| Gene set: TH_DOWN_KIM (C2:PERT:0071) | | Standard name | TH_DOWN_KIM |
| Systematic name | C2:PERT:0071 |
| Brief description | Genes downreguated in human germinal center helper-T (Th) cells versus other CD4+ T-cell types such as naive T cells (from which the others originate), CXCR5+ CCR7+ central memory cells, and CCR7- effector memory cells. |
| Category | C2: Curated |
| Sub-category | PERT: Experimental pertuberation |
| Full description or Abstract | Gene expression profiling was used to compare the gene expression
patterns of human germinal center (GC) T helper (Th) cells with
other CD4+ T-cell subsets (naive, central, and effector memory
T cells). GC-Th cells, specifically localized in germinal centers
to help B cells, are distantly related to central and effector
memory T cells in global gene expression profiles. GC-Th cells
displayed substantial differences in mRNA for adhesion molecules,
chemoattractant receptors, and cytokines compared with other populations.
Distinct expression of transcriptional factors by GC-Th cells
is consistent with the hypothesis that they may be different from
other T cells in cell lineage. Interestingly, CXCL13, a critical
chemokine for B-cell entry to lymphoid follicles, is one of the
most highly up-regulated genes in GC-Th cells. GC-Th cells (but
not other T cells) produce and secrete large amounts of functional
CXCL13 upon T-cell receptor activation, a process that is dependent
on costimulation, requires translation and transcription, and
is dramatically enhanced by activation in the presence of GC-B
cells. This study revealed for the first time the unique gene
expression program of GC-Th cells. |
| Publication URL | 15213097 |
| External links | na |
| Keywords & MeSH headings | Neoplastic,Chemokines,Oligonucleotide Array Sequence Analysis,Lymphocyte Activation,P.H.S.,Immunohistochemistry,Cells,Messenger/metabolism,Leukocytes,T-Lymphocytes,Flow Cytometry,CXC/biosynthesis,Up-Regulation,Preschool,Child,Cultured,Mononuclear/metabolism,metabolism,Helper-Inducer,RNA,Humans,Chemotaxis,Gene Expression Regulation,Enzyme-Linked Immunosorbent Assay,CD4-Positive T-Lymphocytes/metabolism,Germinal Center |
| Organism | Human |
| Contributed by | Kate Stafford |
| Source platform | Seq_Accession |
| Download | grp|xml|map |
| Genes | 27 genes, 27 accessions (Toggle view) |