XX
XX
XX
FA GR-alpha
XX
SY glucocorticoid
receptor; GR; NR3C1; GR alpha.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda;
mammalia;
OC eutheria; primates
XX
XX
CL C0002;
CC (rec); 2.1.1.1.1.1.
XX
SZ 777 AA; 85.7 kDa (cDNA),
88-94 kDa (SDS)
XX
XX
SC SwissProt #P04150
XX
FT 26 401 PF02155; GCR.
FT 78 262 trans-activating domain
(tau1) [18].
FT 187 285 amino-terminal activation function
AF-1 [2].
FT 187 285 functinal cooperation with STAT5 [2].
FT 418 489 SM00399; ZnF_C4.
FT 419 494 PF00105; zf-C4.
FT 421 441 zinc finger 1 (C-X2-C-X13-C-X2-C).
FT 421 486 region
C, DNA-binding domain (DBD) [22].
FT 457 476 zinc finger 2
(C-X5-C-X9-C-X2-C).
FT 482 777 C-terminal ligand binding domain,
LBD [2].
FT 487 555 region D.
FT 526 556 trans-activating
domain (tau2) [19].
FT 532 697 hsp90-contacting region.
FT 556 777 region E, hormone-binding domain (HBD).
FT 565
729 SM00430; HOLI.
FT 568 753 PF00104; hormone_rec.
FT
728 777 replaced by 728-742 in GR beta.
FT 748 762 AF-2 domain
(transactivation activity) [1].
XX
SF 2 splice variants
alpha and beta (742 AA), differing in
SF
their C-termini [24];
SF the first zinc finger binds specifically
to the GRE, the second enhances
SF the affinity [14];
SF AGRND within the second finger mediates homodimerization and
contributes to
SF the differential DNA-binding specificity
against other nuclear receptors
SF [9];
SF G->E-variant
(after 3rd Cys of the zinc finger region) recognizes GRE as
SF well as ERE;
SF AGRND -> KYEGK (between 1st Cys doublet
of the 2nd zinc finger): conversion
SF to a TRE-binding receptor;
SF cooperative binding to a double GRE through tau1 domain;
XX
FF activator or repressor in response to glucocorticoid
hormones [17];
FF binds hormone, translocates into the nucleus,
and activates transcription
FF of hormone-sensitive gene in
contrast to beta isoform which does
FF not activate
known hormone-sensitive genes [24];
FF cooperating with other
transcription factors, it may act through composite
FF elements
[20] [10];
FF can be inhibited by physical interaction with
c-Jun or c-Fos [11] [12];
FF represses Oct-1 DNA binding [4];
FF leukemic cell lethality through DBD (1st zinc finger and 1/2
of second) [7];
FF often provides glucocorticoid-dependent
gene activation acting as a
FF co-activator rather than a
DNA-binding factor, may function as a
FF co-activator for
STAT5 [2].;
XX
IN T00029; AP-1; human, Homo sapiens.
IN T00123; c-Fos; human, Homo sapiens.
IN T00133; c-Jun; human,
Homo sapiens.
IN T00990; FKBP59; human, Homo sapiens.
IN T00337; GR-alpha; human, Homo sapiens.
IN T01920; GR-beta;
human, Homo sapiens.
IN T00993; hsp56; human, Homo sapiens.
IN T00992; Hsp90; human, Homo sapiens.
IN T01466; POU2F1;
hamster, Cricetulus griseus.
IN T00644; POU2F1a; mouse, Mus
musculus.
XX
XX
XX
XX
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RT novel orphan nuclear receptor ERR3
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RA Stoecklin E., Wissler M., Moriggl
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RT Specific DNA binding of Stat5, but not of
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RT required for their functional
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RT transcription.
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RA Ku Tai P.-K., Albers M. W., Chang
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RT Association of a 59-kilodalton
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RA Kutoh E., Stroemstedt P.-E., Poellinger
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RT Functional interference between the ubiquitous and constitutive
octamer
RT transcription factor 1 (OTF-1) and the glucocorticoid
receptor by direct
RT protein-protein interaction involving
the homeo subdomain of OTF-1
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RA
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RA Livingston D. J., Benasutti M.
RT Expression
and characterization of the human FKBP52, an immunophilin that
RT associates with the 90-kDa heat shock protein and is a component
of steroid
RT receptor proteins
RL Proc. Natl. Acad. Sci.
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RA J.-A., Poellinger L., Nilsson
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RT High level expression of functional full length and
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RT glucocorticoid receptor in chinese hamster ovary
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RA Nazareth L. V., Harbour
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RT Mapping the human glucocorticoid
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RA
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RT Mechanism of synergistic
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RT glucocorticoid
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RA Dahlman-Wright
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RT Interaction
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RT dimer is mediated by a short segment of five amino acids
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RT Repression of the human glycoprotein
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RT transcriptional
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RT Antitumor promotion and antiinflammation: Down-modulation
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RT activity by glucocorticoid hormone
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RT Functional antagonism between oncoprotein c-Jun and the glucocorticoid
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RA Forman B. M., Samuels H. H.
RT
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RT zipper model
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RT Solution structure of the glucocorticoid
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RA Sanchez E.
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RT Hsp56: A novel heat shock protein associated with untransformed
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RT receptor complexes
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RA Umesono K., Evans R. M.
RT Determinants of target gene
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RL
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RA Akerblom I., Slater E. P., Beato M., Baxter J.
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RT Negative regulation by glucocorticoids
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RA Oro A. E., Hollenberg S. M., Evans R.
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RT Transcriptional inhibition by a glucocorticoid receptor-beta-galactosidase
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RT Multiple and cooperative trans-activation domains
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RT glucocorticoid receptor
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RT Synergistic action
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RT Primary structure
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XX