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Gene set: PANCREAS_CHR6_AGUIRRE (C2:CLIN:0005)
Standard namePANCREAS_CHR6_AGUIRRE
Systematic nameC2:CLIN:0005
Brief descriptionGenes on chromosome 6 with copy-number-driven expression in pancreatic adenocarcinoma.
CategoryC2: Curated
Sub-categoryCLIN: Clinical
Full description or Abstract
The pancreatic adenocarcinoma genome harbors multiple amplifications
and deletions, pointing to the existence of numerous oncogenes
and tumor suppressor genes driving the genesis and progression
of this lethal cancer. Here, array comparative genomic hybridization
on a cDNA microarray platform and informatics tools have been
used to define the copy number alterations in a panel of 24 pancreatic
adenocarcinoma cell lines and 13 primary tumor specimens. This
high-resolution genomic analysis has identified all known regional
gains and losses as well as many previously uncharacterized highly
recurrent copy number alterations. A systematic prioritization
scheme has selected 64 focal minimal common regions (MCRs) of
recurrent copy number change. These MCRs possess a median size
of 2.7 megabases (Mb), with 21 (33%) MCRs spanning 1 Mb or less
(median of 0.33 Mb) and possessing an average of 15 annotated
genes. Furthermore, complementary expression profile analysis
of a significant fraction of the genes residing within these 64
prioritized MCRs has enabled the identification of a subset of
candidates with statistically significant association between
gene dosage and mRNA expression. Thus, the integration of DNA
and RNA profiles provides a highly productive entry point for
the discovery of genes involved in the pathogenesis of pancreatic
adenocarcinoma. 
Publication URL15199222
External linksna
Keywords & MeSH headingsCell Line,Oligonucleotide Array Sequence Analysis,Genome,P.H.S.,Pancreatic Neoplasms,Nucleic Acid Hybridization/methods,Chromosomes/genetics,Animals,Human,Humans,Homozygote,Gene Expression,Chromosomes,Computational Biology/methods,Pair 17,genetics,Protein p16/genetics,Gene Deletion,Gene Dosage,Tumor
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

32 genes, 53 accessions (Toggle view)

AccessionGeneTitleLinks
213545_x_atSNX3sorting nexin 3Source|GeneCards
219307_atC6ORF210chromosome 6 open reading frame 210Source|GeneCards
208781_x_atSNX3sorting nexin 3Source|GeneCards
217185_s_atZNF259zinc finger protein 259Source|GeneCards
201915_atSEC63SEC63-like (S. cerevisiae)Source|GeneCards
212899_atCDC2L6cell division cycle 2-like 6 (CDK8-like)Source|GeneCards
201197_atAMD1adenosylmethionine decarboxylase 1Source|GeneCards
213451_x_atTNXBtenascin XBSource|GeneCards
203427_atASF1AASF1 anti-silencing function 1 homolog A (S. cerevisiae)Source|GeneCards
203376_atCDC40cell division cycle 40 homolog (yeast)Source|GeneCards
221786_atC6ORF120chromosome 6 open reading frame 120Source|GeneCards
205340_atZBTB24zinc finger and BTB domain containing 24Source|GeneCards
221569_atAHI1Abelson helper integration siteSource|GeneCards
221493_atTSPYL1TSPY-like 1Source|GeneCards
217931_atTNRC5trinucleotide repeat containing 5Source|GeneCards
203656_atKIAA0274KIAA0274Source|GeneCards
203430_atHEBP2heme binding protein 2Source|GeneCards
201196_s_atAMD1adenosylmethionine decarboxylase 1Source|GeneCards
219115_s_atIL20RAinterleukin 20 receptor, alphaSource|GeneCards
208654_s_atCD164CD164 antigen, sialomucinSource|GeneCards
209315_atHBS1LHBS1-like (S. cerevisiae)Source|GeneCards
203377_s_atCDC40cell division cycle 40 homolog (yeast)Source|GeneCards
201916_s_atSEC63SEC63-like (S. cerevisiae)Source|GeneCards
209314_s_atHBS1LHBS1-like (S. cerevisiae)Source|GeneCards
205622_atSMPD2sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)Source|GeneCards
201914_s_atSEC63SEC63-like (S. cerevisiae)Source|GeneCards
208070_s_atREV3LREV3-like, catalytic subunit of DNA polymerase zeta (yeast)Source|GeneCards
212897_atCDC2L6cell division cycle 2-like 6 (CDK8-like)Source|GeneCards
210939_s_atGRM1glutamate receptor, metabotropic 1Source|GeneCards
209479_atC6ORF80chromosome 6 open reading frame 80Source|GeneCards
202511_s_atAPG5LAPG5 autophagy 5-like (S. cerevisiae)Source|GeneCards
202512_s_atAPG5LAPG5 autophagy 5-like (S. cerevisiae)Source|GeneCards
208405_s_atCD164CD164 antigen, sialomucinSource|GeneCards
209316_s_atHBS1LHBS1-like (S. cerevisiae)Source|GeneCards
218603_atHECAheadcase homolog (Drosophila)Source|GeneCards
220841_s_atAHI1Abelson helper integration siteSource|GeneCards
218376_s_atMICAL1microtubule associated monoxygenase, calponin and LIM domain containing 1Source|GeneCards
210940_s_atGRM1glutamate receptor, metabotropic 1Source|GeneCards
210648_x_atSNX3sorting nexin 3Source|GeneCards
210639_s_atAPG5LAPG5 autophagy 5-like (S. cerevisiae)Source|GeneCards
208653_s_atCD164CD164 antigen, sialomucinSource|GeneCards
218949_s_atQRSL1glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1Source|GeneCards
203836_s_atMAP3K5mitogen-activated protein kinase kinase kinase 5Source|GeneCards
207299_s_atGRM1glutamate receptor, metabotropic 1Source|GeneCards
200067_x_atSNX3sorting nexin 3 /// sorting nexin 3Source|GeneCards
220842_atAHI1Abelson helper integration siteSource|GeneCards
219126_atPHF10PHD finger protein 10Source|GeneCards
202513_s_atPPP2R5Dprotein phosphatase 2, regulatory subunit B (B56), delta isoformSource|GeneCards
204165_atWASF1WAS protein family, member 1Source|GeneCards
214206_atSMPD2Sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)Source|GeneCards
201833_atHDAC2histone deacetylase 2Source|GeneCards
218948_atQRSL1glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1Source|GeneCards
203428_s_atASF1AASF1 anti-silencing function 1 homolog A (S. cerevisiae)Source|GeneCards


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