[an error occurred while processing this directive]
Gene set: V$HMEF2_Q6 (C3:TFAC:0207)
Standard nameV$HMEF2_Q6
Systematic nameC3:TFAC:0207
Brief descriptionGenes with 3'UTR containing motif SKYTAAAAATAACYCH. Motif does not match any known transcription factor
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

Toggle abstract view

XX
 XX
 XX
 FA MEF-2
 XX
 SY MEF-2; MEF-2A; MEF2.

XX
 OS human, Homo sapiens
 OC eukaryota; animalia; metazoa;
chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria; primates

XX
 HO D-MEF2 (Drosophila)
 XX
 CL C0014; MADS; 4.4.1.1.1.1.

XX
 SZ 507 AA; 54.8 kDa (cDNA)
 XX
 XX
 SC conceptually
translated from EMBL/GenBank/DDBJ #X68505
 XX
 FT 1 59 PF00319;
SRF-TF.
 FT 1 60 SM00432; MADS.
 FT 3 57 MADS box.
 FT
58 86 MEF2 domain.
 FT 87 132 replaced by 87-130 in aMEF-2.

FT 141 186 serine-/threonine-rich region (20/46).
 FT 289 296
absent in RSRFC4/RSRFC9.
 FT 312 312 threonine phosphorylation
site.
 FT 319 319 threonine phosphorylation site.
 FT 355
355 serin phosphorylation site.
 FT 420 446 glutamine-/proline-rich
region (27/27).
 XX
 SF alternative splicing leads to aMEF-2,
RSRFC4, RSRFC9;
 SF direct interaction with other myogenic
factors (bHLH proteins MyoD,
 SF myogenin, MRF4), but not with
E2 proteins [7];
 SF G2E mutant exhibits MCM1-binding specificity
[5];
 SF heterodimerization with MEF-2D [1];
 XX
 CP
cardiac, smooth, skeletal muscle, less in placenta, brain, lung,
kidney
 CP [8]; P19 cells differentiated into neurons or endodermal
cells,
 CP undifferentiated P19 cells [4]
 CN liver [8]

XX
 FF activator [8];
 FF involved in myogenesis [8] [6];

FF cooperates with myogenic bHLH factors through E-box for gene
activation in
 FF skeletal muscle cells [7];
 FF MADS domain
of MEF2A is both necessary and sufficient for binding to MyoD

FF [7];
 FF synergistic activation of transcription in neurogenic
lineages with MASH1
 FF [4];
 FF threonines 312 and 319
are phosphorylation sites for p38 [1] [2];
 FF serine 355 is
a phosphorylation site for p38 [2];
 FF phosphorylation of
MEF-2A in a MEF-2A/MEF-2D heterodimer enhances
 FF MEF-2-dependent
gene expression [1].;
 XX
 IN T01537; MRF4; mouse, Mus musculus.

IN T00525; MyoD; human, Homo sapiens.
 IN T00526; MyoD; mouse,
Mus musculus.
 IN T00528; myogenin; mouse, Mus musculus.

XX
 XX
 XX
 XX
 RN [1]; RE0015211.
 RX MEDLINE;
99077942.
 RA Zhao M., New L., Kravchenko VV., Kato Y., Gram
H., di Padova F., Olson E.
 RA N., Ulevitch R. J., Han J.

RT Regulation of the MEF2 family of transcription factors by p38

RL Mol. Cell. Biol. 19:21-30 (1999).
 RN [2]; RE0015225.

RX MEDLINE; 99303824.
 RA Ornatsky O. I., Cox D. M., Tangirala
P., Andreucci J. J., Quinn Z. A.,
 RA Wrana J. L., Prywes R.,
Yu Y. T., McDermott J. C.
 RT Post-translational control of
the MEF2A transcriptional regulatory protein
 RL Nucleic Acids
Res. 27:2646-2654 (1999).
 RN [3]; RE0004143.
 RX MEDLINE;
96104596.
 RA Fickett J. W.
 RT Quantitative discrimination
of MEF2 sites
 RL Mol. Cell. Biol. 16:437-441 (1996).
 RN
[4]; RE0015139.
 RX MEDLINE; 97059111.
 RA Black B.L., Ligon
K.L., Zhang Y., Olson E.N.
 RT Cooperative transcriptional
activation by the neurogenic basic
 RT helix-loop-helix protein
MASH1 and members of the myocyte enhancer factor-2
 RT (MEF2)
family
 RL J. Biol. Chem. 271:26659-26663 (1996).
 RN [5];
RE0004114.
 RX MEDLINE; 95349573.
 RA Nurrish S. J., Treisman
R.
 RT DNA binding specificity determinants in MADS-box transcription
factors
 RL Mol. Cell. Biol. 15:4076-4085 (1995).
 RN [6];
RE0010487.
 RX MEDLINE; 95257952.
 RA Naidu P. S., Ludolph
D. C., To R. Q., Hinterberger T. J., Konieczny S. F.
 RT Myogenin
and MEF2 function synergistically to activate the MRF4 promoter

RT during myogenesis
 RL Mol. Cell. Biol. 15:2707-2718 (1995).

RN [7]; RE0004142.
 RX MEDLINE; 95063991.
 RA Kaushal S.,
Schneider J. W., Nadal-Ginard B., Mahdavi V.
 RT Activation
of the myogenic lineage by MEF2A, a factor that induces and

RT cooperates with MyoD
 RL Science 266:1236-1240 (1994).

RN [8]; RE0000768.
 RX MEDLINE; 92387551.
 RA Yu Y.-T.,
Breitbart R. E., Smoot L. B., Lee Y., Mahdavi V., Nadal-Ginard
B.
 RT Human myocyte-specific enhancer factor 2 comprises a
group of
 RT tissue-restricted MADS box transcription factors

RL Genes Dev. 6:1783-1798 (1992).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

142 genes, 142 accessions (Toggle view)

AccessionGeneTitleLinks
HAS2HAS2hyaluronan synthase 2Source|GeneCards
ZNF533ZNF533Zinc finger protein 533Source|GeneCards
COLQCOLQcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesteraseSource|GeneCards
ZNF238ZNF238zinc finger protein 238Source|GeneCards
KBTBD5KBTBD5kelch repeat and BTB (POZ) domain containing 5Source|GeneCards
ART5ART5ADP-ribosyltransferase 5Source|GeneCards
LOC148898LOC148898hypothetical protein BC007899Source|GeneCards
HOXB5HOXB5homeo box B5Source|GeneCards
CAPN1CAPN1calpain 1, (mu/I) large subunitSource|GeneCards
ARPP-21ARPP-21cyclic AMP-regulated phosphoprotein, 21 kDSource|GeneCards
PAK6PAK6p21(CDKN1A)-activated kinase 6Source|GeneCards
SMYD1SMYD1SET and MYND domain containing 1Source|GeneCards
FLJ13725FAM65Afamily with sequence similarity 65, member ASource|GeneCards
FBXO40FBXO40F-box protein 40Source|GeneCards
FLJ11088FLJ11088GGA binding partnerSource|GeneCards
MYH6MYH6myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)Source|GeneCards
GPC4GPC4glypican 4Source|GeneCards
CDW92CDW92CDW92 antigenSource|GeneCards
SLCO2A1SLCO2A1solute carrier organic anion transporter family, member 2A1Source|GeneCards
MAS1MAS1MAS1 oncogeneSource|GeneCards
EP300EP300E1A binding protein p300Source|GeneCards
HDAC7AHDAC7Ahistone deacetylase 7ASource|GeneCards
PDLIM1PDLIM1PDZ and LIM domain 1 (elfin)Source|GeneCards
KCNJ9KCNJ9potassium inwardly-rectifying channel, subfamily J, member 9Source|GeneCards
CASQ2CASQ2calsequestrin 2 (cardiac muscle)Source|GeneCards
C20ORF35C20ORF35chromosome 20 open reading frame 35Source|GeneCards
FGF5FGF5fibroblast growth factor 5Source|GeneCards
CKMCKMcreatine kinase, muscleSource|GeneCards
TIMP2TIMP2tissue inhibitor of metalloproteinase 2Source|GeneCards
MGC45562MGC45562hypothetical protein MGC45562Source|GeneCards
NEDD4NEDD4neural precursor cell expressed, developmentally down-regulated 4Source|GeneCards
SP6SP6Sp6 transcription factorSource|GeneCards
TNNI3KTNNI3KTNNI3 interacting kinaseSource|GeneCards
BMP4BMP4bone morphogenetic protein 4Source|GeneCards
MAB21L2MAB21L2mab-21-like 2 (C. elegans)Source|GeneCards
UBXD3UBXD3UBX domain containing 3Source|GeneCards
ITGB3BPITGB3BPintegrin beta 3 binding protein (beta3-endonexin)Source|GeneCards
ARHGEF15ARHGEF15Rho guanine nucleotide exchange factor (GEF) 15Source|GeneCards
MTF1MTF1metal-regulatory transcription factor 1Source|GeneCards
SLC13A1SLC13A1solute carrier family 13 (sodium/sulfate symporters), member 1Source|GeneCards
MYL2MYL2myosin, light polypeptide 2, regulatory, cardiac, slowSource|GeneCards
EYA1EYA1eyes absent homolog 1 (Drosophila)Source|GeneCards
FLJ25476FLJ25476FLJ25476 proteinSource|GeneCards
MYL1MYL1myosin, light polypeptide 1, alkali; skeletal, fastSource|GeneCards
C7ORF20C7ORF20chromosome 7 open reading frame 20Source|GeneCards
ITGA7ITGA7integrin, alpha 7Source|GeneCards
ZFPM2ZFPM2zinc finger protein, multitype 2Source|GeneCards
NR4A1NR4A1nuclear receptor subfamily 4, group A, member 1Source|GeneCards
KCNN1KCNN1potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1Source|GeneCards
TSC1TSC1tuberous sclerosis 1Source|GeneCards
LYNLYNv-yes-1 Yamaguchi sarcoma viral related oncogene homologSource|GeneCards
MYH4MYH4myosin, heavy polypeptide 4, skeletal muscleSource|GeneCards
AICDAAICDAactivation-induced cytidine deaminaseSource|GeneCards
KCNK9KCNK9potassium channel, subfamily K, member 9Source|GeneCards
CRTAPCRTAPcartilage associated proteinSource|GeneCards
DYRK2DYRK2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2Source|GeneCards
KIAA1446KIAA1446brain-enriched guanylate kinase-associated proteinSource|GeneCards
GATA4GATA4GATA binding protein 4Source|GeneCards
CACNA2D3CACNA2D3calcium channel, voltage-dependent, alpha 2/delta 3 subunitSource|GeneCards
TAIP-2TAIP-2TGF-beta induced apotosis protein 2Source|GeneCards
FLJ44313FLJ44313FLJ44313 proteinSource|GeneCards
NFIXNFIXnuclear factor I/X (CCAAT-binding transcription factor)Source|GeneCards
OR8B8OR8B8olfactory receptor, family 8, subfamily B, member 8Source|GeneCards
SYNPO2LSYNPO2Lsynaptopodin 2-likeSource|GeneCards
PENKPENKproenkephalinSource|GeneCards
MLC1SAMLC1SAmyosin light chain 1 slow aSource|GeneCards
EHD1EHD1EH-domain containing 1Source|GeneCards
SCML1SCML1sex comb on midleg-like 1 (Drosophila)Source|GeneCards
EPHA7EPHA7EphA7Source|GeneCards
SLITRK1SLITRK1SLIT and NTRK-like family, member 1Source|GeneCards
ZNF143ZNF143zinc finger protein 143 (clone pHZ-1)Source|GeneCards
PRICKLE2PRICKLE2prickle-like 2 (Drosophila)Source|GeneCards
GRIN2BGRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2BSource|GeneCards
STARD13STARD13START domain containing 13Source|GeneCards
DMDDMDdystrophin (muscular dystrophy, Duchenne and Becker types)Source|GeneCards
WFDC1WFDC1WAP four-disulfide core domain 1Source|GeneCards
HDAC9HDAC9histone deacetylase 9Source|GeneCards
NDPNDPNorrie disease (pseudoglioma)Source|GeneCards
FLJ39779FLJ39779FLJ39779 proteinSource|GeneCards
SSPNSSPNsarcospan (Kras oncogene-associated gene)Source|GeneCards
MYO9AMYO9Amyosin IXASource|GeneCards
ZNF436ZNF436zinc finger protein 436Source|GeneCards
ZIC4ZIC4Zic family member 4Source|GeneCards
SSH3SSH3slingshot homolog 3 (Drosophila)Source|GeneCards
AF5Q31AFF4AF4/FMR2 family, member 4Source|GeneCards
MBNL1MBNL1muscleblind-like (Drosophila)Source|GeneCards
CHES1CHES1checkpoint suppressor 1Source|GeneCards
DLL4DLL4delta-like 4 (Drosophila)Source|GeneCards
DNAJA2DNAJA2DnaJ (Hsp40) homolog, subfamily A, member 2Source|GeneCards
CDC42EP3CDC42EP3CDC42 effector protein (Rho GTPase binding) 3Source|GeneCards
CA7CA7carbonic anhydrase VIISource|GeneCards
FLJ41603FLJ41603FLJ41603 proteinSource|GeneCards
AKAP12AKAP12A kinase (PRKA) anchor protein (gravin) 12Source|GeneCards
SLC3A1SLC3A1 1Source|GeneCards
PAQR9PAQR9progestin and adipoQ receptor family member IXSource|GeneCards
DKK1DKK1dickkopf homolog 1 (Xenopus laevis)Source|GeneCards
TPM2TPM2tropomyosin 2 (beta)Source|GeneCards
KRTHB3KRTHB3keratin, hair, basic, 3Source|GeneCards
MGC3040MGC3040hypothetical protein MGC3040Source|GeneCards
SMPXSMPXsmall muscle protein, X-linkedSource|GeneCards
GRK7GRK7G protein-coupled receptor kinase 7Source|GeneCards
SMARCA1SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1Source|GeneCards
FLJ40869FLJ40869hypothetical protein FLJ40869Source|GeneCards
TNNC1TNNC1troponin C type 1 (slow)Source|GeneCards
KIAA0663ZC3H11Azinc finger CCCH-type containing 11ASource|GeneCards
JUNJUNv-jun sarcoma virus 17 oncogene homolog (avian)Source|GeneCards
SOX2SOX2SRY (sex determining region Y)-box 2Source|GeneCards
COL13A1COL13A1collagen, type XIII, alpha 1Source|GeneCards
LUZP1LUZP1leucine zipper protein 1Source|GeneCards
GNG11GNG11guanine nucleotide binding protein (G protein), gamma 11Source|GeneCards
USP47USP47ubiquitin specific protease 47Source|GeneCards
LMCD1LMCD1LIM and cysteine-rich domains 1Source|GeneCards
DKFZP564B167BRP44brain protein 44Source|GeneCards
ENO3ENO3enolase 3, (beta, muscle)Source|GeneCards
DDX6DDX6DEAD (Asp-Glu-Ala-Asp) box polypeptide 6Source|GeneCards
PHOSPHO1PHOSPHO1phosphatase, orphan 1Source|GeneCards
FLJ20668MARCH1membrane-associated ring finger (C3HC4) 1Source|GeneCards
HAPLN1HAPLN1hyaluronan and proteoglycan link protein 1Source|GeneCards
JPH2JPH2junctophilin 2Source|GeneCards
IL17BIL17Binterleukin 17BSource|GeneCards
C21ORF29C21ORF29chromosome 21 open reading frame 29Source|GeneCards
ARL6IP2ARL6IP2ADP-ribosylation-like factor 6 interacting protein 2Source|GeneCards
SLC26A9SLC26A9solute carrier family 26, member 9Source|GeneCards
BRUNOL4BRUNOL4bruno-like 4, RNA binding protein (Drosophila)Source|GeneCards
PPP1R16BPPP1R16Bprotein phosphatase 1, regulatory (inhibitor) subunit 16BSource|GeneCards
PPP2R2BPPP2R2Bprotein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoformSource|GeneCards
ELMO3ELMO3engulfment and cell motility 3 (ced-12 homolog, C. elegans)Source|GeneCards
MBNL2MBNL2muscleblind-like 2 (Drosophila)Source|GeneCards
TGFB1I4TSC22D1TSC22 domain family, member 1Source|GeneCards
EDG1EDG1endothelial differentiation, sphingolipid G-protein-coupled receptor, 1Source|GeneCards
CKMT2CKMT2creatine kinase, mitochondrial 2 (sarcomeric)Source|GeneCards
AB026190KLHL20kelch-like 20 (Drosophila)Source|GeneCards
CSPG3CSPG3chondroitin sulfate proteoglycan 3 (neurocan)Source|GeneCards
TBC1D16TBC1D16TBC1 domain family, member 16Source|GeneCards
FOSFOSv-fos FBJ murine osteosarcoma viral oncogene homologSource|GeneCards
FLJ41841FLJ41841FLJ41841 proteinSource|GeneCards
FLJ37478FLJ37478hypothetical protein FLJ37478Source|GeneCards
SOX14SOX14SRY (sex determining region Y)-box 14Source|GeneCards
MAP2K5MAP2K5mitogen-activated protein kinase kinase 5Source|GeneCards
FGF6FGF6fibroblast growth factor 6Source|GeneCards
HS3ST5HS3ST5heparan sulfate (glucosamine) 3-O-sulfotransferase 5Source|GeneCards
GTF3C3GTF3C3general transcription factor IIIC, polypeptide 3, 102kDaSource|GeneCards

[an error occurred while processing this directive]