XX
XX
XX
FA HOXA3
XX
SY Hox-1.5; Hoxa-3; HOX1E
(human).
XX
OS mouse, Mus musculus
OC eukaryota; animalia;
metazoa; chordata; vertebrata; tetrapoda; mammalia;
OC eutheria;
rodentia; myomorpha; muridae; murinae
XX
HO Pb (Drosophila)
XX
CL C0006; homeo; 3.1.1.2.9.
XX
SZ 443 AA; 46.4
kDa (cDNA)
XX
XX
SC translated from EMBL #Y11717
XX
FT 79 138 proline-rich region (31/60).
FT 79 138 PS50099;
PRO_RICH_1.
FT 156 161 Antp type conserved hexapeptide.
FT 192 251 homeo domain.
FT 192 254 SM00389; HOX.
FT 193
249 PF00046; homeobox.
FT 289 326 PS50099; PRO_RICH_2.
XX
SF differential binding specificity in comparison with
Msx-1 or En-1 is
SF defined by nucleotides 3'-flanking to
the TAAT core of the recognition
SF sequence due to kinetic
reasons [3];
SF the homeo domain of HOXA3 differs from HOXD3
and HOXB3 only in one amino
SF acid residue [2];
XX
CP aortic trunk, kidney, lung, pharynx, spinal cord, spinal ganglia,
spleen,
CP stomach, thyroid [4]
XX
FF required for
development of thymus and parathyroid and for full development
FF of thyroid and submaxillary tissue [4];
FF mutants have
defects in heart and arteries and reveal cranofacial
FF abnormalities,
similar to human DiGeorge's syndrome [4];
FF also expressed
in certain kidney substructures [1];
FF subject to autoregulation
[7];
XX
XX
XX
XX
RN [1]; RE0014517.
RA
Davies J. A., Brandli A. W.
RT The Kidney Development Database;
URL:
RT http://www.ana.ed.ac.uk/anatomy/database/kidbase/tranfack.html
RL Internet : (1997).
RN [2]; RE0013202.
RX MEDLINE; 96323206.
RA Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.
RT Sequence
and expression of the murine Hoxd-3 homeobox gene
RL Proc.
Natl. Acad. Sci. USA 93:8247-8252 (1996).
RN [3]; RE0003871.
RX MEDLINE; 93204981.
RA Catron K. M., Iller N., Abate C.
RT Nucleotides flanking a conserved TAAT core dictate the DNA
binding
RT specifity of three murine homeodomain proteins
RL Mol. Cell. Biol. 13:2354-2365 (1993).
RN [4]; RE0003873.
RX MEDLINE; 91194760.
RA Chisaka O., Capecchi M. R.
RT
Regionally restricted developmental defects resulting from targeted
RT disruption of the mouse homeobox gene hox-1.5
RL Nature
350:473-479 (1991).
RN [5]; RE0006757.
RX MEDLINE; 89064559.
RA Gaunt S. J.
RT Mouse homeobox gene transcripts occupy different
but overlapping domains in
RT embryonic germ layers and organs:
a comparison of Hox-3.1 and Hox-1.5
RL Development 103:135-144
(1988).
RN [6]; RE0006758.
RX MEDLINE; 88211484.
RA
Gaunt S. J.
RT Homoeobox gene Hox-1.5 expression in mouse
embryos: earliest detection by
RT in situ hybridization is
during gastrulation
RL Development 101:51-60 (1987).
RN
[7]; RE0002306.
RX MEDLINE; 87092283.
RA Fainsod A., Bogarad
L. D., Ruusala T., Lubin M., Crothers D. M., Ruddle F.
RA
H.
RT The homeo domain of a murine protein binds 5' to its
own homeo box
RL Proc. Natl. Acad. Sci. USA 83:9532-9536 (1986).
RN [8]; RE0003872.
RX MEDLINE; 85024859.
RA McGinnis W.,
Hart C. P., Gehring W. J., Ruddle F. H.
RT Molecular cloning
and chromosome mapping of a mouse DNA sequence homologous
RT to homeotic genes of Drosophila
RL Cell 38:675-680 (1984).
XX