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Gene set: WIELAND_HEPB (C2:PERT:0055)
Standard nameWIELAND_HEPB
Systematic nameC2:PERT:0055
Brief descriptionGenes induced in the liver during hepatitis B viral clearance in chimpanzees.
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Previous studies in hepatitis B virus (HBV)-infected humans and
chimpanzees suggest that control of HBV infection involves the
cells, effector functions, and molecular mediators of the immune
response. The objective of the current study was to identify,
in the liver of acutely HBV-infected chimpanzees, the spectrum
of virus-induced and immune response-related genes that regulate
the infection. The results demonstrate that HBV does not induce
any genes during entry and expansion, suggesting it is a stealth
virus early in the infection. In contrast, a large number of T
cell-derived IFN-gamma-regulated genes are induced in the liver
during viral clearance, reflecting the impact of an adaptive T
cell response that inhibits viral replication and kills infected
cells, thereby terminating the infection. 
Publication URL15100412
External linksna
Keywords & MeSH headingsHepatitis B,Hepatitis B virus/physiology,Genome,P.H.S.,genetics,Pan troglodytes,Gene Expression Regulation,Viral,Liver/metabolism/virology,immunology,Humans
OrganismChimpanzee
Contributed byKate Stafford
Source platformHG_U133A
Downloadgrp|xml|map
Genes

106 genes, 107 accessions (Toggle view)

AccessionGeneTitleLinks
221087_s_atAPOL3apolipoprotein L, 3Source|GeneCards
204588_s_atSLC7A7solute carrier family 7 (cationic amino acid transporter, y+ system), member 7Source|GeneCards
210982_s_atHLA-DRAmajor histocompatibility complex, class II, DR alphaSource|GeneCards
201930_atMCM6MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)Source|GeneCards
208829_atTAPBPTAP binding protein (tapasin)Source|GeneCards
204122_atTYROBPTYRO protein tyrosine kinase binding proteinSource|GeneCards
204670_x_atHLA-DRB1major histocompatibility complex, class II, DR beta 1Source|GeneCards
213539_atCD3DCD3D antigen, delta polypeptide (TiT3 complex)Source|GeneCards
206420_atIGSF6immunoglobulin superfamily, member 6Source|GeneCards
203554_x_atPTTG1pituitary tumor-transforming 1Source|GeneCards
217028_atCXCR4chemokine (C-X-C motif) receptor 4Source|GeneCards
202963_atRFX5regulatory factor X, 5 (influences HLA class II expression)Source|GeneCards
204118_atCD48CD48 antigen (B-cell membrane protein) /// CD48 antigen (B-cell membrane protein)Source|GeneCards
204820_s_atBTN3A3 /// BTN3A2butyrophilin, subfamily 3, member A3 /// butyrophilin, subfamily 3, member A2Source|GeneCards
219505_atCECR1cat eye syndrome chromosome region, candidate 1Source|GeneCards
201422_atIFI30interferon, gamma-inducible protein 30Source|GeneCards
204232_atFCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptideSource|GeneCards
202748_atGBP2guanylate binding protein 2, interferon-inducible /// guanylate binding protein 2, interferon-inducibleSource|GeneCards
211430_s_atIGH@ /// IGHG1 /// Ibulin heavy constant gamma 3 (G3m marker) /// immunoglobulin heavy constant muSource|GeneCards
205692_s_atCD38CD38 antigen (p45)Source|GeneCards
206666_atGZMKgranzyme K (serine protease, granzyme 3; tryptase II) /// granzyme K (serine protease, granzyme 3; tryptase II)Source|GeneCards
201141_atGPNMBglycoprotein (transmembrane) nmbSource|GeneCards
211991_s_atHLA-DPA1major histocompatibility complex, class II, DP alpha 1Source|GeneCards
219014_atPLAC8placenta-specific 8Source|GeneCards
217478_s_atHLA-DMAmajor histocompatibility complex, class II, DM alphaSource|GeneCards
211656_x_atHLA-DQB1major histocompatibility complex, class II, DQ beta 1 /// major histocompatibility complex, class II, DQ beta 1Source|GeneCards
209568_s_atRGL1ral guanine nucleotide dissociation stimulator-like 1Source|GeneCards
209762_x_atSP110SP110 nuclear body proteinSource|GeneCards
214677_x_atIGL@ /// IGLC1 /// In lambda variable 2-14 /// immunoglobulin lambda joining 3Source|GeneCards
202953_atC1QBcomplement component 1, q subcomponent, beta polypeptideSource|GeneCards
219506_atC1ORF54chromosome 1 open reading frame 54Source|GeneCards
200905_x_atHLA-Emajor histocompatibility complex, class I, ESource|GeneCards
202659_atPSMB10proteasome (prosome, macropain) subunit, beta type, 10Source|GeneCards
208966_x_atIFI16interferon, gamma-inducible protein 16Source|GeneCards
203416_atCD53CD53 antigenSource|GeneCards
209140_x_atHLA-Bmajor histocompatibility complex, class I, BSource|GeneCards
213193_x_atTRBV19 /// TRBC1T cell receptor beta variable 19 /// T cell receptor beta variable 19 /// T cell receptor beta constant 1 /// T cell receptor beta constant 1Source|GeneCards
215313_x_atHLA-Amajor histocompatibility complex, class I, ASource|GeneCards
218805_atGIMAP5GTPase, IMAP family member 5 /// GTPase, IMAP family member 5Source|GeneCards
202411_atIFI27interferon, alpha-inducible protein 27Source|GeneCards
213603_s_atRAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)Source|GeneCards
217984_atRNASET2ribonuclease T2Source|GeneCards
200872_atS100A10S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))Source|GeneCards
221081_s_atFLJ22457hypothetical protein FLJ22457Source|GeneCards
200814_atPSME1proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)Source|GeneCards
201859_atPRG1proteoglycan 1, secretory granuleSource|GeneCards
211762_s_atKPNA2karyopherin alpha 2 (RAG cohort 1, importin alpha 1) /// karyopherin alpha 2 (RAG cohort 1, importin alpha 1)Source|GeneCards
213975_s_atLYZ /// LILRB1lysozyme (renal amyloidosis) /// leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1Source|GeneCards
215806_x_atTRGC2 /// TRGV9 ///T-cell receptor gamma chain V region PT-gamma-1/2 precursor /// TCR gamma alternate reading frame proteinSource|GeneCards
201649_atUBE2L6ubiquitin-conjugating enzyme E2L 6Source|GeneCards
204279_atPSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2)Source|GeneCards
204834_atFGL2fibrinogen-like 2Source|GeneCards
201487_atCTSCcathepsin CSource|GeneCards
200975_atPPT1palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)Source|GeneCards
207111_atEMR1egf-like module containing, mucin-like, hormone receptor-like 1Source|GeneCards
200839_s_atCTSBcathepsin BSource|GeneCards
218627_atFLJ11259hypothetical protein FLJ11259Source|GeneCards
206680_atCD5LCD5 antigen-like (scavenger receptor cysteine rich family)Source|GeneCards
204440_atCD83CD83 antigen (activated B lymphocytes, immunoglobulin superfamily)Source|GeneCards
213293_s_atTRIM22tripartite motif-containing 22Source|GeneCards
209906_atC3AR1complement component 3a receptor 1Source|GeneCards
204787_atVSIG4V-set and immunoglobulin domain containing 4Source|GeneCards
212737_atGM2AGM2 ganglioside activatorSource|GeneCards
209619_atCD74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)Source|GeneCards
209813_x_atTRGC2 /// TRGV9 ///milar to T-cell receptor gamma chain C region PT-gamma-1/2 /// similar to T-cell receptor gamma chain C region PT-gamma-1/2 /// similar to T-cell receptor gamma chain V region PT-gamma-1/2 precursor /// similar to T-cell receptor gamma chain V region PT-gamma-1/2 precursor /// TCR gamma alternate reading frame protein /// TCR gamma alternate reading frame proteinSource|GeneCards
202589_atTYMSthymidylate synthetaseSource|GeneCards
218543_s_atPARP12poly (ADP-ribose) polymerase family, member 12Source|GeneCards
200021_atCFL1cofilin 1 (non-muscle) /// cofilin 1 (non-muscle)Source|GeneCards
216526_x_atHLA-Cmajor histocompatibility complex, class I, CSource|GeneCards
202954_atUBE2Cubiquitin-conjugating enzyme E2CSource|GeneCards
207571_x_atC1ORF38chromosome 1 open reading frame 38Source|GeneCards
201137_s_atHLA-DPB1major histocompatibility complex, class II, DP beta 1Source|GeneCards
201890_atRRM2ribonucleotide reductase M2 polypeptideSource|GeneCards
219148_atPBKPDZ binding kinaseSource|GeneCards
214511_x_atFCGR1A /// LOC440607Fc fragment of IgG, high affinity Ia, receptor (CD64) /// Fc-gamma receptor I B2Source|GeneCards
201762_s_atPSME2proteasome (prosome, macropain) activator subunit 2 (PA28 beta)Source|GeneCards
1405_i_atCCL5chemokine (C-C motif) ligand 5Source|GeneCards
208079_s_atSTK6serine/threonine kinase 6Source|GeneCards
200743_s_atTPP1tripeptidyl peptidase ISource|GeneCards
221978_atHLA-Fmajor histocompatibility complex, class I, FSource|GeneCards
221059_s_atCOTL1coactosin-like 1 (Dictyostelium)Source|GeneCards
215223_s_atSOD2superoxide dismutase 2, mitochondrialSource|GeneCards
217933_s_atLAP3leucine aminopeptidase 3Source|GeneCards
210163_atCXCL11chemokine (C-X-C motif) ligand 11Source|GeneCards
201720_s_atLAPTM5lysosomal associated multispanning membrane protein 5Source|GeneCards
204912_atIL10RAinterleukin 10 receptor, alphaSource|GeneCards
203507_atCD68CD68 antigenSource|GeneCards
216250_s_atLPXNleupaxinSource|GeneCards
205488_atGZMArase 3)Source|GeneCards
219622_atRAB20RAB20, member RAS oncogene familySource|GeneCards
202270_atGBP1guanylate binding protein 1, interferon-inducible, 67kDa /// guanylate binding protein 1, interferon-inducible, 67kDaSource|GeneCards
205890_s_atUBDubiquitin DSource|GeneCards
208949_s_atLGALS3 /// GALIGlectin, galactoside-binding, soluble, 3 (galectin 3) /// galectin-3 internal geneSource|GeneCards
217764_s_atRAB31RAB31, member RAS oncogene familySource|GeneCards
210951_x_atRAB27ARAB27A, member RAS oncogene familySource|GeneCards
203879_atPIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide /// phosphoinositide-3-kinase, catalytic, delta polypeptideSource|GeneCards
201891_s_atB2Mbeta-2-microglobulinSource|GeneCards
204070_atRARRES3retinoic acid receptor responder (tazarotene induced) 3Source|GeneCards
204698_atISG20interferon stimulated exonuclease gene 20kDaSource|GeneCards
204533_atCXCL10chemokine (C-X-C motif) ligand 10Source|GeneCards
208998_atUCP2uncoupling protein 2 (mitochondrial, proton carrier)Source|GeneCards
200629_atWARStryptophanyl-tRNA synthetaseSource|GeneCards
201288_atARHGDIBRho GDP dissociation inhibitor (GDI) betaSource|GeneCards
209969_s_atSTAT1signal transducer and activator of transcription 1, 91kDaSource|GeneCards
203915_atCXCL9chemokine (C-X-C motif) ligand 9Source|GeneCards
203932_atHLA-DMBmajor histocompatibility complex, class II, DM beta /// major histocompatibility complex, class II, DM betaSource|GeneCards
218009_s_atPRC1protein regulator of cytokinesis 1Source|GeneCards


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