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Gene set: PEL_DOWN_KLEIN (C2:PERT:0042)
Standard namePEL_DOWN_KLEIN
Systematic nameC2:PERT:0042
Brief descriptionGenes downregulated in AIDS-related primary effusion lymphoma (PEL) cells compared to normal B cells and other tumor subtypes.
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
AIDS-related primary effusion lymphoma (PEL) is an HIV-associated
malignancy characterized by the ability of the tumor cells to
specifically home in the serous body cavities. Here we used gene
expression profile analysis (about 12 000 genes) to further define
the phenotype of PEL and to investigate the lymphoma relationship
to normal B cells and to other tumor subtypes, including non-Hodgkin
lymphomas (NHLs) of immunocompetent hosts and AIDS-associated
NHL (AIDS-NHL). The results showed that PEL displayed a common
gene expression profile that is clearly distinct from all NHLs
of immunocompetent hosts and AIDS-NHL subtypes and, in contrast
to those, is not related to germinal center (GC) or memory B cells.
The gene expression profile of PEL was defined as plasmablastic
because it showed features of both immunoblasts identified by
Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines
and AIDS immunoblastic lymphoma, and plasma cells, as defined
by multiple myeloma cell lines. Finally, our results identify
a set of genes specifically expressed in PEL tumor cells. Their
expression was validated at the protein level, suggesting their
potential pathogenetic and clinical significance. 
Publication URL12531789
External linksna
Keywords & MeSH headingsetiology,Gene Expression Profiling/methods,Lymphoma,Non-P.H.S.,P.H.S.,Comparative Study,classification,Transcription,Phenotype,Humans,pathology,B-Lymphocytes/immunology,Non-Hodgkin/genetics/pathology,genetics,Genetic,HIV Infections/complications/genetics
OrganismHuman
Contributed byKate Stafford
Source platformHG_U95Av2
Downloadgrp|xml|map
Genes

57 genes, 67 accessions (Toggle view)

AccessionGeneTitleLinks
37406_atMAPRE2Microtubule-associated protein, RP/EB family, member 2Source|GeneCards
1096_g_atCD19CD19 antigenSource|GeneCards
37598_atRASSF2Ras association (RalGDS/AF-6) domain family 2Source|GeneCards
38774_atSTX7Syntaxin 7Source|GeneCards
1717_s_atBIRC3baculoviral IAP repeat-containing 3Source|GeneCards
33999_f_atLOC90925hypothetical protein LOC90925Source|GeneCards
1518_atETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)Source|GeneCards
41585_atKIAA0746KIAA0746 proteinSource|GeneCards
1004_atBLR1Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)Source|GeneCards
34000_r_atLOC90925hypothetical protein LOC90925Source|GeneCards
33396_atGSTP1glutathione S-transferase piSource|GeneCards
1003_s_atBLR1Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)Source|GeneCards
31869_atNA
36634_atBTG2BTG family, member 2Source|GeneCards
38578_atTNFRSF7tumor necrosis factor receptor superfamily, member 7Source|GeneCards
794_atPTPN6protein tyrosine phosphatase, non-receptor type 6Source|GeneCards
37417_atPOU2F2POU domain, class 2, transcription factor 2Source|GeneCards
38391_atCAPGcapping protein (actin filament), gelsolin-likeSource|GeneCards
37162_atCCDC6coiled-coil domain containing 6Source|GeneCards
32941_atIRF8interferon regulatory factor 8Source|GeneCards
41337_atAESamino-terminal enhancer of splitSource|GeneCards
38893_atNCF4neutrophil cytosolic factor 4, 40kDaSource|GeneCards
41790_atALDH5A1aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)Source|GeneCards
36192_atSCRN1secernin 1Source|GeneCards
1977_s_atETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)Source|GeneCards
34210_atCD52CD52 antigen (CAMPATH-1 antigen)Source|GeneCards
40749_atMS4A1membrane-spanning 4-domains, subfamily A, member 1Source|GeneCards
38522_s_atCD22 /// MAGCD22 antigen /// myelin associated glycoproteinSource|GeneCards
35974_atLRMPlymphoid-restricted membrane proteinSource|GeneCards
829_s_atGSTP1glutathione S-transferase piSource|GeneCards
38992_atDEKDEK oncogene (DNA binding)Source|GeneCards
37021_atCTSHcathepsin HSource|GeneCards
37692_atDBIdiazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)Source|GeneCards
37479_atCD72CD72 antigenSource|GeneCards
37974_atMSL3L1male-specific lethal 3-like 1 (Drosophila)Source|GeneCards
38968_atSH3BP5SH3-domain binding protein 5 (BTK-associated)Source|GeneCards
40621_atPAWRPRKC, apoptosis, WT1, regulatorSource|GeneCards
36773_f_atHLA-DQB1major histocompatibility complex, class II, DQ beta 1Source|GeneCards
37344_atHLA-DMAmajor histocompatibility complex, class II, DM alphaSource|GeneCards
41609_atHLA-DMBmajor histocompatibility complex, class II, DM betaSource|GeneCards
38075_atSYPL1synaptophysin-like 1Source|GeneCards
34498_atVNN2vanin 2Source|GeneCards
37988_atCD79BCD79B antigen (immunoglobulin-associated beta)Source|GeneCards
34224_atFADS3fatty acid desaturase 3Source|GeneCards
619_s_atMS4A1membrane-spanning 4-domains, subfamily A, member 1Source|GeneCards
35149_atCD40CD40 antigen (TNF receptor superfamily member 5)Source|GeneCards
41356_atBCL11AB-cell CLL/lymphoma 11A (zinc finger protein)Source|GeneCards
38242_atBLNKB-cell linkerSource|GeneCards
41503_atZHX2zinc fingers and homeoboxes 2Source|GeneCards
34376_atPKIGprotein kinase (cAMP-dependent, catalytic) inhibitor gammaSource|GeneCards
37043_atID3inhibitor of DNA binding 3, dominant negative helix-loop-helix proteinSource|GeneCards
35238_atTRAF5TNF receptor-associated factor 5Source|GeneCards
36812_atBCAR3breast cancer anti-estrogen resistance 3Source|GeneCards
36878_f_atHLA-DQB1major histocompatibility complex, class II, DQ beta 1Source|GeneCards
35883_atSPIBSpi-B transcription factor (Spi-1/PU.1 related)Source|GeneCards
37112_atC6ORF32chromosome 6 open reading frame 32Source|GeneCards
266_s_atCD24CD24 antigen (small cell lung carcinoma cluster 4 antigen)Source|GeneCards
37565_atMMDmonocyte to macrophage differentiation-associatedSource|GeneCards
38017_atCD79ACD79A antigen (immunoglobulin-associated alpha)Source|GeneCards
40723_atSIT1signaling threshold regulating transmembrane adaptor 1Source|GeneCards
38894_g_atNCF4neutrophil cytosolic factor 4, 40kDa /// neutrophil cytosolic factor 4, 40kDaSource|GeneCards
38018_g_atCD79ACD79A antigen (immunoglobulin-associated alpha)Source|GeneCards
41355_atBCL11AB-cell CLL/lymphoma 11A (zinc finger protein)Source|GeneCards
36595_s_atGATMglycine amidinotransferase (L-arginine:glycine amidinotransferase)Source|GeneCards
41352_atST6GAL1ST6 beta-galactosamide alpha-2,6-sialyltranferase 1Source|GeneCards
36009_atGPX7glutathione peroxidase 7Source|GeneCards
39929_atKIAA0922KIAA0922 proteinSource|GeneCards


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