XX
XX
XX
FA E2F-1
XX
SY E2F.
XX
OS
mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata;
vertebrata; tetrapoda; mammalia;
OC eutheria; rodentia; myomorpha;
muridae; murinae
XX
XX
CL C0023; fork head; 3.3.3.1.1.
XX
SZ 430 AA; 46.3 kDa (cDNA)
XX
XX
SC translated
from EMBL #L21973
XX
FT 1 119 cyclin A/cdk2 binding.
FT 84 179 DNA-binding domain.
FT 104 122 basic region.
FT 118 335 PF02319; E2F_TDP.
FT 123 176 potential helix-loop-helix
domain.
FT 123 137 helix I.
FT 145 186 dimerization domain.
FT 151 176 helix II.
FT 194 229 potential leucine zipper (VL3CL).
FT 361 430 transcription activating region.
FT 402 419 Rb-binding
region.
XX
SF prior to crystal structure belongs to bHLH-zip
factors [1];
SF gene mapped to the chromosome 2;
SF near
the Agouti and c-src loci [5];
XX
FF transcriptional regulator;
FF activator [5] [3];
FF mediate growth factor-initiated signal
transduction [5];
FF induced p53-independent apoptosis in
transgenic mice [2];
XX
IN T01377; E2F-BF; mouse, Mus
musculus.
IN T01378; E2F-I; mouse, Mus musculus.
IN T00206;
E4; adenovirus type 5.
IN T01301; E4; adenovirus type 2.
XX
XX
XX
XX
RN [1]; RE0015322.
RX MEDLINE;
99190701.
RA Zheng N., Fraenkel E., Pabo C. O., Pavletich
N. P.
RT Structural basis of DNA recognition by the heterodimeric
cell cycle
RT transcription factor E2F-DP
RL Genes Dev.
13:666-674 (1999).
RN [2]; RE0015297.
RX MEDLINE; 98337455.
RA Holmberg C., Helin K., Sehested M., Karlstrom O.
RT E2F-1-induced
p53-independent apoptosis in transgenic mice
RL Oncogene 17:143-155
(1998).
RN [3]; RE0014062.
RX MEDLINE; 98025478.
RA
Dagnino L., Fry C. J., Bartley S. M., Farnham P., Gallie B. L.,
Phillips R.
RA A.
RT Expression patterns of the E2F family
of transcription factors during mouse
RT nervous system development
RL Mech. Dev. 66:13-25 (1997).
RN [4]; RE0012577.
RX MEDLINE;
96251288.
RA Botz J., Zerfass-Thome K., Spitkovsky D., Delius
H., Vogt B., Eilers M.,
RA Hatzigeorgiou A., Jansen-Duerr
P.
RT Cell cycle regulation of the murine cyclin E gene depends
on an E2F binding
RT site in the promoter
RL Mol. Cell.
Biol. 16:3401-3409 (1996).
RN [5]; RE0003315.
RX MEDLINE;
94158858.
RA Li Y., Slansky J. E., Myers D. J., Drinkwater
N. R., Kaelin W. G., Farnham
RA P. J.
RT Cloning, chromosomal
location, and characterization of mouse E2F1
RL Mol. Cell.
Biol. 14:1861-1869 (1994).
RN [6]; RE0002921.
RX MEDLINE;
93030749.
RA Nevins R.
RT E2F: A link between the Rb tumor
suppressor protein and viral oncoproteins
RL Science 258:424-429
(1992).
RN [7]; RE0000163.
RX MEDLINE; 91256306.
RA
Chellappan S. P., Hiebert S., Mudryj M., Horowitz J. M., Nevins
J. R.
RT The E2F transcription factor is a cellular target
for the RB protein
RL Cell 65:1053-1061 (1991).
RN [8];
RE0000164.
RX MEDLINE; 91292527.
RA Mudryj M., Devoto
S. H., Hiebert S. W., Hunter T., Pines J., Nevins J. R.
RT
Cell cycle regulation of the E2F transcription factor involves
an
RT interaction with cyclin A
RL Cell 65:1243-1253 (1991).
RN [9]; RE0000165.
RX MEDLINE; 91256307.
RA Bagchi S.,
Weinmann R., Raychaudhuri P.
RT The retinoblastoma protein
copurifies with E2F-I; an E1A-regulated
RT inhibitor of the
transcription factor E2F
RL Cell 65:1063-1072 (1991).
RN [10]; RE0000795.
RX MEDLINE; 91293581.
RA Raychaudhuri
P., Bagchi S., Devoto S. H., Kraus V. B., Moran E., Nevins J.
RA R.
RT Domains of the adenovirus E1A protein required for
oncogenic activity are
RT also required for dissociation of
E2F transcription factor complexes
RL Genes Dev. 5:1200-1211
(1991).
RN [11]; RE0001158.
RX MEDLINE; 91374588.
RA Neill S. D., Nevins J. R.
RT Genetic analysis of the adenovirus
E4 6/7 trans activator: interaction with
RT E2F and induction
of a stable DNA-protein complex are critical for activity
RL J. Virol. 65:5364-5373 (1991).
RN [12]; RE0001169.
RX MEDLINE; 92046356.
RA Phelps W. C., Bagchi S., Barnes J.
A., Raychaudhuri P., Kraus V., Muenger
RA K., Howley P. M.,
Nevins J. R.
RT Analysis of trans activation by human papilloma
virus type 16 E7 and
RT adenovirus 12S E1A suggests a common
mechanism
RL J. Virol. 65:6922-6930 (1991).
RN [13]; RE0000162.
RX MEDLINE; 90352701.
RA Bagchi S., Raychaudhuri P., Nevins
J. R.
RT Adenovirus E1A proteins can dissociate heteromeric
complexes involving the
RT E2F transcription factor: a novel
mechanism for E1A trans-activation
RL Cell 62:659-669 (1990).
RN [14]; RE0002387.
RX MEDLINE; 90175426.
RA Neill S.
D., Hemstrom C., Virtanen A., Nevins J. R.
RT An adenovirus
E4 gene product trans-activates E2 transcription and
RT stimulates
stable E2F binding through a direct association with E2F
RL
Proc. Natl. Acad. Sci. USA 87:2008-2012 (1990).
RN [15]; RE0002739.
RX MEDLINE; 90291982.
RA Mudryj M., Hiebert S. W., Nevins
J. R.
RT A role for the adenovirus inducible E2F transcription
factor in a
RT proliferation dependent signal transduction
pathway
RL EMBO J. 9:2179-2184 (1990).
RN [16]; RE0000060.
RX MEDLINE; 87102873.
RA Cordingley M. G., Riegel A. T., Hager
G. L.
RT Steroid-Dependent Interaction of Transcription Factors
with the Inducible
RT Promoter of Mouse Mammary Tumor Virus
In Vivo
RL Cell 48:261-270 (1987).
XX