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Gene set: PML_RAR_ROSS (C2:PERT:0052)
Standard namePML_RAR_ROSS
Systematic nameC2:PERT:0052
Brief descriptionGenes that distinguish pediatric acute myeloid leukemia (AML) subtype t(15;17)[PML-RAR-alpha].
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Contemporary treatment of pediatric acute myeloid leukemia (AML)
requires the assignment of patients to specific risk groups. To
explore whether expression profiling of leukemic blasts could
accurately distinguish between the known risk groups of AML, we
analyzed 130 pediatric and 20 adult AML diagnostic bone marrow
or peripheral blood samples using the Affymetrix U133A microarray.
Class discriminating genes were identified for each of the major
prognostic subtypes of pediatric AML, including t(15;17)[PML-RARalpha],
t(8;21)[AML1-ETO], inv(16) [CBFbeta-MYH11], MLL chimeric fusion
genes, and cases classified as FAB-M7. When subsets of these genes
were used in supervised learning algorithms, an overall classification
accuracy of more than 93% was achieved. Moreover, we were able
to use the expression signatures generated from the pediatric
samples to accurately classify adult de novo AMLs with the same
genetic lesions. The class discriminating genes also provided
novel insights into the molecular pathobiology of these leukemias.
Finally, using a combined pediatric data set of 130 AMLs and 137
acute lymphoblastic leukemias, we identified an expression signature
for cases with MLL chimeric fusion genes irrespective of lineage.
Surprisingly, AMLs containing partial tandem duplications of MLL
failed to cluster with MLL chimeric fusion gene cases, suggesting
a significant difference in their underlying mechanism of transformation.
Publication URL15226186
External linksna
Keywords & MeSH headingsTranscription Factors/genetics,Prognosis,Acute,Gene Expression Profiling,P.H.S.,classification,Oncogene Proteins,Proto-Oncogenes/genetics,Risk Factors,Blood,Fusion/genetics,Humans,Leukemia,genetics,Myelocytic,Child,DNA-Binding Proteins/genetics,Cluster Analysis,Algorithms,Tandem Repeat Sequences,Bone Marrow
OrganismHuman
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

79 genes, 100 accessions (Toggle view)

AccessionGeneTitleLinks
219225_atPGBD5piggyBac transposable element derived 5Source|GeneCards
212187_x_atPTGDSprostaglandin D2 synthase 21kDa (brain)Source|GeneCards
202260_s_atSTXBP1syntaxin binding protein 1Source|GeneCards
209960_atHGFhepatocyte growth factor (hepapoietin A; scatter factor)Source|GeneCards
202956_atARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)Source|GeneCards
214582_atPDE3Bphosphodiesterase 3B, cGMP-inhibitedSource|GeneCards
203949_atMPOmyeloperoxidaseSource|GeneCards
205624_atCPA3carboxypeptidase A3 (mast cell)Source|GeneCards
221636_s_atMOSC2MOCO sulphurase C-terminal domain containing 2Source|GeneCards
201591_s_atNISCHnischarinSource|GeneCards
212285_s_atAGRNagrinSource|GeneCards
213355_atST3GAL6ST3 beta-galactoside alpha-2,3-sialyltransferase 6Source|GeneCards
203948_s_atMPOmyeloperoxidaseSource|GeneCards
200825_s_atHYOU1hypoxia up-regulated 1Source|GeneCards
200654_atP4HBprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1)Source|GeneCards
205518_s_atCMAHcytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-N-acetylneuraminate monooxygenase)Source|GeneCards
212566_atMAP4microtubule-associated protein 4Source|GeneCards
212204_atDKFZP564G2022DKFZP564G2022 proteinSource|GeneCards
211663_x_atPTGDSprostaglandin D2 synthase 21kDa (brain) /// prostaglandin D2 synthase 21kDa (brain)Source|GeneCards
212012_atPXDNperoxidasin homolog (Drosophila)Source|GeneCards
209686_atS100BS100 calcium binding protein, beta (neural)Source|GeneCards
39248_atAQP3aquaporin 3Source|GeneCards
38487_atSTAB1stabilin 1Source|GeneCards
218922_s_atLASS4LAG1 longevity assurance homolog 4 (S. cerevisiae)Source|GeneCards
221042_s_atCLMNcalmin (calponin-like, transmembrane)Source|GeneCards
212509_s_atMXRA7matrix-remodelling associated 7Source|GeneCards
216614_atFAM20CFamily with sequence similarity 20, member CSource|GeneCards
201063_atRCN1reticulocalbin 1, EF-hand calcium binding domainSource|GeneCards
200986_atSERPING1serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)Source|GeneCards
207895_atNAALADL1N-acetylated alpha-linked acidic dipeptidase-like 1Source|GeneCards
221850_x_atCTGLF1 /// LOC399753protein /// hypothetical gene supported by AK093334; AL833330; BC020871; BC032492Source|GeneCards
200945_s_atSEC31L1SEC31-like 1 (S. cerevisiae)Source|GeneCards
203916_atNDST2N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2Source|GeneCards
211936_atHSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Source|GeneCards
201952_atALCAMactivated leukocyte cell adhesion moleculeSource|GeneCards
212810_s_atSLC1A4solute carrier family 1 (glutamate/neutral amino acid transporter), member 4Source|GeneCards
210997_atHGFhepatocyte growth factor (hepapoietin A; scatter factor)Source|GeneCards
212599_atAUTS2autism susceptibility candidate 2Source|GeneCards
45687_atMGC3121hypothetical protein MGC3121Source|GeneCards
209099_x_atJAG1jagged 1 (Alagille syndrome)Source|GeneCards
203364_s_atKIAA0652KIAA0652 gene productSource|GeneCards
100201581_at
210755_atHGFhepatocyte growth factor (hepapoietin A; scatter factor)Source|GeneCards
217961_atFLJ20551hypothetical protein FLJ20551Source|GeneCards
203074_atANXA8annexin A8Source|GeneCards
3.2206335_at
200935_atCALRcalreticulinSource|GeneCards
216268_s_atJAG1jagged 1 (Alagille syndrome)Source|GeneCards
210999_s_atGRB10growth factor receptor-bound protein 10Source|GeneCards
203221_atTLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)Source|GeneCards
204446_s_atALOX5arachidonate 5-lipoxygenaseSource|GeneCards
205505_atGCNT1glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)Source|GeneCards
214203_s_atPRODHproline dehydrogenase (oxidase) 1Source|GeneCards
205110_s_atFGF13fibroblast growth factor 13Source|GeneCards
213385_atCHN2Chimerin (chimaerin) 2Source|GeneCards
216320_x_atMST1macrophage stimulating 1 (hepatocyte growth factor-like)Source|GeneCards
219167_atRASL12RAS-like, family 12Source|GeneCards
203151_atMAP1Amicrotubule-associated protein 1ASource|GeneCards
204099_atSMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3Source|GeneCards
210140_atCST7cystatin F (leukocystatin)Source|GeneCards
214228_x_atTNFRSF4tumor necrosis factor receptor superfamily, member 4Source|GeneCards
217653_x_atNA
218714_atMGC3121hypothetical protein MGC3121Source|GeneCards
209961_s_atHGFhepatocyte growth factor (hepapoietin A; scatter factor)Source|GeneCards
213380_x_atMSTP9macrophage stimulating, pseudogene 9Source|GeneCards
219491_atLRFN4leucine rich repeat and fibronectin type III domain containing 4Source|GeneCards
205899_atCCNA1cyclin A1Source|GeneCards
37408_atMRC2mannose receptor, C type 2Source|GeneCards
221971_x_atCTGLF1 /// LOC399753protein /// similar to centaurin, gamma-like family, member 1; ARF GTPase-activating protein; Em:AC012044.1Source|GeneCards
209574_s_atC18ORF1chromosome 18 open reading frame 1Source|GeneCards
213348_atCDKN1CCyclin-dependent kinase inhibitor 1C (p57, Kip2)Source|GeneCards
214315_x_atCALRcalreticulinSource|GeneCards
214450_atCTSWcathepsin W (lymphopain) /// cathepsin W (lymphopain)Source|GeneCards
213492_atCOL2A1collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)Source|GeneCards
210998_s_atHGFhepatocyte growth factor (hepapoietin A; scatter factor)Source|GeneCards
202650_s_atKIAA0195KIAA0195 gene productSource|GeneCards
211748_x_atPTGDSprostaglandin D2 synthase 21kDa (brain) /// prostaglandin D2 synthase 21kDa (brain)Source|GeneCards
204150_atSTAB1stabilin 1Source|GeneCards
202660_atITPR2Inositol 1,4,5-triphosphate receptor, type 2Source|GeneCards
210794_s_atMEG3maternally expressed 3Source|GeneCards
212013_atPXDNperoxidasin homolog (Drosophila)Source|GeneCards
201596_x_atKRT18keratin 18Source|GeneCards
204425_atARHGAP4Rho GTPase activating protein 4Source|GeneCards
201069_atMMP2matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)Source|GeneCards
205614_x_atMST1macrophage stimulating 1 (hepatocyte growth factor-like)Source|GeneCards
221799_atCSGLCA-Tchondroitin sulfate glucuronyltransferaseSource|GeneCards
202718_atIGFBP2insulin-like growth factor binding protein 2, 36kDaSource|GeneCards
202655_atARMETarginine-rich, mutated in early stage tumorsSource|GeneCards
212953_x_atCALRcalreticulinSource|GeneCards
205382_s_atDFD component of complement (adipsin)Source|GeneCards
219868_s_atANKFY1ankyrin repeat and FYVE domain containing 1Source|GeneCards
213942_atEGFL3EGF-like-domain, multiple 3Source|GeneCards
217419_x_atAGRNagrinSource|GeneCards
202662_s_atITPR2inositol 1,4,5-triphosphate receptor, type 2Source|GeneCards
221804_s_atFAM45B /// FAM45Afamily with sequence similarity 45, member B /// family with sequence similarity 45, member ASource|GeneCards
206105_atAFF2AF4/FMR2 family, member 2Source|GeneCards
205047_s_atASNSasparagine synthetaseSource|GeneCards
219527_atMOSC2MOCO sulphurase C-terminal domain containing 2Source|GeneCards
218618_s_atFNDC3Bfibronectin type III domain containing 3BSource|GeneCards
207106_s_atLTKleukocyte tyrosine kinaseSource|GeneCards


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