[an error occurred while processing this directive]
Gene set: TGASTMAGC_V$NFE2_01 (C3:REPM:0153)
Standard nameTGASTMAGC_V$NFE2_01
Systematic nameC3:REPM:0153
Brief descriptionGenes with 3'UTR containing motif TGASTMAGC which matches annotation for NFE2: nuclear factor (erythroid-derived 2), 45kDa
CategoryC3: Motif
Sub-categoryREPM: Representative motifs
Full description or Abstract

Toggle abstract view

XX
 XX
 XX
 FA NF-E2 p45
 XX
 SY nuclear factor
erythroid 2 p45.
 XX
 OS mouse, Mus musculus
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; rodentia; myomorpha; muridae; murinae
 XX

HO Cnc (D. melanogaster)
 XX
 CL C0008; bZIP; 1.1.1.4.1.

XX
 SZ 373 AA; 41.6 kDa (cDNA), 45 kDa (SDS)
 XX
 XX

SC translated from EMBL #L09600
 XX
 FT 225 267 extended
homology with Nrf1.
 FT 264 328 PF00170; bZIP.
 FT 264 328
SM00338; BRLZ.
 FT 268 287 basic region.
 FT 294 329 leucine
zipper (L3AML).
 XX
 SF bZIP domain is similar to that of
AP-1 components;
 SF outside bZIP: similar to Cnc (D. melanogaster);

SF no homodimeric DNA-binding, obligate heterodimer with a ubiquitous
Maf
 SF component (NF-E2 p18) [4], which in most cases corresponds
to MafK [5];
 XX
 CP spleen, bone marrow [4]; pluripotent
hematopoietic stem cells [3]
 CN brain, heart, kidney, large
intestine, liver, skeletal muscle, testis [4]
 XX
 FF binding
to the shorter half of an asymmetrical AP-1-like motif [5];

FF erythroid-specific component of NF-E2 [4];
 FF the ubiquitous
MafK component of NF-E2 appears to be present in limiting

FF amounts [4];
 FF p45 effects on erythrocyte-specific regulations
seem to be redundant since
 FF they can be compensated in p45-null
mice [1];
 FF however, in megakaryocytes it is absolutely required
for cell maturation
 FF and platelet formation [2];
 XX

IN T01436; MafF; chick, Gallus gallus.
 IN T01437; MafG; chick,
Gallus gallus.
 IN T01434; MafK; chick, Gallus domesticus.

IN T01435; MafK; mouse, Mus musculus.
 XX
 XX
 XX

XX
 RN [1]; RE0006604.
 RX MEDLINE; 96004604.
 RA Shivdasani
R. A., Orkin S. H.
 RT Erythropoiesis and globin gene expression
in mice lacking the transcription
 RT factor NF-E2
 RL Proc.
Natl. Acad. Sci. USA 92:8690-8694 (1995).
 RN [2]; RE0006608.

RX MEDLINE; 95292337.
 RA Shivdasani R. A., Rosenblatt M. F.,
Zucker-Franklin D., Jackson C. W., Hunt
 RA P., Saris C. J.
M., Orkin S. H.
 RT Transcription factor NF-E2 is required
for platelet formation independent
 RT of the actions of thrombopoietin/MGDF
in megakaryocyte development
 RL Cell 81:695-704 (1995).

RN [3]; RE0013450.
 RX MEDLINE; 95273411.
 RA Orlic D.,
Anderson S., Biesecker L. G., Sorrentino B. P., Bodine D. M.

RT Pluripotent hematopoietic stem cells contain high levels of
mRNA for c-kit,
 RT GATA-2, p45 NF-E2, and c-myb and low levels
or no mRNA for c-fms and the
 RT receptors for granulocyte
colony-stimulating factor and interleukins 5 and
 RT 7.

RL Proc. Natl. Acad. Sci. USA 92:4601-4605 (1995).
 RN [4];
RE0002919.
 RX MEDLINE; 93226042.
 RA Andrews N. C., Erdjument-Bromage
H., Davidson M. B., Tempst P., Orkin S. H.
 RT Erythroid transcription
factor NF-E2 is a haematopoietic-specific
 RT basic-leucine
zipper protein
 RL Nature 362:722-728 (1993).
 RN [5]; RE0003521.

RX MEDLINE; 94089658.
 RA Andrews N. C., Kotkow K. J., Ney
P. A., Erdjument-Bromage H., Tempst P.,
 RA Orkin S. H.

RT The ubiquitous subunit of erythroid transcription factor NF-E2
is a small
 RT basic-leucine zipper protein related to the
v-Maf oncogene
 RL Proc. Natl. Acad. Sci. USA 90:11488-11492
(1993).
 RN [6]; RE0004917.
 RX MEDLINE; 93278095.
 RA
Crossley M., Orkin S.
 RT Regulation of the beta-globin locus

RL Curr. Opin. Gen. Dev. 3:232-237 (1993).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

198 genes, 198 accessions (Toggle view)

AccessionGeneTitleLinks
ABCA2ABCA2ATP-binding cassette, sub-family A (ABC1), member 2Source|GeneCards
GSTP1GSTP1glutathione S-transferase piSource|GeneCards
RTN3RTN3reticulon 3Source|GeneCards
LOC55954LOC55954hypothetical protein LOC55954Source|GeneCards
ABHD4ABHD4abhydrolase domain containing 4Source|GeneCards
PAK6PAK6p21(CDKN1A)-activated kinase 6Source|GeneCards
PSMD11PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 11Source|GeneCards
MMP19MMP19matrix metalloproteinase 19Source|GeneCards
E2F3E2F3E2F transcription factor 3Source|GeneCards
CPA6CPA6carboxypeptidase A6Source|GeneCards
ELA1ELA1elastase 1, pancreaticSource|GeneCards
TMEM24TMEM24transmembrane protein 24Source|GeneCards
DDX17DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17Source|GeneCards
MYO10MYO10myosin XSource|GeneCards
GABARAPL1GABARAPL1GABA(A) receptor-associated protein like 1Source|GeneCards
FLJ35767FLJ35767FLJ35767 proteinSource|GeneCards
MGC4677MGC4677hypothetical protein MGC4677Source|GeneCards
PSMD12PSMD12proteasome (prosome, macropain) 26S subunit, non-ATPase, 12Source|GeneCards
LAMA3LAMA3laminin, alpha 3Source|GeneCards
DKFZP434B0335DKFZP434B0335DKFZP434B0335 proteinSource|GeneCards
SH3BGRL2SH3BGRL2SH3 domain binding glutamic acid-rich protein like 2Source|GeneCards
SLITRK6SLITRK6SLIT and NTRK-like family, member 6Source|GeneCards
DTNADTNAdystrobrevin, alphaSource|GeneCards
NRD1NRD1nardilysin (N-arginine dibasic convertase)Source|GeneCards
CD44CD44CD44 antigen (homing function and Indian blood group system)Source|GeneCards
TNXBTNXBtenascin XBSource|GeneCards
DUSP13DUSP13dual specificity phosphatase 13Source|GeneCards
CPNE8CPNE8copine VIIISource|GeneCards
EYA1EYA1eyes absent homolog 1 (Drosophila)Source|GeneCards
LIMK1LIMK1LIM domain kinase 1Source|GeneCards
GADD45AGADD45Agrowth arrest and DNA-damage-inducible, alphaSource|GeneCards
FLJ35827EML3echinoderm microtubule associated protein like 3Source|GeneCards
TIAL1TIAL1TIA1 cytotoxic granule-associated RNA binding protein-like 1Source|GeneCards
AKT3AKT3v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)Source|GeneCards
KIAA0152KIAA0152KIAA0152 gene productSource|GeneCards
C5ORF16C5ORF16chromosome 5 open reading frame 16Source|GeneCards
MAP2K1MAP2K1mitogen-activated protein kinase kinase 1Source|GeneCards
CLCCLCCharcot-Leyden crystal proteinSource|GeneCards
SEC24DSEC24DSEC24 related gene family, member D (S. cerevisiae)Source|GeneCards
RICSRICSRho GTPase-activating proteinSource|GeneCards
ADRA1AADRA1Aadrenergic, alpha-1A-, receptorSource|GeneCards
CLDN15CLDN15claudin 15Source|GeneCards
TLX2TLX2T-cell leukemia, homeobox 2Source|GeneCards
LENEPLENEPlens epithelial proteinSource|GeneCards
BAZ2ABAZ2Abromodomain adjacent to zinc finger domain, 2ASource|GeneCards
IL18RAPIL18RAPinterleukin 18 receptor accessory proteinSource|GeneCards
EIF4G1EIF4G1eukaryotic translation initiation factor 4 gamma, 1Source|GeneCards
RAB13RAB13RAB13, member RAS oncogene familySource|GeneCards
P2RXL1P2RXL1purinergic receptor P2X-like 1, orphan receptorSource|GeneCards
PPP2CAPPP2CAprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformSource|GeneCards
CALB2CALB2calbindin 2, 29kDa (calretinin)Source|GeneCards
PEA15PEA15phosphoprotein enriched in astrocytes 15Source|GeneCards
LOC90768LOC90768hypothetical protein LOC90768Source|GeneCards
SNCGSNCGsynuclein, gamma (breast cancer-specific protein 1)Source|GeneCards
TTC1TTC1tetratricopeptide repeat domain 1Source|GeneCards
PSMD7PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)Source|GeneCards
SKP1ASKP1AS-phase kinase-associated protein 1A (p19A)Source|GeneCards
ZA20D1ZA20D1zinc finger, A20 domain containing 1Source|GeneCards
SLC22A1LSSLC22A1LSsolute carrier family 22 (organic cation transporter), member 1-like antisenseSource|GeneCards
ADCK4ADCK4aarF domain containing kinase 4Source|GeneCards
ROM1ROM1retinal outer segment membrane protein 1Source|GeneCards
ENO1ENO1enolase 1, (alpha)Source|GeneCards
MMP9MMP9matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Source|GeneCards
PROCRPROCRprotein C receptor, endothelial (EPCR)Source|GeneCards
MYBPHMYBPHmyosin binding protein HSource|GeneCards
NCDNNCDNneurochondrinSource|GeneCards
ADAM15ADAM15a disintegrin and metalloproteinase domain 15 (metargidin)Source|GeneCards
SLC16A6SLC16A6solute carrier family 16 (monocarboxylic acid transporters), member 6Source|GeneCards
VDRVDRVitamin D (1,25- dihydroxyvitamin D3) receptorSource|GeneCards
ABCF3ABCF3ATP-binding cassette, sub-family F (GCN20), member 3Source|GeneCards
CMASCMAScytidine monophosphate N-acetylneuraminic acid synthetaseSource|GeneCards
RBBP7RBBP7retinoblastoma binding protein 7Source|GeneCards
MDM2MDM2Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)Source|GeneCards
CSGLCA-TCSGLCA-TKIAA1402 proteinSource|GeneCards
BACH1BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 1Source|GeneCards
DLX1DLX1distal-less homeo box 1Source|GeneCards
RAB3DRAB3DRAB3D, member RAS oncogene familySource|GeneCards
ETV5ETV5ets variant gene 5 (ets-related molecule)Source|GeneCards
IDSIDSiduronate 2-sulfatase (Hunter syndrome)Source|GeneCards
SMPXSMPXsmall muscle protein, X-linkedSource|GeneCards
LRRFIP2LRRFIP2leucine rich repeat (in FLII) interacting protein 2Source|GeneCards
PVALBPVALBparvalbuminSource|GeneCards
SNCBSNCBsynuclein, betaSource|GeneCards
CA9CA9carbonic anhydrase IXSource|GeneCards
SLC22A18SLC22A18solute carrier family 22 (organic cation transporter), member 18Source|GeneCards
EIF4EEIF4Eeukaryotic translation initiation factor 4ESource|GeneCards
PNUTL2SEPT4septin 4Source|GeneCards
ALDOAALDOAaldolase A, fructose-bisphosphateSource|GeneCards
S100A2S100A2S100 calcium binding protein A2Source|GeneCards
CLIC1CLIC1chloride intracellular channel 1Source|GeneCards
C14ORF140C14ORF140chromosome 14 open reading frame 140Source|GeneCards
ENO3ENO3enolase 3, (beta, muscle)Source|GeneCards
PRDM1PRDM1PR domain containing 1, with ZNF domainSource|GeneCards
HDAC3HDAC3histone deacetylase 3Source|GeneCards
PLS3PLS3plastin 3 (T isoform)Source|GeneCards
NUDT10NUDT10nudix (nucleoside diphosphate linked moiety X)-type motif 10Source|GeneCards
CRYBA2CRYBA2crystallin, beta A2Source|GeneCards
SERPINB5SERPINB5serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5Source|GeneCards
PDE4DPDE4Dphosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)Source|GeneCards
TUBB4TUBB4tubulin, beta 4Source|GeneCards
ARHGAP8ARHGAP8Rho GTPase activating protein 8Source|GeneCards
BTKBTKBruton agammaglobulinemia tyrosine kinaseSource|GeneCards
MPP5MPP5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)Source|GeneCards
PLCD1PLCD1phospholipase C, delta 1Source|GeneCards
MDFIMDFIMyoD family inhibitorSource|GeneCards
GAPDGAPDglyceraldehyde-3-phosphate dehydrogenaseSource|GeneCards
GADD45GGADD45Ggrowth arrest and DNA-damage-inducible, gammaSource|GeneCards
MGC16491FAM46Bfamily with sequence similarity 46, member BSource|GeneCards
VAT1VAT1Vesicle amine transport protein 1 homolog (T californica)Source|GeneCards
VASPVASPvasodilator-stimulated phosphoproteinSource|GeneCards
FLJ36525ALS2CLALS2 C-terminal likeSource|GeneCards
XLKD1XLKD1extracellular link domain containing 1Source|GeneCards
PLEC1PLEC1plectin 1, intermediate filament binding protein 500kDaSource|GeneCards
WDFY3WDFY3WD repeat and FYVE domain containing 3Source|GeneCards
ITPKCITPKCinositol 1,4,5-trisphosphate 3-kinase CSource|GeneCards
SPTA1SPTA1spectrin, alpha, erythrocytic 1 (elliptocytosis 2)Source|GeneCards
USP13USP13ubiquitin specific protease 13 (isopeptidase T-3)Source|GeneCards
TUBA6TUBA6tubulin alpha 6Source|GeneCards
FBXO30FBXO30F-box protein 30Source|GeneCards
FBXO2FBXO2F-box only protein 2Source|GeneCards
NUDT11NUDT11nudix (nucleoside diphosphate linked moiety X)-type motif 11Source|GeneCards
HS3ST2HS3ST2heparan sulfate (glucosamine) 3-O-sulfotransferase 2Source|GeneCards
PPP2R2CPPP2R2Cprotein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoformSource|GeneCards
UNQ2446UNQ2446MRCC2446Source|GeneCards
SNX10SNX10sorting nexin 10Source|GeneCards
LOC91056LOC91056hypothetical protein BC004895Source|GeneCards
FGF11FGF11fibroblast growth factor 11Source|GeneCards
MGC10772PRR7proline rich 7 (synaptic)Source|GeneCards
ABCB6ABCB6ATP-binding cassette, sub-family B (MDR/TAP), member 6Source|GeneCards
SLC26A1SLC26A1solute carrier family 26 (sulfate transporter), member 1Source|GeneCards
MT3MT3metallothionein 3 (growth inhibitory factor (neurotrophic))Source|GeneCards
PADI4PADI4peptidyl arginine deiminase, type IVSource|GeneCards
XPOTXPOTexportin, tRNA (nuclear export receptor for tRNAs)Source|GeneCards
ABCD1ABCD1ATP-binding cassette, sub-family D (ALD), member 1Source|GeneCards
LRP1BLRP1Blow density lipoprotein-related protein 1B (deleted in tumors)Source|GeneCards
RB1CC1RB1CC1RB1-inducible coiled-coil 1Source|GeneCards
SYT2SYT2synaptotagmin IISource|GeneCards
NEFHNEFHneurofilament, heavy polypeptide 200kDaSource|GeneCards
FBXO44FBXO44F-box protein 44Source|GeneCards
PHLDA2PHLDA2pleckstrin homology-like domain, family A, member 2Source|GeneCards
RABEP1RABEP1rabaptin, RAB GTPase binding effector protein 1Source|GeneCards
MMRN2MMRN2Multimerin 2Source|GeneCards
CAMKK1CAMKK1calcium/calmodulin-dependent protein kinase kinase 1, alphaSource|GeneCards
LOC147991DPY19L3dpy-19-like 3 (C. elegans)Source|GeneCards
SQSTM1SQSTM1sequestosome 1Source|GeneCards
FBI4C4ORF12chromosome 4 open reading frame 12Source|GeneCards
SPATS2SPATS2spermatogenesis associated, serine-rich 2Source|GeneCards
MCART1MCART1mitochondrial carrier triple repeat 1Source|GeneCards
BNIP3BNIP3BCL2/adenovirus E1B 19kDa interacting protein 3Source|GeneCards
PSMD2PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 2Source|GeneCards
MAP4MAP4microtubule-associated protein 4Source|GeneCards
FLT1FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)Source|GeneCards
LOC196463LOC196463hypothetical protein LOC196463Source|GeneCards
SYNPOSYNPOsynaptopodinSource|GeneCards
TUBA1TUBA1tubulin, alpha 1 (testis specific)Source|GeneCards
APBA2BPAPBA2BPamyloid beta (A4) precursor protein-binding, family A, member 2 binding proteinSource|GeneCards
SFTPCSFTPCsurfactant, pulmonary-associated protein CSource|GeneCards
TUBA4TUBA4tubulin, alpha 4Source|GeneCards
DIRAS1DIRAS1DIRAS family, GTP-binding RAS-like 1Source|GeneCards
ANGPTL4ANGPTL4angiopoietin-like 4Source|GeneCards
PSMD1PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 1Source|GeneCards
IL6IL6interleukin 6 (interferon, beta 2)Source|GeneCards
TLL1TLL1tolloid-like 1Source|GeneCards
TZFPZBTB32zinc finger and BTB domain containing 32Source|GeneCards
MGC16703MGC16703alpha tubulin-likeSource|GeneCards
LCN7LCN7lipocalin 7Source|GeneCards
FOSL1FOSL1FOS-like antigen 1Source|GeneCards
LOC51333LOC51333mesenchymal stem cell protein DSC43Source|GeneCards
SYTL1SYTL1synaptotagmin-like 1Source|GeneCards
ASSASSargininosuccinate synthetaseSource|GeneCards
HSPA9BHSPA9Bheat shock 70kDa protein 9B (mortalin-2)Source|GeneCards
FLJ36268FLJ36268FLJ36268 proteinSource|GeneCards
PFN1PFN1profilin 1Source|GeneCards
KIAA0182KIAA0182KIAA0182 proteinSource|GeneCards
KIAA0779TMCC1transmembrane and coiled-coil domain family 1Source|GeneCards
PPP1R9BPPP1R9Bprotein phosphatase 1, regulatory subunit 9B, spinophilinSource|GeneCards
CDH23CDH23cadherin related 23Source|GeneCards
DTX2DTX2deltex homolog 2 (Drosophila)Source|GeneCards
BLMHBLMHbleomycin hydrolaseSource|GeneCards
GASGALNSgalactosamine (N-acetyl)-6-sulfate sulfatase (Morquio syndrome, mucopolysaccharidosis type IVA)Source|GeneCards
FLJ21019FLJ21019hypothetical protein FLJ21019Source|GeneCards
FGF9FGF9fibroblast growth factor 9 (glia-activating factor)Source|GeneCards
MGC35440MGC35440hypothetical protein MGC35440Source|GeneCards
DHRS3DHRS3dehydrogenase/reductase (SDR family) member 3Source|GeneCards
LRRC2LRRC2leucine rich repeat containing 2Source|GeneCards
TARSHABI3BPABI gene family, member 3 (NESH) binding proteinSource|GeneCards
MFN2MFN2mitofusin 2Source|GeneCards
FLJ35695FLJ35695FLJ35695 proteinSource|GeneCards
DNCH1DNCH1dynein, cytoplasmic, heavy polypeptide 1Source|GeneCards
MAPRE3MAPRE3microtubule-associated protein, RP/EB family, member 3Source|GeneCards
RIT1RIT1Ras-like without CAAX 1Source|GeneCards
NR1D1NR1D1nuclear receptor subfamily 1, group D, member 1Source|GeneCards
OMGOMGoligodendrocyte myelin glycoproteinSource|GeneCards
C6ORF166C6ORF166chromosome 6 open reading frame 166Source|GeneCards
CRYGSCRYGScrystallin, gamma SSource|GeneCards
PTPRNPTPRNprotein tyrosine phosphatase, receptor type, NSource|GeneCards
BAG2BAG2BCL2-associated athanogene 2Source|GeneCards
PSMA3PSMA3proteasome (prosome, macropain) subunit, alpha type, 3Source|GeneCards

[an error occurred while processing this directive]