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Gene set: V$CREBP1CJUN_01 (C3:TFAC:0019)
Standard nameV$CREBP1CJUN_01
Systematic nameC3:TFAC:0019
Brief descriptionGenes with 3'UTR containing motif TGACGTYA which matches annotation for JUN: v-jun sarcoma virus 17 oncogene homolog (avian)
ATF2: activating transcription factor 2
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA CRE-BP1
 XX
 SY ATF-2; CRE-BP1;
HB16; XBP4 (mouse); TREB-7; CREBP1.
 XX
 OS human, Homo
sapiens
 OC eukaryota; animalia; metazoa; chordata; vertebrata;
tetrapoda; mammalia;
 OC eutheria; primates
 XX
 XX

CL C0008; bZIP; 1.1.1.6.3.1.
 XX
 SZ 505 AA; 54.5 kDa (cDNA),
69 kDa (SDS)
 XX
 XX
 SC SwissProt #P15336
 XX

FT 1 143 region supporting E1A responsiveness [22].
 FT 1 109
minimal trans-activation domain [3].
 FT 25 49 PF00096; zf-C2H2.

FT 27 49 potential zinc finger (Cys2His2 type) [22].
 FT 62
62 serine, PKA phosphorylation site in vitro [21].
 FT 69 69
threonine phosphorylated by JNK [8].
 FT 71 71 threonine phosphorylated
by JNK [8].
 FT 100 100 potential PKA phosphorylation site
[26].
 FT 110 195 modulation of intramolecular inhibition [3].

FT 121 121 potential PKC phosphorylation site [26].
 FT 150
247 missing in CRE-BP2 [23].
 FT 320 340 serine-/threonine-rich
region (12/21).
 FT 340 340 serine, PKC phosphorylation site
in vitro [21].
 FT 350 414 PF00170; bZIP.
 FT 350 414 SM00338;
BRLZ.
 FT 353 377 basic region [26].
 FT 367 367 serine,
PKC phosphorylation site in vitro [21].
 FT 380 408 leucine
zipper (L5) [26].
 FT 387 417 serine-/threonine-rich region
(15/31).
 XX
 SF Tax interacts with the basic domain and
thereby enhances homodimerization
 SF [11] [5] [6];
 SF
this contact alters also the DNA-binding selectivity [5];

SF the zinc finger structure is important for trans-activation
by the
 SF homodimer [15];
 SF bound to DNA, CRE-BP1 interacts
with E1A via N-terminal regions comprising
 SF the zinc finger
motif as essential element [22] [16];
 SF in the heterodimer
with c-Jun, trans-activation is mainly achieved by the
 SF
c-Jun moiety [15];
 SF no heterodimerization with deltaCREB
[24];
 SF DNA-bending towards the minor groove when heterodimerized
with c-Fos or
 SF Fra-2 [19];
 SF with c-Jun: beinding in
the opposite direction, similar to that caused by
 SF CRE-BP1
homodimers [19];
 XX
 EX adrenal gland (right and left),,,adult;very
low; northern blot; mRNA
 EX (poly-A); [1].
 EX amygdaloid
body,,,adult;none; northern blot; mRNA (poly-A); [1].
 EX brain,,,adult;very
high; northern blot; mRNA (poly-A); [1].
 EX cerebellum,,,adult;high;
northern blot; mRNA (poly-A); [1].
 EX heart,,,adult;none;
northern blot; mRNA (poly-A); [1].
 EX kidney (right and left),,,adult;high;
northern blot; mRNA (poly-A); [1].
 EX liver,,,adult;none;
northern blot; mRNA (poly-A); [1].
 EX lung (right and left),,,adult;high;
northern blot; mRNA (poly-A); [1].
 EX meninges of brain,,,adult;high;
northern blot; mRNA (poly-A); [1].
 EX meninges of spinal cord,,,adult;high;
northern blot; mRNA (poly-A); [1].
 EX muscles,,,adult;high;
northern blot; mRNA (poly-A); [1].
 EX spinal cord,,,adult;high;
northern blot; mRNA (poly-A); [1].
 EX spleen,,,adult;high;
northern blot; mRNA (poly-A); [1].
 EX stomach,,,adult;high;
northern blot; mRNA (poly-A); [1].
 EX thalamus,,,adult;very
low; northern blot; mRNA (poly-A); [1].
 EX thymus,,,adult;high;
northern blot; mRNA (poly-A); [1].
 XX
 FF activator, cAMP-independent
[15];
 FF stronger activator as heterodimer with c-Jun than
as homodimer [15];
 FF activation capability is masked by the
bZIP domain by direct intramolecular
 FF interaction [22] [3];

FF release of this inhibition depends on an intermediate sequence
and works in
 FF a cell-specific manner [3];
 FF transcriptional
activation is stimulated by Rb involving CRE-BP1 in cell
 FF
cycle control [14];
 FF interacts with E1A and places its transactivation
domain at a viral
 FF promoter;
 FF mediates E1A-induced
trans-activation through the potential zinc finger
 FF (part.
important: C27 and C32) and the leucine zipper (in particular
3rd
 FF and 4th Leu) [22] [16];
 FF altered DNA-binding
specificity after complexing with HBV pX [20] or with
 FF HTLV-I
Tax [11];
 FF in vitro phosphorylation by PKA and PKC, function
unclear;
 FF phosphorylation by a JNK/SAPK kinase of the MAPK
family at Thr-69 and
 FF Thr-71 is essential for trans-activation
[8];
 FF it mediates activation in response to UV or other
cellular stresses [7] and
 FF to Rb as well as E1A [8];

FF binding activity can be induced by IL-1 and TPA [2];
 XX

IN T01313; ATF3; human, Homo sapiens.
 IN T00051; ATF; human,
Homo sapiens.
 IN T00122; c-Fos; mouse, Mus musculus.
 IN
T00123; c-Fos; human, Homo sapiens.
 IN T00131; c-Jun; mouse,
Mus musculus.
 IN T00132; c-Jun; rat, Rattus norvegicus.

IN T00133; c-Jun; human, Homo sapiens.
 IN T00134; c-Jun; chick,
Gallus gallus.
 IN T00135; c-Jun; hamster.
 IN T00167; CRE-BP1;
human, Homo sapiens.
 IN T01017; CRE-BP2; mouse, Mus musculus.

IN T01308; CRE-BPa; human, Homo sapiens.
 IN T00967; E1A 12S
protein; adenovirus.
 IN T00209; E1A 13S protein; adenovirus
type 2.
 IN T01991; Fra-2; human, Homo sapiens.
 IN T01980;
HMG Y; human, Homo sapiens.
 IN T00593; NF-kappaB1; human,
Homo sapiens.
 IN T00722; pRb; human, Homo sapiens.
 IN
T01384; pX; HBV, human hepatitis B virus.
 IN T00594; RelA;
human, Homo sapiens.
 IN T00793; Tax; HTLV-I, human T-cell
lymphotropic virus type I.
 XX
 XX
 XX
 XX
 RN
[1]; RE0001462.
 RX MEDLINE; 90205810.
 RA Kara C. J., Liou
H.-C., Ivashkiv L. B., Glimcher L. H.
 RT A cDNA for a human
cyclic AMP response element-binding protein which is
 RT distinct
from CREB and expressed preferentially in brain
 RL Mol. Cell.
Biol. 10:1347-1357 (1990).
 RN [2]; RE0013940.
 RX MEDLINE;
99384291.
 RA Cirillo G., Casalino L., Vallone D., Caracciolo
A., De Cesare D., Verde P.
 RT Role of distinct mitogen-activated
protein kinase pathways and cooperation
 RT between Ets-2,
ATF-2, and Jun family members in human urokinase-type
 RT plasminogen
activator gene induction by interleukin-1 and tetradecanoyl

RT phorbol acetate
 RL Mol. Cell. Biol. 19:6340-6252 (1999).

RN [3]; RE0006672.
 RX MEDLINE; 96173617.
 RA Li X.-Y.,
Green M. R.
 RT Intramolecular inhibition of activating transcription
factor-2 function by
 RT its DNA-binding domain
 RL Genes
Dev. 10:517-527 (1996).
 RN [4]; RE0004148.
 RX MEDLINE;
95145592.
 RA Nakamura T., Okuyama S., Okamoto S., Nakajima
T., Sekiya S., Oda K.
 RT Down-regulation of the cyclin A promoter
in differentiating human embryonal
 RT carcinoma cells is mediated
by depletion of ATF-1 and ATF-2 in the complex
 RL Exp. Cell
Res. 216:422-430 (1995).
 RN [5]; RE0005255.
 RX MEDLINE;
95364956.
 RA Perini G., Wagner S., Green M. R.
 RT Recognition
of bZIP proteins by the human T-cell leukemia virus
 RT transactivator
Tax
 RL Nature 376:602-605 (1995).
 RN [6]; RE0005256.

RX MEDLINE; 95364957.
 RA Baranger A. M., Palmer C. R., Hamm
M. K., Giebler H. A., Brauweiler A.,
 RA Nyborg J. K., Schepartz
A.
 RT Mechanism of DNA-binding enhancement by the human T-cell
leukaemia virus
 RT transcativator Tax
 RL Nature 376:606-608
(1995).
 RN [7]; RE0005263.
 RX MEDLINE; 95255237.
 RA
van Dam H., Wilhelm D., Herr I., Steffen A., Herrlich P., Angel
P.
 RT ATF-2 is preferentially activated by stress-activated
protein kinases to
 RT mediate c-jun induction in response
to genotoxic agents
 RL EMBO J. 14:1798-1811 (1995).
 RN
[8]; RE0006670.
 RX MEDLINE; 95125448.
 RA Gupta S., Campbell
D., Derijard B., Davis R. J.
 RT Transcription factor ATF2
regulation by the JNK signal transduction pathway
 RL Science
267:389-393 (1995).
 RN [9]; RE0013937.
 RX MEDLINE; 95349959.

RA De Cesare D., Vallone D., Caracciolo A., Sassone-Corsi P.,
Nerlov C., Verde
 RA P.
 RT Heterodimerization of c-Jun
with ATF-2 and c-Fos is required for positive
 RT and negative
regulation of the human urokinase enhancer
 RL Oncogene 11:365-376
(1995).
 RN [10]; RE0001081.
 RX MEDLINE; 93179432.

RA Nomura N., Zu Y.-L., Maekawa T., Tabata S., Akiyama T., Ishii
S.
 RT Isolation and characterization of a novel member of
the gene family
 RT encoding the cAMP response element-binding
protein CRE-BP1
 RL J. Biol. Chem. 268:4259-4266 (1993).

RN [11]; RE0002710.
 RX MEDLINE; 94023981.
 RA Wagner S.,
Green M. R.
 RT HTLV-I Tax protein stimulation of DNA binding
of bZIP proteins by enhancing
 RT dimerization
 RL Science
262:395-399 (1993).
 RN [12]; RE0004521.
 RX MEDLINE; 94019389.

RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., DeRaemy-Schenk
A.-M.,
 RA Chen B. P. C., Hai T., DeLamarter J. F., Whelan
J.
 RT Cyclic AMP-independent ATF family members interact with
NF-kappaB and
 RT function in the activation of the E-selectin
promoter in response to
 RT cytokines
 RL Mol. Cell. Biol.
13:7180-7190 (1993).
 RN [13]; RE0004643.
 RX MEDLINE; 93360983.

RA Kerppola T. K., Curran T.
 RT Selective DNA bending by a
variety of bZIP proteins
 RL Mol. Cell. Biol. 13:5479-5489
(1993).
 RN [14]; RE0001911.
 RX MEDLINE; 92350254.

RA Kim S.-J., Wagner S., Liu F., O'Reilly M. A., Robbins P. D.,
Green M. R.
 RT Retinoblastoma gene product activates expressionof
the human TGF-beta2 gene
 RT through transcription factor ATF-2

RL Nature 358:331-334 (1992).
 RN [15]; RE0001029.
 RX MEDLINE;
92011551.
 RA Matsuda S., Maekawa T., Ishii S.
 RT Identification
of the functional domains of the transcriptional regulator

RT CRE-BP1
 RL J. Biol. Chem. 266:18188-18193 (1991).
 RN
[16]; RE0001107.
 RX MEDLINE; 92084723.
 RA Zu Y.-L., Maekawa
T., Matsuda S., Ishii S.
 RT Complete putative metal finger
and leucine zipper structures of CRE-BP1 are
 RT required for
the E1A-induced trans-activation
 RL J. Biol. Chem. 266:24134-24139
(1991).
 RN [17]; RE0001663.
 RX MEDLINE; 91342628.

RA Jones C., Lee K. A. W.
 RT E1A-mediated activation of the
adenovirus E4 promoter can occur
 RT independently of the cellular
transcription factor E4F
 RL Mol. Cell. Biol. 11:4297-4305
(1991).
 RN [18]; RE0002247.
 RX MEDLINE; 91360276.

RA Maguire K., Shi X.-P., Horikoshi N., Rappaport J., Rosenberg
M., Weinmann R.
 RT Interactions between adenovirus E1A and
members of the AP-1 family of
 RT cellular transcription factors

RL Oncogene 6:1417-1422 (1991).
 RN [19]; RE0002561.
 RX
MEDLINE; 91219443.
 RA Hai T., Curran T.
 RT Cross-family
dimerization of transcription factors Fos/Jun and ATF/CREB

RT alters DNA binding specificity
 RL Proc. Natl. Acad. Sci.
USA 88:3720-3724 (1991).
 RN [20]; RE0002717.
 RX MEDLINE;
91227910.
 RA Maguire H. F., Hoeffler J. P., Siddiqui A.

RT HBV X protein alters the DNA binding specificity of CREB and
ATF-2 by
 RT protein-protein interactions
 RL Science 252:842-844
(1991).
 RN [21]; RE0003151.
 RX MEDLINE; 92095966.

RA Sakurai A., Maekawa T., Sudo T., Ishii S., Kishimoto A.

RT Phosphorylation of cAMP response element-binding protein, CRE-BP1,
by
 RT cAMP-dependent protein kinase and protein kinase c*

RL Biochem. Biophys. Res. Commun. 181:629-635 (1991).
 RN [22];
RE0000186.
 RX MEDLINE; 90304881.
 RA Liu F., Green M. R.
R.
 RT A specific member of the ATF transcription factor family
can mediate
 RT transcription activation by the adenovirus
E1a protein
 RL Cell 61:1217-1224 (1990).
 RN [23]; RE0001241.

RX MEDLINE; 90205841.
 RA Ivashkiv L. B., Liou H.-C., Kara
C. J., Lamph W. W., Verma I. M., Glimcher
 RA L. H.
 RT
mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic
AMP, but
 RT not to the 12-O-tetradecanoylphorbol-13-acetate,
response element
 RL Mol. Cell. Biol. 10:1609-1621 (1990).

RN [24]; RE0002246.
 RX MEDLINE; 90191714.
 RA Benbrook
D. M., Jones N. C.
 RT Heterodimer formation between CREB and
JUN proteins
 RL Oncogene 5:295-302 (1990).
 RN [25]; RE0003157.

RX MEDLINE; 90316112.
 RA Yoshimura T., Fujisawa J.-I., Yoshida
M.
 RT Multiple cDNA clones encoding nuclear proteins that
bind to the
 RT tax-dependent enhancer of HTLV-1: all contain
a leucine zipper structure
 RT and basic amino acid domain

RL EMBO J. 9:2537-2542 (1990).
 RN [26]; RE0000335.
 RX
MEDLINE; 90005408.
 RA Maekawa T., Sakura H., Kanei-Ishii C.,
Sudo T., Yoshimura T., Fujisawa
 RA J.-I., Yoshida M., Ishii
S.
 RT Leucine zipper structure of the protein CRE-BP1 binding
to the cyclic AMP
 RT response element in brain
 RL EMBO
J. 8:2023-2328 (1989).
 RN [27]; RE0000666.
 RX MEDLINE;
90185187.
 RA Hai T., Liu F., Coukos W. J., Green M. R.

RT Transcription factor ATF cDNA clones: an extensive family of
leucine zipper
 RT proteins able to selectively form DNA-binding
heterodimers
 RL Genes Dev. 3:2083-2090 (1989).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

266 genes, 266 accessions (Toggle view)

AccessionGeneTitleLinks
CXCL16CXCL16chemokine (C-X-C motif) ligand 16Source|GeneCards
C6ORF209C6ORF209chromosome 6 open reading frame 209Source|GeneCards
ZNF184ZNF184zinc finger protein 184 (Kruppel-like)Source|GeneCards
RPIP8RPIP8RaP2 interacting protein 8Source|GeneCards
NDUFA10NDUFA10NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDaSource|GeneCards
MAP1LC3AMAP1LC3Amicrotubule-associated protein 1 light chain 3 alphaSource|GeneCards
CENPECENPEcentromere protein E, 312kDaSource|GeneCards
FOXD3FOXD3forkhead box D3Source|GeneCards
IRX4IRX4iroquois homeobox protein 4Source|GeneCards
PPM2CPPM2Cprotein phosphatase 2C, magnesium-dependent, catalytic subunitSource|GeneCards
CLDN6CLDN6claudin 6Source|GeneCards
FLJ14451ZC3H10zinc finger CCCH-type containing 10Source|GeneCards
ANAPC10ANAPC10anaphase promoting complex subunit 10Source|GeneCards
EGR1EGR1early growth response 1Source|GeneCards
CLDN7CLDN7claudin 7Source|GeneCards
SLC18A2SLC18A2solute carrier family 18 (vesicular monoamine), member 2Source|GeneCards
RBM18RBM18RNA binding motif protein 18Source|GeneCards
HS3ST3A1HS3ST3A1heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1Source|GeneCards
PFASPFASphosphoribosylformylglycinamidine synthase (FGAR amidotransferase)Source|GeneCards
GEMGEMGTP binding protein overexpressed in skeletal muscleSource|GeneCards
ELOVL5ELOVL5ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)Source|GeneCards
KCNF1KCNF1potassium voltage-gated channel, subfamily F, member 1Source|GeneCards
ZNF593ZNF593zinc finger protein 593Source|GeneCards
SUV39H2SUV39H2suppressor of variegation 3-9 homolog 2 (Drosophila)Source|GeneCards
JUNDJUNDjun D proto-oncogeneSource|GeneCards
PITX2PITX2paired-like homeodomain transcription factor 2Source|GeneCards
UBE2HUBE2Hubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)Source|GeneCards
LOC144747LOC144747hypothetical protein LOC144747Source|GeneCards
MRGPRFMRGPRFMAS-related GPR, member FSource|GeneCards
ZHX2ZHX2transcription factor ZHX2Source|GeneCards
LOC399947LOC399947similar to expressed sequence AI593442Source|GeneCards
GPR49LGR5leucine-rich repeat-containing G protein-coupled receptor 5Source|GeneCards
NDUFB2NDUFB2NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDaSource|GeneCards
FLJ30678CXORF43chromosome X open reading frame 43Source|GeneCards
PTPRUPTPRUprotein tyrosine phosphatase, receptor type, USource|GeneCards
DIO2DIO2deiodinase, iodothyronine, type IISource|GeneCards
C6ORF170C6ORF170chromosome 6 open reading frame 170Source|GeneCards
SYNGR3SYNGR3synaptogyrin 3Source|GeneCards
SCAMP5SCAMP5secretory carrier membrane protein 5Source|GeneCards
KIAA0082KIAA0082KIAA0082Source|GeneCards
UNQ1912UNQ1912HGS_RE408Source|GeneCards
RUSC1RUSC1RUN and SH3 domain containing 1Source|GeneCards
ETV6ETV6ets variant gene 6 (TEL oncogene)Source|GeneCards
PEG3PEG3paternally expressed 3Source|GeneCards
PAFAH1B1PAFAH1B1platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDaSource|GeneCards
NOL4NOL4nucleolar protein 4Source|GeneCards
CDS1CDS1CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1Source|GeneCards
THADATHADAthyroid adenoma associatedSource|GeneCards
CHMP1.5CHMP1Bchromatin modifying protein 1BSource|GeneCards
DDX28DDX28DEAD (Asp-Glu-Ala-Asp) box polypeptide 28Source|GeneCards
PCSK1PCSK1proprotein convertase subtilisin/kexin type 1Source|GeneCards
ZMYND15ZMYND15zinc finger, MYND domain containing 15Source|GeneCards
VGFVGFVGF nerve growth factor inducibleSource|GeneCards
MYL6MYL6myosin, light polypeptide 6, alkali, smooth muscle and non-muscleSource|GeneCards
CCNA2CCNA2cyclin A2Source|GeneCards
USP48USP48ubiquitin specific protease 48Source|GeneCards
OGDHOGDHoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)Source|GeneCards
SULT4A1SULT4A1sulfotransferase family 4A, member 1Source|GeneCards
C14ORF127NUBPLNucleotide binding protein-likeSource|GeneCards
FLJ44313FLJ44313FLJ44313 proteinSource|GeneCards
SLC38A1SLC38A1solute carrier family 38, member 1Source|GeneCards
SENP2SENP2sentrin-specific proteaseSource|GeneCards
MLF2MLF2myeloid leukemia factor 2Source|GeneCards
BNIP3LBNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-likeSource|GeneCards
C1ORF35C1ORF35chromosome 1 open reading frame 35Source|GeneCards
YWHAZYWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideSource|GeneCards
GLIGLI1glioma-associated oncogene homolog 1 (zinc finger protein)Source|GeneCards
RBP5RBP5Retinol binding protein 5, cellularSource|GeneCards
CBX8CBX8chromobox homolog 8 (Pc class homolog, Drosophila)Source|GeneCards
ARF4LARF4LADP-ribosylation factor 4-likeSource|GeneCards
FLJ32549FLJ32549hypothetical protein FLJ32549Source|GeneCards
IRX6IRX6iroquois homeobox protein 6Source|GeneCards
TRAF4TRAF4TNF receptor-associated factor 4Source|GeneCards
HCRTR2HCRTR2hypocretin (orexin) receptor 2Source|GeneCards
YME1L1YME1L1YME1-like 1 (S. cerevisiae)Source|GeneCards
BAT5BAT5HLA-B associated transcript 5Source|GeneCards
NCAM1NCAM1neural cell adhesion molecule 1Source|GeneCards
HHIPHHIPhedgehog interacting proteinSource|GeneCards
SPATA7SPATA7spermatogenesis associated 7Source|GeneCards
LTBP1LTBP1latent transforming growth factor beta binding protein 1Source|GeneCards
ORF1-FL49ORF1-FL49putative nuclear protein ORF1-FL49Source|GeneCards
ZBTB11ZBTB11zinc finger and BTB domain containing 11Source|GeneCards
SYT11SYT11synaptotagmin XISource|GeneCards
OSR1OSR1odd-skipped related 1 (Drosophila)Source|GeneCards
FLJ10902TMEM39Atransmembrane protein 39ASource|GeneCards
SPAG9SPAG9sperm associated antigen 9Source|GeneCards
AF5Q31AFF4AF4/FMR2 family, member 4Source|GeneCards
DEPDC4DEPDC4DEP domain containing 4Source|GeneCards
NUP214NUP214nucleoporin 214kDaSource|GeneCards
TP53INP2TP53INP2tumor protein p53 inducible nuclear protein 2Source|GeneCards
RNF44RNF44ring finger protein 44Source|GeneCards
MADDMADDMAP-kinase activating death domainSource|GeneCards
ZNF335ZNF335zinc finger protein 335Source|GeneCards
MGC3794TIPRLTIP41, TOR signalling pathway regulator-like (S. cerevisiae)Source|GeneCards
FLJ22170FLJ22170hypothetical protein FLJ22170Source|GeneCards
NF1NF1neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)Source|GeneCards
DDX51DDX51DEAD (Asp-Glu-Ala-Asp) box polypeptide 51Source|GeneCards
SNF1LKSNF1LKSNF1-like kinaseSource|GeneCards
MITFMITFmicrophthalmia-associated transcription factorSource|GeneCards
B3GALT2B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2Source|GeneCards
MGC2629ZBTB37zinc finger and BTB domain containing 37Source|GeneCards
MGC29898MGC29898hypothetical protein MGC29898Source|GeneCards
FLJ25477FLJ25477hypothetical protein FLJ25477Source|GeneCards
GARNL2PGARNL2PGTPase activating Rap/RanGAP domain-like 2 pseudogeneSource|GeneCards
NIFIE14NIFIE14seven transmembrane domain proteinSource|GeneCards
CAMK2DCAMK2Dcalcium/calmodulin-dependent protein kinase (CaM kinase) II deltaSource|GeneCards
WISP1WISP1WNT1 inducible signaling pathway protein 1Source|GeneCards
FLJ10581RNMTL1RNA methyltransferase like 1Source|GeneCards
MGC21688MGC21688hypothetical protein MGC21688Source|GeneCards
BREBREbrain and reproductive organ-expressed (TNFRSF1A modulator)Source|GeneCards
SP1SP1Sp1 transcription factorSource|GeneCards
DCTN1DCTN1dynactin 1 (p150, glued homolog, Drosophila)Source|GeneCards
AHI1AHI1Abelson helper integration siteSource|GeneCards
LOC253982LOC253982hypothetical protein LOC253982Source|GeneCards
DNTTIP1DNTTIP1deoxynucleotidyltransferase, terminal, interacting protein 1Source|GeneCards
STAT3STAT3signal transducer and activator of transcription 3 (acute-phase response factor)Source|GeneCards
UCNUCNurocortinSource|GeneCards
CHPFCHPFchondroitin polymerizing factorSource|GeneCards
LOC130617LOC130617hypothetical protein BC018415Source|GeneCards
TNFAIP1TNFAIP1tumor necrosis factor, alpha-induced protein 1 (endothelial)Source|GeneCards
TRPC1TRPC1transient receptor potential cation channel, subfamily C, member 1Source|GeneCards
PPP2R2APPP2R2Aprotein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoformSource|GeneCards
BRAFBRAFv-raf murine sarcoma viral oncogene homolog B1Source|GeneCards
NUPL2NUPL2nucleoporin like 2Source|GeneCards
THOC1THOC1THO complex 1Source|GeneCards
SEC24CSEC24CSEC24 related gene family, member C (S. cerevisiae)Source|GeneCards
HOXB9HOXB9homeo box B9Source|GeneCards
PARD6APARD6Apar-6 partitioning defective 6 homolog alpha (C.elegans)Source|GeneCards
KIAA0669TSC22D2TSC22 domain family, member 2Source|GeneCards
CSTF3CSTF3cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDaSource|GeneCards
PER1PER1period homolog 1 (Drosophila)Source|GeneCards
CLSTN3CLSTN3calsyntenin 3Source|GeneCards
LENG9LENG9leukocyte receptor cluster (LRC) member 9Source|GeneCards
CD2APCD2APCD2-associated proteinSource|GeneCards
ZIM2ZIM2zinc finger, imprinted 2Source|GeneCards
WNT10AWNT10Awingless-type MMTV integration site family, member 10ASource|GeneCards
HS3ST2HS3ST2heparan sulfate (glucosamine) 3-O-sulfotransferase 2Source|GeneCards
MRRFMRRFmitochondrial ribosome recycling factorSource|GeneCards
NCALDNCALDneurocalcin deltaSource|GeneCards
HAS1HAS1hyaluronan synthase 1Source|GeneCards
PRR3PRR3Proline rich 3Source|GeneCards
SNAP25SNAP25synaptosomal-associated protein, 25kDaSource|GeneCards
MAP3K13MAP3K13mitogen-activated protein kinase kinase kinase 13Source|GeneCards
ZNF576ZNF576zinc finger protein 576Source|GeneCards
ING4ING4inhibitor of growth family, member 4Source|GeneCards
FLJ13725FAM65Afamily with sequence similarity 65, member ASource|GeneCards
PNMA3PNMA3paraneoplastic antigen MA3Source|GeneCards
NEUROD6NEUROD6neurogenic differentiation 6Source|GeneCards
SEMA4CSEMA4Csema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4CSource|GeneCards
NR2E1NR2E1nuclear receptor subfamily 2, group E, member 1Source|GeneCards
LOC90410LOC90410intraflagellar transport protein IFT20Source|GeneCards
ALS2ALS2amyotrophic lateral sclerosis 2 (juvenile)Source|GeneCards
GPM6BGPM6Bglycoprotein M6BSource|GeneCards
ELL2ELL2elongation factor, RNA polymerase II, 2Source|GeneCards
SLC7A3SLC7A3solute carrier family 7 (cationic amino acid transporter, y+ system), member 3Source|GeneCards
FLJ35976C1ORF104chromosome 1 open reading frame 104Source|GeneCards
RAD51CRAD51CRAD51 homolog C (S. cerevisiae)Source|GeneCards
STAG1STAG1Stromal antigen 1Source|GeneCards
TGIF2TGIF2TGFB-induced factor 2 (TALE family homeobox)Source|GeneCards
FLJ11126DDX19ADEAD (Asp-Glu-Ala-As) box polypeptide 19ASource|GeneCards
ID1ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix proteinSource|GeneCards
EPB41EPB41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)Source|GeneCards
PSK-1SEZ6L2seizure related 6 homolog (mouse)-like 2Source|GeneCards
ATP6V0CATP6V0CATPase, H+ transporting, lysosomal 16kDa, V0 subunit cSource|GeneCards
MCAMMCAMmelanoma cell adhesion moleculeSource|GeneCards
NUP98NUP98nucleoporin 98kDaSource|GeneCards
KCNA5KCNA5potassium voltage-gated channel, shaker-related subfamily, member 5Source|GeneCards
TM4SF2TM4SF2transmembrane 4 superfamily member 2Source|GeneCards
YTHDC2YTHDC2YTH domain containing 2Source|GeneCards
FLJ12750VPS37Bvacuolar protein sorting 37B (yeast)Source|GeneCards
TEX14TEX14testis expressed sequence 14Source|GeneCards
HIST1H4EHIST1H4Ehistone 1, H4eSource|GeneCards
CDX4CDX4caudal type homeo box transcription factor 4Source|GeneCards
RBJRBJRas-associated protein Rap1Source|GeneCards
FLT1FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)Source|GeneCards
RCE1RCE1RCE1 homolog, prenyl protein protease (S. cerevisiae)Source|GeneCards
AREGAREGamphiregulin (schwannoma-derived growth factor)Source|GeneCards
SCG2SCG2Secretogranin II (chromogranin C)Source|GeneCards
RBKSRBKSribokinaseSource|GeneCards
ZFYVE27ZFYVE27zinc finger, FYVE domain containing 27Source|GeneCards
PNMA6APNMA6Aparaneoplastic antigen like 6ASource|GeneCards
PHC1PHC1polyhomeotic-like 1 (Drosophila)Source|GeneCards
MAFFMAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)Source|GeneCards
CHGBCHGBchromogranin B (secretogranin 1)Source|GeneCards
OSBPL9OSBPL9oxysterol binding protein-like 9Source|GeneCards
CYLDCYLDcylindromatosis (turban tumor syndrome)Source|GeneCards
LOC93380TMEM32transmembrane protein 32Source|GeneCards
PHACTR3PHACTR3Phosphatase and actin regulator 3Source|GeneCards
CENTA1CENTA1centaurin, alpha 1Source|GeneCards
ABCE1ABCE1ATP-binding cassette, sub-family E (OABP), member 1Source|GeneCards
RAB25RAB25RAB25, member RAS oncogene familySource|GeneCards
ST13ST13suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)Source|GeneCards
P15RSP15RShypothetical protein FLJ10656Source|GeneCards
DKFZP434B168C1ORF73chromosome 1 open reading frame 73Source|GeneCards
CLCN3CLCN3chloride channel 3Source|GeneCards
EBFEBFearly B-cell factorSource|GeneCards
24432ACDadrenocortical dysplasia homolog (mouse)Source|GeneCards
ZNF367ZNF367zinc finger protein 367Source|GeneCards
TRAP1TRAP1TNF receptor-associated protein 1Source|GeneCards
RAI1RAI1retinoic acid induced 1Source|GeneCards
FLJ12666C1ORF108chromosome 1 open reading frame 108Source|GeneCards
PPP1R15APPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15ASource|GeneCards
CRHCRHcorticotropin releasing hormoneSource|GeneCards
HSPCBHSPCBheat shock 90kDa protein 1, betaSource|GeneCards
DAAM2DAAM2dishevelled associated activator of morphogenesis 2Source|GeneCards
THTHtyrosine hydroxylaseSource|GeneCards
LDHALDHAlactate dehydrogenase ASource|GeneCards
LOC63929LOC63929hypothetical protein LOC63929Source|GeneCards
EPHA2EPHA2EphA2Source|GeneCards
RPL41RPL41ribosomal protein L41Source|GeneCards
PPM1APPM1Aprotein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoformSource|GeneCards
SYNCRIPSYNCRIPsynaptotagmin binding, cytoplasmic RNA interacting proteinSource|GeneCards
DKFZP761C169GPBP1GC-rich promoter binding protein 1Source|GeneCards
HOXC10HOXC10homeo box C10Source|GeneCards
C17ORF25C17ORF25chromosome 17 open reading frame 25Source|GeneCards
SLC25A25SLC25A25solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25Source|GeneCards
PDLIM3PDLIM3PDZ and LIM domain 3Source|GeneCards
KIAA1259KIAA1259hypothetical protein KIAA1259Source|GeneCards
PNRC1PNRC1proline-rich nuclear receptor coactivator 1Source|GeneCards
MAOAMAOAmonoamine oxidase ASource|GeneCards
MAPK10MAPK10mitogen-activated protein kinase 10Source|GeneCards
NR4A2NR4A2nuclear receptor subfamily 4, group A, member 2Source|GeneCards
PIPPINPIPPINRNA-binding protein pippinSource|GeneCards
ELAVL1ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)Source|GeneCards
RELBRELBv-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)Source|GeneCards
CREMCREMcAMP responsive element modulatorSource|GeneCards
APG5LAPG5LAPG5 autophagy 5-like (S. cerevisiae)Source|GeneCards
GNL1GNL1guanine nucleotide binding protein-like 1Source|GeneCards
EEF2EEF2eukaryotic translation elongation factor 2Source|GeneCards
RPS29RPS29ribosomal protein S29Source|GeneCards
G3BP2G3BP2Ras-GTPase activating protein SH3 domain-binding protein 2Source|GeneCards
AVPI1AVPI1arginine vasopressin-induced 1Source|GeneCards
GTF3C1GTF3C1general transcription factor IIIC, polypeptide 1, alpha 220kDaSource|GeneCards
SSTSSTsomatostatinSource|GeneCards
ARIH1ARIH1ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)Source|GeneCards
WFDC3WFDC3WAP four-disulfide core domain 3Source|GeneCards
MAFMAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)Source|GeneCards
UMPSUMPSuridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)Source|GeneCards
SDHBSDHBsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)Source|GeneCards
DSCR1DSCR1Down syndrome critical region gene 1Source|GeneCards
C19ORF4C19ORF4chromosome 19 open reading frame 4Source|GeneCards
IKBKBIKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaSource|GeneCards
CCBL1CCBL1cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)Source|GeneCards
LMCD1LMCD1LIM and cysteine-rich domains 1Source|GeneCards
MGC4308MGC4308hypothetical protein MGC4308Source|GeneCards
DUSP1DUSP1dual specificity phosphatase 1Source|GeneCards
C14ORF4C14ORF4chromosome 14 open reading frame 4Source|GeneCards
RNF7RNF7ring finger protein 7Source|GeneCards
DHX36DHX36DEAH (Asp-Glu-Ala-His) box polypeptide 36Source|GeneCards
DKFZP761D221SGIP1SH3-domain GRB2-like (endophilin) interacting protein 1Source|GeneCards
PLCD3PLCD3phospholipase C, delta 3Source|GeneCards
ARL6IP2ARL6IP2ADP-ribosylation-like factor 6 interacting protein 2Source|GeneCards
RAB6IP1RAB6IP1RAB6 interacting protein 1Source|GeneCards
KCTD8KCTD8potassium channel tetramerisation domain containing 8Source|GeneCards
GPR3GPR3G protein-coupled receptor 3Source|GeneCards
LOC130940LOC130940hypothetical protein BC015395Source|GeneCards
PPARGC1APPARGC1Aperoxisome proliferative activated receptor, gamma, coactivator 1, alphaSource|GeneCards
MBNL2MBNL2muscleblind-like 2 (Drosophila)Source|GeneCards
RAMPZNF198zinc finger protein 198Source|GeneCards
PKP4PKP4plakophilin 4Source|GeneCards
GNB4GNB4guanine nucleotide binding protein (G protein), beta polypeptide 4Source|GeneCards
MGC3162NOC4Lnucleolar complex associated 4 homolog (S. cerevisiae)Source|GeneCards
FLJ20399DUS2Ldihydrouridine synthase 2-like (SMM1, S. cerevisiae)Source|GeneCards
FGF6FGF6fibroblast growth factor 6Source|GeneCards
ADCY8ADCY8adenylate cyclase 8 (brain)Source|GeneCards
KIAA0863KIAA0863KIAA0863 proteinSource|GeneCards

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