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Gene set: MOUSE_MYC_TGFA_DOWN (C2:MODL:0024)
Standard nameMOUSE_MYC_TGFA_DOWN
Systematic nameC2:MODL:0024
Brief descriptionGenes down-regulated in hepatoma tissue of Myc+Tgfa transgenic mice
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers. 
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

66 genes, 66 accessions (Toggle view)

GeneTitleLinks
IGFALSinsulin-like growth factor binding protein, acid labile subunitSource|GeneCards
FABP1fatty acid binding protein 1, liverSource|GeneCards
PSEN2presenilin 2 (Alzheimer disease 4)Source|GeneCards
AQP8aquaporin 8Source|GeneCards
BAATbile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)Source|GeneCards
CMAHcytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-N-acetylneuraminate monooxygenase)Source|GeneCards
KHKketohexokinase (fructokinase)Source|GeneCards
NETO2neuropilin (NRP) and tolloid (TLL)-like 2Source|GeneCards
ACOX1acyl-Coenzyme A oxidase 1, palmitoylSource|GeneCards
CPT2carnitine palmitoyltransferase IISource|GeneCards
HSPC009HSPC009 proteinSource|GeneCards
CA3carbonic anhydrase III, muscle specificSource|GeneCards
ORM1 /// ORM2orosomucoid 1 /// orosomucoid 2Source|GeneCards
CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1Source|GeneCards
SLC25A22solute carrier family 25 (mitochondrial carrier: glutamate), member 22Source|GeneCards
RGS16regulator of G-protein signalling 16Source|GeneCards
CRISP2cysteine-rich secretory protein 2Source|GeneCards
IL1RAPinterleukin 1 receptor accessory proteinSource|GeneCards
KYNUkynureninase (L-kynurenine hydrolase)Source|GeneCards
HADH2hydroxyacyl-Coenzyme A dehydrogenase, type IISource|GeneCards
ELOVL5ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)Source|GeneCards
CA5Acarbonic anhydrase VA, mitochondrialSource|GeneCards
DCTdopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)Source|GeneCards
AASSaminoadipate-semialdehyde synthaseSource|GeneCards
ABAT4-aminobutyrate aminotransferaseSource|GeneCards
IGF1insulin-like growth factor 1 (somatomedin C)Source|GeneCards
TNNC2troponin C2, fastSource|GeneCards
HALhistidine ammonia-lyaseSource|GeneCards
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)Source|GeneCards
HSD11B1hydroxysteroid (11-beta) dehydrogenase 1Source|GeneCards
EGFRepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Source|GeneCards
HPD4-hydroxyphenylpyruvate dioxygenaseSource|GeneCards
PXMP2peroxisomal membrane protein 2, 22kDaSource|GeneCards
EPHX2epoxide hydrolase 2, cytoplasmicSource|GeneCards
ORM2orosomucoid 2Source|GeneCards
G0S2putative lymphocyte G0/G1 switch geneSource|GeneCards
OATornithine aminotransferase (gyrate atrophy)Source|GeneCards
C14ORF140chromosome 14 open reading frame 140Source|GeneCards
ABCG2ATP-binding cassette, sub-family G (WHITE), member 2Source|GeneCards
SLC27A5solute carrier family 27 (fatty acid transporter), member 5Source|GeneCards
ETNK2ethanolamine kinase 2Source|GeneCards
C14ORF140chromosome 14 open reading frame 140Source|GeneCards
MCM10MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)Source|GeneCards
TDO2tryptophan 2,3-dioxygenaseSource|GeneCards
BHMTbetaine-homocysteine methyltransferaseSource|GeneCards
GPR37G protein-coupled receptor 37 (endothelin receptor type B-like)Source|GeneCards
FABP2fatty acid binding protein 2, intestinalSource|GeneCards
TRPV2transient receptor potential cation channel, subfamily V, member 2Source|GeneCards
PTP4A3protein tyrosine phosphatase type IVA, member 3Source|GeneCards
KLF15Kruppel-like factor 15Source|GeneCards
C4BPAcomplement component 4 binding protein, alphaSource|GeneCards
HLA-DMAmajor histocompatibility complex, class II, DM alphaSource|GeneCards
LIPClipase, hepaticSource|GeneCards
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)Source|GeneCards
MMDmonocyte to macrophage differentiation-associatedSource|GeneCards
RGNregucalcin (senescence marker protein-30)Source|GeneCards
OTCornithine carbamoyltransferaseSource|GeneCards
ALDH1A1aldehyde dehydrogenase 1 family, member A1Source|GeneCards
MOSC1MOCO sulphurase C-terminal domain containing 1Source|GeneCards
CYP2F1cytochrome P450, family 2, subfamily F, polypeptide 1Source|GeneCards
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 2Source|GeneCards
G6PCglucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)Source|GeneCards
HAO1hydroxyacid oxidase (glycolate oxidase) 1Source|GeneCards
ALAS2aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia)Source|GeneCards
NR1H3nuclear receptor subfamily 1, group H, member 3Source|GeneCards
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 2Source|GeneCards


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