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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: SA_CASPASE_CASCADE (C2:PATH:0227)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>SA_CASPASE_CASCADE</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PATH:0227</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PATH: Pathway database</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><div id='myvar_a_vis'><pre>na</pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'>More details for this gene set:<br><a href='http://www.sigmaaldrich.com/Area_of_Interest/Life_Science/Cell_Signaling/Scientific_Resources/Pathway_Slides___Charts/Caspase_Cascade.html' target='EXTERNAL'>http://www.sigmaaldrich.com/Area_of_Interest/Life_Science/Cell_Signaling/Scientific_Resources/Pathway_Slides___Charts/Caspase_Cascade.html</a><br></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Generic</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'><a href='http://www.sigmaaldrich.com/Area_of_Interest/Biochemicals/Enzyme_Explorer/Key_Resources.html' target='EXTERNAL'>SigmaAldrich</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Gene_Symbol</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='SA_CASPASE_CASCADE.grp'>grp</a>|<a href='SA_CASPASE_CASCADE.xml'>xml</a>|<a href='SA_CASPASE_CASCADE.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>19 genes, 19 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='3' class='fancy' border='0'><tr><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td>CASP9</td><td>caspase 9, apoptosis-related cysteine protease</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CASP9' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CASP9' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>BIRC3</td><td>baculoviral IAP repeat-containing 3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BIRC3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BIRC3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SREBF1</td><td>sterol regulatory element binding transcription factor 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SREBF1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SREBF1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>PRF1</td><td>perforin 1 (pore forming protein)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=PRF1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?PRF1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>GZMB</td><td>granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GZMB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GZMB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>DFFB</td><td>DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DFFB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DFFB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CASP7</td><td>caspase 7, apoptosis-related cysteine protease</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CASP7' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CASP7' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CASP3</td><td>caspase 3, apoptosis-related cysteine protease</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CASP3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CASP3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>BIRC4</td><td>baculoviral IAP repeat-containing 4</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BIRC4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BIRC4' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr></tr><tr><td>SCAP</td><td>SREBP CLEAVAGE-ACTIVATING PROTEIN</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SCAP' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SCAP' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>BIRC2</td><td>baculoviral IAP repeat-containing 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BIRC2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BIRC2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CASP8</td><td>caspase 8, apoptosis-related cysteine protease</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CASP8' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CASP8' target='EXTERNAL'>GeneCards</a></td></tr><tr></tr><tr><td>DFFA</td><td>DNA fragmentation factor, 45kDa, alpha polypeptide</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=DFFA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?DFFA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>CASP10</td><td>caspase 10, apoptosis-related cysteine protease</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CASP10' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CASP10' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>APAF1</td><td>apoptotic protease activating factor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=APAF1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?APAF1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td>SREBF2</td><td>sterol regulatory element binding transcription factor 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SREBF2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SREBF2' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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