[an error occurred while processing this directive]
Gene set: MOUSE_MYC_DOWN (C2:MODL:0020)
Standard nameMOUSE_MYC_DOWN
Systematic nameC2:MODL:0020
Brief descriptionGenes down-regulated in hepatoma tissue of Myc transgenic mice
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers. 
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

65 genes, 65 accessions (Toggle view)

GeneTitleLinks
IGF2insulin-like growth factor 2 (somatomedin A)Source|GeneCards
KLK5kallikrein 5Source|GeneCards
KIAA0882KIAA0882 proteinSource|GeneCards
HSPH1heat shock 105kDa/110kDa protein 1Source|GeneCards
C8ORF4chromosome 8 open reading frame 4Source|GeneCards
AQP8aquaporin 8Source|GeneCards
ABCC10ATP-binding cassette, sub-family C (CFTR/MRP), member 10Source|GeneCards
HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1Source|GeneCards
EFEMP1EGF-containing fibulin-like extracellular matrix protein 1Source|GeneCards
NETO2neuropilin (NRP) and tolloid (TLL)-like 2Source|GeneCards
CFHcomplement factor HSource|GeneCards
PNLIPRP1pancreatic lipase-related protein 1Source|GeneCards
MEOX2mesenchyme homeo box 2 (growth arrest-specific homeo box)Source|GeneCards
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1Source|GeneCards
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Source|GeneCards
ORM1 /// ORM2orosomucoid 1 /// orosomucoid 2Source|GeneCards
DMBT1deleted in malignant brain tumors 1Source|GeneCards
RGS16regulator of G-protein signalling 16Source|GeneCards
SFXN1sideroflexin 1Source|GeneCards
KYNUkynureninase (L-kynurenine hydrolase)Source|GeneCards
ELOVL5ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)Source|GeneCards
CFH /// CFHL1complement factor H /// complement factor H-related 1Source|GeneCards
DCTdopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)Source|GeneCards
TBC1D8TBC1 domain family, member 8 (with GRAM domain)Source|GeneCards
AASSaminoadipate-semialdehyde synthaseSource|GeneCards
ZG16zymogen granule protein 16Source|GeneCards
IGF1insulin-like growth factor 1 (somatomedin C)Source|GeneCards
HALhistidine ammonia-lyaseSource|GeneCards
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Source|GeneCards
RARRES1retinoic acid receptor responder (tazarotene induced) 1Source|GeneCards
REG1Aregenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)Source|GeneCards
IGFBP2insulin-like growth factor binding protein 2, 36kDaSource|GeneCards
PNLIPpancreatic lipaseSource|GeneCards
EGFRepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Source|GeneCards
ELA2elastase 2, neutrophilSource|GeneCards
CTRCchymotrypsin C (caldecrin)Source|GeneCards
SATB1special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's)Source|GeneCards
ORM2orosomucoid 2Source|GeneCards
G0S2putative lymphocyte G0/G1 switch geneSource|GeneCards
C8ORF4chromosome 8 open reading frame 4Source|GeneCards
C14ORF140chromosome 14 open reading frame 140Source|GeneCards
C18ORF22chromosome 18 open reading frame 22Source|GeneCards
C14ORF140chromosome 14 open reading frame 140Source|GeneCards
BHMTbetaine-homocysteine methyltransferaseSource|GeneCards
SERPINA3serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3Source|GeneCards
TDO2tryptophan 2,3-dioxygenaseSource|GeneCards
FGGfibrinogen, gamma polypeptideSource|GeneCards
KLF15Kruppel-like factor 15Source|GeneCards
FKBP5FK506 binding protein 5Source|GeneCards
SLC37A4solute carrier family 37 (glycerol-6-phosphate transporter), member 4Source|GeneCards
C4BPAcomplement component 4 binding protein, alphaSource|GeneCards
HRSP12heat-responsive protein 12Source|GeneCards
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)Source|GeneCards
PCOLCEprocollagen C-endopeptidase enhancerSource|GeneCards
OTCornithine carbamoyltransferaseSource|GeneCards
MOSC1MOCO sulphurase C-terminal domain containing 1Source|GeneCards
HBP1HMG-box transcription factor 1Source|GeneCards
MT2Ametallothionein 2ASource|GeneCards
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 2Source|GeneCards
CYP2F1cytochrome P450, family 2, subfamily F, polypeptide 1Source|GeneCards
G6PCglucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)Source|GeneCards
HAO1hydroxyacid oxidase (glycolate oxidase) 1Source|GeneCards
DPYDdihydropyrimidine dehydrogenaseSource|GeneCards
IL1R1interleukin 1 receptor, type ISource|GeneCards
POGZpogo transposable element with ZNF domainSource|GeneCards


[an error occurred while processing this directive]