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Gene set: YAGI_AML_PROGNOSIS (C2:PERT:0056)
Standard nameYAGI_AML_PROGNOSIS
Systematic nameC2:PERT:0056
Brief descriptionGenes associated with clinical prognosis in pediatric acute myeloid leukemia.
CategoryC2: Curated
Sub-categoryPERT: Experimental pertuberation
Full description or Abstract
Most patients with acute myeloid leukemia (AML) enter complete
remission (CR) after treatment with chemotherapy, but a large
number of them experience relapse with resistant disease. To identify
genes that are associated with their prognoses, we analyzed gene
expression in 54 pediatric patients with AML using an oligonucleotide
microarray that contained 12 566 probe sets. A supervised approach
using the Student t test selected a prognostic set of 35 genes,
some of which are associated with the regulation of cell cycle
and apoptosis. Most of these genes had not previously been reported
to be associated with prognosis and were not correlated with morphologically
classified French-American-British (FAB) subtypes or with karyotypes.
These results indicate the existence of prognosis-associated genes
that are independent of cell lineage and cytogenetic abnormalities,
and they can provide therapeutic direction for individual risk-adapted
therapy for pediatric AML patients. 
Publication URL12738660
External linksna
Keywords & MeSH headingsPrognosis,Adolescent,Newborn,Male,Gene Expression Profiling,Infant,Female,Predictive Value of Tests,Myeloid,Humans,Leukemia,Genetic/genetics,genetics,Preschool,Child,Translocation,diagnosis
OrganismHuman
Contributed byKate Stafford
Source platformHG_U95Av2
Downloadgrp|xml|map
Genes

35 genes, 36 accessions (Toggle view)

AccessionGeneTitleLinks
33963_atAZU1azurocidin 1 (cationic antimicrobial protein 37)Source|GeneCards
36958_atZYXzyxinSource|GeneCards
40147_atVAT1vesicle amine transport protein 1 homolog (T californica)Source|GeneCards
32806_atBZRPbenzodiazapine receptor (peripheral)Source|GeneCards
41396_atCYLN2cytoplasmic linker 2Source|GeneCards
36963_atPGDphosphogluconate dehydrogenaseSource|GeneCards
36661_s_atCD14CD14 antigenSource|GeneCards
38016_atHNRPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)Source|GeneCards
33683_atTI-227Hhypothetical protein TI-227HSource|GeneCards
35536_atECE2endothelin converting enzyme 2Source|GeneCards
38628_atGCN5L2GCN5 general control of amino-acid synthesis 5-like 2 (yeast)Source|GeneCards
37298_atGABARAPGABA(A) receptor-associated proteinSource|GeneCards
605_atVAT1vesicle amine transport protein 1 homolog (T californica)Source|GeneCards
41523_atRAB32RAB32, member RAS oncogene familySource|GeneCards
34905_atGRIK5glutamate receptor, ionotropic, kainate 5Source|GeneCards
1207_atCDK6cyclin-dependent kinase 6Source|GeneCards
36167_atATP6V0BATPase, H+ transporting, lysosomal 21kDa, V0 subunit c''Source|GeneCards
33390_atSTK17BSerine/threonine kinase 17b (apoptosis-inducing)Source|GeneCards
40198_atVDAC1voltage-dependent anion channel 1Source|GeneCards
39345_atNPC2Niemann-Pick disease, type C2Source|GeneCards
37729_atXPO1exportin 1 (CRM1 homolog, yeast)Source|GeneCards
1241_atPTP4A2protein tyrosine phosphatase type IVA, member 2Source|GeneCards
38233_atHOMER3homer homolog 3 (Drosophila)Source|GeneCards
41763_g_atTIAL1TIA1 cytotoxic granule-associated RNA binding protein-like 1Source|GeneCards
36879_atECGF1endothelial cell growth factor 1 (platelet-derived)Source|GeneCards
38614_s_atOGTO-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)Source|GeneCards
1985_s_atNME1non-metastatic cells 1, protein (NM23A) expressed inSource|GeneCards
36338_atLUZP1leucine zipper protein 1Source|GeneCards
1461_atNFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaSource|GeneCards
38789_atTKTtransketolase (Wernicke-Korsakoff syndrome)Source|GeneCards
32675_atBST1bone marrow stromal cell antigen 1Source|GeneCards
39011_atENSAendosulfine alphaSource|GeneCards
33944_atAPLP2amyloid beta (A4) precursor-like protein 2Source|GeneCards
35631_atPOLR2Hpolymerase (RNA) II (DNA directed) polypeptide HSource|GeneCards
39353_atHSPE1heat shock 10kDa protein 1 (chaperonin 10)Source|GeneCards
288_s_atLBRlamin B receptorSource|GeneCards


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