[an error occurred while processing this directive]
Gene set: MOUSE_E2F1_UP (C2:MODL:0017)
Standard nameMOUSE_E2F1_UP
Systematic nameC2:MODL:0017
Brief descriptionGenes up-regulated in hepatoma tissue of E2f1 transgenic mice
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers.
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

63 genes, 63 accessions (Toggle view)

GeneTitleLinks
LR8LR8 proteinSource|GeneCards
CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1Source|GeneCards
KIAA1462KIAA1462 proteinSource|GeneCards
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)Source|GeneCards
RAD51L1RAD51-like 1 (S. cerevisiae)Source|GeneCards
ANXA2annexin A2Source|GeneCards
ANXA5annexin A5Source|GeneCards
HOXC6homeo box C6Source|GeneCards
CTSEcathepsin ESource|GeneCards
GPC3glypican 3Source|GeneCards
LCN2lipocalin 2 (oncogene 24p3)Source|GeneCards
CD74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)Source|GeneCards
XDHxanthine dehydrogenaseSource|GeneCards
TFF3trefoil factor 3 (intestinal)Source|GeneCards
IGFBP1insulin-like growth factor binding protein 1Source|GeneCards
KRT23keratin 23 (histone deacetylase inducible)Source|GeneCards
BCL2A1BCL2-related protein A1Source|GeneCards
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)Source|GeneCards
COL5A2collagen, type V, alpha 2Source|GeneCards
GGHgamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)Source|GeneCards
PPLperiplakinSource|GeneCards
TCTEL1t-complex-associated-testis-expressed 1-like 1Source|GeneCards
MMP12matrix metalloproteinase 12 (macrophage elastase)Source|GeneCards
FABP4fatty acid binding protein 4, adipocyteSource|GeneCards
IFI44interferon-induced protein 44Source|GeneCards
IFIT2interferon-induced protein with tetratricopeptide repeats 2Source|GeneCards
CXADRcoxsackie virus and adenovirus receptorSource|GeneCards
NT5E5'-nucleotidase, ecto (CD73)Source|GeneCards
ANXA1annexin A1Source|GeneCards
KRT8keratin 8Source|GeneCards
MCL1myeloid cell leukemia sequence 1 (BCL2-related)Source|GeneCards
SPINK1serine protease inhibitor, Kazal type 1Source|GeneCards
RPL36ribosomal protein L36Source|GeneCards
COL1A1collagen, type I, alpha 1Source|GeneCards
MFGE8milk fat globule-EGF factor 8 proteinSource|GeneCards
TM4SF4transmembrane 4 superfamily member 4Source|GeneCards
PLATplasminogen activator, tissueSource|GeneCards
CD63CD63 antigen (melanoma 1 antigen)Source|GeneCards
GSTM1glutathione S-transferase M1Source|GeneCards
CXCL10chemokine (C-X-C motif) ligand 10Source|GeneCards
LEPRleptin receptorSource|GeneCards
FMO3flavin containing monooxygenase 3Source|GeneCards
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)Source|GeneCards
CSTBcystatin B (stefin B)Source|GeneCards
SPON2spondin 2, extracellular matrix proteinSource|GeneCards
TUBB2tubulin, beta, 2Source|GeneCards
TAGLN2transgelin 2Source|GeneCards
GSTM2glutathione S-transferase M2 (muscle)Source|GeneCards
CASP4caspase 4, apoptosis-related cysteine proteaseSource|GeneCards
NUCB2nucleobindin 2Source|GeneCards
CPEcarboxypeptidase ESource|GeneCards
RHOBras homolog gene family, member BSource|GeneCards
ACTG1actin, gamma 1Source|GeneCards
LY6Elymphocyte antigen 6 complex, locus ESource|GeneCards
CTSScathepsin SSource|GeneCards
UAP1L1UDP-N-acteylglucosamine pyrophosphorylase 1-like 1Source|GeneCards
SHCBP1likely ortholog of mouse Shc SH2-domain binding protein 1Source|GeneCards
PLSCR1phospholipid scramblase 1Source|GeneCards
PALMDpalmdelphinSource|GeneCards
DEFB1defensin, beta 1Source|GeneCards
USP18ubiquitin specific protease 18Source|GeneCards
ACTG2actin, gamma 2, smooth muscle, entericSource|GeneCards
LPLlipoprotein lipaseSource|GeneCards

[an error occurred while processing this directive]