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Gene set: PANCREAS_CHR19_AGUIRRE (C2:CLIN:0012)
Standard namePANCREAS_CHR19_AGUIRRE
Systematic nameC2:CLIN:0012
Brief descriptionGenes on chromosome 19 with copy-number-driven expression in pancreatic adenocarcinoma.
CategoryC2: Curated
Sub-categoryCLIN: Clinical
Full description or Abstract
The pancreatic adenocarcinoma genome harbors multiple amplifications
and deletions, pointing to the existence of numerous oncogenes
and tumor suppressor genes driving the genesis and progression
of this lethal cancer. Here, array comparative genomic hybridization
on a cDNA microarray platform and informatics tools have been
used to define the copy number alterations in a panel of 24 pancreatic
adenocarcinoma cell lines and 13 primary tumor specimens. This
high-resolution genomic analysis has identified all known regional
gains and losses as well as many previously uncharacterized highly
recurrent copy number alterations. A systematic prioritization
scheme has selected 64 focal minimal common regions (MCRs) of
recurrent copy number change. These MCRs possess a median size
of 2.7 megabases (Mb), with 21 (33%) MCRs spanning 1 Mb or less
(median of 0.33 Mb) and possessing an average of 15 annotated
genes. Furthermore, complementary expression profile analysis
of a significant fraction of the genes residing within these 64
prioritized MCRs has enabled the identification of a subset of
candidates with statistically significant association between
gene dosage and mRNA expression. Thus, the integration of DNA
and RNA profiles provides a highly productive entry point for
the discovery of genes involved in the pathogenesis of pancreatic
adenocarcinoma. 
Publication URL15199222
External linksna
Keywords & MeSH headingsCell Line,Oligonucleotide Array Sequence Analysis,Genome,P.H.S.,Pancreatic Neoplasms,Nucleic Acid Hybridization/methods,Chromosomes/genetics,Animals,Human,Humans,Homozygote,Gene Expression,Chromosomes,Computational Biology/methods,Pair 17,genetics,Protein p16/genetics,Gene Deletion,Gene Dosage,Tumor
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

73 genes, 110 accessions (Toggle view)

AccessionGeneTitleLinks
205917_atZNF264zinc finger protein 264Source|GeneCards
201221_s_atSNRP70small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen)Source|GeneCards
202621_atIRF3interferon regulatory factor 3Source|GeneCards
206161_s_atSYT5synaptotagmin VSource|GeneCards
211141_s_atCNOT3CCR4-NOT transcription complex, subunit 3Source|GeneCards
50376_atZNF444zinc finger protein 444Source|GeneCards
215326_atNA
58367_s_atZNF419zinc finger protein 419Source|GeneCards
202093_s_atPAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)Source|GeneCards
213690_s_atNA
214335_atRPL18Ribosomal protein L18Source|GeneCards
221870_atEHD2EH-domain containing 2Source|GeneCards
218849_s_atPPP1R13Lprotein phosphatase 1, regulatory (inhibitor) subunit 13 likeSource|GeneCards
218707_atZNF444zinc finger protein 444Source|GeneCards
220748_s_atZNF580zinc finger protein 580Source|GeneCards
217903_atSTRN4striatin, calmodulin binding protein 4Source|GeneCards
216273_atZNF272zinc finger protein 272Source|GeneCards
220605_s_atSIRT2sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)Source|GeneCards
218381_s_atU2AF2U2 (RNU2) small nuclear RNA auxiliary factor 2Source|GeneCards
206296_x_atMAP4K1mitogen-activated protein kinase kinase kinase kinase 1Source|GeneCards
217661_x_atSIX5sine oculis homeobox homolog 5 (Drosophila)Source|GeneCards
206531_atDPF1D4, zinc and double PHD fingers family 1Source|GeneCards
206182_atZNF134zinc finger protein 134 (clone pHZ-15)Source|GeneCards
213402_atLOC126208hypothetical protein LOC126208Source|GeneCards
221494_x_atEIF3S12eukaryotic translation initiation factor 3, subunit 12Source|GeneCards
206357_atOPA3optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)Source|GeneCards
214219_x_atMAP4K1mitogen-activated protein kinase kinase kinase kinase 1Source|GeneCards
218132_s_atTSEN34tRNA splicing endonuclease 34 homolog (SEN34, S. cerevisiae)Source|GeneCards
219102_atRCN3reticulocalbin 3, EF-hand calcium binding domainSource|GeneCards
205264_atCD3EAPCD3E antigen, epsilon polypeptide associated proteinSource|GeneCards
208478_s_atBAXBCL2-associated X proteinSource|GeneCards
220284_atDKKL1dickkopf-like 1 (soggy)Source|GeneCards
202407_s_atPRPF31PRP31 pre-mRNA processing factor 31 homolog (yeast)Source|GeneCards
214317_x_atRPS9Ribosomal protein S9Source|GeneCards
202044_atGRLF1glucocorticoid receptor DNA binding factor 1Source|GeneCards
208105_atGIPRgastric inhibitory polypeptide receptorSource|GeneCards
219228_atZNF331zinc finger protein 331Source|GeneCards
200826_atSNRPD2small nuclear ribonucleoprotein D2 polypeptide 16.5kDaSource|GeneCards
216279_atZNF272zinc finger protein 272Source|GeneCards
220088_atC5R1complement component 5 receptor 1 (C5a ligand)Source|GeneCards
219826_atZNF419zinc finger protein 419Source|GeneCards
209783_atDBPD site of albumin promoter (albumin D-box) binding proteinSource|GeneCards
221860_atNA
200050_atZNF146zinc finger protein 146 /// zinc finger protein 146Source|GeneCards
210008_s_atMRPS12mitochondrial ribosomal protein S12Source|GeneCards
200716_x_atRPL13Aribosomal protein L13aSource|GeneCards
202045_s_atGRLF1glucocorticoid receptor DNA binding factor 1Source|GeneCards
217062_atNA
207860_atNCR1natural cytotoxicity triggering receptor 1Source|GeneCards
200715_x_atRPL13Aribosomal protein L13aSource|GeneCards
211833_s_atBAXBCL2-associated X proteinSource|GeneCards
217747_s_atRPS9ribosomal protein S9Source|GeneCards
214171_s_atU2AF2U2 (RNU2) small nuclear RNA auxiliary factor 2Source|GeneCards
212716_s_atEIF3S12eukaryotic translation initiation factor 3, subunit 12Source|GeneCards
212790_x_atRPL13Aribosomal protein L13aSource|GeneCards
206491_s_atNAPAN-ethylmaleimide-sensitive factor attachment protein, alphaSource|GeneCards
202726_atLIG1ligase I, DNA, ATP-dependentSource|GeneCards
203239_s_atCNOT3CCR4-NOT transcription complex, subunit 3Source|GeneCards
201979_s_atPPP5Cprotein phosphatase 5, catalytic subunitSource|GeneCards
213691_atNA
204330_s_atMRPS12mitochondrial ribosomal protein S12Source|GeneCards
200022_atRPL18ribosomal protein L18 /// ribosomal protein L18Source|GeneCards
209179_s_atLENG4leukocyte receptor cluster (LRC) member 4Source|GeneCards
205634_x_atZDHHC24zinc finger, DHHC-type containing 24Source|GeneCards
218382_s_atU2AF2U2 (RNU2) small nuclear RNA auxiliary factor 2Source|GeneCards
45297_atEHD2EH-domain containing 2Source|GeneCards
202153_s_atNUP62nucleoporin 62kDaSource|GeneCards
200922_atKDELR1KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1Source|GeneCards
214448_x_atNFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, betaSource|GeneCards
204399_s_atEML2echinoderm microtubule associated protein like 2Source|GeneCards
205437_atZNF211zinc finger protein 211Source|GeneCards
200820_atPSMD8proteasome (prosome, macropain) 26S subunit, non-ATPase, 8Source|GeneCards
217088_s_atNCR1natural cytotoxicity triggering receptor 1Source|GeneCards
202120_x_atAP2S1adaptor-related protein complex 2, sigma 1 subunitSource|GeneCards
217950_atNOSIPnitric oxide synthase interacting proteinSource|GeneCards
211047_x_atAP2S1adaptor-related protein complex 2, sigma 1 subunit /// adaptor-related protein complex 2, sigma 1 subunitSource|GeneCards
206162_x_atSYT5synaptotagmin VSource|GeneCards
214062_x_atNFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, betaSource|GeneCards
217627_atZNF573zinc finger protein 573Source|GeneCards
33814_atPAK4p21(CDKN1A)-activated kinase 4Source|GeneCards
210890_x_atKIR2DL1killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1Source|GeneCards
209782_s_atDBPD site of albumin promoter (albumin D-box) binding proteinSource|GeneCards
208751_atNAPAN-ethylmaleimide-sensitive factor attachment protein, alphaSource|GeneCards
204331_s_atMRPS12mitochondrial ribosomal protein S12Source|GeneCards
216670_atKLK13kallikrein 13Source|GeneCards
217066_s_atDMPKdystrophia myotonica-protein kinaseSource|GeneCards
208074_s_atAP2S1adaptor-related protein complex 2, sigma 1 subunitSource|GeneCards
202046_s_atGRLF1glucocorticoid receptor DNA binding factor 1Source|GeneCards
214471_x_atLHBluteinizing hormone beta polypeptideSource|GeneCards
206109_atFUT1fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)Source|GeneCards
201459_atRUVBL2RuvB-like 2 (E. coli)Source|GeneCards
221141_x_atEPN1epsin 1Source|GeneCards
217315_s_atKLK13kallikrein 13Source|GeneCards
208916_atSLC1A5solute carrier family 1 (neutral amino acid transporter), member 5Source|GeneCards
221549_atGRWD1glutamate-rich WD repeat containing 1Source|GeneCards
218702_atSARS2seryl-tRNA synthetase 2Source|GeneCards
207753_atZNF304zinc finger protein 304Source|GeneCards
38269_atPRKD2protein kinase D2Source|GeneCards
203154_s_atPAK4p21(CDKN1A)-activated kinase 4Source|GeneCards
201673_s_atGYS1glycogen synthase 1 (muscle)Source|GeneCards
219011_atPLEKHA4pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4Source|GeneCards
202408_s_atPRPF31PRP31 pre-mRNA processing factor 31 homolog (yeast)Source|GeneCards
209282_atPRKD2protein kinase D2Source|GeneCards
204398_s_atEML2echinoderm microtubule associated protein like 2Source|GeneCards
220233_atFBXO17F-box protein 17Source|GeneCards
218215_s_atNR1H2nuclear receptor subfamily 1, group H, member 2Source|GeneCards
211411_atFUT1Fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)Source|GeneCards
205341_atEHD2EH-domain containing 2Source|GeneCards
200646_s_atNUCB1nucleobindin 1Source|GeneCards
206445_s_atHRMT1L2HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae)Source|GeneCards


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