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Gene set: V$LEF1_Q6 (C3:TFAC:0359)
Standard nameV$LEF1_Q6
Systematic nameC3:TFAC:0359
Brief descriptionGenes with 3'UTR containing motif SWWCAAAGGG which matches annotation for LEF1: lymphoid enhancer-binding factor 1
TCF1: Transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA LEF-1
 XX
 SY lymphoid enhancer
binding factor 1; lymphoid enhancing factor 1; human
 SY LEF-1;
TCF-1alpha; hLEF-1.
 XX
 OS human, Homo sapiens
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; primates
 XX
 CL C0015; HMG.
 XX
 SZ
399 AA; 44.2 kDa (cDNA); 55 kDa (SDS)
 XX
 XX
 SC translated
from ref. [18] and ref. [1]; AA 389-399 are dedicated as LEF-1N

SC tail ref. [1]
 XX
 FT 1 33 repressing domain.
 FT
1 56 beta-catenin interacting domain [14]; conflict 1-60 [1].

FT 1 71 encoded by exon 1 [1].
 FT 14 52 adidic region (14/39).

FT 72 93 encoded by exon 2 [1].
 FT 80 135 trans-activation
domain A [17].
 FT 82 273 proline rich region (36/192).

FT 94 133 encoded by exon 3 [1].
 FT 134 182 encoded by exon
4 [1].
 FT 174 256 trans-activation domain B [17].
 FT 183
213 encoded by exon 5 [1].
 FT 214 241 encoded by exon 6 [1].

FT 242 281 encoded by exon 7 [1].
 FT 244 286 proline and histidine
rich region (17/43) [18].
 FT 282 336 encoded by exon 8 [1].

FT 297 372 HMG domain (295-362 [18], 297-364 [1]).
 FT 298
368 SM00398; HMG.
 FT 299 367 PF00505; HMG_box.
 FT 337
372 encoded by exon 9 [1].
 FT 372 399 encoded by exon 10 [1].

FT 374 382 B box (essential for nuclear transposition) [13], conflict:

FT 372-383 NLS (nuclear localisation signal) [1].
 FT 389 399
LEF-1N tail [1].
 XX
 SF the LEF-1 gene (52 kb) is located
on chromosome 4 [1], exon structure:
 SF 1,2,3, 3a, 3b, 4,5,6,7,8,9,10,11,12
[1];
 SF sequence-specific DNA-binding is mediated by the disordered
N-terminal part
 SF of the L-shaped HMG domain and by its third
alpha-helix [16];
 SF binds to pyrimidine-rich elements 5�-YCTTTG-3�
[18];
 SF no appreciable T cell-specific enhancer activity
in the absence of the
 SF flanking CRE and TCF-2alpha/ets-binding
sites --> direct interaction with
 SF CREB and TCF-2alpha/ets
proteins? [20];
 SF hLEF-1 binds DNA as a monomer but cannot
function on its own to enhance
 SF transcription [17];

SF formerly TCF-1alpha;
 SF a shorter cDNA clone reveals a
protein which lacks AA 214-241 [18];
 SF gene located on chromosome
4 [19];
 SF for in vitro binding to the wild-type hLEF site
in the TCRalpha enhancer a
 SF truncated protein bearing AA
297-377 is sufficient [17];
 SF alanine substitution mutagenesis
and EMSA shows that AA 25-27 and 32-34 are
 SF not necessary
for beta-catenin binding [7];
 SF the transactivating domain
normally provided by beta-catenin can be
 SF replaced by other
transactivating domains [6];
 XX
 CP T-cells; thymus

XX
 FF contents a potent transcriptional activation domain
which mediates
 FF context-specific activation of the TCFalpha
enhancer [17];
 FF can form a complex with beta-catenin (in
the nucleus) and thus activates
 FF gene transcription;

FF member of the Wnt-/ Wingless-signal transduction cascade;

FF uncontrolled activation of gene transcription by the beta-catenin/
LEF-1
 FF complex may contribute to tumor progression;

FF c-myc and cyclin D1 contain LEF-1 binding sequences in promoter
region [2];
 FF upon Wnt-1 signaling combined with beta-catenin
binding the transcriptional
 FF activity of LEF-1 rises;

FF LEF-1 can activate transcription thus from a synthetic enhancer
containing
 FF multimerized binding sites in contrast to the
activation of the TCFalpha
 FF enhancer where LEF-1 can only
activate transcription upon a specific
 FF context of transcription
factors;
 FF in the TCFalpha enhancer LEF-1 collaborates with
AML1-, Ets-1 and CREB;
 FF the activation potential in this
context is further dependent on ALY which
 FF associates with
the context dependent activation domains of LEF-1 and AML-1;

FF taken together LEF-1 can exert two different roles: in association
with
 FF beta-Catenin it can mediate transcriptional activation
in a
 FF context-independent manner, whereas it regulates -
together with ALY -
 FF transcription in a context specific
way [7];
 FF the ability of LEF-1 to induce oncogenic transformation
was shown by
 FF generating covalent linked LEF-1 and beta-catenin
(or other transactivating
 FF domains) [6];
 FF beta-catenin
stabilizing mutations result in LEF-1 transactivation leading

FF to development of human tumours of hair matrix differentiation
[4];
 XX
 IN T02872; beta-catenin; human, Homo sapiens.

IN T02984; beta-catenin; mouse, Mus musculus.
 XX
 XX

XX
 XX
 RN [1]; RE0014765.
 RX MEDLINE; 20221598.

RA Hovanes K., Li T. W. H., Waterman M. L.
 RT The human LEF-1
gene contains a promoter preferentially active in
 RT lymphocytes
and encodes multiple isoforms derived from alternative splicing

RL Nucleic Acids Res. 28:1994-2003 (2000).
 RN [2]; RE0014041.

RX MEDLINE; 99254073.
 RA Shtutman M., Zhurinsky J., Simcha
I., Albanese C., D'Amico M., Pestell R.,
 RA Ben-Ze'ev A.

RT The cyclin D1 gene is a target of the beta-catenin/ Lef-1 pathway

RL Proc. Natl. Acad. Sci. USA 96:5522-5527 (1999).
 RN [3];
RE0014053.
 RX MEDLINE; 99425167.
 RA McGrew L. L., Takemaru
K.-I., Bates R., Moon R. T.
 RT Direct regulation of the Xenopus
engrailed-2 promoter by the Wnt signaling
 RT pathway, and
a molecular screen for Wnt-responsive genes, confirm a role

RT for Wnt signaling during neural patterning in Xenopus
 RL
Mech. Dev. 87:21-32 (1999).
 RN [4]; RE0014096.
 RX MEDLINE;
99206611.
 RA Chan E. F., Gat U., McNiff J. M., Fuchs E.

RT A common human skin tumour is caused by activating mutations
in beta-catenin
 RL Nat. Genet. 21:410-413 (1999).
 RN [5];
RE0014099.
 RX MEDLINE; 99340256.
 RA Gradl D., Kuhl M.,
Wedlich D.
 RT The Wnt/Wg signal transducer beta-catenin controls
fibronectin expression
 RL Mol. Cell. Biol. 19:5576-5587 (1999).

RN [6]; RE0014351.
 RX MEDLINE; 99093503.
 RA Aoki M., Hecht
A., Kruse U., Kemler R., Vogt P. K.
 RT Nuclear endpoint of
Wnt signaling: neoplastic transformation induced by
 RT transactivating
lymphoid-enhancing factor 1
 RL Proc. Natl. Acad. Sci. USA
96:139-144 (1999).
 RN [7]; RE0014336.
 RX MEDLINE; 98336286.

RA Hsu S.-C., Galceran J., Grosschedl R.
 RT Modulation of
transcriptional regulation by LEF-1 in response to Wnt-1
 RT
signaling and association with beta-catenin
 RL Mol. Cell.
Biol. 18:4807-4818 (1998).
 RN [8]; RE0014048.
 RX MEDLINE;
98058732.
 RA Giese K., Pagel J., Grosschedl R.
 RT Functional
analysis of DNA bending and unwinding by the high mobility group

RT domain of LEF-1
 RL Proc. Natl. Acad. Sci. USA 94:12845-12850
(1997).
 RN [9]; RE0014050.
 RX MEDLINE; 97452550.
 RA
Brannon M., Gomperts M., Sumoy L., Moon R. T., Kimelman D.

RT A beta-catenin/XTcf-3 complex binds to the siamois promoter
to regulate
 RT dorsal axis specification in Xenopus
 RL
Genes Dev. 11:2359-2370 (1997).
 RN [10]; RE0014090.
 RX
MEDLINE; 98104245.
 RA McKendry R., Hsu S.-C., Harland R. M.,
Grosschedl R.
 RT LEF-1/TCF proteins mediate Wnt-inducible
transcription from Xenopus
 RT nodal-related 3 promoter

RL Dev. Biol. 192:420-431 (1997).
 RN [11]; RE0006108.

RX MEDLINE; 96338228.
 RA Behrens J., von Kries J. P., Kuehl
M., Bruhn L., Wedlich D., Grosschedl R.,
 RA Birchmeier W.

RT Functional interaction of beta-catenin with the transcription
factor LEF -1
 RL Nature 382:638-642 (1996).
 RN [12]; RE0014049.

RX MEDLINE; 97169230.
 RA Haynes T. L., Thomas M. B., Dusing
M. R., Valerius M. T., Potter S. S.,
 RA Wiginton D. A.

RT An enhancer LEF-1/TCF-1 site is essential for insertin site-independent

RT transgene expression in thymus
 RL Nucleic Acids Res. 24:5034-5044
(1996).
 RN [13]; RE0014054.
 RX MEDLINE; 96205953.

RA Prieve M. G., Guttridge K. L., Munguia J. E., Waterman M. L.

RT The nuclear localization signal of lymphoid enhancer factor-1
is recognized
 RT by two differentially expressed Srp1-nuclear
localization sequence receptor
 RT proteins
 RL J. Biol.
Chem. 271:7654-7658 (1996).
 RN [14]; RE0014185.
 RX MEDLINE;
97047308.
 RA Huber O., Korn R., McLaughlin J., Ohsugi M.,
Herrmann B. G., Kemler R.
 RT Nuclear localization of beta-catenin
by interaction with transcription
 RT factor LEF-1
 RL Mech.
Dev. 59:3-10 (1996).
 RN [15]; RE0011357.
 RX MEDLINE; 95385995.

RA Sheridan P. L., Sheline C. T., Cannon K., Voz M. L., Pazin
M. J., Kadonaga
 RA J. T., Jones K. A.
 RT Activation of
the HIV-1 enhancer by the LEF-1 HMG protein on
 RT nucleosome-assembled
DNA in vitro
 RL Genes Dev. 9:2090-2104 (1995).
 RN [16];
RE0004366.
 RX MEDLINE; 95080249.
 RA Read C. M., Cary P.
D., Preston N. S., Lnenicek-Allen M., Crane-Robinson C.
 RT
The DNA sequence specificity of HMG boxes lies in the minor wing
of the
 RT structure
 RL EMBO J. 13:5639-5646 (1994).

RN [17]; RE0004365.
 RX MEDLINE; 94074899.
 RA Carlsson
P., Waterman M. L., Jones K. A.
 RT The hLEF/TCF-1alpha HMG
protein contains a context-dependent
 RT transcriptional activation
domain that induces the TCRalpha enhancer in T
 RT cells

RL Genes Dev. 7:2418-2430 (1993).
 RN [18]; RE0000694.

RX MEDLINE; 91184620.
 RA Waterman M. L., Fischer W. H., Jones
K. A.
 RT A thymus-specific member of the HMG protein family
regulates the human
 RT T-cell receptor Calpha enhancer

RL Genes Dev. 5:656-669 (1991).
 RN [19]; RE0004363.
 RX
MEDLINE; 92090734.
 RA Giese K., Amsterdam A., Grosschedl R.

RT DNA-binding properties of the HMG domain of the lymphoid-specific

RT transcriptional regulator LEF-1
 RL Genes Dev. 5:2567-2578
(1991).
 RN [20]; RE0001944.
 RX MEDLINE; 91190842.

RA Waterman M. L., Jones K.
 RT Purification of TCF-1alpha,
a T-cell-specific transcription factor that
 RT activates the
T-cell receptor Calpha gene enhancer in a context-dependent

RT manner
 RL New Biol. 2:621-636 (1990).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

269 genes, 269 accessions (Toggle view)

AccessionGeneTitleLinks
ZNF184ZNF184zinc finger protein 184 (Kruppel-like)Source|GeneCards
MMP21MMP21matrix metallopeptidase 21Source|GeneCards
CDK6CDK6cyclin-dependent kinase 6Source|GeneCards
SLC17A6SLC17A6solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6Source|GeneCards
TRPM1TRPM1transient receptor potential cation channel, subfamily M, member 1Source|GeneCards
NFYANFYAnuclear transcription factor Y, alphaSource|GeneCards
C1ORF39FNBP1Lformin binding protein 1-likeSource|GeneCards
TNFRSF19TNFRSF19tumor necrosis factor receptor superfamily, member 19Source|GeneCards
TFCP2TFCP2transcription factor CP2Source|GeneCards
PIM2PIM2pim-2 oncogeneSource|GeneCards
ZNF532ZNF532zinc finger protein 532Source|GeneCards
GPC4GPC4glypican 4Source|GeneCards
LMO3LMO3LIM domain only 3 (rhombotin-like 2)Source|GeneCards
ODF2ODF2outer dense fiber of sperm tails 2Source|GeneCards
ED1EDAectodysplasin ASource|GeneCards
SH3BGRLSH3BGRLSH3 domain binding glutamic acid-rich protein likeSource|GeneCards
PIM1PIM1pim-1 oncogeneSource|GeneCards
MGC87042MGC87042similar to Six transmembrane epithelial antigen of prostateSource|GeneCards
LOC116236LOC116236hypothetical protein LOC116236Source|GeneCards
MYCL1MYCL1v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)Source|GeneCards
ZNF499ZNF499zinc finger protein 499Source|GeneCards
MLPCSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)Source|GeneCards
JUNDJUNDjun D proto-oncogeneSource|GeneCards
STEAPSTEAPsix transmembrane epithelial antigen of the prostateSource|GeneCards
GAP43GAP43growth associated protein 43Source|GeneCards
LOC144747LOC144747hypothetical protein LOC144747Source|GeneCards
CORO1CCORO1Ccoronin, actin binding protein, 1CSource|GeneCards
CRIP2CRIP2cysteine-rich protein 2Source|GeneCards
ABHD2ABHD2abhydrolase domain containing 2Source|GeneCards
SESN3SESN3sestrin 3Source|GeneCards
CLDN4CLDN4claudin 4Source|GeneCards
FLJ38964FLJ38964hypothetical protein FLJ38964Source|GeneCards
NRP2NRP2neuropilin 2Source|GeneCards
ASCL4ASCL4class II bHLH protein ASCL4Source|GeneCards
TNXBTNXBtenascin XBSource|GeneCards
NRCAMNRCAMneuronal cell adhesion moleculeSource|GeneCards
ETV6ETV6ets variant gene 6 (TEL oncogene)Source|GeneCards
LHX4LHX4LIM homeobox 4Source|GeneCards
MGC3123MGC3123hypothetical protein MGC3123Source|GeneCards
PAK1PAK1p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)Source|GeneCards
PTP4A1PTP4A1protein tyrosine phosphatase type IVA, member 1Source|GeneCards
FLJ26184C16ORF47chromosome 16 open reading frame 47Source|GeneCards
PLSCR3PLSCR3phospholipid scramblase 3Source|GeneCards
C10ORF26C10ORF26chromosome 10 open reading frame 26Source|GeneCards
KHDRBS1KHDRBS1KH domain containing, RNA binding, signal transduction associated 1Source|GeneCards
UHRF1UHRF1ubiquitin-like, containing PHD and RING finger domains, 1Source|GeneCards
MYH4MYH4myosin, heavy polypeptide 4, skeletal muscleSource|GeneCards
HOXD3HOXD3homeo box D3Source|GeneCards
LAF4LAF4lymphoid nuclear protein related to AF4Source|GeneCards
AMACOAMACOA-domain containing protein similar to matrilin and collagenSource|GeneCards
ARID1AARID1AAT rich interactive domain 1A (SWI- like)Source|GeneCards
SIX1SIX1sine oculis homeobox homolog 1 (Drosophila)Source|GeneCards
SHFM3FBXW4F-box and WD-40 domain protein 4Source|GeneCards
EFNA4EFNA4ephrin-A4Source|GeneCards
MGC45428DCAMKL2doublecortin and CaM kinase-like 2Source|GeneCards
LIFRLIFRleukemia inhibitory factor receptorSource|GeneCards
FLJ44313FLJ44313FLJ44313 proteinSource|GeneCards
CHRNA9CHRNA9cholinergic receptor, nicotinic, alpha polypeptide 9Source|GeneCards
HABP2HABP2hyaluronan binding protein 2Source|GeneCards
MLC1SAMLC1SAmyosin light chain 1 slow aSource|GeneCards
KLHL5KLHL5kelch-like 5 (Drosophila)Source|GeneCards
ZNF216ZA20D2zinc finger, A20 domain containing 2Source|GeneCards
RGS3RGS3regulator of G-protein signalling 3Source|GeneCards
HOXD10HOXD10homeo box D10Source|GeneCards
SIX4SIX4sine oculis homeobox homolog 4 (Drosophila)Source|GeneCards
MAP2K6MAP2K6mitogen-activated protein kinase kinase 6Source|GeneCards
CHN2CHN2chimerin (chimaerin) 2Source|GeneCards
FLJ32642VPS37Avacuolar protein sorting 37A (yeast)Source|GeneCards
LRP8LRP8low density lipoprotein receptor-related protein 8, apolipoprotein e receptorSource|GeneCards
BASP1BASP1brain abundant, membrane attached signal protein 1Source|GeneCards
MAFBMAFBv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)Source|GeneCards
SLC17A2SLC17A2Solute carrier family 17 (sodium phosphate), member 2Source|GeneCards
FLJ25530FLJ25530hypothetical protein FLJ25530Source|GeneCards
ELF5ELF5E74-like factor 5 (ets domain transcription factor)Source|GeneCards
MAP3K11MAP3K11mitogen-activated protein kinase kinase kinase 11Source|GeneCards
DMXL1DMXL1Dmx-like 1Source|GeneCards
CCNL2CCNL2cyclin L2Source|GeneCards
EYA2EYA2eyes absent homolog 2 (Drosophila)Source|GeneCards
HOXD9HOXD9homeo box D9Source|GeneCards
ARHGAP20ARHGAP20Rho GTPase activating protein 20Source|GeneCards
PANK3PANK3pantothenate kinase 3Source|GeneCards
ABL1ABL1v-abl Abelson murine leukemia viral oncogene homolog 1Source|GeneCards
EBF2EBF2early B-cell factor 2Source|GeneCards
SYT11SYT11synaptotagmin XISource|GeneCards
FLJ10407TMEM48transmembrane protein 48Source|GeneCards
EYA3EYA3eyes absent homolog 3 (Drosophila)Source|GeneCards
SDC1SDC1syndecan 1Source|GeneCards
HECTD1HECTD1HECT domain containing 1Source|GeneCards
FLJ13197FLJ13197hypothetical protein FLJ13197Source|GeneCards
SORBS1SORBS1sorbin and SH3 domain containing 1Source|GeneCards
RNF44RNF44ring finger protein 44Source|GeneCards
C3FC3Fputative protein similar to nessy (Drosophila)Source|GeneCards
GABRG2GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 2Source|GeneCards
SMARCC1SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1Source|GeneCards
SLCO5A1SLCO5A1solute carrier organic anion transporter family, member 5A1Source|GeneCards
CDC14ACDC14ACDC14 cell division cycle 14 homolog A (S. cerevisiae)Source|GeneCards
TTT, brachyury homolog (mouse)Source|GeneCards
SERTAD4SERTAD4SERTA domain containing 4Source|GeneCards
HOXD12HOXD12homeo box D12Source|GeneCards
TCF7TCF7transcription factor 7 (T-cell specific, HMG-box)Source|GeneCards
FGF10FGF10fibroblast growth factor 10Source|GeneCards
DDEF2DDEF2development and differentiation enhancing factor 2Source|GeneCards
NKD1NKD1naked cuticle homolog 1 (Drosophila)Source|GeneCards
EPHB3EPHB3EphB3Source|GeneCards
PAX3PAX3paired box gene 3 (Waardenburg syndrome 1)Source|GeneCards
HRHRhairless homolog (mouse)Source|GeneCards
FLJ34690FLJ34690hypothetical protein FLJ34690Source|GeneCards
ELK3ELK3ELK3, ETS-domain protein (SRF accessory protein 2)Source|GeneCards
DHX40DHX40DEAH (Asp-Glu-Ala-His) box polypeptide 40Source|GeneCards
SH3BP5SH3BP5SH3-domain binding protein 5 (BTK-associated)Source|GeneCards
SUOXSUOXsulfite oxidaseSource|GeneCards
INSM1INSM1insulinoma-associated 1Source|GeneCards
UTXUTXubiquitously transcribed tetratricopeptide repeat gene, X chromosomeSource|GeneCards
SOX5SOX5SRY (sex determining region Y)-box 5Source|GeneCards
C14ORF43C14ORF43chromosome 14 open reading frame 43Source|GeneCards
HOXB7HOXB7homeo box B7Source|GeneCards
SEN54LTSEN54tRNA splicing endonuclease 54 homolog (SEN54, S. cerevisiae)Source|GeneCards
PDE4DPDE4Dphosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)Source|GeneCards
SLC26A9SLC26A9solute carrier family 26, member 9Source|GeneCards
GDF1GDF1growth differentiation factor 1Source|GeneCards
RBMXRBMXRNA binding motif protein, X-linkedSource|GeneCards
BMI1PCGF4polycomb group ring finger 4Source|GeneCards
HYPBHYPBhuntingtin interacting protein BSource|GeneCards
TUBB4TUBB4tubulin, beta 4Source|GeneCards
RPL23ARPL23Aribosomal protein L23aSource|GeneCards
NFATC4NFATC4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4Source|GeneCards
FOXP2FOXP2forkhead box P2Source|GeneCards
WNT6WNT6wingless-type MMTV integration site family, member 6Source|GeneCards
DEPDC2DEPDC2DEP domain containing 2Source|GeneCards
PYMWIBGwithin bgcn homolog (Drosophila)Source|GeneCards
DQX1DQX1DEAQ RNA-dependent ATPase DQX1Source|GeneCards
HOXB4HOXB4homeo box B4Source|GeneCards
EIF2B4EIF2B4eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDaSource|GeneCards
TUBA3TUBA3tubulin, alpha 3Source|GeneCards
ZNF238ZNF238zinc finger protein 238Source|GeneCards
GCLGCAgrancalcin, EF-hand calcium binding proteinSource|GeneCards
ABRABRactive BCR-related geneSource|GeneCards
CPNE1CPNE1RNA binding motif protein 12Source|GeneCards
HS6ST1HS6ST1heparan sulfate 6-O-sulfotransferase 1Source|GeneCards
ABCD2ABCD2ATP-binding cassette, sub-family D (ALD), member 2Source|GeneCards
EIF2C1EIF2C1eukaryotic translation initiation factor 2C, 1Source|GeneCards
KLF3KLF3Kruppel-like factor 3 (basic)Source|GeneCards
MESDC1MESDC1mesoderm development candidate 1Source|GeneCards
C11ORF8C11ORF8chromosome 11 open reading frame 8Source|GeneCards
CCL25CCL25chemokine (C-C motif) ligand 25Source|GeneCards
CLASP1CLASP1cytoplasmic linker associated protein 1Source|GeneCards
SEMA4CSEMA4Csema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4CSource|GeneCards
IVNS1ABPIVNS1ABPinfluenza virus NS1A binding proteinSource|GeneCards
LOC146174LOC146174hypothetical protein LOC146174Source|GeneCards
SP8SP8Sp8 transcription factorSource|GeneCards
C6ORF130C6ORF130chromosome 6 open reading frame 130Source|GeneCards
ABCD1ABCD1ATP-binding cassette, sub-family D (ALD), member 1Source|GeneCards
PUNCPUNCputative neuronal cell adhesion moleculeSource|GeneCards
TGIF2TGIF2TGFB-induced factor 2 (TALE family homeobox)Source|GeneCards
CACNA2D1CACNA2D1calcium channel, voltage-dependent, alpha 2/delta subunit 1Source|GeneCards
C20ORF17C20ORF17chromosome 20 open reading frame 17Source|GeneCards
COL18A1COL18A1collagen, type XVIII, alpha 1Source|GeneCards
LRRN1LRRN1leucine rich repeat neuronal 1Source|GeneCards
KCNJ13KCNJ13potassium inwardly-rectifying channel, subfamily J, member 13Source|GeneCards
C6ORF81C6ORF81chromosome 6 open reading frame 81Source|GeneCards
C14ORF31C14ORF31chromosome 14 open reading frame 31Source|GeneCards
DOCK3DOCK3dedicator of cytokinesis 3Source|GeneCards
ADAM19ADAM19a disintegrin and metalloproteinase domain 19 (meltrin beta)Source|GeneCards
HSD11B1HSD11B1hydroxysteroid (11-beta) dehydrogenase 1Source|GeneCards
KIF5AKIF5Akinesin family member 5ASource|GeneCards
COL15A1COL15A1collagen, type XV, alpha 1Source|GeneCards
CHD2CHD2chromodomain helicase DNA binding protein 2Source|GeneCards
C2ORF27C2ORF27Chromosome 2 open reading frame 27Source|GeneCards
SEZ6SEZ6seizure related 6 homolog (mouse)Source|GeneCards
ARRDC3ARRDC3arrestin domain containing 3Source|GeneCards
DACH1DACH1dachshund homolog 1 (Drosophila)Source|GeneCards
TGIFTGIFTGFB-induced factor (TALE family homeobox)Source|GeneCards
HIVEP1HIVEP1human immunodeficiency virus type I enhancer binding protein 1Source|GeneCards
CDX1CDX1caudal type homeo box transcription factor 1Source|GeneCards
LOC286480LOC286480Ubiquitin-conjugating enzyme E2E 4 pseudogeneSource|GeneCards
PRRX1PRRX1paired related homeobox 1Source|GeneCards
SNX17SNX17sorting nexin 17Source|GeneCards
SOX11SOX11SRY (sex determining region Y)-box 11Source|GeneCards
LASS1LASS1LAG1 longevity assurance homolog 1 (S. cerevisiae)Source|GeneCards
SPRY4SPRY4sprouty homolog 4 (Drosophila)Source|GeneCards
CNOT7CNOT7CCR4-NOT transcription complex, subunit 7Source|GeneCards
C6ORF82C6ORF82chromosome 6 open reading frame 82Source|GeneCards
DGKADGKAdiacylglycerol kinase, alpha 80kDaSource|GeneCards
NARFNARFnuclear prelamin A recognition factorSource|GeneCards
C20ORF160C20ORF160chromosome 20 open reading frame 160Source|GeneCards
DSG4DSG4desmoglein 4Source|GeneCards
PHC1PHC1polyhomeotic-like 1 (Drosophila)Source|GeneCards
ANKRD28ANKRD28ankyrin repeat domain 28Source|GeneCards
CDK5R1CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)Source|GeneCards
SLC7A8SLC7A8solute carrier family 7 (cationic amino acid transporter, y+ system), member 8Source|GeneCards
LHX9LHX9LIM homeobox 9Source|GeneCards
DSG3DSG3desmoglein 3 (pemphigus vulgaris antigen)Source|GeneCards
KATNAL1KATNAL1Katanin p60 subunit A-like 1Source|GeneCards
ZCWCC3ZCWCC3zinc finger, CW-type with coiled-coil domain 3Source|GeneCards
PCBP1PCBP1poly(rC) binding protein 1Source|GeneCards
FOXA1FOXA1forkhead box A1Source|GeneCards
CASKIN2CASKIN2CASK interacting protein 2Source|GeneCards
BMP7BMP7bone morphogenetic protein 7 (osteogenic protein 1)Source|GeneCards
MPZL1MPZL1myelin protein zero-like 1Source|GeneCards
IGF1RIGF1Rinsulin-like growth factor 1 receptorSource|GeneCards
DCXDCXdoublecortex; lissencephaly, X-linked (doublecortin)Source|GeneCards
MCF2LMCF2LMCF.2 cell line derived transforming sequence-likeSource|GeneCards
KRTHA2KRTHA2keratin, hair, acidic, 2Source|GeneCards
SLC22A8SLC22A8solute carrier family 22 (organic anion transporter), member 8Source|GeneCards
PRDM13PRDM13PR domain containing 13Source|GeneCards
ACVR1BACVR1Bactivin A receptor, type IBSource|GeneCards
NEUROD4NEUROD4neurogenic differentiation 4Source|GeneCards
FGF17FGF17fibroblast growth factor 17Source|GeneCards
CA14CA14carbonic anhydrase XIVSource|GeneCards
FLJ13842ZMAT4zinc finger, matrin type 4Source|GeneCards
CNKSR2CNKSR2connector enhancer of kinase suppressor of Ras 2Source|GeneCards
DHX9DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 9Source|GeneCards
WNT3WNT3wingless-type MMTV integration site family, member 3Source|GeneCards
C9ORF39C9ORF39chromosome 9 open reading frame 39Source|GeneCards
MLLT6MLLT6myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6Source|GeneCards
EFNA1EFNA1ephrin-A1Source|GeneCards
HOXC11HOXC11homeo box C11Source|GeneCards
SLC25A28SLC25A28solute carrier family 25, member 28Source|GeneCards
SHC3SHC3src homology 2 domain containing transforming protein C3Source|GeneCards
PCBP4PCBP4poly(rC) binding protein 4Source|GeneCards
ZIC4ZIC4Zic family member 4Source|GeneCards
ELAVL2ELAVL2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)Source|GeneCards
SCRT2SCRT2scratch homolog 2, zinc finger protein (Drosophila)Source|GeneCards
EDN3EDN3endothelin 3Source|GeneCards
FLJ39739FLJ39739FLJ39739 proteinSource|GeneCards
SYNCRIPSYNCRIPsynaptotagmin binding, cytoplasmic RNA interacting proteinSource|GeneCards
NR6A1NR6A1nuclear receptor subfamily 6, group A, member 1Source|GeneCards
HOXC10HOXC10homeo box C10Source|GeneCards
TCF7L2TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Source|GeneCards
DPYSL3DPYSL3dihydropyrimidinase-like 3Source|GeneCards
BAZ1ABAZ1Abromodomain adjacent to zinc finger domain, 1ASource|GeneCards
BCL7CBCL7CB-cell CLL/lymphoma 7CSource|GeneCards
DPYSL4DPYSL4dihydropyrimidinase-like 4Source|GeneCards
C9ORF58C9ORF58chromosome 9 open reading frame 58Source|GeneCards
MGC33584MGC33584Hypothetical protein MGC33584Source|GeneCards
LOC90313LOC90313hypothetical protein BC004507Source|GeneCards
BCAR3BCAR3breast cancer anti-estrogen resistance 3Source|GeneCards
KCTD4KCTD4potassium channel tetramerisation domain containing 4Source|GeneCards
GABRB2GABRB2gamma-aminobutyric acid (GABA) A receptor, beta 2Source|GeneCards
SULT2A1SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1Source|GeneCards
BAHD1BAHD1bromo adjacent homology domain containing 1Source|GeneCards
ARIH1ARIH1ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)Source|GeneCards
PACSIN3PACSIN3protein kinase C and casein kinase substrate in neurons 3Source|GeneCards
FSTFSTfollistatinSource|GeneCards
IBRDC3IBRDC3IBR domain containing 3Source|GeneCards
ROBO4ROBO4roundabout homolog 4, magic roundabout (Drosophila)Source|GeneCards
WEE1WEE1WEE1 homolog (S. pombe)Source|GeneCards
PTPRJPTPRJprotein tyrosine phosphatase, receptor type, JSource|GeneCards
HOXA10HOXA10homeo box A10Source|GeneCards
RPP21RPP21ribonuclease P 21kDa subunitSource|GeneCards
KCNH8KCNH8potassium voltage-gated channel, subfamily H (eag-related), member 8Source|GeneCards
KCND2KCND2potassium voltage-gated channel, Shal-related subfamily, member 2Source|GeneCards
OAZ2OAZ2ornithine decarboxylase antizyme 2Source|GeneCards
THSD1THSD1thrombospondin, type I, domain 1Source|GeneCards
OTX2OTX2orthodenticle homolog 2 (Drosophila)Source|GeneCards
NHLH2NHLH2nescient helix loop helix 2Source|GeneCards
IRS4IRS4insulin receptor substrate 4Source|GeneCards
FLJ14299ZNF703zinc finger protein 703Source|GeneCards
LOC90525LOC90525hypothetical protein BC007586Source|GeneCards
SARM1SARM1sterile alpha and TIR motif containing 1Source|GeneCards
CGNCGNcingulinSource|GeneCards
B3GNT5B3GNT5UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5Source|GeneCards
RKHD3RKHD3ring finger and KH domain containing 3Source|GeneCards
FLJ14107FLJ14107hypothetical protein FLJ14107Source|GeneCards
EIF4A2EIF4A2eukaryotic translation initiation factor 4A, isoform 2Source|GeneCards
FLJ21308PARP8Poly (ADP-ribose) polymerase family, member 8Source|GeneCards
SOX14SOX14SRY (sex determining region Y)-box 14Source|GeneCards
NSBP1NSBP1nucleosomal binding protein 1Source|GeneCards
ST6GALIIST6GAL2ST6 beta-galactosamide alpha-2,6-sialyltranferase 2Source|GeneCards

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