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Gene set: TARTE_PC (C2:PERT:0058)
Standard nameTARTE_PC
Systematic nameC2:PERT:0058
Brief descriptionGenes overexpressed in polyclonal plasmablastic cells (PPCs), mature plasma cells isolated from tonsils (TPCs), and mature plasma cells isolated from bone marrow (BMPCs), as compared to B cells purified from peripheral blood (PBBs) and tonsils (TBCs).
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract

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Plasma cells (PCs), the end point of B-cell differentiation, are
a heterogeneous cell compartment comprising several cell subsets
from short-lived highly proliferative plasmablasts to long-lived
nondividing fully mature PCs. Whereas the major transcription
factors driving the differentiation of B cells to PCs were recently
identified, the subtle genetic changes that underlie the transition
from plasmablasts to mature PCs are poorly understood. We recently
described an in vitro model making it possible to obtain a large
number of cells with the morphologic, phenotypic, and functional
characteristics of normal polyclonal plasmablastic cells (PPCs).
Using Affymetrix microarrays we compared the gene expression profiles
of these PPCs with those of mature PCs isolated from tonsils (TPCs)
and bone marrow (BMPCs), and with those of B cells purified from
peripheral blood (PBB cells) and tonsils (TBCs). Unsupervised
principal component analysis clearly distinguished the 5 cell
populations on the basis of their differentiation and proliferation
status. Detailed statistical analysis allowed the identification
of 85 PC genes and 40 B-cell genes, overexpressed, respectively,
in the 3 PC subsets or in the 2 B-cell subsets. In addition, several
signaling molecules and antiapoptotic proteins were found to be
induced in BMPCs compared with PPCs and could be involved in the
accumulation and prolonged survival of BMPCs in close contact
with specialized stromal microenvironment. These data should help
to better understand the molecular events that regulate commitment
to a PC fate, mediate PC maintenance in survival niches, and could
facilitate PC immortalization in plasma cell dyscrasias. 
Publication URL12663452
External linksna
Keywords & MeSH headingsCell Differentiation/genetics,RNA,Plasma Cells,Gene Expression Profiling,Oligonucleotide Array Sequence Analysis,Comparative Study,Paracrine Communication/genetics,B-Lymphocytes,Cell Communication/genetics,Cell Separation,Complementary/genetics,Humans,Developmental,Signal Transduction/genetics,Reverse Transcriptase Polymerase Chain Reaction,Gene Expression Regulation,Cell Line/cytology/metabolism,metabolism
OrganismHuman
Contributed byKate Stafford
Source platformHu6800
Downloadgrp|xml|map
Genes

81 genes, 85 accessions (Toggle view)

AccessionGeneTitleLinks
L13720_atGAS6growth arrest-specific 6Source|GeneCards
M64098_atHDLBPhigh density lipoprotein binding protein (vigilin)Source|GeneCards
D29643_atDDOSTdolichyl-diphosphooligosaccharide-protein glycosyltransferaseSource|GeneCards
U95626_rna1_atCCR2chemokine (C-C motif) receptor 2Source|GeneCards
U65093_atCITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2Source|GeneCards
M63928_atTNFRSF7tumor necrosis factor receptor superfamily, member 7Source|GeneCards
D32050_atAARSalanyl-tRNA synthetaseSource|GeneCards
U10362_atLMAN2lectin, mannose-binding 2Source|GeneCards
M88458_atKDELR2KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2Source|GeneCards
M77836_atPYCR1pyrroline-5-carboxylate reductase 1Source|GeneCards
U81006_atTM9SF2transmembrane 9 superfamily member 2Source|GeneCards
U60644_atPLD3phospholipase D family, member 3Source|GeneCards
M20566_atIL6Rinterleukin 6 receptorSource|GeneCards
Z29574_atTNFRSF17tumor necrosis factor receptor superfamily, member 17Source|GeneCards
U25182_atPRDX4peroxiredoxin 4Source|GeneCards
M57710_atLGALS3 /// GALIGlectin, galactoside-binding, soluble, 3 (galectin 3) /// galectin-3 internal geneSource|GeneCards
X63679_atTRAM1translocation associated membrane protein 1Source|GeneCards
L40391_atTMP21transmembrane trafficking proteinSource|GeneCards
X74837_atMAN1A1mannosidase, alpha, class 1A, member 1Source|GeneCards
U88629_atELL2elongation factor, RNA polymerase II, 2Source|GeneCards
X72475_atNA
U52682_atIRF4interferon regulatory factor 4Source|GeneCards
Z18951_atCAV1caveolin 1, caveolae protein, 22kDaSource|GeneCards
L33881_atPRKCIprotein kinase C, iotaSource|GeneCards
M36341_atARF4ADP-ribosylation factor 4Source|GeneCards
Z36531_atFGL2fibrinogen-like 2Source|GeneCards
U89606_atPDXKpyridoxal (pyridoxine, vitamin B6) kinaseSource|GeneCards
U25956_atSELPLGselectin P ligandSource|GeneCards
L10284_atCANXcalnexinSource|GeneCards
X93921_atDUSP7dual specificity phosphatase 7Source|GeneCards
U31628_atIL15RAinterleukin 15 receptor, alphaSource|GeneCards
L06419_atPLOD1procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1Source|GeneCards
Z81326_atSERPINI1serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1Source|GeneCards
L17128_atGGCXgamma-glutamyl carboxylaseSource|GeneCards
U11037_atSEL1Lsel-1 suppressor of lin-12-like (C. elegans)Source|GeneCards
D89289_atFUT8fucosyltransferase 8 (alpha (1,6) fucosyltransferase)Source|GeneCards
D37931_atRNASE4ribonuclease, RNase A family, 4Source|GeneCards
M83751_atARMETarginine-rich, mutated in early stage tumorsSource|GeneCards
M23294_atHEXBhexosaminidase B (beta polypeptide)Source|GeneCards
X55885_atKDELR1KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1Source|GeneCards
AB001325_atAQP3aquaporin 3Source|GeneCards
X96754_atIGKCImmunoglobulin kappa constantSource|GeneCards
Z12830_atSSR1signal sequence receptor, alpha (translocon-associated protein alpha)Source|GeneCards
AJ000480_atTRIB1tribbles homolog 1 (Drosophila)Source|GeneCards
Y00282_atRPN2ribophorin IISource|GeneCards
X17042_atPRG1proteoglycan 1, secretory granuleSource|GeneCards
D31762_atTRAM2translocation associated membrane protein 2Source|GeneCards
D84276_atCD38CD38 antigen (p45)Source|GeneCards
M14219_atSSR1signal sequence receptor, alpha (translocon-associated protein alpha)Source|GeneCards
X78687_atNEU1sialidase 1 (lysosomal sialidase)Source|GeneCards
L42450_atPDK1pyruvate dehydrogenase kinase, isoenzyme 1Source|GeneCards
X55330_atAGAaspartylglucosaminidaseSource|GeneCards
D49489_atPDIA6protein disulfide isomerase family A, member 6Source|GeneCards
U88047_atARID3AAT rich interactive domain 3A (BRIGHT- like)Source|GeneCards
M19645_atHSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Source|GeneCards
Y09022_atALG3asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase)Source|GeneCards
L25085_atSEC61BSec61 beta subunitSource|GeneCards
X69910_atCKAP4cytoskeleton-associated protein 4Source|GeneCards
U60519_atCASP10caspase 10, apoptosis-related cysteine proteaseSource|GeneCards
HG3872-HT4142_atNA
X57398_atNOMO1 /// NOMO2 ///NODAL modulator 1 /// NODAL modulator 2 /// NODAL modulator 3Source|GeneCards
U47025_s_atPYGBphosphorylase, glycogen; brainSource|GeneCards
U65785_atHYOU1hypoxia up-regulated 1Source|GeneCards
D14658_atSPCS2signal peptidase complex subunit 2 homolog (S. cerevisiae)Source|GeneCards
X57809_atIGL@immunoglobulin lambda locusSource|GeneCards
M61827_rna1_s_atSPNsialophorin (gpL115, leukosialin, CD43)Source|GeneCards
X90999_atHAGHhydroxyacylglutathione hydrolaseSource|GeneCards
D87989_atSLC35B1solute carrier family 35, member B1Source|GeneCards
D14659_atKIAA0103KIAA0103Source|GeneCards
M75099_atFKBP2FK506 binding protein 2, 13kDaSource|GeneCards
J02783_atP4HBprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1)Source|GeneCards
S83365_atYIF1AYip1 interacting factor homolog A (S. cerevisiae)Source|GeneCards
X53586_rna1_atITGA6integrin, alpha 6Source|GeneCards
X76732_atNUCB2nucleobindin 2Source|GeneCards
D49490_atPDIA5protein disulfide isomerase family A, member 5Source|GeneCards
HG3790-HT4060_atNA
X57303_atSLC7A1solute carrier family 7 (cationic amino acid transporter, y+ system), member 1Source|GeneCards
Y00281_atRPN1ribophorin ISource|GeneCards
X95876_atCXCR3chemokine (C-X-C motif) receptor 3Source|GeneCards
X51755_cds5_s_atIGLC1immunoglobulin lambda constant 1 (Mcg marker)Source|GeneCards
X15187_atTRA1tumor rejection antigen (gp96) 1Source|GeneCards
M63573_atPPIBpeptidylprolyl isomerase B (cyclophilin B)Source|GeneCards
L38961_atITM1integral membrane protein 1Source|GeneCards
D82061_atHSD17B8hydroxysteroid (17-beta) dehydrogenase 8Source|GeneCards
M32334_atICAM2intercellular adhesion molecule 2Source|GeneCards


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