XX
XX
XX
FA AhR
XX
SY AhR; Ah receptor; dioxin
receptor; XRE-binding factor; aryl hydrocarbon
SY receptor.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa;
chordata; vertebrata; tetrapoda; mammalia;
OC eutheria; rodentia;
myomorpha; muridae; murinae
XX
XX
CL C0010; bHLH;
1.2.6.0.1.
XX
SZ 853 AA; 96.2 kDa (cDNA), 95 kDa (SDS)
[13] [11], 257 (sedim.) [13]; 121
SZ (sedim., ligand-binding
subunit) [13]
XX
XX
SC conceptually translated from
EMBL/GenBank/DDBJ #U04860
XX
FT 31 38 basic region.
FT 33 87 SM00353; HLH.
FT 36 80 PF00010; HLH.
FT 39 80
helix-loop-helix domain.
FT 111 177 SM00091; PAS.
FT 111
175 PF00989; PAS.
FT 116 378 PAS domain.
FT 270 340 SM00091;
PAS.
FT 346 387 SM00086; PAC.
FT 346 387 PF00785; PAC.
FT 596 653 glutamine-rich region (20/58).
XX
SF 95 kDa:
ligand-binding subunit;
SF Stokes radius: 7.0 nm;
SF dissociation
into subunits upon treatment with 0.4 M KCl sedimenting with
SF 4.9-5.6 S [13];
SF faster dissociation than murine complex
[13];
SF interacts with hsp90 [9] [8];
SF DNA-binding
of the heterodimer with Arnt is much stronger than that of Ahr
SF homodimer [4];
XX
CP highest levels in liver, lower
in thymus, kidney, lung [2]
XX
FF activator, binds to
xenobiotic response element [7];
FF quickly up-regulated by
aryl hydrocarbons (e.g. TCDD) within 30 min,
FF down-regulated
requiring an additional, labile factor over the subsequent 2
FF h [1];
XX
IN T00992; Hsp90; human, Homo sapiens.
XX
XX
XX
XX
RN [1]; RE0003540.
RX MEDLINE;
95198710.
RA Haas N. B., Cantwell C. A., Johnson P. F., Burch
J. B. E.
RT DNA-binding specificity of the PAR basic leucine
zipper protein VBP
RT partially overlaps those of the C/EBP
and CREB/ATF families and is
RT influenced by domains that
flank the core basic region
RL Mol. Cell. Biol. 15:1923-1932
(1995).
RN [2]; RE0004039.
RX MEDLINE; 94344763.
RA
Carver L. A., Hogenesch J. B., Bradfield C. A.
RT Tissue specific
expression of the rat Ah-receptor and ARNT mRNAs
RL Nucleic
Acids Res. 22:3038-3044 (1994).
RN [3]; RE0004040.
RX
MEDLINE; 94344074.
RA Reick M., Robertson R. W., Pasco D.
S., Fagan J. B.
RT Down-regulation of nuclear aryl hydrocarbon
receptor DNA-binding and
RT transactivation functions: requirement
for a labile or inducible factor
RL Mol. Cell. Biol. 14:5653-5660
(1994).
RN [4]; RE0005839.
RX MEDLINE; 94140877.
RA
Mason G. G. F., Witte A. M., Whitelaw M. L., Antonsson C., McGuire
J.,
RA Wilhelmsson A., Poellinger L., Gustafsson J. A.
RT Purification of the DNA binding form of dioxin receptor
RL J. Biol. Chem. 269:4438-4449 (1994).
RN [5]; RE0000879.
RX MEDLINE; 90130485.
RA Nemoto T., Mason G. F., Wilhelmsson
A., Cuthill S., Hapgood J., Gustafsson
RA J. A., Poellinger
L.
RT Activation of the Dioxin and Glucocorticoid Receptors
to a DNA Binding
RT State under Cell-free Conditions
RL
J. Biol. Chem. 256:2269-2277 (1990).
RN [6]; RE0000990.
RX MEDLINE; 91056130.
RA Elferink C. J., Gasiewicz T. A.,
Whitlock jr J. P.
RT Protein-DNA interactions at a dioxin-responsive
enhancer
RL J. Biol. Chem. 265:20708-20712 (1990).
RN
[7]; RE0002274.
RX MEDLINE; 89098930.
RA Hapgood J., Cuthill
S., Denis M., Poellinger L., Gustafsson J.-A.
RT Specific
protein-DNA interactions at a xenobiotic-responsive element:
RT Copurification of dioxin receptor and DNA-binding affinity
RL Proc. Natl. Acad. Sci. USA 86:60-64 (1989).
RN [8]; RE0000019.
RX MEDLINE; 88339968.
RA Denis M., Cuthill S., Wikstroem A.-C.,
Poellinger L., Gustafsson J.-A.
RT Association of the dioxin
receptor with the Mr 90.000 heat shock protein: a
RT structural
kinship with the glucocorticoid receptor
RL Biochem. Biophys.
Res. Commun. 155:801-807 (1988).
RN [9]; RE0001108.
RX
MEDLINE; 88330913.
RA Perdew G. H.
RT Association of the
Ah receptor with the 90-kDa heat shock protein
RL J. Biol.
Chem. 263:13802-13806 (1988).
RN [10]; RE0002273.
RX MEDLINE;
88190105.
RA Denison M. S., Fisher J. M., Whitlock jr J. P.
RT Inducible, receptor-dependent protein-DNA interactions at a
RT dioxin-responsive transcriptional activator
RL Proc. Natl.
Acad. Sci. USA 85:2528-2532 (1988).
RN [11]; RE0001109.
RX MEDLINE; 87137635.
RA Cuthill S., Poellinger L., Gustafsson
J.-A.
RT The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin
in the mouse hepatoma
RT cell line Hepa 1c1c7
RL J. Biol.
Chem. 262:3477-3481 (1987).
RN [12]; RE0004042.
RX MEDLINE;
87230998.
RA Fujisawa-Sehara A., Sogawa K., Yamane M., Fuji-Kurijama
Y.
RT Characterization of xenobiotic response elements upstream
from the
RT drug-metabolizing cytochrome P450c gene: a similarity
to glucocorticoid
RT regulatoty elements
RL Nucleic Acids
Res. 15:4179-4191 (1987).
RN [13]; RE0001099.
RX MEDLINE;
86140207.
RA Denison M. S., Vella L. M., Okeys A. B.
RT
Structure and function of the Ah receptor for
RT 2,3,7,8-tetrachlorodibenzo-p-dioxin
RL J. Biol. Chem. 261:3987-3995 (1986).
XX