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Gene set: PANCREAS_CHR12_AGUIRRE (C2:CLIN:0009)
Standard namePANCREAS_CHR12_AGUIRRE
Systematic nameC2:CLIN:0009
Brief descriptionGenes on chromosome 1 with copy-number-driven expression in pancreatic adenocarcinoma.
CategoryC2: Curated
Sub-categoryCLIN: Clinical
Full description or Abstract
The pancreatic adenocarcinoma genome harbors multiple amplifications
and deletions, pointing to the existence of numerous oncogenes
and tumor suppressor genes driving the genesis and progression
of this lethal cancer. Here, array comparative genomic hybridization
on a cDNA microarray platform and informatics tools have been
used to define the copy number alterations in a panel of 24 pancreatic
adenocarcinoma cell lines and 13 primary tumor specimens. This
high-resolution genomic analysis has identified all known regional
gains and losses as well as many previously uncharacterized highly
recurrent copy number alterations. A systematic prioritization
scheme has selected 64 focal minimal common regions (MCRs) of
recurrent copy number change. These MCRs possess a median size
of 2.7 megabases (Mb), with 21 (33%) MCRs spanning 1 Mb or less
(median of 0.33 Mb) and possessing an average of 15 annotated
genes. Furthermore, complementary expression profile analysis
of a significant fraction of the genes residing within these 64
prioritized MCRs has enabled the identification of a subset of
candidates with statistically significant association between
gene dosage and mRNA expression. Thus, the integration of DNA
and RNA profiles provides a highly productive entry point for
the discovery of genes involved in the pathogenesis of pancreatic
adenocarcinoma. 
Publication URL15199222
External linksna
Keywords & MeSH headingsCell Line,Oligonucleotide Array Sequence Analysis,Genome,P.H.S.,Pancreatic Neoplasms,Nucleic Acid Hybridization/methods,Chromosomes/genetics,Animals,Human,Humans,Homozygote,Gene Expression,Chromosomes,Computational Biology/methods,Pair 17,genetics,Protein p16/genetics,Gene Deletion,Gene Dosage,Tumor
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

60 genes, 89 accessions (Toggle view)

AccessionGeneTitleLinks
200663_atCD63CD63 antigen (melanoma 1 antigen)Source|GeneCards
218604_atLEMD3LEM domain containing 3Source|GeneCards
218417_s_atFLJ20489hypothetical protein FLJ20489Source|GeneCards
217178_atRARGretinoic acid receptor, gammaSource|GeneCards
200833_s_atRAP1BRAP1B, member of RAS oncogene familySource|GeneCards
220036_s_atLMBR1Llimb region 1 homolog (mouse)-likeSource|GeneCards
206194_atHOXC4 /// FLJ12825homeo box C4 /// hypothetical gene supported by AK022887; AK056417Source|GeneCards
204189_atRARGretinoic acid receptor, gammaSource|GeneCards
205209_atACVR1Bactivin A receptor, type IBSource|GeneCards
204254_s_atVDRvitamin D (1,25- dihydroxyvitamin D3) receptorSource|GeneCards
209281_s_atATP2B1ATPase, Ca++ transporting, plasma membrane 1Source|GeneCards
220157_x_atPLEKHA9 /// PLEKHA8phoinositide binding specific) member 8Source|GeneCards
208891_atDUSP6dual specificity phosphatase 6Source|GeneCards
209338_atTFCP2transcription factor CP2Source|GeneCards
219118_atFKBP11FK506 binding protein 11, 19 kDaSource|GeneCards
218520_atTBK1TANK-binding kinase 1Source|GeneCards
206745_atHOXC11homeo box C11Source|GeneCards
212160_atXPOTexportin, tRNA (nuclear export receptor for tRNAs)Source|GeneCards
211937_atEIF4Beukaryotic translation initiation factor 4BSource|GeneCards
214008_atPTK9PTK9 protein tyrosine kinase 9Source|GeneCards
213198_atACVR1Bactivin A receptor, type IBSource|GeneCards
218911_atYEATS4YEATS domain containing 4Source|GeneCards
218416_s_atFLJ20489hypothetical protein FLJ20489Source|GeneCards
0016_x_at
212861_atMGC11308hypothetical protein MGC11308Source|GeneCards
207132_x_atPFDN5prefoldin 5Source|GeneCards
209530_atCACNB3calcium channel, voltage-dependent, beta 3 subunitSource|GeneCards
219206_x_atCGI-119CGI-119 proteinSource|GeneCards
203676_atGNSglucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)Source|GeneCards
200011_s_atARF3ADP-ribosylation factor 3 /// ADP-ribosylation factor 3Source|GeneCards
211622_s_atARF3ADP-ribosylation factor 3 /// ADP-ribosylation factor 3Source|GeneCards
210908_s_atPFDN5prefoldin 5Source|GeneCards
208838_atCAND1cullin-associated and neddylation-dissociated 1Source|GeneCards
218324_s_atSPATS2spermatogenesis associated, serine-rich 2Source|GeneCards
218111_s_atCMAScytidine monophosphate N-acetylneuraminic acid synthetaseSource|GeneCards
206446_s_atELA2Aelastase 2ASource|GeneCards
213356_x_atHNRPA1 /// LOC284387ing protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) /// similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) /// similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) /// similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) /// similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) /// similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) /// similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) /// similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) /// similar to heterogeneous nuclear ribonucleoprotein A1 /// similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) /// similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP)Source|GeneCards
212930_atATP2B1ATPase, Ca++ transporting, plasma membrane 1Source|GeneCards
202968_s_atDYRK2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2Source|GeneCards
218936_s_atHSPC128HSPC128 proteinSource|GeneCards
218988_atSLC35E3solute carrier family 35, member E3Source|GeneCards
202592_atBLOC1S1biogenesis of lysosome-related organelles complex-1, subunit 1Source|GeneCards
221683_s_atCEP290centrosome protein cep290Source|GeneCards
213701_atDKFZP434N2030hypothetical protein DKFZp434N2030Source|GeneCards
214007_s_atPTK9PTK9 protein tyrosine kinase 9Source|GeneCards
217726_atCOPZ1coatomer protein complex, subunit zeta 1Source|GeneCards
203123_s_atSLC11A2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2Source|GeneCards
215716_s_atATP2B1ATPase, Ca++ transporting, plasma membrane 1Source|GeneCards
207483_s_atCAND1cullin-associated and neddylation-dissociated 1Source|GeneCards
202556_s_atMCRS1microspherule protein 1Source|GeneCards
218556_atORMDL2ORM1-like 2 (S. cerevisiae)Source|GeneCards
213850_s_atSFRS2IPsplicing factor, arginine/serine-rich 2, interacting proteinSource|GeneCards
207627_s_atTFCP2transcription factor CP2Source|GeneCards
200803_s_atTEGTtestis enhanced gene transcript (BAX inhibitor 1)Source|GeneCards
209376_x_atSFRS2IPsplicing factor, arginine/serine-rich 2, interacting proteinSource|GeneCards
200804_atTEGTtestis enhanced gene transcript (BAX inhibitor 1)Source|GeneCards
212335_atGNSglucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)Source|GeneCards
201745_atPTK9PTK9 protein tyrosine kinase 9Source|GeneCards
214334_x_atDAZAP2 /// LOC401029DAZ associated protein 2 /// similar to DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2)Source|GeneCards
203124_s_atSLC11A2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2Source|GeneCards
202970_atDYRK2Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2Source|GeneCards
204188_s_atRARGretinoic acid receptor, gammaSource|GeneCards
207029_atKITLGKIT ligandSource|GeneCards
201604_s_atPPP1R12Aprotein phosphatase 1, regulatory (inhibitor) subunit 12ASource|GeneCards
201805_atPRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunitSource|GeneCards
209679_s_atLOC57228hypothetical protein from clone 643Source|GeneCards
204255_s_atVDRvitamin D (1,25- dihydroxyvitamin D3) receptorSource|GeneCards
212126_atCBX5Chromobox homolog 5 (HP1 alpha homolog, Drosophila)Source|GeneCards
219117_s_atFKBP11FK506 binding protein 11, 19 kDaSource|GeneCards
208839_s_atCAND1cullin-associated and neddylation-dissociated 1Source|GeneCards
214280_x_atHNRPA1heterogeneous nuclear ribonucleoprotein A1Source|GeneCards
202971_s_atDYRK2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2Source|GeneCards
222077_s_atRACGAP1Rac GTPase activating protein 1Source|GeneCards
201947_s_atCCT2chaperonin containing TCP1, subunit 2 (beta)Source|GeneCards
222304_x_atOR7E47Polfactory receptor, family 7, subfamily E, member 47 pseudogeneSource|GeneCards
218220_atC12ORF10chromosome 12 open reading frame 10Source|GeneCards
200794_x_atDAZAP2DAZ associated protein 2Source|GeneCards
206989_s_atSFRS2IPsplicing factor, arginine/serine-rich 2, interacting proteinSource|GeneCards
222040_atHNRPA1heterogeneous nuclear ribonucleoprotein A1Source|GeneCards
221919_atNA
218685_s_atSMUG1single-strand selective monofunctional uracil DNA glycosylaseSource|GeneCards
214002_atMYL6myosin, light polypeptide 6, alkali, smooth muscle and non-muscleSource|GeneCards
200921_s_atBTG1B-cell translocation gene 1, anti-proliferativeSource|GeneCards
34726_atCACNB3calcium channel, voltage-dependent, beta 3 subunitSource|GeneCards
212334_atGNSglucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)Source|GeneCards
201603_atPPP1R12Aprotein phosphatase 1, regulatory (inhibitor) subunit 12ASource|GeneCards
208892_s_atDUSP6dual specificity phosphatase 6Source|GeneCards
40465_atDDX23DEAD (Asp-Glu-Ala-Asp) box polypeptide 23Source|GeneCards
221821_s_atFLJ20436hypothetical protein FLJ20436Source|GeneCards


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