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Gene set: MOUSE_MYC_E2F1_UP (C2:MODL:0021)
Standard nameMOUSE_MYC_E2F1_UP
Systematic nameC2:MODL:0021
Brief descriptionGenes up-regulated in hepatoma tissue of Myc+E2f1 transgenic mice
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers.
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

57 genes, 57 accessions (Toggle view)

GeneTitleLinks
LR8LR8 proteinSource|GeneCards
CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1Source|GeneCards
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)Source|GeneCards
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)Source|GeneCards
RAD51L1RAD51-like 1 (S. cerevisiae)Source|GeneCards
ANXA2annexin A2Source|GeneCards
TPRtranslocated promoter region (to activated MET oncogene)Source|GeneCards
ANXA5annexin A5Source|GeneCards
GPC3glypican 3Source|GeneCards
LCN2lipocalin 2 (oncogene 24p3)Source|GeneCards
KIF20Akinesin family member 20ASource|GeneCards
CD74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)Source|GeneCards
PTGDSprostaglandin D2 synthase 21kDa (brain)Source|GeneCards
LAMA5laminin, alpha 5Source|GeneCards
IGFBP1insulin-like growth factor binding protein 1Source|GeneCards
BCL2A1BCL2-related protein A1Source|GeneCards
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)Source|GeneCards
NUSAP1nucleolar and spindle associated protein 1Source|GeneCards
PPLperiplakinSource|GeneCards
MMP12matrix metalloproteinase 12 (macrophage elastase)Source|GeneCards
ROCK1Rho-associated, coiled-coil containing protein kinase 1Source|GeneCards
IFIT2interferon-induced protein with tetratricopeptide repeats 2Source|GeneCards
IFI44interferon-induced protein 44Source|GeneCards
FABP4fatty acid binding protein 4, adipocyteSource|GeneCards
SPP1secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)Source|GeneCards
KRT8keratin 8Source|GeneCards
CISHcytokine inducible SH2-containing proteinSource|GeneCards
SPINK1serine protease inhibitor, Kazal type 1Source|GeneCards
UNC13Bunc-13 homolog B (C. elegans)Source|GeneCards
COL1A1collagen, type I, alpha 1Source|GeneCards
CD63CD63 antigen (melanoma 1 antigen)Source|GeneCards
PLATplasminogen activator, tissueSource|GeneCards
SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3Source|GeneCards
SMC4L1SMC4 structural maintenance of chromosomes 4-like 1 (yeast)Source|GeneCards
HLA-DQA1 /// HLA-DQAmajor histocompatibility complex, class II, DQ alpha 1 /// major histocompatibility complex, class II, DQ alpha 2Source|GeneCards
FMO3flavin containing monooxygenase 3Source|GeneCards
HLA-DQA1major histocompatibility complex, class II, DQ alpha 1Source|GeneCards
SLC1A4solute carrier family 1 (glutamate/neutral amino acid transporter), member 4Source|GeneCards
CSTBcystatin B (stefin B)Source|GeneCards
TAGLN2transgelin 2Source|GeneCards
VIL1villin 1Source|GeneCards
LY6Dlymphocyte antigen 6 complex, locus DSource|GeneCards
NUCB2nucleobindin 2Source|GeneCards
ACTG1actin, gamma 1Source|GeneCards
LY6Elymphocyte antigen 6 complex, locus ESource|GeneCards
CD72CD72 antigenSource|GeneCards
CTSScathepsin SSource|GeneCards
COL1A2collagen, type I, alpha 2Source|GeneCards
UAP1L1UDP-N-acteylglucosamine pyrophosphorylase 1-like 1Source|GeneCards
PLSCR1phospholipid scramblase 1Source|GeneCards
PALMDpalmdelphinSource|GeneCards
CDC2cell division cycle 2, G1 to S and G2 to MSource|GeneCards
DEFB1defensin, beta 1Source|GeneCards
USP18ubiquitin specific protease 18Source|GeneCards
ICAM1intercellular adhesion molecule 1 (CD54), human rhinovirus receptorSource|GeneCards
CXCL9chemokine (C-X-C motif) ligand 9Source|GeneCards
LPLlipoprotein lipaseSource|GeneCards

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