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Gene set: V$AP4_Q6 (C3:TFAC:0110)
Standard nameV$AP4_Q6
Systematic nameC3:TFAC:0110
Brief descriptionGenes with 3'UTR containing motif CWCAGCTGGN which matches annotation for TFAP4: transcription factor AP-4 (activating enhancer binding protein 4)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA AP-4
 XX
 SY AP4.
 XX
 OS
human, Homo sapiens
 OC eukaryota; animalia; metazoa; chordata;
vertebrata; tetrapoda; mammalia;
 OC eutheria; primates

XX
 XX
 HO GT-IIBalpha, GT-IIBbeta
 XX
 CL C0012;
bHLH-ZIP; 1.3.1.4.1.
 XX
 SZ >321 AA; >36.7 kDa (cDNA),
48 kDa (SDS)
 XX
 XX
 SC SwissProt #Q01664
 XX

FT 29 43 basic region.
 FT 32 83 PF00010; HLH.
 FT 37 88
SM00353; HLH.
 FT 44 83 helix-loop-helix domain.
 FT 82
103 leucine zipper 1(L4 c-Myc-like).
 FT 134 162 leucine zipper
2 (L2EL2 c-Jun-like).
 FT 176 205 glutamine-rich region (13/30).

FT 208 227 proline-rich region (11/20).
 FT 270 319 acidic
region (15/50).
 XX
 SF leucine zipper structures are dispensable
for DNA-binding, but are required
 SF for dimerization in the
absence of DNA [2];
 SF ZIP 2 mainly supports homodimerization,
but may be substituted by ZIP 1;
 SF heterodimerization with
E12 only after truncation of both leucine zipper
 SF motifs
[2];
 XX
 FF functional interaction with AP-1
 XX

IN T00036; AP-4; human, Homo sapiens.
 IN T00204; E12; human,
Homo sapiens.
 IN T00675; E12; rat, Rattus norvegicus.

IN T01787; E12; clawed frog, Xenopus laevis.
 XX
 XX

XX
 XX
 RN [1]; RE0002420.
 RX MEDLINE; 92115708.

RA Dang C. V., Dolde C., Gillison M. L., Kato G. J.
 RT Discrimination
between related DNA sites by a single amino acid residue of

RT Myc-related basic-helix-loop-helix proteins
 RL Proc. Natl.
Acad. Sci. USA 89:599-602 (1992).
 RN [2]; RE0000665.
 RX
MEDLINE; 91065520.
 RA Hu Y. F., Luescher B., Admon A., Mermod
N., Tjian R.
 RT Transcription factor AP-4 contains multiple
dimerization domains that
 RT regulate dimer specificity

RL Genes Dev. 4:1741-1752 (1990).
 RN [3]; RE0000148.
 RX
MEDLINE; 89354548.
 RA Mermod N., O'Neill E. A., Kelly T. J.,
Tjian R.
 RT The Proline-Rich Transcriptional Activator of
CTF/NF-I Is Distinct from the
 RT Replication and DNA Binding
Domain
 RL Cell 58:741-753 (1989).
 RN [4]; RE0000398.

RX MEDLINE; 89091127.
 RA Comb M., Mermod N., Hyman S. E.,
Pearlberg J., Ross M. E., Goodman H. M.
 RT Proteins bound
adjacent DNA elements act synergistically to regulate human

RT proenkephalin cAMP inducible transcription
 RL EMBO J. 7:3793-3805
(1988).
 RN [5]; RE0001814.
 RX MEDLINE; 88189275.
 RA
Mermod N., Williams T. J., Tjian R.
 RT Enhancer binding factors
AP-4 and AP-1 act in concert to activate SV40 late
 RT transcription
in vitro
 RL Nature 332:557-561 (1988).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

231 genes, 231 accessions (Toggle view)

AccessionGeneTitleLinks
PITX3PITX3paired-like homeodomain transcription factor 3Source|GeneCards
KSR2KSR2kinase suppressor of ras 2Source|GeneCards
PDE3APDE3Aphosphodiesterase 3A, cGMP-inhibitedSource|GeneCards
HDAC4HDAC4histone deacetylase 4Source|GeneCards
ABHD4ABHD4abhydrolase domain containing 4Source|GeneCards
BCL11BBCL11BB-cell CLL/lymphoma 11B (zinc finger protein)Source|GeneCards
FOXD3FOXD3forkhead box D3Source|GeneCards
C20ORF178C20ORF178chromosome 20 open reading frame 178Source|GeneCards
BTF3L1BTF3L1basic transcription factor 3, like 1Source|GeneCards
FHL3FHL3four and a half LIM domains 3Source|GeneCards
FBXO40FBXO40F-box protein 40Source|GeneCards
NXPH3NXPH3neurexophilin 3Source|GeneCards
RPS6KB1RPS6KB1ribosomal protein S6 kinase, 70kDa, polypeptide 1Source|GeneCards
MGC35338MGC35338hypothetical protein MGC35338Source|GeneCards
CTDSP1CTDSP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1Source|GeneCards
DKFZP564J047C1ORF49chromosome 1 open reading frame 49Source|GeneCards
SUV39H2SUV39H2suppressor of variegation 3-9 homolog 2 (Drosophila)Source|GeneCards
RAI17RAI17retinoic acid induced 17Source|GeneCards
VPS45AVPS45Avacuolar protein sorting 45A (yeast)Source|GeneCards
SOX12SOX12SRY (sex determining region Y)-box 12Source|GeneCards
TPM3TPM3tropomyosin 3Source|GeneCards
C14ORF27CLEC14AC-type lectin domain family 14, member ASource|GeneCards
UNQ564OLFML1olfactomedin-like 1Source|GeneCards
ARHGEF2ARHGEF2rho/rac guanine nucleotide exchange factor (GEF) 2Source|GeneCards
MGC13024MGC13024hypothetical protein MGC13024Source|GeneCards
DOCK4DOCK4dedicator of cytokinesis 4Source|GeneCards
SCAMP5SCAMP5secretory carrier membrane protein 5Source|GeneCards
STOML2STOML2stomatin (EPB72)-like 2Source|GeneCards
EPOREPORerythropoietin receptorSource|GeneCards
RAB27ARAB27ARAB27A, member RAS oncogene familySource|GeneCards
PTPN7PTPN7protein tyrosine phosphatase, non-receptor type 7Source|GeneCards
EMP3EMP3epithelial membrane protein 3Source|GeneCards
C10ORF118C10ORF118chromosome 10 open reading frame 118Source|GeneCards
D1S155ECSDE1cold shock domain containing E1, RNA-bindingSource|GeneCards
CHRNGCHRNGcholinergic receptor, nicotinic, gamma polypeptideSource|GeneCards
EYA1EYA1eyes absent homolog 1 (Drosophila)Source|GeneCards
TRAPPC3TRAPPC3trafficking protein particle complex 3Source|GeneCards
CACNB2CACNB2calcium channel, voltage-dependent, beta 2 subunitSource|GeneCards
HOXC12HOXC12homeo box C12Source|GeneCards
FBXL11FBXL11F-box and leucine-rich repeat protein 11Source|GeneCards
FRAS1FRAS1Fraser syndrome 1Source|GeneCards
MGC2941PHF23PHD finger protein 23Source|GeneCards
TNRC4TNRC4trinucleotide repeat containing 4Source|GeneCards
VGFVGFVGF nerve growth factor inducibleSource|GeneCards
HAPLN2HAPLN2hyaluronan and proteoglycan link protein 2Source|GeneCards
AICDAAICDAactivation-induced cytidine deaminaseSource|GeneCards
GNB3GNB3guanine nucleotide binding protein (G protein), beta polypeptide 3Source|GeneCards
ARID1AARID1AAT rich interactive domain 1A (SWI- like)Source|GeneCards
KIRREL2KIRREL2kin of IRRE like 2 (Drosophila)Source|GeneCards
PTPRSPTPRSprotein tyrosine phosphatase, receptor type, SSource|GeneCards
MUC15MUC15mucin 15Source|GeneCards
ABLIM1ABLIM1actin binding LIM protein 1Source|GeneCards
MLC1SAMLC1SAmyosin light chain 1 slow aSource|GeneCards
MGC3234MGC3234hypothetical protein MGC3234Source|GeneCards
SMARCA2SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Source|GeneCards
PRICKLE1PRICKLE1prickle-like 1 (Drosophila)Source|GeneCards
KIAA0296ZNF646zinc finger protein 646Source|GeneCards
LCKLCKlymphocyte-specific protein tyrosine kinaseSource|GeneCards
TRAF4TRAF4TNF receptor-associated factor 4Source|GeneCards
RTKNRTKNrhotekinSource|GeneCards
STARD13STARD13START domain containing 13Source|GeneCards
MYBPHMYBPHmyosin binding protein HSource|GeneCards
CROC4C1ORF61chromosome 1 open reading frame 61Source|GeneCards
MGC29814MGC29814hypothetical protein MGC29814Source|GeneCards
ESRRAESRRAestrogen-related receptor alphaSource|GeneCards
ZRANB1ZRANB1zinc finger, RAN-binding domain containing 1Source|GeneCards
DLL3DLL3delta-like 3 (Drosophila)Source|GeneCards
EYA3EYA3eyes absent homolog 3 (Drosophila)Source|GeneCards
ZNFN1A2ZNFN1A2zinc finger protein, subfamily 1A, 2 (Helios)Source|GeneCards
MID2MID2midline 2Source|GeneCards
WDTC1WDTC1WD and tetratricopeptide repeats 1Source|GeneCards
CLECSF8CLECSF8C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8Source|GeneCards
SARGC1ORF116chromosome 1 open reading frame 116Source|GeneCards
SORBS1SORBS1sorbin and SH3 domain containing 1Source|GeneCards
PABPC5PABPC5poly(A) binding protein, cytoplasmic 5Source|GeneCards
AKAP2AKAP2A kinase (PRKA) anchor protein 2Source|GeneCards
FLJ40217SLC25A35solute carrier family 25, member 35Source|GeneCards
RASL12RASL12RAS-like, family 12Source|GeneCards
BACH1BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 1Source|GeneCards
CADPSCADPSCa2+-dependent activator protein for secretionSource|GeneCards
FNDC5FNDC5fibronectin type III domain containing 5Source|GeneCards
CBX6CBX6chromobox homolog 6Source|GeneCards
TFAP4TFAP4transcription factor AP-4 (activating enhancer binding protein 4)Source|GeneCards
FLJ10759TRIM62tripartite motif-containing 62Source|GeneCards
MGC17299MGC17299hypothetical protein MGC17299Source|GeneCards
TCF7TCF7transcription factor 7 (T-cell specific, HMG-box)Source|GeneCards
GRCAGPR162G protein-coupled receptor 162Source|GeneCards
HMGN2HMGN2high-mobility group nucleosomal binding domain 2Source|GeneCards
COL7A1COL7A1collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)Source|GeneCards
RGS7RGS7regulator of G-protein signalling 7Source|GeneCards
DKFZP434F0318DKFZP434F0318hypothetical protein DKFZp434F0318Source|GeneCards
MGC4504MGC4504hypothetical protein MGC4504Source|GeneCards
CPEB3CPEB3cytoplasmic polyadenylation element binding protein 3Source|GeneCards
ERN1ERN1ER to nucleus signalling 1Source|GeneCards
NPPANPPAnatriuretic peptide precursor ASource|GeneCards
ARHGAP24ARHGAP24Rho GTPase activating protein 24Source|GeneCards
PRKCQPRKCQprotein kinase C, thetaSource|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
INPPL1INPPL1inositol polyphosphate phosphatase-like 1Source|GeneCards
HRD1SYVN1synovial apoptosis inhibitor 1, synoviolinSource|GeneCards
HFE2HFE2Hemochromatosis type 2 (juvenile)Source|GeneCards
ZNF385ZNF385zinc finger protein 385Source|GeneCards
TLP19TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum)Source|GeneCards
XPNPEP1XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, solubleSource|GeneCards
XCL2XCL2chemokine (C motif) ligand 2Source|GeneCards
TRPC4TRPC4transient receptor potential cation channel, subfamily C, member 4Source|GeneCards
SIX5SIX5sine oculis homeobox homolog 5 (Drosophila)Source|GeneCards
PLXNB3PLXNB3plexin B3Source|GeneCards
VAT1VAT1Vesicle amine transport protein 1 homolog (T californica)Source|GeneCards
FLJ39421FLJ39421hypothetical protein FLJ39421Source|GeneCards
PGFPGFplacental growth factor, vascular endothelial growth factor-related proteinSource|GeneCards
RBMS3RBMS3RNA binding motif, single stranded interacting proteinSource|GeneCards
BSCL2BSCL2Bernardinelli-Seip congenital lipodystrophy 2 (seipin)Source|GeneCards
MGC19531PPM1Jprotein phosphatase 1J (PP2C domain containing)Source|GeneCards
VAMP3VAMP3vesicle-associated membrane protein 3 (cellubrevin)Source|GeneCards
SOSTSOSTsclerosteosisSource|GeneCards
ZNF238ZNF238zinc finger protein 238Source|GeneCards
TRPV1TRPV1transient receptor potential cation channel, subfamily V, member 1Source|GeneCards
MGC50896CNIH2cornichon homolog 2 (Drosophila)Source|GeneCards
HOXB5HOXB5homeo box B5Source|GeneCards
RAMP2RAMP2receptor (calcitonin) activity modifying protein 2Source|GeneCards
DKFZP547I014DKFZP547I014Ribosomal protein L23a pseudogene 13Source|GeneCards
MAP3K13MAP3K13mitogen-activated protein kinase kinase kinase 13Source|GeneCards
MESDC1MESDC1mesoderm development candidate 1Source|GeneCards
FLJ13725FAM65Afamily with sequence similarity 65, member ASource|GeneCards
H63CASC4cancer susceptibility candidate 4Source|GeneCards
FGF12FGF12fibroblast growth factor 12Source|GeneCards
OR10J1OR10J1olfactory receptor, family 10, subfamily J, member 1Source|GeneCards
UBTFUBTFupstream binding transcription factor, RNA polymerase ISource|GeneCards
RXRGRXRGretinoid X receptor, gammaSource|GeneCards
KCNQ4KCNQ4potassium voltage-gated channel, KQT-like subfamily, member 4Source|GeneCards
PROK2PROK2prokineticin 2Source|GeneCards
GPP34RGOLPH3Lgolgi phosphoprotein 3-likeSource|GeneCards
ID3ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix proteinSource|GeneCards
NEUROG3NEUROG3neurogenin 3Source|GeneCards
LOC56901LOC56901NADH:ubiquinone oxidoreductase MLRQ subunit homologSource|GeneCards
FLJ35976C1ORF104chromosome 1 open reading frame 104Source|GeneCards
TNFSF4TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)Source|GeneCards
LOC51057LOC51057hypothetical protein LOC51057Source|GeneCards
PCDH12PCDH12protocadherin 12Source|GeneCards
HSD11B1HSD11B1hydroxysteroid (11-beta) dehydrogenase 1Source|GeneCards
NDST2NDST2N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2Source|GeneCards
FBXO24FBXO24F-box only protein 24Source|GeneCards
RNF153MARCH5membrane-associated ring finger (C3HC4) 5Source|GeneCards
ASB16ASB16ankyrin repeat and SOCS box-containing 16Source|GeneCards
GATA3GATA3GATA binding protein 3Source|GeneCards
LATLATlinker for activation of T cellsSource|GeneCards
TNNT2TNNT2troponin T2, cardiacSource|GeneCards
FMO5FMO5flavin containing monooxygenase 5Source|GeneCards
MYLKMYLKmyosin, light polypeptide kinaseSource|GeneCards
INHAINHAinhibin, alphaSource|GeneCards
RAB3ARAB3ARAB3A, member RAS oncogene familySource|GeneCards
LRRN5LRRN5leucine rich repeat neuronal 5Source|GeneCards
TMOD4TMOD4tropomodulin 4 (muscle)Source|GeneCards
ABTB2ABTB2ankyrin repeat and BTB (POZ) domain containing 2Source|GeneCards
GNG3GNG3guanine nucleotide binding protein (G protein), gamma 3Source|GeneCards
CNNM2CNNM2cyclin M2Source|GeneCards
ANXA8ANXA8annexin A8Source|GeneCards
NESNESnestinSource|GeneCards
JMJD1CJMJD1Cjumonji domain containing 1CSource|GeneCards
SPOCK2SPOCK2sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2Source|GeneCards
PTCH2PTCH2patched homolog 2 (Drosophila)Source|GeneCards
RAB30RAB30RAB30, member RAS oncogene familySource|GeneCards
FILIP1FILIP1filamin A interacting protein 1Source|GeneCards
C9ORF150C9ORF150chromosome 9 open reading frame 150Source|GeneCards
PCYT1BPCYT1Bphosphate cytidylyltransferase 1, choline, beta isoformSource|GeneCards
KUAKUAubiquitin-conjugating enzyme variant KuaSource|GeneCards
ELF4ELF4E74-like factor 4 (ets domain transcription factor)Source|GeneCards
WNT4WNT4wingless-type MMTV integration site family, member 4Source|GeneCards
HOXA6HOXA6homeo box A6Source|GeneCards
SYTL1SYTL1synaptotagmin-like 1Source|GeneCards
KCNE1LKCNE1Lpotassium voltage-gated channel, Isk-related family, member 1-likeSource|GeneCards
GAS7GAS7growth arrest-specific 7Source|GeneCards
AMPHAMPHamphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)Source|GeneCards
GRIN2BGRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2BSource|GeneCards
LBX1LBX1transcription factor similar to D. melanogaster homeodomain protein lady bird lateSource|GeneCards
RASL10BRASL10BRAS-like, family 10, member BSource|GeneCards
FBXL3BFBXL21F-box and leucine-rich repeat protein 21Source|GeneCards
OBSCNOBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEFSource|GeneCards
PRKACAPRKACAProtein kinase, cAMP-dependent, catalytic, alphaSource|GeneCards
SPTBN1SPTBN1spectrin, beta, non-erythrocytic 1Source|GeneCards
RASGEF1ARASGEF1ARasGEF domain family, member 1ASource|GeneCards
WNT9AWNT9Awingless-type MMTV integration site family, member 9ASource|GeneCards
OAZINOAZINornithine decarboxylase antizyme inhibitorSource|GeneCards
FLJ20716FAM70Afamily with sequence similarity 70, member ASource|GeneCards
KIAA1747LOC57795hypothetical protein from clone 24828Source|GeneCards
RASGRF2RASGRF2Ras protein-specific guanine nucleotide-releasing factor 2Source|GeneCards
EPHA2EPHA2EphA2Source|GeneCards
KCNN2KCNN2potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2Source|GeneCards
PALM2PALM2paralemmin 2Source|GeneCards
NANOS1NANOS1nanos homolog 1 (Drosophila)Source|GeneCards
SYTL2SYTL2synaptotagmin-like 2Source|GeneCards
MLLT7MLLT7myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7Source|GeneCards
CREB3L1CREB3L1cAMP responsive element binding protein 3-like 1Source|GeneCards
WNT2BWNT2Bwingless-type MMTV integration site family, member 2BSource|GeneCards
ASB5ASB5ankyrin repeat and SOCS box-containing 5Source|GeneCards
PHLDB1PHLDB1pleckstrin homology-like domain, family B, member 1Source|GeneCards
KLF13KLF13Kruppel-like factor 13Source|GeneCards
C9ORF58C9ORF58chromosome 9 open reading frame 58Source|GeneCards
LOC143458LOC143458hypothetical protein LOC143458Source|GeneCards
PTK7PTK7PTK7 protein tyrosine kinase 7Source|GeneCards
TMOD3TMOD3tropomodulin 3 (ubiquitous)Source|GeneCards
EMILIN3EMILIN3Elastin microfibril interfacer 3Source|GeneCards
GRIK3GRIK3glutamate receptor, ionotropic, kainate 3Source|GeneCards
KUA-UEVKUA-UEVubiquitin-conjugating enzyme E2 variant 1Source|GeneCards
DHRS3DHRS3dehydrogenase/reductase (SDR family) member 3Source|GeneCards
RUNX1RUNX1runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)Source|GeneCards
KIAA0913KIAA0913KIAA0913 proteinSource|GeneCards
ELA3AELA3Aelastase 3A, pancreatic (protease E)Source|GeneCards
GLTSCR1GLTSCR1glioma tumor suppressor candidate region gene 1Source|GeneCards
C17ORF28C17ORF28chromosome 17 open reading frame 28Source|GeneCards
ZNF398ZNF398zinc finger protein 398Source|GeneCards
PICALMPICALMphosphatidylinositol binding clathrin assembly proteinSource|GeneCards
FGF8FGF8fibroblast growth factor 8 (androgen-induced)Source|GeneCards
CACNA1GCACNA1Gcalcium channel, voltage-dependent, alpha 1G subunitSource|GeneCards
FLJ30294FLJ30294hypothetical protein FLJ30294Source|GeneCards
ADRBK1ADRBK1adrenergic, beta, receptor kinase 1Source|GeneCards
LOXL4LOXL4lysyl oxidase-like 4Source|GeneCards
LOC56965LOC56965hypothetical protein from EUROIMAGE 1977056Source|GeneCards
FLJ10970FLJ10970hypothetical protein FLJ10970Source|GeneCards
ARNTARNTaryl hydrocarbon receptor nuclear translocatorSource|GeneCards
FLJ11280FAM63Afamily with sequence similarity 63, member ASource|GeneCards
CBFA2T3CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 3Source|GeneCards
PROSTEINSLC45A3solute carrier family 45, member 3Source|GeneCards
KCNMA1KCNMA1potassium large conductance calcium-activated channel, subfamily M, alpha member 1Source|GeneCards
HS3ST4HS3ST4heparan sulfate (glucosamine) 3-O-sulfotransferase 4Source|GeneCards
BCL2L2BCL2L2BCL2-like 2Source|GeneCards
SASTMAST1microtubule associated serine/threonine kinase 1Source|GeneCards
FOSL2FOSL2FOS-like antigen 2Source|GeneCards
FLJ38723FLJ38723hypothetical protein FLJ38723Source|GeneCards
FLJ13479ZNF668zinc finger protein 668Source|GeneCards

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