XX
XX
XX
FA HNF-1A
XX
SY APF; HNF1; HNF-1alpha;
LF-B1; HNF-1A.
XX
OS mouse, Mus musculus
OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;
OC eutheria; rodentia; myomorpha; muridae; murinae
XX
CL C0006; homeo; 3.1.1.12.1.1.
XX
SZ 628 AA; 67.2 kDa
(cDNA), 92-98 kDa (SDS)
XX
XX
SC SwissProt #P22361
XX
FT 1 31 dimerization domain (by similarity).
FT 1 176
PF04814; HNF-1_N.
FT 161 186 POUs A subdomain homolog.
FT 199 279 homeo domain.
FT 199 282 SM00389; HOX.
FT 208
219 helix 1 [1].
FT 226 240 helix 2 [1].
FT 261 274 helix
3 [1].
FT 280 539 PF04812; HNF-1B_C.
FT 281 318 activation
domain II (ADII).
FT 289 314 proline-rich region (10/26).
FT 540 628 PF04813; HNF-1A_C.
FT 546 628 activation domain
I (ADI).
FT 583 627 serine-/threonine-rich region (20/45).
XX
SF glycosylation;
SF similar factor in lung: 110 +
120 kDa (SDS);
SF dimerizes in the absence of DNA [5];
SF unusual for homeobox genes, gene regions encoding helix 2 and
3 are
SF separated by an intron [2];
XX
CP liver,
intestine, spleen, stomach, kidney
CN lung
XX
FF induced
in F9 cells by RA, plateau after 5d [4]
XX
IN T00889;
HNF-1B; rat, Rattus norvegicus.
IN T00890; HNF-1B; mouse,
Mus musculus.
XX
XX
XX
XX
RN [1]; RE0004697.
RX MEDLINE; 93259120.
RA Leiting B., de Francesco R., Tomei
L., Cortese R., Otting G., Whthrich K.
RT The three-dimensional
NMR-solution structure of the polypeptide fragment
RT 195-286
of the LFB1/HNF1 transcription factor from rat liver comprises
a
RT non-classical homeodomain
RL EMBO J. 12:1797-1803
(1993).
RN [2]; RE0004692.
RX MEDLINE; 92375726.
RA
Bach I., Pontoglio M., Yaniv M.
RT Structure of the gene encoding
hepatocyte nuclear factor 1 (HNF1)
RL Nucleic Acids Res. 20:4199-4204
(1992).
RN [3]; RE0004693.
RX MEDLINE; 92131134.
RA
Kuo C. J., Conley P. B., Chen L., Sladek F. M., Darnell J. E.,
Crabtree G.
RA R.
RT A transcriptional hierarchy involved
in mammalian cell-type specification
RL Nature 355:457-461
(1992).
RN [4]; RE0000510.
RX MEDLINE; 91293099.
RA
Kuo C. J., Mendel D. B., Hansen L. P., Crabtree G. R.
RT Independent
regulation of HNF-1alpha and HNF-1beta by retinoic acid in F9
RT teratocarcinoma cells
RL EMBO J. 10:2231-2236 (1991).
RN [5]; RE0000675.
RX MEDLINE; 91257571.
RA Mendel D.
B., Hansen L. P., Graves M. K., Conley P. B., Crabtree G. R.
RT HNF-1alpha and HNF-1beta (vHNF-1) share dimerization and homeo
domains, but
RT not activation domains, and form heterodimers
in vitro
RL Genes Dev. 5:1042-1056 (1991).
RN [6]; RE0001582.
RX MEDLINE; 91117244.
RA Liu J.-K., DiPersio C. M., Zaret
K. S.
RT Extracellular signals that regulate liver transcription
factors during
RT hepatic differentiation in vitro
RL
Mol. Cell. Biol. 11:773-784 (1991).
RN [7]; RE0001365.
RX MEDLINE; 90287137.
RA Abraham L. J., Bradshaw A. D., Shiels
B. R., Northemann W., Hudson G., Fey
RA G. H.
RT Hepatic
Transcription of the Acute-Phase alpha1-Inhibitor III Gene Is
RT Controlled by a Novel Combination of cis-Acting Regulatory
Elements
RL Mol. Cell. Biol. 10:3483-3491 (1990).
RN [8];
RE0002415.
RX MEDLINE; 91088607.
RA Kuo C. J., Conley
P. B., Hsieh C.-L., Francke U., Crabtree S.
RT Molecular cloning,
functional expression, and chromosomal localization of
RT
mouse hepatocyte nuclear factor 1
RL Proc. Natl. Acad. Sci.
USA 87:9838-9842 (1990).
RN [9]; RE0001386.
RX MEDLINE;
90097936.
RA Chang H.-K., Wang B.-Y., Yuh C.-H., Wei C.-L.,
Ting L.-P.
RT A Liver-Specific Nuclear Factor Interacts with
the Promoter Region of the
RT Large Surface Protein Gene of
Human Hepatitis B Virus
RL Mol. Cell. Biol. 9:5189-5197 (1989).
RN [10]; RE0001392.
RX MEDLINE; 90097908.
RA Tsutsumi
K.-I., Ito K., Ishikawa K.
RT Developmental Appearance of
Transcription Factors That Regulate
RT Liver-Specific Expression
of the Aldolase B Gene
RL Mol. Cell. Biol. 9:4923-4931 (1989).
RN [11]; RE0002595.
RX MEDLINE; 88042798.
RA Courtois
G., Morgan J. G., Campbell L. A., Fourel G., Crabtree G. R.
RT Interaction of a liver-specific nuclear factor with the fibrinogen
and
RT alpha1-antitrypsin promoters
RL Science 238:688-692
(1987).
XX