| Gene set: UNDERHILL_PROLIFERATION (C2:PERT:0087) | | Standard name | UNDERHILL_PROLIFERATION |
| Systematic name | C2:PERT:0087 |
| Brief description | Cell cycle- and proliferation-related genes underexpressed in plasma cells. |
| Category | C2: Curated |
| Sub-category | PERT: Experimental pertuberation |
| Full description or Abstract | The formation of terminally differentiated plasma cells represents
the critical final step in B-cell differentiation. In this study,
utilizing oligonucleotide microarray analysis, we describe the
highly specialized genetic profile exhibited by terminally differentiated
plasma cells. A total of 1476 known genes were differentially
expressed by plasma cells compared with B cells. Plasma cells
displayed an up-regulation, induction, or a selective retention
of a unique constellation of transcription factors, including
members of the AP-1, nuclear factor-kappaB (NF-kappaB), nuclear
factor of activated T cells (NFAT), and octamer binding factor
families. Interestingly, plasma cells also displayed a down-regulation
of several RNA polymerase I- related factors, consistent with
terminal differentiation, and exhibited a down-regulation of the
TATA box binding protein. Furthermore, plasma cells displayed
alterations in multiple components of the Wnt and Notch signaling
pathways and showed a unique pattern of apoptosis and proliferation-associated
genes. Unexpectedly, plasma cells displayed an up-regulation of
2 factors normally associated with microenvironmental positioning
of neuronal cells, reelin and neuropilin-1. These results supply
insight into the developmental genetics of plasma cell differentiation
and provide a foundation for further analysis of plasma cell biology.
|
| Publication URL | 12543863 |
| External links | na |
| Keywords & MeSH headings | Organ Specificity,Knockout,Gene Expression Profiling/methods,Plasma Cells,P.H.S.,Immunoglobulin M/genetics,Transcription,Blotting,Inbred C57BL,immunology,Western,Cell Cycle/immunology,Crosses,Reverse Transcriptase Polymerase Chain Reaction,Mice,Genetic,Cell Differentiation,cytology,Cell Division,physiology,Cell Cycle Proteins/genetics |
| Organism | Human |
| Contributed by | Kate Stafford |
| Source platform | Seq_Accession |
| Download | grp|xml|map |
| Genes | 19 genes, 19 accessions (Toggle view) |