XX
XX
XX
FA LUN-1
XX
SY lung.
XX
OS
human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata;
vertebrata; tetrapoda; mammalia;
OC eutheria; primates
XX
XX
CL C0049; RING.
XX
SZ 1045 AA; 119.2 kDa
(calc)
XX
XX
SC translated from EMBL #AB045732
XX
FT 13 28 PEST sequence [1].
FT 103 141 RING finger
domain [1].
FT 103 141 PF00097; zf-C3HC4.
FT 103 141 SM00184;
RING.
FT 293 365 putative leucine zipper [1].
FT 386 432
PEST sequence [1].
FT 490 509 PEST sequence [1].
FT 616
645 putative bipartite nuclear localization signal [1].
FT
616 622 putative NLS (nuclear localization signal) [1].
FT
700 703 putative SUMO-1 conjugation site [1].
FT 836 839 putative
SUMO-1 conjugation site [1].
FT 921 950 PEST sequence [1].
FT 999 1024 PEST sequence [1].
XX
SF Zn2+ ions with either
Mg2+, Mn2+ or Ca2+ are essential for the binding of
SF LUN
to DNA [1];
SF binds to a palindromic binding consensus (TCCCAgcacttTGGGA)
[1];
SF splice variant LUN-2 ;
XX
CP (cell
lines:) T98, Molt-4, (adult:) most highly expressed in lung (alveolar
CP epithelium), moderade expression in heart, brain, skeletal
muscle, kidney,
CP liver, spleen, pancreas [1]
XX
FF might be an important transcriptional regulator for lung cancer-associated
FF genes including E-cadherin and talin [1]
XX
XX
XX
XX
RN [1]; RE0016839.
RX MEDLINE; 21216701.
RA Chu D., Kakazu N., Gorrin-Rivas M. J., Lu H. P., Kawata M.,
Abe T., Ueda
RA K., Adachi Y.
RT Cloning and characterization
of LUN, a novel ring finger protein that is
RT highly expressed
in lung and specifically binds to a palindromic sequence
RL
J. Biol. Chem. 276:14004-14013 (2001).
XX