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Gene set: TH_UP_KIM (C2:PERT:0072)
Standard nameTH_UP_KIM
Systematic nameC2:PERT:0072
Brief descriptionGenes upreguated in human germinal center helper-T (Th) cells versus other CD4+ T-cell types such as naive T cells (from which the others originate), CXCR5+ CCR7+ central memory cells, and CCR7- effector memory cells.
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Gene expression profiling was used to compare the gene expression
patterns of human germinal center (GC) T helper (Th) cells with
other CD4+ T-cell subsets (naive, central, and effector memory
T cells). GC-Th cells, specifically localized in germinal centers
to help B cells, are distantly related to central and effector
memory T cells in global gene expression profiles. GC-Th cells
displayed substantial differences in mRNA for adhesion molecules,
chemoattractant receptors, and cytokines compared with other populations.
Distinct expression of transcriptional factors by GC-Th cells
is consistent with the hypothesis that they may be different from
other T cells in cell lineage. Interestingly, CXCL13, a critical
chemokine for B-cell entry to lymphoid follicles, is one of the
most highly up-regulated genes in GC-Th cells. GC-Th cells (but
not other T cells) produce and secrete large amounts of functional
CXCL13 upon T-cell receptor activation, a process that is dependent
on costimulation, requires translation and transcription, and
is dramatically enhanced by activation in the presence of GC-B
cells. This study revealed for the first time the unique gene
expression program of GC-Th cells. 
Publication URL15213097
External linksna
Keywords & MeSH headingsNeoplastic,Chemokines,Oligonucleotide Array Sequence Analysis,Lymphocyte Activation,P.H.S.,Immunohistochemistry,Cells,Messenger/metabolism,Leukocytes,T-Lymphocytes,Flow Cytometry,CXC/biosynthesis,Up-Regulation,Preschool,Child,Cultured,Mononuclear/metabolism,metabolism,Helper-Inducer,RNA,Humans,Chemotaxis,Gene Expression Regulation,Enzyme-Linked Immunosorbent Assay,CD4-Positive T-Lymphocytes/metabolism,Germinal Center
OrganismHuman
Contributed byKate Stafford
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

67 genes, 67 accessions (Toggle view)

AccessionGeneTitleLinks
KLHL6KLHL6kelch-like 6 (Drosophila)Source|GeneCards
MAN1A1MAN1A1mannosidase, alpha, class 1A, member 1Source|GeneCards
PON2PON2paraoxonase 2Source|GeneCards
FLJ22729C17ORF42chromosome 17 open reading frame 42Source|GeneCards
AA281797
H84871
PHACTR2PHACTR2phosphatase and actin regulator 2Source|GeneCards
AA479499
NCKAP1NCKAP1NCK-associated protein 1Source|GeneCards
STAU2STAU2staufen, RNA binding protein, homolog 2 (Drosophila)Source|GeneCards
STAMBPSTAMBPSTAM binding proteinSource|GeneCards
WDR11WDR11Bromodomain and WD repeat domain containing 2Source|GeneCards
AA291159
SAS10SAS10disrupter of silencing 10Source|GeneCards
AA465171
ETS1ETS1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)Source|GeneCards
TBC1D4TBC1D4TBC1 domain family, member 4Source|GeneCards
CAS1CAS1O-acetyltransferaseSource|GeneCards
IQGAP1IQGAP1IQ motif containing GTPase activating protein 1Source|GeneCards
LZTFL1LZTFL1leucine zipper transcription factor-like 1Source|GeneCards
AA286807
OSTM1OSTM1osteopetrosis associated transmembrane protein 1Source|GeneCards
HPRT1HPRT1hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)Source|GeneCards
PRKACBPRKACBprotein kinase, cAMP-dependent, catalytic, betaSource|GeneCards
RUFY1RUFY1RUN and FYVE domain containing 1Source|GeneCards
AI095794
CGI-119TMBIM4transmembrane BAX inhibitor motif containing 4Source|GeneCards
FEM1BFEM1Bfem-1 homolog b (C. elegans)Source|GeneCards
ZNF638ZNF638zinc finger protein 638Source|GeneCards
HDHD1AHDHD1Ahaloacid dehalogenase-like hydrolase domain containing 1ASource|GeneCards
CPSF2CPSF2cleavage and polyadenylation specific factor 2, 100kDaSource|GeneCards
AP1S2AP1S2adaptor-related protein complex 1, sigma 2 subunitSource|GeneCards
KIAA1815KIAA1815KIAA1815Source|GeneCards
CREBL2CREBL2cAMP responsive element binding protein-like 2Source|GeneCards
CHI3L2CHI3L2chitinase 3-like 2Source|GeneCards
MYH10MYH10myosin, heavy polypeptide 10, non-muscleSource|GeneCards
BCL6BCL6B-cell CLL/lymphoma 6 (zinc finger protein 51)Source|GeneCards
CXCL13CXCL13chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)Source|GeneCards
AMPD3AMPD3adenosine monophosphate deaminase (isoform E)Source|GeneCards
PAWRPAWRPRKC, apoptosis, WT1, regulatorSource|GeneCards
R24848
AA259115
ZNF518ZNF518zinc finger protein 518Source|GeneCards
DC-UbPDC-UBPdendritic cell-derived ubiquitin-like proteinSource|GeneCards
SLC35F5SLC35F5solute carrier family 35, member F5Source|GeneCards
STK39STK39serine threonine kinase 39 (STE20/SPS1 homolog, yeast)Source|GeneCards
AA938245
WRBWRBtryptophan rich basic proteinSource|GeneCards
N26517
HIBCHHIBCH3-hydroxyisobutyryl-Coenzyme A hydrolaseSource|GeneCards
SH2D1ASH2D1ASH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)Source|GeneCards
ACTR3ACTR3ARP3 actin-related protein 3 homolog (yeast)Source|GeneCards
PPP3CBPPP3CBprotein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)Source|GeneCards
TOXTOXthymus high mobility group box protein TOXSource|GeneCards
PAR1F2Rcoagulation factor II (thrombin) receptorSource|GeneCards
AA479352
AA424556
CHGBCHGBchromogranin B (secretogranin 1)Source|GeneCards
SIAT8DSIAT8Dsialyltransferase 8D (alpha-2, 8-polysialyltransferase)Source|GeneCards
DNAJB6DNAJB6DnaJ (Hsp40) homolog, subfamily B, member 6Source|GeneCards
STAT1STAT1signal transducer and activator of transcription 1, 91kDaSource|GeneCards
POU2AF1POU2AF1POU domain, class 2, associating factor 1Source|GeneCards
GIMAP4GIMAP4GTPase, IMAP family member 4Source|GeneCards
LOC91137LOC91137hypothetical protein BC017169Source|GeneCards
MDM4MDM4Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)Source|GeneCards
FLJ10330PRPF38BPRP38 pre-mRNA processing factor 38 (yeast) domain containing BSource|GeneCards
EGR2EGR2early growth response 2 (Krox-20 homolog, Drosophila)Source|GeneCards


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