XX
XX
XX
FA CP2
XX
SY alpha-CP2a; alpha-CP2a,
alpha-CP2b; CP-2; LSF; SEF-1; alpha-CP2; LBP-1c;
SY SAA enhancer
factor 1.
XX
OS mouse, Mus musculus
OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;
OC eutheria; rodentia; myomorpha; muridae; murinae
XX
XX
HO Elf-1 (Drosophila)
XX
CL C0051; Grainyhead;
4.9.1.0.1.1.
XX
SZ 502 AA; 57.0 kDa (cDNA), 64-66 kDa
(SDS)
XX
XX
SC translated from EMBL #M84809
XX
FT 37 501 PF04516; CP2.
FT 39 292 DNA-binding domain.
FT 63 270 distantly related to Elf-1.
FT 236 248 basic region.
FT 258 398 serine-/threonine-/proline-rich region (S-T-P domain).
FT 381 501 dimerisation domain.
FT 404 413 glutamine-rich
region.
XX
SF belongs to the Granyhead-like family of
TFs, together with Drosophila
SF Elf-1/NTF-1 factors, and
likely presents novel type of DNA binding;
SF recognizes DNA
elements consisting of two directly repeated half-sites [5];
SF glutamine-rich region, phosphorylation;
XX
EX adrenal
gland (right + left),,,Theiler Stage 15;detectable; RNA-in situ
EX hybridization (not further specified); RNA (undefined); [1].
EX adrenal gland (right + left),,,Theiler Stage 16;detectable;
RNA-in situ
EX hybridization (not further specified); RNA
(undefined); [1].
EX adrenal gland (right + left),,,Theiler
Stage 18;detectable; RNA-in situ
EX hybridization (not further
specified); RNA (undefined); [1].
EX adrenal gland (right
+ left),,,Theiler Stage 19;detectable; RNA-in situ
EX hybridization
(not further specified); RNA (undefined); [1].
EX adrenal
gland (right + left),,,Theiler Stage 20;detectable; RNA-in situ
EX hybridization (not further specified); RNA (undefined); [1].
EX adrenal gland (right + left),,,Theiler Stage 21;detectable;
RNA-in situ
EX hybridization (not further specified); RNA
(undefined); [1].
EX adrenal gland (right + left),,,adult;detectable;
RNA-in situ hybridization
EX (not further specified); RNA
(undefined); [1].
EX adrenal gland (right + left),,,adult;detectable;
RT-PCR; total RNA; [1].
EX adrenal gland (right + left),,,adult;detectable;
western blot; protein;
EX [1].
EX brain,,,Theiler Stage
16;detectable; RNA-in situ hybridization (not further
EX specified);
RNA (undefined); [1].
EX brain,,,Theiler Stage 17;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX brain,,,Theiler Stage 18;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX brain,,,Theiler Stage 19;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX brain,,,Theiler Stage 20;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX brain,,,adult;detectable; RT-PCR; total
RNA; [1].
EX brain,,,adult;detectable; western blot; protein;
[1].
EX future brain,,,Theiler Stage 15;detectable; RNA-in
situ hybridization (not
EX further specified); RNA (undefined);
[1].
EX gonadal ridge,,,Theiler Stage 17;detectable; RNA-in
situ hybridization (not
EX further specified); RNA (undefined);
[1].
EX gonadal ridge,,,Theiler Stage 18;detectable; RNA-in
situ hybridization (not
EX further specified); RNA (undefined);
[1].
EX gonadal ridge,,,Theiler Stage 19;detectable; RNA-in
situ hybridization (not
EX further specified); RNA (undefined);
[1].
EX gonadal ridge,,,Theiler Stage 20;detectable; RNA-in
situ hybridization (not
EX further specified); RNA (undefined);
[1].
EX heart,,,Theiler Stage 15;detectable; RNA-in situ hybridization
(not further
EX specified); RNA (undefined); [1].
EX heart,,,Theiler
Stage 16;detectable; RNA-in situ hybridization (not further
EX specified); RNA (undefined); [1].
EX heart,,,Theiler Stage
17;detectable; RNA-in situ hybridization (not further
EX specified);
RNA (undefined); [1].
EX heart,,,Theiler Stage 18;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX heart,,,Theiler Stage 19;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX heart,,,Theiler Stage 20;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX heart,,,Theiler Stage 21;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX heart,,,adult;detectable; RT-PCR; total
RNA; [1].
EX heart,,,adult;detectable; western blot; protein;
[1].
EX hepatic primordium,,,Theiler Stage 15;detectable;
RNA-in situ hybridization
EX (not further specified); RNA
(undefined); [1].
EX hepatic primordium,,,Theiler Stage 16;detectable;
RNA-in situ hybridization
EX (not further specified); RNA
(undefined); [1].
EX kidney (right and left),,,adult;detectable;
RT-PCR; total RNA; [1].
EX kidney (right and left),,,adult;detectable;
western blot; protein; [1].
EX liver bud,,,Theiler Stage 13;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [1].
EX liver bud,,,Theiler Stage 14;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [1].
EX liver,,,Theiler Stage 17;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX liver,,,Theiler Stage 18;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX liver,,,Theiler Stage 19;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX liver,,,Theiler Stage 20;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX liver,,,Theiler Stage 21;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [1].
EX liver,,,adult;detectable; RT-PCR; total
RNA; [1].
EX liver,,,adult;detectable; western blot; protein;
[1].
EX lung bud,,,Theiler Stage 15;detectable; RNA-in situ
hybridization (not
EX further specified); RNA (undefined);
[1].
EX lung bud,,,Theiler Stage 16;detectable; RNA-in situ
hybridization (not
EX further specified); RNA (undefined);
[1].
EX lung bud,,,Theiler Stage 17;detectable; RNA-in situ
hybridization (not
EX further specified); RNA (undefined);
[1].
EX lung bud,,,Theiler Stage 18;detectable; RNA-in situ
hybridization (not
EX further specified); RNA (undefined);
[1].
EX lung bud,,,Theiler Stage 19;detectable; RNA-in situ
hybridization (not
EX further specified); RNA (undefined);
[1].
EX lung bud,,,Theiler Stage 20;detectable; RNA-in situ
hybridization (not
EX further specified); RNA (undefined);
[1].
EX lung,,,Theiler Stage 21;detectable; RNA-in situ hybridization
(not further
EX specified); RNA (undefined); [1].
EX lung,,,adult;detectable;
RT-PCR; total RNA; [1].
EX lung,,,adult;detectable; western
blot; protein; [1].
EX metanephros,,,Theiler Stage 16;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [1].
EX metanephros,,,Theiler Stage 17;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [1].
EX metanephros,,,Theiler Stage 18;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [1].
EX metanephros,,,Theiler Stage 19;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [1].
EX metanephros,,,Theiler Stage 20;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [1].
EX metanephros,,,Theiler Stage 21;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [1].
EX muscles,,,Theiler Stage 20;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [1].
EX muscles,,,Theiler Stage 21;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [1].
EX muscles,,,adult;detectable; RT-PCR; total
RNA; [1].
EX muscles,,,adult;detectable; western blot; protein;
[1].
EX nephric vesicles,,,Theiler Stage 15;detectable; RNA-in
situ hybridization
EX (not further specified); RNA (undefined);
[1].
EX ovary,,,Theiler Stage 21;detectable; RNA-in situ hybridization
(not further
EX specified); RNA (undefined); [1].
EX ovary,,,adult;detectable;
RT-PCR; total RNA; [1].
EX ovary,,,adult;detectable; western
blot; protein; [1].
EX precursor of muscles,,,Theiler Stage
15;detectable; RNA-in situ
EX hybridization (not further specified);
RNA (undefined); [1].
EX precursor of muscles,,,Theiler Stage
16;detectable; RNA-in situ
EX hybridization (not further specified);
RNA (undefined); [1].
EX precursor of muscles,,,Theiler Stage
17;detectable; RNA-in situ
EX hybridization (not further specified);
RNA (undefined); [1].
EX precursor of muscles,,,Theiler Stage
18;detectable; RNA-in situ
EX hybridization (not further specified);
RNA (undefined); [1].
EX precursor of muscles,,,Theiler Stage
19;detectable; RNA-in situ
EX hybridization (not further specified);
RNA (undefined); [1].
EX spleen,,,Theiler Stage 22;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [1].
EX spleen,,,adult;detectable; RT-PCR; total
RNA; [1].
EX spleen,,,adult;detectable; western blot; protein;
[1].
EX testis (right and left),,,Theiler Stage 21;detectable;
RNA-in situ
EX hybridization (not further specified); RNA
(undefined); [1].
EX testis (right and left),,,adult;detectable;
RT-PCR; total RNA; [1].
EX testis (right and left),,,adult;detectable;
western blot; protein; [1].
EX thymus primordium,,,Theiler
Stage 20;detectable; RNA-in situ hybridization
EX (not further
specified); RNA (undefined); [1].
EX thymus primordium,,,Theiler
Stage 21;detectable; RNA-in situ hybridization
EX (not further
specified); RNA (undefined); [1].
EX thymus,,,adult;detectable;
RT-PCR; total RNA; [1].
EX thymus,,,adult;detectable; western
blot; protein; [1].
EX urogenital ridge,,,Theiler Stage 14;detectable;
RNA-in situ hybridization
EX (not further specified); RNA
(undefined); [1].
EX urogenital ridge,,,Theiler Stage 15;detectable;
RNA-in situ hybridization
EX (not further specified); RNA
(undefined); [1].
EX urogenital ridge,,,Theiler Stage 16;detectable;
RNA-in situ hybridization
EX (not further specified); RNA
(undefined); [1].
XX
FF activator [3];
FF appears
to be functionally limiting in nuclear B cell extracts;
FF
activates transcription of alpha-globin gene [8] [9] [6] [7],
of the major
FF acute phase gene SAA3 [3].;
XX
XX
XX
XX
RN [1]; RE0008932.
RA Swendeman S. L., Spielholz
C., Jenkins N. A., Gilbert D. J., Copeland N.
RA G., Sheffery
M.
RT Characterization of the genomic structure, chromosomal
location, promoter
RT and developmental expression of the
alpha-globin transcription factor CP2
RL J. Biol. Chem. 269:11663-11671
(1994).
RN [2]; RE0023445.
RX MEDLINE; 12888489.
RA
Venkatesan K., McManus H. R., Mello C. C., Smith T. F., Hansen
U.
RT Functional conservation between members of an ancient
duplicated
RT transcription factor family, LSF/Grainyhead.
RL Nucleic Acids Res. 31:4304-4316 (2003).
RN [3]; RE0022225.
RX MEDLINE; 10455131.
RA Bing Z., Reddy S. A., Ren Y., Qin
J., Liao W. S.
RT Purification and characterization of the
serum amyloid A3 enhancer factor.
RL J. Biol. Chem. 274:24649-24656
(1999).
RN [4]; RE0007054.
RX MEDLINE; 94277052.
RA
Huang J. H., Liao W. S.-L.
RT Induction of the mouse serum
amyloid A3 gene by cytokines requires both
RT C/EBP family
proteins and a novel constitutive nuclear factor
RL Mol. Cell.
Biol. 14:4475-4484 (1994).
RN [5]; RE0003047.
RX MEDLINE;
93352618.
RA Lim L. C., Fang L., Swendeman S. L., Sheffery
M.
RT Characterization of the molecularly cloned murine alpha-globin
RT transcription factor CP2
RL J. Biol. Chem. 268:18008-18017
(1993).
RN [6]; RE0001633.
RX MEDLINE; 92123208.
RA
Lim L. C., Swendeman S. L., Sheffery M.
RT Molecular cloning
of the alpha-globin transcription factor CP2
RL Mol. Cell.
Biol. 12:828-835 (1992).
RN [7]; RE0002945.
RX MEDLINE;
91042527.
RA Kim C. G., Swendeman S. L., Barnhart K. M., Sheffery
M.
RT Promoter elements and erythroid cell nuclear factors
that regulate
RT alpha-globin gene transcription in vitro
RL Mol. Cell. Biol. 10:5958-5966 (1990).
RN [8]; RE0001257.
RX MEDLINE; 89096909.
RA Barnhart K. M., Kim C. G., Banerji
S. S., Sheffery M.
RT Identification and Characterization
of Multiple Erythroid Cell Proteins
RT That Interact with
the Promoter of the Murine alpha-Globin Gene
RL Mol. Cell.
Biol. 8:3215-3226 (1988).
RN [9]; RE0001258.
RX MEDLINE;
89039854.
RA Kim C. G., Barnhart K. M., Sheffery M.
RT
Purification of Multiple Erythroid Cell Proteins That Bind the
Promoter of
RT the alpha-Globin Gene
RL Mol. Cell. Biol.
8:4270-4281 (1988).
XX