| Full description or Abstract | Increased Myc gene copy number is observed in human prostate cancer.
To define Myc's functional role, we generated transgenic mice
expressing human c-Myc in the mouse prostate. All mice developed
murine prostatic intraepithelial neoplasia followed by invasive
adenocarcinoma. Microarray-based expression profiling identified
a Myc prostate cancer expression signature, which included the
putative human tumor suppressor NXK3.1. Human prostate tumor databases
revealed modules of human genes that varied in concert with the
Myc prostate cancer signature. This module includes the Pim-1
kinase, a gene known to cooperate with Myc in tumorigenesis, and
defines a subset of human, "Myc-like" human cancers. This approach
illustrates how genomic technologies can be applied to mouse cancer
models to guide evaluation of human tumor databases. |
| Keywords & MeSH headings | Gene Expression Profiling,P.H.S.,Proto-Oncogene Proteins/metabolism,Prostate,Androgens/metabolism,Human,Neoplastic/physiology,Support,Orchiectomy,Homeodomain Proteins/metabolism,Genes,genetics,Mice,Neovascularization,Transgenic,physiopathology,Male,Transcription Factors/metabolism,Non-P.H.S.,Animals,Pathologic,Protein-Serine-Threonine Kinases/metabolism,Prostatic Neoplasms,Gene Expression Regulation,physiology,myc,Prostatic Intraepithelial Neoplasia/physiopathology |