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<hr><table align='center' width='75%' border='0' cols='2'><th colspan='2' class='highlight'>Gene set: TARTE_BCELL (C2:PERT:0060)</th><tr><td bgcolor='#99CCFF' width='25%'>Standard name</td><td width='75%'>TARTE_BCELL</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Systematic name</td><td width='75%'>C2:PERT:0060</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Brief description</td><td width='75%'>Genes overexpressed in B cells purified from peripheral blood (PBBs) and tonsils (TBCs), as compared to polyclonal plasmablastic cells (PPCs), mature plasma cells isolated from tonsils (TPCs), and mature plasma cells isolated from bone marrow (BMPCs).</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Category</td><td width='75%'>C2: Curated</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Sub-category</td><td width='75%'>PERT: Experimental pertuberation</td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Full description or Abstract</td><td width='75%'><p><a onClick="switchAbstract('myvar_a');" title='Toggle abstract view'>Toggle abstract view</a><div id='myvar_a'><pre>Plasma cells (PCs), the end point of B-cell differentiation, are
a heterogeneous cell compartment comprising several cell subsets
from short-lived highly proliferative plasmablasts to long-lived
nondividing fully mature PCs. Whereas the major transcription
factors driving the differentiation of B cells to PCs were recently
identified, the subtle genetic changes that underlie the transition
from plasmablasts to mature PCs are poorly understood. We recently
described an in vitro model making it possible to obtain a large
number of cells with the morphologic, phenotypic, and functional
characteristics of normal polyclonal plasmablastic cells (PPCs).
Using Affymetrix microarrays we compared the gene expression profiles
of these PPCs with those of mature PCs isolated from tonsils (TPCs)
and bone marrow (BMPCs), and with those of B cells purified from
peripheral blood (PBB cells) and tonsils (TBCs). Unsupervised
principal component analysis clearly distinguished the 5 cell
populations on the basis of their differentiation and proliferation
status. Detailed statistical analysis allowed the identification
of 85 PC genes and 40 B-cell genes, overexpressed, respectively,
in the 3 PC subsets or in the 2 B-cell subsets. In addition, several
signaling molecules and antiapoptotic proteins were found to be
induced in BMPCs compared with PPCs and could be involved in the
accumulation and prolonged survival of BMPCs in close contact
with specialized stromal microenvironment. These data should help
to better understand the molecular events that regulate commitment
to a PC fate, mediate PC maintenance in survival niches, and could
facilitate PC immortalization in plasma cell dyscrasias. </pre></div></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Publication URL</td><td width='75%'><a href='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12663452' target='EXTERNAL'>12663452</a></td></tr><tr><td bgcolor='#99CCFF' width='25%'>External links</td><td width='75%'><font color='#C0C0C0'>na</font></td></tr><tr><td bgcolor='#99CCFF' width='25%'>Keywords & MeSH headings</td><td width='75%'>Cell Differentiation/genetics,RNA,Plasma Cells,Gene Expression Profiling,Oligonucleotide Array Sequence Analysis,Comparative Study,Paracrine Communication/genetics,B-Lymphocytes,Cell Communication/genetics,Cell Separation,Complementary/genetics,Humans,Developmental,Signal Transduction/genetics,Reverse Transcriptase Polymerase Chain Reaction,Gene Expression Regulation,Cell Line/cytology/metabolism,metabolism</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Organism</td><td width='75%'>Human</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Contributed by</td><td width='75%'>Kate Stafford</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Source platform</td><td width='75%'>Hu6800</td></tr><tr><td bgcolor='#99CCFF' width='25%'>Download</td><td width='75%'><a href='TARTE_BCELL.grp'>grp</a>|<a href='TARTE_BCELL.xml'>xml</a>|<a href='TARTE_BCELL.xls'>map</a></td></tr><tr><td valign='top' bgcolor='#99CCFF' width='25%'>Genes</td><td><p>38 genes, 40 accessions (<a onClick="switchGeneTable('myvar_g');" title='Toggle view'>Toggle view</a>)<div id='myvar_g'><table cols='4' class='fancy' border='0'><tr><th align='center'>Accession</th><th align='center'>Gene</th><th align='center'>Title</th><th align='center'>Links</th></tr><tr><td width='75%'>HG4322-HT4592_at</td><td>NA</td></tr><tr><td width='75%'>D50683_at</td><td>TGFBR2</td><td>transforming growth factor, beta receptor II (70/80kDa)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TGFBR2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TGFBR2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X82200_at</td><td>TRIM22</td><td>tripartite motif-containing 22</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=TRIM22' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?TRIM22' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>D26070_at</td><td>ITPR1</td><td>inositol 1,4,5-triphosphate receptor, type 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ITPR1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ITPR1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X07203_at</td><td>MS4A1</td><td>membrane-spanning 4-domains, subfamily A, member 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MS4A1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MS4A1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U83115_at</td><td>AIM1</td><td>absent in melanoma 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=AIM1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?AIM1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M91196_at</td><td>IRF8</td><td>interferon regulatory factor 8</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IRF8' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IRF8' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>AF009674_at</td><td>AXIN1</td><td>axin 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=AXIN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?AXIN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X74301_s_at</td><td>MHC2TA</td><td>MHC class II transactivator</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MHC2TA' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MHC2TA' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>D80006_at</td><td>MOBK1B</td><td>MOB1, Mps One Binder kinase activator-like 1B (yeast)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MOBK1B' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MOBK1B' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U19247_rna1_s_at</td><td>IFNGR1</td><td>interferon gamma receptor 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IFNGR1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IFNGR1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X94232_at</td><td>MAPRE2</td><td>microtubule-associated protein, RP/EB family, member 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MAPRE2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MAPRE2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>HG1111-HT1111_at</td><td>NA</td></tr><tr><td width='75%'>U32645_at</td><td>ELF4</td><td>E74-like factor 4 (ets domain transcription factor)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=ELF4' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?ELF4' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X68149_at</td><td>BLR1</td><td>Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BLR1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BLR1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U68485_at</td><td>BIN1</td><td>bridging integrator 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BIN1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BIN1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>D86960_at</td><td>LPGAT1</td><td>lysophosphatidylglycerol acyltransferase 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LPGAT1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LPGAT1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X61587_at</td><td>RHOG</td><td>ras homolog gene family, member G (rho G)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RHOG' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RHOG' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U89922_s_at</td><td>LTB</td><td>lymphotoxin beta (TNF superfamily, member 3)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LTB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LTB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>S76617_at</td><td>BLK</td><td>B lymphoid tyrosine kinase</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=BLK' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?BLK' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M93056_at</td><td>SERPINB1</td><td>serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SERPINB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SERPINB1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U19523_at</td><td>GCH1</td><td>GTP cyclohydrolase 1 (dopa-responsive dystonia)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GCH1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GCH1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>L19872_at</td><td>AHR</td><td>aryl hydrocarbon receptor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=AHR' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?AHR' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M97287_at</td><td>SATB1</td><td>special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=SATB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?SATB1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X67235_s_at</td><td>HHEX</td><td>hematopoietically expressed homeobox</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HHEX' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HHEX' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X85750_at</td><td>MMD</td><td>monocyte to macrophage differentiation-associated</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=MMD' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?MMD' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X14046_at</td><td>CD37</td><td>CD37 antigen</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CD37' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CD37' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M92287_at</td><td>CCND3</td><td>cyclin D3</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CCND3' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CCND3' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>D63482_at</td><td>GIT2</td><td>G protein-coupled receptor kinase interactor 2</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GIT2' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GIT2' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>Z35227_at</td><td>RHOH</td><td>ras homolog gene family, member H</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RHOH' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RHOH' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M58459_at</td><td>RPS4Y1</td><td>ribosomal protein S4, Y-linked 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=RPS4Y1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?RPS4Y1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U91616_at</td><td>NFKBIE</td><td>nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NFKBIE' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NFKBIE' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M22638_at</td><td>LYL1</td><td>lymphoblastic leukemia derived sequence 1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LYL1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LYL1' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>L42324_at</td><td>GPR18</td><td>G protein-coupled receptor 18</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=GPR18' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?GPR18' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>Z11697_at</td><td>CD83</td><td>CD83 antigen (activated B lymphocytes, immunoglobulin superfamily)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=CD83' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?CD83' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X52425_at</td><td>IL4R</td><td>interleukin 4 receptor</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=IL4R' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?IL4R' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U95740_rna1_at</td><td>LKAP</td><td>limkain b1</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=LKAP' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?LKAP' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>U15085_at</td><td>HLA-DMB</td><td>major histocompatibility complex, class II, DM beta</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=HLA-DMB' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?HLA-DMB' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>X75042_at</td><td>REL</td><td>v-rel reticuloendotheliosis viral oncogene homolog (avian)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=REL' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?REL' target='EXTERNAL'>GeneCards</a></td></tr><tr><td width='75%'>M58603_at</td><td>NFKB1</td><td>nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)</td><td><a href='http://genome-www5.stanford.edu/cgi-bin/SMD/source/sourceResult?option=Name&choice=Gene&organism=Hs&criteria=NFKB1' target='EXTERNAL'>Source</a>|<a href='http://genome-www.stanford.edu/cgi-bin/genecards/carddisp?NFKB1' target='EXTERNAL'>GeneCards</a></td></tr></table></div></td></tr></table></div><br><hr>
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