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Gene set: MOUSE_MYC_TGFA_UP (C2:MODL:0023)
Standard nameMOUSE_MYC_TGFA_UP
Systematic nameC2:MODL:0023
Brief descriptionGenes up-regulated in hepatoma tissue of Myc+Tgfa transgenic mice
CategoryC2: Curated
Sub-categoryMODL: Animal Model
Full description or Abstract
Genetically modified mice have been extensively used for analyzing
the molecular events that occur during tumor development. In many,
if not all, cases, however, it is uncertain to what extent the
mouse models reproduce features observed in the corresponding
human conditions. This is due largely to lack of precise methods
for direct and comprehensive comparison at the molecular level
of the mouse and human tumors. Here we use global gene expression
patterns of 68 hepatocellular carcinomas (HCCs) from seven different
mouse models and 91 human HCCs from predefined subclasses to obtain
direct comparison of the molecular features of mouse and human
HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc
E2f1 transgenic mice were most similar to those of the better
survival group of human HCCs, whereas the expression patterns
in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced
mouse HCCs were most similar to those of the poorer survival group
of human HCCs. Gene expression patterns in HCCs from Acox1(-/-)
mice and in ciprofibrate-induced HCCs were least similar to those
observed in human HCCs. We conclude that our approach can effectively
identify appropriate mouse models to study human cancers.
Publication URL15565109
External linksna
Keywords & MeSH headingsGenomics,Apoptosis/genetics,Oligonucleotide Array Sequence Analysis,Gene Expression Profiling,Comparative Study,Animal,Immunohistochemistry,Humans,Liver Neoplasms,Carcinoma,Reverse Transcriptase Polymerase Chain Reaction,genetics,Mice,methods,Disease Models,Transgenic,Cluster Analysis,Hepatocellular
OrganismMouse
Contributed byYujin Hoshida
Source platformGene_Symbol
Downloadgrp|xml|map
Genes

61 genes, 61 accessions (Toggle view)

GeneTitleLinks
IGF2insulin-like growth factor 2 (somatomedin A)Source|GeneCards
ATPIF1ATPase inhibitory factor 1Source|GeneCards
CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1Source|GeneCards
MTHFD2methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolaseSource|GeneCards
GNB2L1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1Source|GeneCards
ANXA2annexin A2Source|GeneCards
BTG2BTG family, member 2Source|GeneCards
RAD51L1RAD51-like 1 (S. cerevisiae)Source|GeneCards
RPS24ribosomal protein S24Source|GeneCards
PSPHphosphoserine phosphataseSource|GeneCards
BTG3BTG family, member 3Source|GeneCards
HTATIP2HIV-1 Tat interactive protein 2, 30kDaSource|GeneCards
LCN2lipocalin 2 (oncogene 24p3)Source|GeneCards
MT3metallothionein 3 (growth inhibitory factor (neurotrophic))Source|GeneCards
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)Source|GeneCards
ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific )Source|GeneCards
TFF3trefoil factor 3 (intestinal)Source|GeneCards
IGFBP1insulin-like growth factor binding protein 1Source|GeneCards
RPL12ribosomal protein L12Source|GeneCards
PPLperiplakinSource|GeneCards
IGFBP6insulin-like growth factor binding protein 6Source|GeneCards
MMP12matrix metalloproteinase 12 (macrophage elastase)Source|GeneCards
RAB3DRAB3D, member RAS oncogene familySource|GeneCards
TFRCtransferrin receptor (p90, CD71)Source|GeneCards
NT5E5'-nucleotidase, ecto (CD73)Source|GeneCards
KRT8keratin 8Source|GeneCards
GIPC2PDZ domain protein GIPC2Source|GeneCards
MFGE8milk fat globule-EGF factor 8 proteinSource|GeneCards
SLPIsecretory leukocyte protease inhibitor (antileukoproteinase)Source|GeneCards
SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3Source|GeneCards
CD63CD63 antigen (melanoma 1 antigen)Source|GeneCards
PLATplasminogen activator, tissueSource|GeneCards
TLR1toll-like receptor 1Source|GeneCards
GSTM1glutathione S-transferase M1Source|GeneCards
CCND1cyclin D1 (PRAD1: parathyroid adenomatosis 1)Source|GeneCards
CNN1calponin 1, basic, smooth muscleSource|GeneCards
NEDD9neural precursor cell expressed, developmentally down-regulated 9Source|GeneCards
SLC1A4solute carrier family 1 (glutamate/neutral amino acid transporter), member 4Source|GeneCards
CSN3casein kappaSource|GeneCards
CSTBcystatin B (stefin B)Source|GeneCards
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)Source|GeneCards
CBR1carbonyl reductase 1Source|GeneCards
TAGLN2transgelin 2Source|GeneCards
VIL1villin 1Source|GeneCards
LY6Dlymphocyte antigen 6 complex, locus DSource|GeneCards
GSTM2glutathione S-transferase M2 (muscle)Source|GeneCards
NDRG1N-myc downstream regulated gene 1Source|GeneCards
LY6Elymphocyte antigen 6 complex, locus ESource|GeneCards
ACTG1actin, gamma 1Source|GeneCards
UAP1L1UDP-N-acteylglucosamine pyrophosphorylase 1-like 1Source|GeneCards
76Pgamma tubulin ring complex protein (76p gene)Source|GeneCards
APPamyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease)Source|GeneCards
PLSCR1phospholipid scramblase 1Source|GeneCards
MGMTO-6-methylguanine-DNA methyltransferaseSource|GeneCards
AKR1B1aldo-keto reductase family 1, member B1 (aldose reductase)Source|GeneCards
MT2Ametallothionein 2ASource|GeneCards
USP18ubiquitin specific protease 18Source|GeneCards
ICAM1intercellular adhesion molecule 1 (CD54), human rhinovirus receptorSource|GeneCards
SERPINA6serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6Source|GeneCards
LPLlipoprotein lipaseSource|GeneCards

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