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Gene set: V$IRF2_01 (C3:TFAC:0032)
Standard nameV$IRF2_01
Systematic nameC3:TFAC:0032
Brief descriptionGenes with 3'UTR containing motif GAAAAGYGAAASY which matches annotation for IRF2: interferon regulatory factor 2
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA IRF-2
 XX
 SY IRF-2; PRDI-BFc; PRDI-BFi.

XX
 OS mouse, Mus musculus
 OC eukaryota; animalia; metazoa;
chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria; rodentia;
myomorpha; muridae; murinae
 XX
 XX
 CL C0022; trp; 3.5.3.0.2.

XX
 SZ 349 AA; 39.5 kDa (cDNA)
 XX
 XX
 SC SwissProt
#P23906
 XX
 FT 1 114 PF00605; IRF.
 FT 1 114 SM00348;
IRF.
 FT 11 77 tryptophan cluster (W-X14-W-X11-W-X19-W-X18-W).

FT 210 267 IAD2, IRF association domain 2 [1].
 XX
 SF highly
similar to IRF-2 (62% identity within the N-terminal part, 25%

SF between the C-terminal sequences), but lacking the acidic region
of IRF-1
 SF [10];
 SF IAD2 domain is conserved between
IRF-1 and IRF-2, but is different in other
 SF family members
[1];
 SF IAD2 is responsible for protein-protein interactions
[1];
 XX
 FF constitutive transcriptional repressor, thus
negative regulator of
 FF interferon-beta expression;
 FF
same DNA binding specificity as IRF-1;
 FF transforming potential,
antagonizing IRF-1 [6];
 FF required for normal hematopoiesis
and B lymphopoieses [5];
 FF enhanced levels after viral infection,
peak after 4h [10];
 FF functional in differentiated cells
only [9];
 FF IRF-1 and IRF-2 are critical transcription factors
in the regulation of
 FF macrophage Interleukin 12 and IFN-gamma
production [2];
 XX
 IN T00402; ICSBP; mouse, Mus musculus.

XX
 XX
 XX
 XX
 RN [1]; RE0017830.
 RX MEDLINE;
20054528.
 RA Meraro D., Hashmueli S., Koren B., Azriel A.,
Oumard A., Kirchhoff S.,
 RA Hauser H., Nagulapalli S., Atchison
M. L., Levi B.- Z.
 RT Protein-protein and DNA-protein interactions
affect the activity of
 RT lymphoid-specific IFN regulatory
factors.
 RL J. Immunol. 163:6468-6478 (1999).
 RN [2];
RE0017930.
 RX MEDLINE; 99343766.
 RA Salkowski C. A., Kopydlowski
K., Blanco J., Cody M. J., McNally R., Vogel
 RA S. N.

RT IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout
mice.
 RL J. Immunol. 163:1529-1536 (1999).
 RN [3]; RE0003469.

RX MEDLINE; 94255467.
 RA Bovolenta C., Driggers P. H., Marks
M. S., Medin J. A., Politis A. D.,
 RA Vogel S. N., Levy D.
E., Sakaguchi K., Appella E., Coligan J. E., Ozato K.
 RT Molecular
interactions between interferon consensus sequence binding

RT protein and members of the interferon regulatory factor family

RL Proc. Natl. Acad. Sci. USA 91:5046-5050 (1994).
 RN [4];
RE0002930.
 RX MEDLINE; 93330247.
 RA Tanaka N., Kawakami
T., Taniguchi T.
 RT Recognition DNA sequences of interferon
regulatory factor 1 (IRF-1) and
 RT IRF-2, regulators of cell
growth and the interferon system
 RL Mol. Cell. Biol. 13:4531-4538
(1993).
 RN [5]; RE0003461.
 RX MEDLINE; 94006548.
 RA
Matsuyama T., Kimura T., Kitagawa M., Pfeffer K., Kawakami T.,
Watanabe N.,
 RA Kuendig T. M., Amakawa R., Kishihara K., Wakeham
A., Potter J., Furlonger
 RA C. L., Narendran A., Suzuki H.,
Ohashi P. S., Paige C. J., Taniguchi T.,
 RA Mak T. W.

RT Targeted disruption of IRF-1 or IRF-2 results in abnormal type
I IFN gene
 RT induction and aberrant lymphocyte developement

RL Cell 75:83-97 (1993).
 RN [6]; RE0003470.
 RX MEDLINE;
93174264.
 RA Harada H., Kitagawa M., Tanaka N., Yamamoto H.,
Harada K., Ishihara M.,
 RA Taniguchi T.
 RT Anti-oncogenic
and oncogenic potentials of interferon regulatory factors-1

RT and -2
 RL Science 259:971-974 (1993).
 RN [7]; RE0001630.

RX MEDLINE; 91246172.
 RA Pleiman C. M., Gimpel S. D., Park
L. S., Harada H., Taniguchi T., Ziegler
 RA S. F.
 RT Organization
of the murine and human interleukin-7 receptor genes: two

RT mRNAs generated by differential splicing and presence of a
type
 RT I-interferon-inducible promoter
 RL Mol. Cell.
Biol. 11:3052-3059 (1991).
 RN [8]; RE0002174.
 RX MEDLINE;
91360341.
 RA Watanabe N., Sakakibara J., Hovanessian A. G.,
Taniguchi T., Fujita T.
 RT Activation of IFN-beta element
by IRF-1 requires a post-translational event
 RT in addition
to IRF-1 synthesis
 RL Nucleic Acids Res. 19:4421-4428 (1991).

RN [9]; RE0000171.
 RX MEDLINE; 91004238.
 RA Harada H.,
Willison K., Sakakibara J., Miyamoto M., Fujita T., Taniguchi
T.
 RT Absence of the type I IFN system in EC cells: transcriptional
activator
 RT (ITF-1) and repressor (IRF-2) genes are developmentally
regulated
 RL Cell 63:303-312 (1990).
 RN [10]; RE0000097.

RX MEDLINE; 89354547.
 RA Harada H., Fujita T., Miyamoto M.,
Kimura Y., Maruyama M., Furia A., Miyata
 RA T., Taniguchi
T.
 RT Structurally similar but functionally distinct factors,
IRF-1 and IRF-2,
 RT bind to the same regulatory elements of
IFN and IFN-inducible genes
 RL Cell 58:729-739 (1989).

XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

130 genes, 130 accessions (Toggle view)

AccessionGeneTitleLinks
MAPK6MAPK6mitogen-activated protein kinase 6Source|GeneCards
ATF3ATF3activating transcription factor 3Source|GeneCards
CDK6CDK6cyclin-dependent kinase 6Source|GeneCards
HDAC4HDAC4histone deacetylase 4Source|GeneCards
CCDC6CCDC6coiled-coil domain containing 6Source|GeneCards
RAPGEF6RAPGEF6Rap guanine nucleotide exchange factor (GEF) 6Source|GeneCards
NSE2FAM84Bfamily with sequence similarity 84, member BSource|GeneCards
PIGRPIGRpolymeric immunoglobulin receptorSource|GeneCards
E2F3E2F3E2F transcription factor 3Source|GeneCards
MCM8MCM8MCM8 minichromosome maintenance deficient 8 (S. cerevisiae)Source|GeneCards
TERF2IPTERF2IPtelomeric repeat binding factor 2, interacting proteinSource|GeneCards
ARHGAP5ARHGAP5Rho GTPase activating protein 5Source|GeneCards
ASH1LASH1Lash1 (absent, small, or homeotic)-like (Drosophila)Source|GeneCards
JMJD1AJMJD1Ajumonji domain containing 1ASource|GeneCards
KARSKARSlysyl-tRNA synthetaseSource|GeneCards
DDX17DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17Source|GeneCards
DLG1DLG1discs, large homolog 1 (Drosophila)Source|GeneCards
M11S1M11S1membrane component, chromosome 11, surface marker 1Source|GeneCards
TAPBPTAPBPTAP binding protein (tapasin)Source|GeneCards
PSME1PSME1proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)Source|GeneCards
FLT3LGFLT3LGfms-related tyrosine kinase 3 ligandSource|GeneCards
FAM13C1FAM13C1family with sequence similarity 13, member C1Source|GeneCards
BHLHB5BHLHB5basic helix-loop-helix domain containing, class B, 5Source|GeneCards
SSB1SSB1SPRY domain-containing SOCS box protein SSB-1Source|GeneCards
RNF159PCGF5polycomb group ring finger 5Source|GeneCards
YAPYY1AP1YY1 associated protein 1Source|GeneCards
BLKBLKB lymphoid tyrosine kinaseSource|GeneCards
FLJ10597C1ORF164chromosome 1 open reading frame 164Source|GeneCards
PEFPEFPEF protein with a long N-terminal hydrophobic domain (peflin)Source|GeneCards
GPR52GPR52G protein-coupled receptor 52Source|GeneCards
FLJ33387FLJ33387hypothetical protein FLJ33387Source|GeneCards
NR3C2NR3C2nuclear receptor subfamily 3, group C, member 2Source|GeneCards
SLC38A2SLC38A2solute carrier family 38, member 2Source|GeneCards
FLJ20477PIGVphosphatidylinositol glycan, class VSource|GeneCards
THRAP1THRAP1Thyroid hormone receptor associated protein 1Source|GeneCards
PROX1PROX1prospero-related homeobox 1Source|GeneCards
SE57-1SE57-1CTCL tumor antigen se57-1Source|GeneCards
CXCL10CXCL10chemokine (C-X-C motif) ligand 10Source|GeneCards
DAP3DAP3death associated protein 3Source|GeneCards
OSMOSMoncostatin MSource|GeneCards
TBX1TBX1T-box 1Source|GeneCards
LDB2LDB2LIM domain binding 2Source|GeneCards
EGFL6EGFL6EGF-like-domain, multiple 6Source|GeneCards
DUSP10DUSP10dual specificity phosphatase 10Source|GeneCards
PSMB9PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2)Source|GeneCards
BST2BST2bone marrow stromal cell antigen 2Source|GeneCards
DNASE1L3DNASE1L3deoxyribonuclease I-like 3Source|GeneCards
GSDMDC1GSDMDC1gasdermin domain containing 1Source|GeneCards
SIPA1SIPA1signal-induced proliferation-associated gene 1Source|GeneCards
PSMB8PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7)Source|GeneCards
HSPC152HSPC152hypothetical protein HSPC152Source|GeneCards
FLJ23598AGBL2ATP/GTP binding protein-like 2Source|GeneCards
KIAA1468KIAA1468KIAA1468 proteinSource|GeneCards
IL11IL11interleukin 11Source|GeneCards
TAP1TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)Source|GeneCards
TRPM3TRPM3transient receptor potential cation channel, subfamily M, member 3Source|GeneCards
BBAPDTX3Ldeltex 3-like (Drosophila)Source|GeneCards
HPCAL1HPCAL1hippocalcin-like 1Source|GeneCards
USP5USP5ubiquitin specific protease 5 (isopeptidase T)Source|GeneCards
FXYD5FXYD5FXYD domain containing ion transport regulator 5Source|GeneCards
OTX1OTX1orthodenticle homolog 1 (Drosophila)Source|GeneCards
HOXA6HOXA6homeo box A6Source|GeneCards
RIMS2RIMS2regulating synaptic membrane exocytosis 2Source|GeneCards
VGLL4VGLL4vestigial like 4 (Drosophila)Source|GeneCards
PRDM16PRDM16PR domain containing 16Source|GeneCards
PDGFCPDGFCplatelet derived growth factor CSource|GeneCards
NPR3NPR3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)Source|GeneCards
BAT5BAT5HLA-B associated transcript 5Source|GeneCards
HIST1H4GHIST1H4Ghistone 1, H4gSource|GeneCards
ME3ME3malic enzyme 3, NADP(+)-dependent, mitochondrialSource|GeneCards
MSX1MSX1msh homeo box homolog 1 (Drosophila)Source|GeneCards
MAP3K11MAP3K11mitogen-activated protein kinase kinase kinase 11Source|GeneCards
CSADCSADcysteine sulfinic acid decarboxylaseSource|GeneCards
NT5C3NT5C35'-nucleotidase, cytosolic IIISource|GeneCards
ZNFN1A2ZNFN1A2zinc finger protein, subfamily 1A, 2 (Helios)Source|GeneCards
CGI-09CGI-09CGI-09 proteinSource|GeneCards
KCNMB3KCNMB3potassium large conductance calcium-activated channel, subfamily M beta member 3Source|GeneCards
IFNB1IFNB1interferon, beta 1, fibroblastSource|GeneCards
SORBS1SORBS1sorbin and SH3 domain containing 1Source|GeneCards
RFX4RFX4regulatory factor X, 4 (influences HLA class II expression)Source|GeneCards
PRKCNPRKD3protein kinase D3Source|GeneCards
CGI-119TMBIM4transmembrane BAX inhibitor motif containing 4Source|GeneCards
TGFB3TGFB3transforming growth factor, beta 3Source|GeneCards
UBDUBDubiquitin DSource|GeneCards
TNFSF13BTNFSF13Btumor necrosis factor (ligand) superfamily, member 13bSource|GeneCards
KCNE4KCNE4potassium voltage-gated channel, Isk-related family, member 4Source|GeneCards
TCIRG1TCIRG1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3Source|GeneCards
ROCK1ROCK1Rho-associated, coiled-coil containing protein kinase 1Source|GeneCards
DLX1DLX1distal-less homeo box 1Source|GeneCards
BALPARP9poly (ADP-ribose) polymerase family, member 9Source|GeneCards
MITFMITFmicrophthalmia-associated transcription factorSource|GeneCards
MGC3040MGC3040hypothetical protein MGC3040Source|GeneCards
TMPRSS5TMPRSS5transmembrane protease, serine 5 (spinesin)Source|GeneCards
IL28BIL28Binterleukin 28B (interferon, lambda 3)Source|GeneCards
B2MB2Mbeta-2-microglobulinSource|GeneCards
ESR1ESR1estrogen receptor 1Source|GeneCards
BBXBBXbobby sox homolog (Drosophila)Source|GeneCards
USF1USF1upstream transcription factor 1Source|GeneCards
SYNE2SYNE2spectrin repeat containing, nuclear envelope 2Source|GeneCards
NDNNDNnecdin homolog (mouse)Source|GeneCards
IL27IL27Interleukin 27Source|GeneCards
LIFLIFleukemia inhibitory factor (cholinergic differentiation factor)Source|GeneCards
SFRS12SFRS12splicing factor, arginine/serine-rich 12Source|GeneCards
GLRA1GLRA1glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome)Source|GeneCards
ASPAASPAaspartoacylase (aminoacylase 2, Canavan disease)Source|GeneCards
LOC91614LOC91614novel 58.3 KDA proteinSource|GeneCards
CUL2CUL2cullin 2Source|GeneCards
DLX4DLX4distal-less homeobox 4Source|GeneCards
PGM5PGM5phosphoglucomutase 5Source|GeneCards
LSM6LSM6LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)Source|GeneCards
KIAA1318RGAG1retrotransposon gag domain containing 1Source|GeneCards
CXORF21CXORF21Chromosome X open reading frame 21Source|GeneCards
ARHGEF6ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6Source|GeneCards
PRKD2PRKD2protein kinase D2Source|GeneCards
FLJ20668MARCH1membrane-associated ring finger (C3HC4) 1Source|GeneCards
UPF2UPF2UPF2 regulator of nonsense transcripts homolog (yeast)Source|GeneCards
BNC2BNC2basonuclin 2Source|GeneCards
IL15RAIL15RAinterleukin 15 receptor, alphaSource|GeneCards
BCL11ABCL11AB-cell CLL/lymphoma 11A (zinc finger protein)Source|GeneCards
IL28AIL28Ainterleukin 28A (interferon, lambda 2)Source|GeneCards
HSXIAPAF1HSXIAPAF1XIAP associated factor-1Source|GeneCards
PRDX5PRDX5peroxiredoxin 5Source|GeneCards
PLXNC1PLXNC1plexin C1Source|GeneCards
RELRELv-rel reticuloendotheliosis viral oncogene homolog (avian)Source|GeneCards
USP18USP18ubiquitin specific protease 18Source|GeneCards
PSMA3PSMA3proteasome (prosome, macropain) subunit, alpha type, 3Source|GeneCards
FLJ20321CASZ1castor homolog 1, zinc finger (Drosophila)Source|GeneCards
EIF4A2EIF4A2eukaryotic translation initiation factor 4A, isoform 2Source|GeneCards
FLJ39827FLJ39827hypothetical protein FLJ39827Source|GeneCards
DDX58DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58Source|GeneCards

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