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Gene set: V$CDPCR1_01 (C3:TFAC:0060)
Standard nameV$CDPCR1_01
Systematic nameC3:TFAC:0060
Brief descriptionGenes with 3'UTR containing motif NATCGATCGS which matches annotation for CUTL1: cut-like 1, CCAAT displacement protein (Drosophila)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA CUTL1
 XX
 SY CDP; CCAAT displacement
protein; cut homeodomain protein; Cux; cut-like
 SY homeodomain
protein; Clox.
 XX
 OS human, Homo sapiens
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; primates
 XX
 XX
 HO cut (Drosophila) 

XX
 CL C0006; homeo; 3.1.1.4.1.
 XX
 SZ 1505 AA; 164.4
kDa (cDNA), 180-200 kDa (SDS)
 XX
 XX
 SC SwissProt #P39880

XX
 FT 542 629 PF02376; CUT.
 FT 551 610 Cut-repeat 1 (CR1).

FT 551 610 involved in binding to S/MAR-binding factor SATB1 

FT [1].
 FT 632 653 missing in putative splice variant.

FT 934 1021 PF02376; CUT.
 FT 943 1007 Cut-repeat 2 (CR2).

FT 943 1007 involved in binding to S/MAR-binding factor SATB1

 FT [1].
 FT 1117 1204 PF02376; CUT.
 FT 1135
1190 Cut-repeat 3 (CR3).
 FT 1244 1306 SM00389; HOX.
 FT
1245 1301 homeo domain.
 FT 1245 1301 involved in binding to
S/MAR-binding factor SATB1 
 FT [1].
 FT 1245
1301 PF00046; homeobox.
 XX
 SF the Clox homolog is a splice
variant [5];
 SF the 3 cut repeats also contribute to DNA-binding,
each individual repeat
 SF and each combination exhibiting
slightly different DNA-binding specificity
 SF [4] [2] [5];

SF CR1 exhibits the most restricted resognition pattern [4];

SF KD (CR3-homeo domain) = 0.03 nM, isolated CR3 at least 100-fold
lower
 SF affinity [2];
 XX
 FF repressor [13] [12] [9]
[8] [6] [3];
 FF may regulate S/MAR-binding factor SATB1 
and may be regulated by
 FF it via protein-protein interaction
[1];
 XX
 XX
 XX
 XX
 RN [1]; RE0015021.
 RX
MEDLINE; 99303784.
 RA Liu J., Barnett A., Neufeld E. J., Dudley
J. P.
 RT Homeoproteins CDP and SATB1interact: potential for
tissue-specific
 RT regulation
 RL Mol. Cell. Biol. 19:4918-4926
(1999).
 RN [2]; RE0002973.
 RX MEDLINE; 95097984.
 RA
Harada R., Berube G., Tamplin O. J., Denis-Larose C., Nepveu A.

RT DNA-binding specificity of the cut repeats from the human cut-like
protein
 RL Mol. Cell. Biol. 15:129-140 (1995).
 RN [3];
RE0003999.
 RX MEDLINE; 95279415.
 RA Lievens P. M., Donady
J. J., Tufarelli C., Neufeld E. J.
 RT Repressor activity of
CCAAT displacement protein in HL-60 myeloid leukemia
 RT cells

RL J. Biol. Chem. 270:12745-12750 (1995).
 RN [4]; RE0002967.

RX MEDLINE; 94329595.
 RA Aufiero B., Neufeld E. J., Orkin
S. H.
 RT Sequence-specific DNA binding of individual cut repeats
of the human CCAAT
 RT displacement/ cut homeodomain protein

RL Proc. Natl. Acad. Sci. USA 91:7757-7761 (1994).
 RN [5];
RE0002972.
 RX MEDLINE; 94131277.
 RA Andres V., Chiara
M. D., Mahdavi V.
 RT A new bipartite DNA-binding domain: cooperative
interaction between the cut
 RT repeat and homeo domain of
the cut homeo proteins
 RL Genes Dev. 8:245-257 (1994).

RN [6]; RE0003358.
 RX MEDLINE; 94254882.
 RA Dufort D.,
Nepveu A.
 RT The human Cut homeodomain protein represses transcription
from the c-myc
 RT promoter
 RL Mol. Cell. Biol. 14:4251-4257
(1994).
 RN [7]; RE0005004.
 RX MEDLINE; 94124559.
 RA
Harada R., Dufort D., Denis-Larose C., Nepveu A.
 RT Conserved
cut repeats in the human cut homeodomain protein function as DNA

RT binding domains
 RL J. Biol. Chem. 269:2062-2067 (1994).

RN [8]; RE0005002.
 RX MEDLINE; 93250973.
 RA Neufeld E.
J., Skalnik D. G., Lievens P. M., Orkin S. H.
 RT Human CCAAT
dis-placement protein is homologous to the Drosophila
 RT homeoprotein,
cut
 RL Nat. Genet. 1:50-55 (1992).
 RN [9]; RE0001031.

RX MEDLINE; 91358470.
 RA Skalnik D. G., Strauss E. C., Orkin
S. H.
 RT CCAAT displacement protein as a repressor of the
myelomonocytic-specific
 RT gp91-phox gene promoter
 RL
J. Biol. Chem. 266:16736-16744 (1991).
 RN [10]; RE0002047.

RX MEDLINE; 89385992.
 RA Mantovani R., Superti-Furga G., Gilman
J., Ottolenghi S.
 RT The deletion of the distal CCAAT box
region of the Agamma-globin gene in
 RT black HPFH abolishes
the binding of the erythroid specific protein NFE3 and
 RT
of the CCAAT displacement protein
 RL Nucleic Acids Res. 17:6681-6691
(1989).
 RN [11]; RE0005005.
 RX MEDLINE; 89150259.

RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M.

RT The protein CDP, but not CP1, footprints on the CCAAT region
of the
 RT g-globin gene in unfractionated B-cell extracts

RL Biochim. Biophys. Acta 1007:237-242 (1989).
 RN [12]; RE0000346.

RX MEDLINE; 89030605.
 RA Superti-Furga G., Barberis A., Schaffner
G., Busslinger M.
 RT The -117 mutation in Greek HPFH affects
the binding of three nuclear
 RT factors to the CCAAT region
of the gamma-globin gene
 RL EMBO J. 7:3099-3107 (1988).

RN [13]; RE0000079.
 RX MEDLINE; 87273497.
 RA Barberis
A., Superti-Furga G., Busslinger M.
 RT Mutually Exclusive
Interaction of the CCAAT-Binding Factor and of a
 RT Displacement
Protein with Overlapping Sequences of a Histone Gene Promoter

RL Cell 50:347-359 (1987).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

131 genes, 131 accessions (Toggle view)

AccessionGeneTitleLinks
MN1MN1meningioma (disrupted in balanced translocation) 1Source|GeneCards
LYPLA3LYPLA3lysophospholipase 3 (lysosomal phospholipase A2)Source|GeneCards
HOXB4HOXB4homeo box B4Source|GeneCards
KCNA1KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)Source|GeneCards
MEIS1MEIS1Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)Source|GeneCards
EXT1EXT1Exostoses (multiple) 1Source|GeneCards
FLJ13912FLJ13912hypothetical protein FLJ13912Source|GeneCards
DPH2L1DPH2L1diptheria toxin resistance protein required for diphthamide biosynthesis-like 1 (S. cerevisiae)Source|GeneCards
EGR1EGR1early growth response 1Source|GeneCards
FGF12FGF12fibroblast growth factor 12Source|GeneCards
ZNF503ZNF503zinc finger protein 503Source|GeneCards
LOC283514LOC283514similar to seven in absentia 2Source|GeneCards
KCNS1KCNS1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1Source|GeneCards
DBCCR1LFAM5Cfamily with sequence similarity 5, member CSource|GeneCards
IL1RAPL1IL1RAPL1interleukin 1 receptor accessory protein-like 1Source|GeneCards
NRXN3NRXN3neurexin 3Source|GeneCards
COL2A1COL2A1collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)Source|GeneCards
MGAT5BMGAT5Bmannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isoenzyme BSource|GeneCards
HH114HH114hypothetical protein HH114Source|GeneCards
PLXNA3PLXNA3plexin A3Source|GeneCards
EEF1A2EEF1A2eukaryotic translation elongation factor 1 alpha 2Source|GeneCards
TLE4TLE4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)Source|GeneCards
LOC51057LOC51057hypothetical protein LOC51057Source|GeneCards
TBC1D14TBC1D14TBC1 domain family, member 14Source|GeneCards
TBX6TBX6T-box 6Source|GeneCards
NTNG2NTNG2netrin G2Source|GeneCards
ERGERGv-ets erythroblastosis virus E26 oncogene like (avian)Source|GeneCards
KDELR2KDELR2KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2Source|GeneCards
RLFRLFRearranged L-myc fusionSource|GeneCards
NR2F6NR2F6nuclear receptor subfamily 2, group F, member 6Source|GeneCards
DIO2DIO2deiodinase, iodothyronine, type IISource|GeneCards
FOXG1BFOXG1Bforkhead box G1BSource|GeneCards
CBFA2T1RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
NR3C2NR3C2nuclear receptor subfamily 3, group C, member 2Source|GeneCards
LIN28LIN28lin-28 homolog (C. elegans)Source|GeneCards
DPP10DPP10dipeptidylpeptidase 10Source|GeneCards
NTRK1NTRK1neurotrophic tyrosine kinase, receptor, type 1Source|GeneCards
FLJ20618FLJ20618hypothetical protein FLJ20618Source|GeneCards
LOC152485LOC152485hypothetical protein LOC152485Source|GeneCards
DGKBDGKBdiacylglycerol kinase, beta 90kDaSource|GeneCards
PFN2PFN2profilin 2Source|GeneCards
SERPINI1SERPINI1serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1Source|GeneCards
RPH3ARPH3Arabphilin 3A homolog (mouse)Source|GeneCards
RNF110PCGF2polycomb group ring finger 2Source|GeneCards
SERPING1SERPING1serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)Source|GeneCards
SLC12A5SLC12A5solute carrier family 12, (potassium-chloride transporter) member 5Source|GeneCards
ITGA7ITGA7integrin, alpha 7Source|GeneCards
HOXB2HOXB2homeo box B2Source|GeneCards
TUBA1TUBA1tubulin, alpha 1 (testis specific)Source|GeneCards
NOL4NOL4nucleolar protein 4Source|GeneCards
FLJ42957FLJ42957FLJ42957 proteinSource|GeneCards
TBX3TBX3T-box 3 (ulnar mammary syndrome)Source|GeneCards
MYST2MYST2MYST histone acetyltransferase 2Source|GeneCards
NOGNOGnogginSource|GeneCards
LOC115509LOC115509hypothetical protein BC014000Source|GeneCards
STAG2STAG2stromal antigen 2Source|GeneCards
SFTPCSFTPCsurfactant, pulmonary-associated protein CSource|GeneCards
DYRK2DYRK2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2Source|GeneCards
GATA4GATA4GATA binding protein 4Source|GeneCards
TUBA4TUBA4tubulin, alpha 4Source|GeneCards
NOVA1NOVA1neuro-oncological ventral antigen 1Source|GeneCards
GRB7GRB7growth factor receptor-bound protein 7Source|GeneCards
DBC1DBC1deleted in bladder cancer 1Source|GeneCards
EMP1EMP1epithelial membrane protein 1Source|GeneCards
FLJ44313FLJ44313FLJ44313 proteinSource|GeneCards
FCHSD1FCHSD1FCH and double SH3 domains 1Source|GeneCards
AP3M2AP3M2adaptor-related protein complex 3, mu 2 subunitSource|GeneCards
HOXC5HOXC5homeo box C5Source|GeneCards
AMBPAMBPalpha-1-microglobulin/bikunin precursorSource|GeneCards
HOXD10HOXD10homeo box D10Source|GeneCards
FLJ25791FLJ25791hypothetical protein FLJ25791Source|GeneCards
CSMD3CSMD3CUB and Sushi multiple domains 3Source|GeneCards
ETV1ETV1ets variant gene 1Source|GeneCards
HOXC6HOXC6homeo box C6Source|GeneCards
MLLMLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)Source|GeneCards
CIB3CIB3calcium and integrin binding family member 3Source|GeneCards
PDCD10PDCD10programmed cell death 10Source|GeneCards
VAX1VAX1ventral anterior homeobox 1Source|GeneCards
BARHL2BARHL2BarH-like 2 (Drosophila)Source|GeneCards
NFIBNFIBnuclear factor I/BSource|GeneCards
MGC33190ATXN7L4ataxin 7-like 4Source|GeneCards
HOXC11HOXC11homeo box C11Source|GeneCards
ZNFN1A2ZNFN1A2zinc finger protein, subfamily 1A, 2 (Helios)Source|GeneCards
PAX8PAX8paired box gene 8Source|GeneCards
MBNL1MBNL1muscleblind-like (Drosophila)Source|GeneCards
STAT5BSTAT5Bsignal transducer and activator of transcription 5BSource|GeneCards
PIGNPIGNphosphatidylinositol glycan, class NSource|GeneCards
RFX4RFX4regulatory factor X, 4 (influences HLA class II expression)Source|GeneCards
NKX2-2NKX2-2NK2 transcription factor related, locus 2 (Drosophila)Source|GeneCards
TCF7L2TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Source|GeneCards
STEAP2STEAP2six transmembrane epithelial antigen of prostate 2Source|GeneCards
INSRRINSRRinsulin receptor-related receptorSource|GeneCards
KCND1KCND1potassium voltage-gated channel, Shal-related subfamily, member 1Source|GeneCards
FLJ30296PTCHD1Patched domain containing 1Source|GeneCards
RTN4RL2RTN4RL2reticulon 4 receptor-like 2Source|GeneCards
NUCKSNUCKS1nuclear casein kinase and cyclin-dependent kinase substrate 1Source|GeneCards
ALS2CR4ALS2CR4amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4Source|GeneCards
CREMCREMcAMP responsive element modulatorSource|GeneCards
TRIB2TRIB2tribbles homolog 2 (Drosophila)Source|GeneCards
PPT2PPT2palmitoyl-protein thioesterase 2Source|GeneCards
MAGMAGmyelin associated glycoproteinSource|GeneCards
FLJ23311E2F8E2F transcription factor 8Source|GeneCards
IL15IL15interleukin 15Source|GeneCards
FLJ14442AGBL4ATP/GTP binding protein-like 4Source|GeneCards
THRATHRAthyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)Source|GeneCards
CUL2CUL2cullin 2Source|GeneCards
GSH-2GSH-2homeobox protein GSH-2Source|GeneCards
ADAM10ADAM10a disintegrin and metalloproteinase domain 10Source|GeneCards
PHF3PHF3PHD finger protein 3Source|GeneCards
HOXA10HOXA10homeo box A10Source|GeneCards
ST7ST7suppression of tumorigenicity 7Source|GeneCards
BHLHB3BHLHB3basic helix-loop-helix domain containing, class B, 3Source|GeneCards
FLJ32384HEXIM2hexamthylene bis-acetamide inducible 2Source|GeneCards
MGC46534ATXN7L2ataxin 7-like 2Source|GeneCards
CPNE6CPNE6copine VI (neuronal)Source|GeneCards
MAOBMAOBmonoamine oxidase BSource|GeneCards
KLF15KLF15Kruppel-like factor 15Source|GeneCards
DUSP4DUSP4dual specificity phosphatase 4Source|GeneCards
NHLH2NHLH2nescient helix loop helix 2Source|GeneCards
BRUNOL4BRUNOL4bruno-like 4, RNA binding protein (Drosophila)Source|GeneCards
CYP26B1CYP26B1cytochrome P450, family 26, subfamily B, polypeptide 1Source|GeneCards
DSCR5DSCR5Down syndrome critical region gene 5Source|GeneCards
INSM2INSM2insulinoma-associated 2Source|GeneCards
C6ORF166C6ORF166chromosome 6 open reading frame 166Source|GeneCards
MGC13053MGC13053hypothetical protein MGC13053Source|GeneCards
GRIK4GRIK4glutamate receptor, ionotropic, kainate 4Source|GeneCards
BTBD3BTBD3BTB (POZ) domain containing 3Source|GeneCards
SONSONSON DNA binding proteinSource|GeneCards
LOC146325LOC146325similar to hypothetical protein FLJ13841Source|GeneCards
STMN2STMN2stathmin-like 2Source|GeneCards
GARTGARTphosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseSource|GeneCards

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