH1myosin, heavy polypeptide 1, skeletal muscle, adultSource|GeneCards
MAT1Amethionine adenosyltransferase I, alphaSource|GeneCards
FABP1fatty acid binding protein 1, liverSource|GeneCards
NDRG2NDRG family member 2Source|GeneCards
CYP7A1cytochrome P450, family 7, subfamily A, polypeptide 1Source|GeneCards
WNT10Bwingless-type MMTV integration site family, member 10BSource|GeneCards
PRODHproline dehydrogenase (oxidase) 1Source|GeneCards
BAATbile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)Source|GeneCards
ALDH3A2aldehyde dehydrogenase 3 family, member A2Source|GeneCards
CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 1Source|GeneCards
NETO2neuropilin (NRP) and tolloid (TLL)-like 2Source|GeneCards
PHYHphytanoyl-CoA hydroxylase (Refsum disease)Source|GeneCards
PNLIPRP1pancreatic lipase-related protein 1Source|GeneCards
ACOX1acyl-Coenzyme A oxidase 1, palmitoylSource|GeneCards
CPT2carnitine palmitoyltransferase IISource|GeneCards
ACSL1acyl-CoA synthetase long-chain family member 1Source|GeneCards
CA3carbonic anhydrase III, muscle specificSource|GeneCards
HOXA5homeo box A5Source|GeneCards
DMBT1deleted in malignant brain tumors 1Source|GeneCards
CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1Source|GeneCards
ALOX12Barachidonate 12-lipoxygenase, 12R typeSource|GeneCards
IL1RAPinterleukin 1 receptor accessory proteinSource|GeneCards
PADI4peptidyl arginine deiminase, type IVSource|GeneCards
CSADcysteine sulfinic acid decarboxylaseSource|GeneCards
PLA2G1Bphospholipase A2, group IB (pancreas)Source|GeneCards
CA5Acarbonic anhydrase VA, mitochondrialSource|GeneCards
AASSaminoadipate-semialdehyde synthaseSource|GeneCards
SELENBP1selenium binding protein 1Source|GeneCards
TNNC2troponin C2, fastSource|GeneCards
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 2Source|GeneCards
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Source|GeneCards
REG1Aregenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)Source|GeneCards
LACTB2lactamase, beta 2Source|GeneCards
PEX11Aperoxisomal biogenesis factor 11ASource|GeneCards
PNLIPpancreatic lipaseSource|GeneCards
ELA2elastase 2, neutrophilSource|GeneCards
CTRCchymotrypsin C (caldecrin)Source|GeneCards
HPD4-hydroxyphenylpyruvate dioxygenaseSource|GeneCards
GSTO1glutathione S-transferase omega 1Source|GeneCards
HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2Source|GeneCards
GLYATglycine-N-acyltransferaseSource|GeneCards
EPHX2epoxide hydrolase 2, cytoplasmicSource|GeneCards
RORCRAR-related orphan receptor CSource|GeneCards
OATornithine aminotransferase (gyrate atrophy)Source|GeneCards
GCDHglutaryl-Coenzyme A dehydrogenaseSource|GeneCards
TNNI2troponin I, skeletal, fastSource|GeneCards
PAHphenylalanine hydroxylaseSource|GeneCards
SLC27A5solute carrier family 27 (fatty acid transporter), member 5Source|GeneCards
KRT4keratin 4Source|GeneCards
EHHADHenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenaseSource|GeneCards
MCM10MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)Source|GeneCards
ACADSBacyl-Coenzyme A dehydrogenase, short/branched chainSource|GeneCards
BHMTbetaine-homocysteine methyltransferaseSource|GeneCards
GPR37G protein-coupled receptor 37 (endothelin receptor type B-like)Source|GeneCards
TRPV2transient receptor potential cation channel, subfamily V, member 2Source|GeneCards
C4BPAcomplement component 4 binding protein, alphaSource|GeneCards
DCXRdicarbonyl/L-xylulose reductaseSource|GeneCards
LIPClipase, hepaticSource|GeneCards
ME1malic enzyme 1, NADP(+)-dependent, cytosolicSource|GeneCards
SAHSA hypertension-associated homolog (rat)Source|GeneCards
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 2Source|GeneCards
RGNregucalcin (senescence marker protein-30)Source|GeneCards
ABCD3ATP-binding cassette, sub-family D (ALD), member 3Source|GeneCards
OTCornithine carbamoyltransferaseSource|GeneCards
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)Source|GeneCards
ALDH1A1aldehyde dehydrogenase 1 family, member A1Source|GeneCards
PON1paraoxonase 1Source|GeneCards
SLC25A13solute carrier family 25, member 13 (citrin)Source|GeneCards
TNNT3troponin T3, skeletal, fastSource|GeneCards
CYP2F1cytochrome P450, family 2, subfamily F, polypeptide 1Source|GeneCards
G6PCglucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)Source|GeneCards
DPYSdihydropyrimidinaseSource|GeneCards
NR1H3nuclear receptor subfamily 1, group H, member 3Source|GeneCards
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 2Source|GeneCards


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