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Gene set: V$LEF1_Q2 (C3:TFAC:0397)
Standard nameV$LEF1_Q2
Systematic nameC3:TFAC:0397
Brief descriptionGenes with 3'UTR containing motif TCAAAG which matches annotation for LEF1: lymphoid enhancer-binding factor 1
TCF1: Transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA LEF-1
 XX
 SY lymphoid enhancer
binding factor 1; lymphoid enhancing factor 1; human
 SY LEF-1;
TCF-1alpha; hLEF-1.
 XX
 OS human, Homo sapiens
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; primates
 XX
 CL C0015; HMG.
 XX
 SZ
399 AA; 44.2 kDa (cDNA); 55 kDa (SDS)
 XX
 XX
 SC translated
from ref. [18] and ref. [1]; AA 389-399 are dedicated as LEF-1N

SC tail ref. [1]
 XX
 FT 1 33 repressing domain.
 FT
1 56 beta-catenin interacting domain [14]; conflict 1-60 [1].

FT 1 71 encoded by exon 1 [1].
 FT 14 52 adidic region (14/39).

FT 72 93 encoded by exon 2 [1].
 FT 80 135 trans-activation
domain A [17].
 FT 82 273 proline rich region (36/192).

FT 94 133 encoded by exon 3 [1].
 FT 134 182 encoded by exon
4 [1].
 FT 174 256 trans-activation domain B [17].
 FT 183
213 encoded by exon 5 [1].
 FT 214 241 encoded by exon 6 [1].

FT 242 281 encoded by exon 7 [1].
 FT 244 286 proline and histidine
rich region (17/43) [18].
 FT 282 336 encoded by exon 8 [1].

FT 297 372 HMG domain (295-362 [18], 297-364 [1]).
 FT 298
368 SM00398; HMG.
 FT 299 367 PF00505; HMG_box.
 FT 337
372 encoded by exon 9 [1].
 FT 372 399 encoded by exon 10 [1].

FT 374 382 B box (essential for nuclear transposition) [13], conflict:

FT 372-383 NLS (nuclear localisation signal) [1].
 FT 389 399
LEF-1N tail [1].
 XX
 SF the LEF-1 gene (52 kb) is located
on chromosome 4 [1], exon structure:
 SF 1,2,3, 3a, 3b, 4,5,6,7,8,9,10,11,12
[1];
 SF sequence-specific DNA-binding is mediated by the disordered
N-terminal part
 SF of the L-shaped HMG domain and by its third
alpha-helix [16];
 SF binds to pyrimidine-rich elements 5�-YCTTTG-3�
[18];
 SF no appreciable T cell-specific enhancer activity
in the absence of the
 SF flanking CRE and TCF-2alpha/ets-binding
sites --> direct interaction with
 SF CREB and TCF-2alpha/ets
proteins? [20];
 SF hLEF-1 binds DNA as a monomer but cannot
function on its own to enhance
 SF transcription [17];

SF formerly TCF-1alpha;
 SF a shorter cDNA clone reveals a
protein which lacks AA 214-241 [18];
 SF gene located on chromosome
4 [19];
 SF for in vitro binding to the wild-type hLEF site
in the TCRalpha enhancer a
 SF truncated protein bearing AA
297-377 is sufficient [17];
 SF alanine substitution mutagenesis
and EMSA shows that AA 25-27 and 32-34 are
 SF not necessary
for beta-catenin binding [7];
 SF the transactivating domain
normally provided by beta-catenin can be
 SF replaced by other
transactivating domains [6];
 XX
 CP T-cells; thymus

XX
 FF contents a potent transcriptional activation domain
which mediates
 FF context-specific activation of the TCFalpha
enhancer [17];
 FF can form a complex with beta-catenin (in
the nucleus) and thus activates
 FF gene transcription;

FF member of the Wnt-/ Wingless-signal transduction cascade;

FF uncontrolled activation of gene transcription by the beta-catenin/
LEF-1
 FF complex may contribute to tumor progression;

FF c-myc and cyclin D1 contain LEF-1 binding sequences in promoter
region [2];
 FF upon Wnt-1 signaling combined with beta-catenin
binding the transcriptional
 FF activity of LEF-1 rises;

FF LEF-1 can activate transcription thus from a synthetic enhancer
containing
 FF multimerized binding sites in contrast to the
activation of the TCFalpha
 FF enhancer where LEF-1 can only
activate transcription upon a specific
 FF context of transcription
factors;
 FF in the TCFalpha enhancer LEF-1 collaborates with
AML1-, Ets-1 and CREB;
 FF the activation potential in this
context is further dependent on ALY which
 FF associates with
the context dependent activation domains of LEF-1 and AML-1;

FF taken together LEF-1 can exert two different roles: in association
with
 FF beta-Catenin it can mediate transcriptional activation
in a
 FF context-independent manner, whereas it regulates -
together with ALY -
 FF transcription in a context specific
way [7];
 FF the ability of LEF-1 to induce oncogenic transformation
was shown by
 FF generating covalent linked LEF-1 and beta-catenin
(or other transactivating
 FF domains) [6];
 FF beta-catenin
stabilizing mutations result in LEF-1 transactivation leading

FF to development of human tumours of hair matrix differentiation
[4];
 XX
 IN T02872; beta-catenin; human, Homo sapiens.

IN T02984; beta-catenin; mouse, Mus musculus.
 XX
 XX

XX
 XX
 RN [1]; RE0014765.
 RX MEDLINE; 20221598.

RA Hovanes K., Li T. W. H., Waterman M. L.
 RT The human LEF-1
gene contains a promoter preferentially active in
 RT lymphocytes
and encodes multiple isoforms derived from alternative splicing

RL Nucleic Acids Res. 28:1994-2003 (2000).
 RN [2]; RE0014041.

RX MEDLINE; 99254073.
 RA Shtutman M., Zhurinsky J., Simcha
I., Albanese C., D'Amico M., Pestell R.,
 RA Ben-Ze'ev A.

RT The cyclin D1 gene is a target of the beta-catenin/ Lef-1 pathway

RL Proc. Natl. Acad. Sci. USA 96:5522-5527 (1999).
 RN [3];
RE0014053.
 RX MEDLINE; 99425167.
 RA McGrew L. L., Takemaru
K.-I., Bates R., Moon R. T.
 RT Direct regulation of the Xenopus
engrailed-2 promoter by the Wnt signaling
 RT pathway, and
a molecular screen for Wnt-responsive genes, confirm a role

RT for Wnt signaling during neural patterning in Xenopus
 RL
Mech. Dev. 87:21-32 (1999).
 RN [4]; RE0014096.
 RX MEDLINE;
99206611.
 RA Chan E. F., Gat U., McNiff J. M., Fuchs E.

RT A common human skin tumour is caused by activating mutations
in beta-catenin
 RL Nat. Genet. 21:410-413 (1999).
 RN [5];
RE0014099.
 RX MEDLINE; 99340256.
 RA Gradl D., Kuhl M.,
Wedlich D.
 RT The Wnt/Wg signal transducer beta-catenin controls
fibronectin expression
 RL Mol. Cell. Biol. 19:5576-5587 (1999).

RN [6]; RE0014351.
 RX MEDLINE; 99093503.
 RA Aoki M., Hecht
A., Kruse U., Kemler R., Vogt P. K.
 RT Nuclear endpoint of
Wnt signaling: neoplastic transformation induced by
 RT transactivating
lymphoid-enhancing factor 1
 RL Proc. Natl. Acad. Sci. USA
96:139-144 (1999).
 RN [7]; RE0014336.
 RX MEDLINE; 98336286.

RA Hsu S.-C., Galceran J., Grosschedl R.
 RT Modulation of
transcriptional regulation by LEF-1 in response to Wnt-1
 RT
signaling and association with beta-catenin
 RL Mol. Cell.
Biol. 18:4807-4818 (1998).
 RN [8]; RE0014048.
 RX MEDLINE;
98058732.
 RA Giese K., Pagel J., Grosschedl R.
 RT Functional
analysis of DNA bending and unwinding by the high mobility group

RT domain of LEF-1
 RL Proc. Natl. Acad. Sci. USA 94:12845-12850
(1997).
 RN [9]; RE0014050.
 RX MEDLINE; 97452550.
 RA
Brannon M., Gomperts M., Sumoy L., Moon R. T., Kimelman D.

RT A beta-catenin/XTcf-3 complex binds to the siamois promoter
to regulate
 RT dorsal axis specification in Xenopus
 RL
Genes Dev. 11:2359-2370 (1997).
 RN [10]; RE0014090.
 RX
MEDLINE; 98104245.
 RA McKendry R., Hsu S.-C., Harland R. M.,
Grosschedl R.
 RT LEF-1/TCF proteins mediate Wnt-inducible
transcription from Xenopus
 RT nodal-related 3 promoter

RL Dev. Biol. 192:420-431 (1997).
 RN [11]; RE0006108.

RX MEDLINE; 96338228.
 RA Behrens J., von Kries J. P., Kuehl
M., Bruhn L., Wedlich D., Grosschedl R.,
 RA Birchmeier W.

RT Functional interaction of beta-catenin with the transcription
factor LEF -1
 RL Nature 382:638-642 (1996).
 RN [12]; RE0014049.

RX MEDLINE; 97169230.
 RA Haynes T. L., Thomas M. B., Dusing
M. R., Valerius M. T., Potter S. S.,
 RA Wiginton D. A.

RT An enhancer LEF-1/TCF-1 site is essential for insertin site-independent

RT transgene expression in thymus
 RL Nucleic Acids Res. 24:5034-5044
(1996).
 RN [13]; RE0014054.
 RX MEDLINE; 96205953.

RA Prieve M. G., Guttridge K. L., Munguia J. E., Waterman M. L.

RT The nuclear localization signal of lymphoid enhancer factor-1
is recognized
 RT by two differentially expressed Srp1-nuclear
localization sequence receptor
 RT proteins
 RL J. Biol.
Chem. 271:7654-7658 (1996).
 RN [14]; RE0014185.
 RX MEDLINE;
97047308.
 RA Huber O., Korn R., McLaughlin J., Ohsugi M.,
Herrmann B. G., Kemler R.
 RT Nuclear localization of beta-catenin
by interaction with transcription
 RT factor LEF-1
 RL Mech.
Dev. 59:3-10 (1996).
 RN [15]; RE0011357.
 RX MEDLINE; 95385995.

RA Sheridan P. L., Sheline C. T., Cannon K., Voz M. L., Pazin
M. J., Kadonaga
 RA J. T., Jones K. A.
 RT Activation of
the HIV-1 enhancer by the LEF-1 HMG protein on
 RT nucleosome-assembled
DNA in vitro
 RL Genes Dev. 9:2090-2104 (1995).
 RN [16];
RE0004366.
 RX MEDLINE; 95080249.
 RA Read C. M., Cary P.
D., Preston N. S., Lnenicek-Allen M., Crane-Robinson C.
 RT
The DNA sequence specificity of HMG boxes lies in the minor wing
of the
 RT structure
 RL EMBO J. 13:5639-5646 (1994).

RN [17]; RE0004365.
 RX MEDLINE; 94074899.
 RA Carlsson
P., Waterman M. L., Jones K. A.
 RT The hLEF/TCF-1alpha HMG
protein contains a context-dependent
 RT transcriptional activation
domain that induces the TCRalpha enhancer in T
 RT cells

RL Genes Dev. 7:2418-2430 (1993).
 RN [18]; RE0000694.

RX MEDLINE; 91184620.
 RA Waterman M. L., Fischer W. H., Jones
K. A.
 RT A thymus-specific member of the HMG protein family
regulates the human
 RT T-cell receptor Calpha enhancer

RL Genes Dev. 5:656-669 (1991).
 RN [19]; RE0004363.
 RX
MEDLINE; 92090734.
 RA Giese K., Amsterdam A., Grosschedl R.

RT DNA-binding properties of the HMG domain of the lymphoid-specific

RT transcriptional regulator LEF-1
 RL Genes Dev. 5:2567-2578
(1991).
 RN [20]; RE0001944.
 RX MEDLINE; 91190842.

RA Waterman M. L., Jones K.
 RT Purification of TCF-1alpha,
a T-cell-specific transcription factor that
 RT activates the
T-cell receptor Calpha gene enhancer in a context-dependent

RT manner
 RL New Biol. 2:621-636 (1990).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

235 genes, 235 accessions (Toggle view)

AccessionGeneTitleLinks
CD3ZCD3ZCD3Z antigen, zeta polypeptide (TiT3 complex)Source|GeneCards
MPZMPZmyelin protein zero (Charcot-Marie-Tooth neuropathy 1B)Source|GeneCards
C10ORF11C10ORF11chromosome 10 open reading frame 11Source|GeneCards
MMP21MMP21matrix metallopeptidase 21Source|GeneCards
FER1L3FER1L3fer-1-like 3, myoferlin (C. elegans)Source|GeneCards
SLC17A6SLC17A6solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6Source|GeneCards
C10ORF12C10ORF12chromosome 10 open reading frame 12Source|GeneCards
TMSL1TMSL1thymosin-like 1Source|GeneCards
CYP2E1CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 1Source|GeneCards
CNTFCNTFciliary neurotrophic factorSource|GeneCards
RALGPS2RALGPS2Ral GEF with PH domain and SH3 binding motif 2Source|GeneCards
FLJ32112C1ORF83chromosome 1 open reading frame 83Source|GeneCards
DGAT2DGAT2diacylglycerol O-acyltransferase homolog 2 (mouse)Source|GeneCards
PCDH16DCHS1dachsous 1 (Drosophila)Source|GeneCards
BHC80PHF21APHD finger protein 21ASource|GeneCards
MYCL1MYCL1v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)Source|GeneCards
SB145LYSMD1LysM, putative peptidoglycan-binding, domain containing 1Source|GeneCards
FLJ14050GRRP1glycine/arginine rich protein 1Source|GeneCards
SORCS1SORCS1VPS10 domain receptor protein SORCS 1Source|GeneCards
TACSTD2TACSTD2tumor-associated calcium signal transducer 2Source|GeneCards
DKFZP434M202TDRD10tudor domain containing 10Source|GeneCards
IQGAP3IQGAP3IQ motif containing GTPase activating protein 3Source|GeneCards
SEMA4GSEMA4Gsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4GSource|GeneCards
ARL3ARL3ADP-ribosylation factor-like 3Source|GeneCards
FLJ38753KLHDC7Akelch domain containing 7ASource|GeneCards
PKD1-LIKEPKD1-LIKEpolycystic kidney disease 1-likeSource|GeneCards
LIN28LIN28lin-28 homolog (C. elegans)Source|GeneCards
PTPN7PTPN7protein tyrosine phosphatase, non-receptor type 7Source|GeneCards
TSG101TSG101tumor susceptibility gene 101Source|GeneCards
CNR2CNR2cannabinoid receptor 2 (macrophage)Source|GeneCards
LOC56181FAM54Bfamily with sequence similarity 54, member BSource|GeneCards
WNT8BWNT8Bwingless-type MMTV integration site family, member 8BSource|GeneCards
RCN1RCN1reticulocalbin 1, EF-hand calcium binding domainSource|GeneCards
AP4B1AP4B1adaptor-related protein complex 4, beta 1 subunitSource|GeneCards
GADD45AGADD45Agrowth arrest and DNA-damage-inducible, alphaSource|GeneCards
OR10A5OR10A5olfactory receptor, family 10, subfamily A, member 5Source|GeneCards
ANK3ANK3ankyrin 3, node of Ranvier (ankyrin G)Source|GeneCards
TIAL1TIAL1TIA1 cytotoxic granule-associated RNA binding protein-like 1Source|GeneCards
LHX4LHX4LIM homeobox 4Source|GeneCards
C1ORF25C1ORF25chromosome 1 open reading frame 25Source|GeneCards
PAK1PAK1p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)Source|GeneCards
CACNB2CACNB2calcium channel, voltage-dependent, beta 2 subunitSource|GeneCards
ADD3ADD3adducin 3 (gamma)Source|GeneCards
FRBZ1ZBTB41zinc finger and BTB domain containing 41Source|GeneCards
HIAT1HIAT1hippocampus abundant transcript 1Source|GeneCards
ELAVL4ELAVL4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)Source|GeneCards
DUSP10DUSP10dual specificity phosphatase 10Source|GeneCards
LRRTM3LRRTM3leucine-rich repeat transmembrane neuronal 3 proteinSource|GeneCards
TIMM10TIMM10translocase of inner mitochondrial membrane 10 homolog (yeast)Source|GeneCards
CAP1CAP1CAP, adenylate cyclase-associated protein 1 (yeast)Source|GeneCards
GAB2GAB2GRB2-associated binding protein 2Source|GeneCards
SIPA1SIPA1signal-induced proliferation-associated gene 1Source|GeneCards
FHR5CFHL5complement factor H-related 5 /// complement factor H-related 5Source|GeneCards
CDC2CDC2cell division cycle 2, G1 to S and G2 to MSource|GeneCards
ARID1AARID1AAT rich interactive domain 1A (SWI- like)Source|GeneCards
EFNA4EFNA4ephrin-A4Source|GeneCards
SHFM3FBXW4F-box and WD-40 domain protein 4Source|GeneCards
INAINAinternexin neuronal intermediate filament protein, alphaSource|GeneCards
DPYDDPYDdihydropyrimidine dehydrogenaseSource|GeneCards
HABP2HABP2hyaluronan binding protein 2Source|GeneCards
FLJ40536FLJ40536FLJ40536 proteinSource|GeneCards
NEK7NEK7NIMA (never in mitosis gene a)-related kinase 7Source|GeneCards
UAP1UAP1UDP-N-acteylglucosamine pyrophosphorylase 1Source|GeneCards
PRDM2PRDM2PR domain containing 2, with ZNF domainSource|GeneCards
REREREREarginine-glutamic acid dipeptide (RE) repeatsSource|GeneCards
LRP8LRP8low density lipoprotein receptor-related protein 8, apolipoprotein e receptorSource|GeneCards
SLC6A9SLC6A9solute carrier family 6 (neurotransmitter transporter, glycine), member 9Source|GeneCards
ELF5ELF5E74-like factor 5 (ets domain transcription factor)Source|GeneCards
CROC4C1ORF61chromosome 1 open reading frame 61Source|GeneCards
UBE4BUBE4Bubiquitination factor E4B (UFD2 homolog, yeast)Source|GeneCards
VAX1VAX1ventral anterior homeobox 1Source|GeneCards
NCDNNCDNneurochondrinSource|GeneCards
ZFYVE9ZFYVE9zinc finger, FYVE domain containing 9Source|GeneCards
C1ORF8TMEM59transmembrane protein 59Source|GeneCards
IL20IL20interleukin 20Source|GeneCards
DC8C1ORF48chromosome 1 open reading frame 48Source|GeneCards
FLJ10407TMEM48transmembrane protein 48Source|GeneCards
C1ORF22C1ORF22chromosome 1 open reading frame 22Source|GeneCards
SORBS1SORBS1sorbin and SH3 domain containing 1Source|GeneCards
HTCD37PRUNEPrune homolog (Drosophila)Source|GeneCards
EIF4EBP2EIF4EBP2eukaryotic translation initiation factor 4E binding protein 2Source|GeneCards
PHTF1PHTF1putative homeodomain transcription factor 1Source|GeneCards
GM117C1ORF52chromosome 1 open reading frame 52Source|GeneCards
HBXAPHBXAPhepatitis B virus x associated proteinSource|GeneCards
SLC43A3SLC43A3solute carrier family 43, member 3Source|GeneCards
MRVI1MRVI1murine retrovirus integration site 1 homologSource|GeneCards
OVOL1OVOL1ovo-like 1(Drosophila)Source|GeneCards
AHCYL1AHCYL1S-adenosylhomocysteine hydrolase-like 1Source|GeneCards
FLJ10199TMEM51transmembrane protein 51Source|GeneCards
MGC35130UBE2Uubiquitin-conjugating enzyme E2U (putative)Source|GeneCards
C1ORF16C1ORF16chromosome 1 open reading frame 16Source|GeneCards
FLJ45983FLJ45983FLJ45983 proteinSource|GeneCards
AMPD3AMPD3adenosine monophosphate deaminase (isoform E)Source|GeneCards
KIAA0663ZC3H11Azinc finger CCCH-type containing 11ASource|GeneCards
S100A3S100A3S100 calcium binding protein A3Source|GeneCards
GRK5GRK5G protein-coupled receptor kinase 5Source|GeneCards
BSNDBSNDbarttinSource|GeneCards
E2IG4LRRC54leucine rich repeat containing 54Source|GeneCards
MOV10MOV10Mov10, Moloney leukemia virus 10, homolog (mouse)Source|GeneCards
NPPANPPAnatriuretic peptide precursor ASource|GeneCards
NAV2NAV2neuron navigator 2Source|GeneCards
SFXN2SFXN2sideroflexin 2Source|GeneCards
PRKRIRPRKRIRprotein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)Source|GeneCards
CEPT1CEPT1choline/ethanolaminephosphotransferaseSource|GeneCards
NEXNNEXNNexilin (F actin binding protein)Source|GeneCards
T1A-2PDPNpodoplaninSource|GeneCards
SLC26A9SLC26A9solute carrier family 26, member 9Source|GeneCards
YARSYARStyrosyl-tRNA synthetaseSource|GeneCards
BMI1PCGF4polycomb group ring finger 4Source|GeneCards
HNRPRHNRPRheterogeneous nuclear ribonucleoprotein RSource|GeneCards
DCLRE1BDCLRE1BDNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)Source|GeneCards
KCNQ1DNKCNQ1DNKCNQ1 downstream neighborSource|GeneCards
SYT13SYT13synaptotagmin XIIISource|GeneCards
PDCPDCphosducinSource|GeneCards
PANK1PANK1pantothenate kinase 1Source|GeneCards
RGL1RGL1Ral guanine nucleotide dissociation stimulator-like 1Source|GeneCards
SMYD2SMYD2SET and MYND domain containing 2Source|GeneCards
BSCL2BSCL2Bernardinelli-Seip congenital lipodystrophy 2 (seipin)Source|GeneCards
C1ORF26C1ORF26chromosome 1 open reading frame 26Source|GeneCards
LOC91056LOC91056hypothetical protein BC004895Source|GeneCards
ZNF238ZNF238zinc finger protein 238Source|GeneCards
DDR2DDR2discoidin domain receptor family, member 2Source|GeneCards
SOX6SOX6SRY (sex determining region Y)-box 6Source|GeneCards
NAV1NAV1neuron navigator 1Source|GeneCards
C11ORF8C11ORF8chromosome 11 open reading frame 8Source|GeneCards
CLCNKACLCNKAchloride channel KaSource|GeneCards
ACTR1AACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast)Source|GeneCards
RASAL2RASAL2RAS protein activator like 2Source|GeneCards
KBTBD4KBTBD4kelch repeat and BTB (POZ) domain containing 4Source|GeneCards
ACSL5ACSL5acyl-CoA synthetase long-chain family member 5Source|GeneCards
GPP34RGOLPH3Lgolgi phosphoprotein 3-likeSource|GeneCards
FLJ37266FLJ37266hypothetical protein FLJ37266Source|GeneCards
SLC16A9SLC16A9Solute carrier family 16 (monocarboxylic acid transporters), member 9Source|GeneCards
PLA2G4APLA2G4Aphospholipase A2, group IVA (cytosolic, calcium-dependent)Source|GeneCards
NEUROG3NEUROG3neurogenin 3Source|GeneCards
RRM1RRM1ribonucleotide reductase M1 polypeptideSource|GeneCards
FIBL-6FIBL-6hemicentinSource|GeneCards
SCAMP3SCAMP3secretory carrier membrane protein 3Source|GeneCards
FLJ11383PCNXL2pecanex-like 2 (Drosophila)Source|GeneCards
RNF159PCGF5polycomb group ring finger 5Source|GeneCards
FRAG1C17ORF41chromosome 17 open reading frame 41Source|GeneCards
SCNM1SCNM1sodium channel modifier 1Source|GeneCards
UCP2UCP2uncoupling protein 2 (mitochondrial, proton carrier)Source|GeneCards
C10ORF76C10ORF76chromosome 10 open reading frame 76Source|GeneCards
FGF19FGF19fibroblast growth factor 19Source|GeneCards
HSD11B1HSD11B1hydroxysteroid (11-beta) dehydrogenase 1Source|GeneCards
CD160CD160CD160 antigenSource|GeneCards
LPHN2LPHN2latrophilin 2Source|GeneCards
FLJ23703C1ORF126chromosome 1 open reading frame 126Source|GeneCards
GBF1GBF1Golgi-specific brefeldin A resistance factor 1Source|GeneCards
CUBNCUBNcubilin (intrinsic factor-cobalamin receptor)Source|GeneCards
PVRL4PVRL4poliovirus receptor-related 4Source|GeneCards
AIM1LAIM1Labsent in melanoma 1-likeSource|GeneCards
CGI-30DPH5DPH5 homolog (S. cerevisiae)Source|GeneCards
PRRX1PRRX1paired related homeobox 1Source|GeneCards
PROX1PROX1prospero-related homeobox 1Source|GeneCards
ASB13ASB13ankyrin repeat and SOCS box-containing 13Source|GeneCards
TLL2TLL2tolloid-like 2Source|GeneCards
HHLRABGAP1LRAB GTPase activating protein 1-likeSource|GeneCards
SH2D4BSH2D4BSH2 domain containing 4BSource|GeneCards
SCUBE2SCUBE2signal peptide, CUB domain, EGF-like 2Source|GeneCards
FLJ45187FLJ45187FLJ45187 proteinSource|GeneCards
CAP350CAP350centrosome-associated protein 350Source|GeneCards
GNG3GNG3guanine nucleotide binding protein (G protein), gamma 3Source|GeneCards
FLJ46111FLJ46111FLJ46111 proteinSource|GeneCards
FLJ10748FLJ10748hypothetical protein FLJ10748Source|GeneCards
PTCH2PTCH2patched homolog 2 (Drosophila)Source|GeneCards
SPOCK2SPOCK2sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2Source|GeneCards
RAB30RAB30RAB30, member RAS oncogene familySource|GeneCards
SV2ASV2Asynaptic vesicle glycoprotein 2ASource|GeneCards
NDUFS3NDUFS3NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)Source|GeneCards
RETRETret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)Source|GeneCards
LEMD1LEMD1LEM domain containing 1Source|GeneCards
ESRRGESRRGestrogen-related receptor gammaSource|GeneCards
SERPINC1SERPINC1serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1Source|GeneCards
ELOVL1ELOVL1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1Source|GeneCards
NDUFC2NDUFC2NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDaSource|GeneCards
SLC22A8SLC22A8solute carrier family 22 (organic anion transporter), member 8Source|GeneCards
PAX6PAX6paired box gene 6 (aniridia, keratitis)Source|GeneCards
SYTL1SYTL1synaptotagmin-like 1Source|GeneCards
BARHL2BARHL2BarH-like 2 (Drosophila)Source|GeneCards
IL19IL19interleukin 19Source|GeneCards
WNT9AWNT9Awingless-type MMTV integration site family, member 9ASource|GeneCards
CYB561D1CYB561D1cytochrome b-561 domain containing 1Source|GeneCards
UBE2D1UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)Source|GeneCards
SLC25A28SLC25A28solute carrier family 25, member 28Source|GeneCards
EPHA2EPHA2EphA2Source|GeneCards
RCOR2RCOR2REST corepressor 2Source|GeneCards
STX5ASTX5Asyntaxin 5ASource|GeneCards
ZNF488ZNF488zinc finger protein 488Source|GeneCards
ACFACFapobec-1 complementation factorSource|GeneCards
C10ORF4C10ORF4chromosome 10 open reading frame 4Source|GeneCards
TCF7L2TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Source|GeneCards
TRIKKCNK18potassium channel, subfamily K, member 18Source|GeneCards
DKK1DKK1dickkopf homolog 1 (Xenopus laevis)Source|GeneCards
MGC47816FAM80Afamily with sequence similarity 80, member ASource|GeneCards
BAI2BAI2brain-specific angiogenesis inhibitor 2Source|GeneCards
MGC5395MGC5395hypothetical protein MGC5395Source|GeneCards
CREMCREMcAMP responsive element modulatorSource|GeneCards
GFRA1GFRA1GDNF family receptor alpha 1Source|GeneCards
EIF4G2EIF4G2eukaryotic translation initiation factor 4 gamma, 2Source|GeneCards
RUNX3RUNX3runt-related transcription factor 3Source|GeneCards
ADAM12ADAM12a disintegrin and metalloproteinase domain 12 (meltrin alpha)Source|GeneCards
DHCR24DHCR2424-dehydrocholesterol reductaseSource|GeneCards
TRIM33TRIM33tripartite motif-containing 33Source|GeneCards
ENTPD7ENTPD7ectonucleoside triphosphate diphosphohydrolase 7Source|GeneCards
FLJ10986FLJ10986hypothetical protein FLJ10986Source|GeneCards
IBRDC3IBRDC3IBR domain containing 3Source|GeneCards
FLJ23441FLJ23441hypothetical protein FLJ23441Source|GeneCards
CTNND1CTNND1catenin (cadherin-associated protein), delta 1Source|GeneCards
LMO1LMO1LIM domain only 1 (rhombotin 1)Source|GeneCards
DYRK3DYRK3dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3Source|GeneCards
COL13A1COL13A1collagen, type XIII, alpha 1Source|GeneCards
FLJ12528TARSL1threonyl-tRNA synthetase-like 1Source|GeneCards
MFN2MFN2mitofusin 2Source|GeneCards
PTPRJPTPRJprotein tyrosine phosphatase, receptor type, JSource|GeneCards
DJ462O23.2NPAL3NIPA-like domain containing 3Source|GeneCards
NICE-4UBAP2Lubiquitin associated protein 2-likeSource|GeneCards
GLUD1GLUD1glutamate dehydrogenase 1Source|GeneCards
MGC46534ATXN7L2ataxin 7-like 2Source|GeneCards
COL11A1COL11A1collagen, type XI, alpha 1Source|GeneCards
TMEM9TMEM9transmembrane protein 9Source|GeneCards
RPA2RPA2replication protein A2, 32kDaSource|GeneCards
DKFZP761D221SGIP1SH3-domain GRB2-like (endophilin) interacting protein 1Source|GeneCards
RNF11RNF11ring finger protein 11Source|GeneCards
ADRBK1ADRBK1adrenergic, beta, receptor kinase 1Source|GeneCards
NHLH2NHLH2nescient helix loop helix 2Source|GeneCards
TSPAN-2TSPAN2tetraspanin 2Source|GeneCards
FLJ11280FAM63Afamily with sequence similarity 63, member ASource|GeneCards
ARNTARNTaryl hydrocarbon receptor nuclear translocatorSource|GeneCards
CGNCGNcingulinSource|GeneCards
SDHCSDHCsuccinate dehydrogenase complex, subunit C, integral membrane protein, 15kDaSource|GeneCards
FLJ20321CASZ1castor homolog 1, zinc finger (Drosophila)Source|GeneCards
PTD015PTD015PTD015 proteinSource|GeneCards
TCERG1LTCERG1Ltranscription elongation regulator 1-likeSource|GeneCards

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