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Gene set: V$MEF2_01 (C3:TFAC:0005)
Standard nameV$MEF2_01
Systematic nameC3:TFAC:0005
Brief descriptionGenes with 3'UTR containing motif CTCTAAAAATAACYCY. Motif does not match any known transcription factor
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA MEF-2
 XX
 SY MEF-2; MEF-2A; MEF2.

XX
 OS human, Homo sapiens
 OC eukaryota; animalia; metazoa;
chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria; primates

XX
 HO D-MEF2 (Drosophila)
 XX
 CL C0014; MADS; 4.4.1.1.1.1.

XX
 SZ 507 AA; 54.8 kDa (cDNA)
 XX
 XX
 SC conceptually
translated from EMBL/GenBank/DDBJ #X68505
 XX
 FT 1 59 PF00319;
SRF-TF.
 FT 1 60 SM00432; MADS.
 FT 3 57 MADS box.
 FT
58 86 MEF2 domain.
 FT 87 132 replaced by 87-130 in aMEF-2.

FT 141 186 serine-/threonine-rich region (20/46).
 FT 289 296
absent in RSRFC4/RSRFC9.
 FT 312 312 threonine phosphorylation
site.
 FT 319 319 threonine phosphorylation site.
 FT 355
355 serin phosphorylation site.
 FT 420 446 glutamine-/proline-rich
region (27/27).
 XX
 SF alternative splicing leads to aMEF-2,
RSRFC4, RSRFC9;
 SF direct interaction with other myogenic
factors (bHLH proteins MyoD,
 SF myogenin, MRF4), but not with
E2 proteins [7];
 SF G2E mutant exhibits MCM1-binding specificity
[5];
 SF heterodimerization with MEF-2D [1];
 XX
 CP
cardiac, smooth, skeletal muscle, less in placenta, brain, lung,
kidney
 CP [8]; P19 cells differentiated into neurons or endodermal
cells,
 CP undifferentiated P19 cells [4]
 CN liver [8]

XX
 FF activator [8];
 FF involved in myogenesis [8] [6];

FF cooperates with myogenic bHLH factors through E-box for gene
activation in
 FF skeletal muscle cells [7];
 FF MADS domain
of MEF2A is both necessary and sufficient for binding to MyoD

FF [7];
 FF synergistic activation of transcription in neurogenic
lineages with MASH1
 FF [4];
 FF threonines 312 and 319
are phosphorylation sites for p38 [1] [2];
 FF serine 355 is
a phosphorylation site for p38 [2];
 FF phosphorylation of
MEF-2A in a MEF-2A/MEF-2D heterodimer enhances
 FF MEF-2-dependent
gene expression [1].;
 XX
 IN T01537; MRF4; mouse, Mus musculus.

IN T00525; MyoD; human, Homo sapiens.
 IN T00526; MyoD; mouse,
Mus musculus.
 IN T00528; myogenin; mouse, Mus musculus.

XX
 XX
 XX
 XX
 RN [1]; RE0015211.
 RX MEDLINE;
99077942.
 RA Zhao M., New L., Kravchenko VV., Kato Y., Gram
H., di Padova F., Olson E.
 RA N., Ulevitch R. J., Han J.

RT Regulation of the MEF2 family of transcription factors by p38

RL Mol. Cell. Biol. 19:21-30 (1999).
 RN [2]; RE0015225.

RX MEDLINE; 99303824.
 RA Ornatsky O. I., Cox D. M., Tangirala
P., Andreucci J. J., Quinn Z. A.,
 RA Wrana J. L., Prywes R.,
Yu Y. T., McDermott J. C.
 RT Post-translational control of
the MEF2A transcriptional regulatory protein
 RL Nucleic Acids
Res. 27:2646-2654 (1999).
 RN [3]; RE0004143.
 RX MEDLINE;
96104596.
 RA Fickett J. W.
 RT Quantitative discrimination
of MEF2 sites
 RL Mol. Cell. Biol. 16:437-441 (1996).
 RN
[4]; RE0015139.
 RX MEDLINE; 97059111.
 RA Black B.L., Ligon
K.L., Zhang Y., Olson E.N.
 RT Cooperative transcriptional
activation by the neurogenic basic
 RT helix-loop-helix protein
MASH1 and members of the myocyte enhancer factor-2
 RT (MEF2)
family
 RL J. Biol. Chem. 271:26659-26663 (1996).
 RN [5];
RE0004114.
 RX MEDLINE; 95349573.
 RA Nurrish S. J., Treisman
R.
 RT DNA binding specificity determinants in MADS-box transcription
factors
 RL Mol. Cell. Biol. 15:4076-4085 (1995).
 RN [6];
RE0010487.
 RX MEDLINE; 95257952.
 RA Naidu P. S., Ludolph
D. C., To R. Q., Hinterberger T. J., Konieczny S. F.
 RT Myogenin
and MEF2 function synergistically to activate the MRF4 promoter

RT during myogenesis
 RL Mol. Cell. Biol. 15:2707-2718 (1995).

RN [7]; RE0004142.
 RX MEDLINE; 95063991.
 RA Kaushal S.,
Schneider J. W., Nadal-Ginard B., Mahdavi V.
 RT Activation
of the myogenic lineage by MEF2A, a factor that induces and

RT cooperates with MyoD
 RL Science 266:1236-1240 (1994).

RN [8]; RE0000768.
 RX MEDLINE; 92387551.
 RA Yu Y.-T.,
Breitbart R. E., Smoot L. B., Lee Y., Mahdavi V., Nadal-Ginard
B.
 RT Human myocyte-specific enhancer factor 2 comprises a
group of
 RT tissue-restricted MADS box transcription factors

RL Genes Dev. 6:1783-1798 (1992).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

149 genes, 149 accessions (Toggle view)

AccessionGeneTitleLinks
HAS2HAS2hyaluronan synthase 2Source|GeneCards
HOXB4HOXB4homeo box B4Source|GeneCards
ZNF533ZNF533Zinc finger protein 533Source|GeneCards
ZNF238ZNF238zinc finger protein 238Source|GeneCards
GRAP2GRAP2GRB2-related adaptor protein 2Source|GeneCards
NACSINEHBP1EH domain binding protein 1Source|GeneCards
CAPN1CAPN1calpain 1, (mu/I) large subunitSource|GeneCards
PAK6PAK6p21(CDKN1A)-activated kinase 6Source|GeneCards
FLJ13725FAM65Afamily with sequence similarity 65, member ASource|GeneCards
FGF12FGF12fibroblast growth factor 12Source|GeneCards
FBXO40FBXO40F-box protein 40Source|GeneCards
MYH6MYH6myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)Source|GeneCards
GPC4GPC4glypican 4Source|GeneCards
PTX1PITX1paired-like homeodomain transcription factor 1Source|GeneCards
TTYH2TTYH2tweety homolog 2 (Drosophila)Source|GeneCards
MAS1MAS1MAS1 oncogeneSource|GeneCards
SH3BGRLSH3BGRLSH3 domain binding glutamic acid-rich protein likeSource|GeneCards
KCNJ9KCNJ9potassium inwardly-rectifying channel, subfamily J, member 9Source|GeneCards
CASQ2CASQ2calsequestrin 2 (cardiac muscle)Source|GeneCards
HH114HH114hypothetical protein HH114Source|GeneCards
ASCL2ASCL2achaete-scute complex-like 2 (Drosophila)Source|GeneCards
FLJ25323FLJ25323FLJ25323 proteinSource|GeneCards
SPICSPIClikely ortholog of mouse Spi-C transcription factor (Spi-1/PU.1 related)Source|GeneCards
CKMCKMcreatine kinase, muscleSource|GeneCards
TIMP2TIMP2tissue inhibitor of metalloproteinase 2Source|GeneCards
NEDD4NEDD4neural precursor cell expressed, developmentally down-regulated 4Source|GeneCards
MGC45562MGC45562hypothetical protein MGC45562Source|GeneCards
ABCA8ABCA8ATP-binding cassette, sub-family A (ABC1), member 8Source|GeneCards
TNNI3KTNNI3KTNNI3 interacting kinaseSource|GeneCards
PRKAG1PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunitSource|GeneCards
AKAP13AKAP13A kinase (PRKA) anchor protein 13Source|GeneCards
HRMT1L3HRMT1L3HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae)Source|GeneCards
SESN3SESN3sestrin 3Source|GeneCards
UBXD3UBXD3UBX domain containing 3Source|GeneCards
HOXA3HOXA3homeo box A3Source|GeneCards
ITGB3BPITGB3BPintegrin beta 3 binding protein (beta3-endonexin)Source|GeneCards
ARHGEF15ARHGEF15Rho guanine nucleotide exchange factor (GEF) 15Source|GeneCards
ARRDC3ARRDC3arrestin domain containing 3Source|GeneCards
VG5QAGGF1angiogenic factor with G patch and FHA domains 1Source|GeneCards
FLJ30058FLJ30058hypothetical protein FLJ30058Source|GeneCards
FLJ45832FLJ45832FLJ45832 proteinSource|GeneCards
WNT8BWNT8Bwingless-type MMTV integration site family, member 8BSource|GeneCards
MYL2MYL2myosin, light polypeptide 2, regulatory, cardiac, slowSource|GeneCards
FLJ25476FLJ25476FLJ25476 proteinSource|GeneCards
EYA1EYA1eyes absent homolog 1 (Drosophila)Source|GeneCards
ANK3ANK3ankyrin 3, node of Ranvier (ankyrin G)Source|GeneCards
C7ORF20C7ORF20chromosome 7 open reading frame 20Source|GeneCards
MYL1MYL1myosin, light polypeptide 1, alkali; skeletal, fastSource|GeneCards
ITGA7ITGA7integrin, alpha 7Source|GeneCards
SLC12A5SLC12A5solute carrier family 12, (potassium-chloride transporter) member 5Source|GeneCards
ZFPM2ZFPM2zinc finger protein, multitype 2Source|GeneCards
KCNN1KCNN1potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1Source|GeneCards
TSC1TSC1tuberous sclerosis 1Source|GeneCards
FLJ35821FLJ35821hypothetical protein FLJ35821Source|GeneCards
LYNLYNv-yes-1 Yamaguchi sarcoma viral related oncogene homologSource|GeneCards
RNF29TRIM55tripartite motif-containing 55Source|GeneCards
AICDAAICDAactivation-induced cytidine deaminaseSource|GeneCards
KCNK9KCNK9potassium channel, subfamily K, member 9Source|GeneCards
MLF1MLF1myeloid leukemia factor 1Source|GeneCards
C6ORF37FAM46Afamily with sequence similarity 46, member ASource|GeneCards
GATA4GATA4GATA binding protein 4Source|GeneCards
CACNA2D3CACNA2D3calcium channel, voltage-dependent, alpha 2/delta 3 subunitSource|GeneCards
KIAA1446KIAA1446brain-enriched guanylate kinase-associated proteinSource|GeneCards
RAB20RAB20RAB20, member RAS oncogene familySource|GeneCards
FLJ10159FLJ10159hypothetical protein FLJ10159Source|GeneCards
NFIXNFIXnuclear factor I/X (CCAAT-binding transcription factor)Source|GeneCards
FLJ44313FLJ44313FLJ44313 proteinSource|GeneCards
LHFPL3LHFPL3lipoma HMGIC fusion partner-like 3Source|GeneCards
SYNPO2LSYNPO2Lsynaptopodin 2-likeSource|GeneCards
SLC7A9SLC7A9solute carrier family 7 (cationic amino acid transporter, y+ system), member 9Source|GeneCards
ESRRGESRRGestrogen-related receptor gammaSource|GeneCards
BMP7BMP7bone morphogenetic protein 7 (osteogenic protein 1)Source|GeneCards
MSX2MSX2msh homeo box homolog 2 (Drosophila)Source|GeneCards
SMARCA2SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Source|GeneCards
RIMS2RIMS2regulating synaptic membrane exocytosis 2Source|GeneCards
PDGFRAPDGFRAplatelet-derived growth factor receptor, alpha polypeptideSource|GeneCards
MGC13168MGC13168hypothetical protein MGC13168Source|GeneCards
GRIK1GRIK1glutamate receptor, ionotropic, kainate 1Source|GeneCards
UBE3AUBE3Aubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)Source|GeneCards
FLJ12903FLJ12903hypothetical protein FLJ12903Source|GeneCards
WFDC1WFDC1WAP four-disulfide core domain 1Source|GeneCards
ITGB6ITGB6integrin, beta 6Source|GeneCards
UBPHUBPHsimilar to ubiquitin binding proteinSource|GeneCards
HDAC9HDAC9histone deacetylase 9Source|GeneCards
NDPNDPNorrie disease (pseudoglioma)Source|GeneCards
SSPNSSPNsarcospan (Kras oncogene-associated gene)Source|GeneCards
MYO9AMYO9Amyosin IXASource|GeneCards
ZIC4ZIC4Zic family member 4Source|GeneCards
TRIM8TRIM8tripartite motif-containing 8Source|GeneCards
SMAD1SMAD1SMAD, mothers against DPP homolog 1 (Drosophila)Source|GeneCards
CDC25BCDC25Bcell division cycle 25BSource|GeneCards
ANP32AANP32Aacidic (leucine-rich) nuclear phosphoprotein 32 family, member ASource|GeneCards
DLL4DLL4delta-like 4 (Drosophila)Source|GeneCards
DPYSL3DPYSL3dihydropyrimidinase-like 3Source|GeneCards
CDC42EP3CDC42EP3CDC42 effector protein (Rho GTPase binding) 3Source|GeneCards
CA7CA7carbonic anhydrase VIISource|GeneCards
MYOZ2MYOZ2myozenin 2Source|GeneCards
AKAP12AKAP12A kinase (PRKA) anchor protein (gravin) 12Source|GeneCards
DKK1DKK1dickkopf homolog 1 (Xenopus laevis)Source|GeneCards
TPM2TPM2tropomyosin 2 (beta)Source|GeneCards
KRTHB3KRTHB3keratin, hair, basic, 3Source|GeneCards
CENTB2CENTB2centaurin, beta 2Source|GeneCards
SYT10SYT10synaptotagmin 10Source|GeneCards
EPHB1EPHB1EphB1Source|GeneCards
SMPXSMPXsmall muscle protein, X-linkedSource|GeneCards
SYT14LSYT14Lsynaptotagmin XIV-likeSource|GeneCards
GRK7GRK7G protein-coupled receptor kinase 7Source|GeneCards
SMARCA1SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1Source|GeneCards
ZNF281ZNF281zinc finger protein 281Source|GeneCards
TNNC1TNNC1troponin C type 1 (slow)Source|GeneCards
KIAA0663ZC3H11Azinc finger CCCH-type containing 11ASource|GeneCards
JUNJUNv-jun sarcoma virus 17 oncogene homolog (avian)Source|GeneCards
SOX2SOX2SRY (sex determining region Y)-box 2Source|GeneCards
COL13A1COL13A1collagen, type XIII, alpha 1Source|GeneCards
TIAF1TIAF1TGFB1-induced anti-apoptotic factor 1Source|GeneCards
LUZP1LUZP1leucine zipper protein 1Source|GeneCards
USP47USP47ubiquitin specific protease 47Source|GeneCards
HOXA10HOXA10homeo box A10Source|GeneCards
DKFZP564B167BRP44brain protein 44Source|GeneCards
LMCD1LMCD1LIM and cysteine-rich domains 1Source|GeneCards
PHOSPHO1PHOSPHO1phosphatase, orphan 1Source|GeneCards
IGJIGJimmunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptidesSource|GeneCards
HAPLN1HAPLN1hyaluronan and proteoglycan link protein 1Source|GeneCards
JPH2JPH2junctophilin 2Source|GeneCards
DMP1DMP1dentin matrix acidic phosphoproteinSource|GeneCards
IL17BIL17Binterleukin 17BSource|GeneCards
MEF2CMEF2CMADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)Source|GeneCards
C21ORF29C21ORF29chromosome 21 open reading frame 29Source|GeneCards
ARL6IP2ARL6IP2ADP-ribosylation-like factor 6 interacting protein 2Source|GeneCards
SLC26A9SLC26A9solute carrier family 26, member 9Source|GeneCards
ASPHASPHaspartate beta-hydroxylaseSource|GeneCards
ELMO3ELMO3engulfment and cell motility 3 (ced-12 homolog, C. elegans)Source|GeneCards
MBNL2MBNL2muscleblind-like 2 (Drosophila)Source|GeneCards
TGFB1I4TSC22D1TSC22 domain family, member 1Source|GeneCards
EDG1EDG1endothelial differentiation, sphingolipid G-protein-coupled receptor, 1Source|GeneCards
CKMT2CKMT2creatine kinase, mitochondrial 2 (sarcomeric)Source|GeneCards
AB026190KLHL20kelch-like 20 (Drosophila)Source|GeneCards
CSPG3CSPG3chondroitin sulfate proteoglycan 3 (neurocan)Source|GeneCards
GNASGNASGNAS complex locusSource|GeneCards
TBC1D16TBC1D16TBC1 domain family, member 16Source|GeneCards
FOSFOSv-fos FBJ murine osteosarcoma viral oncogene homologSource|GeneCards
FLJ41841FLJ41841FLJ41841 proteinSource|GeneCards
CNGA1CNGA1cyclic nucleotide gated channel alpha 1Source|GeneCards
TRDNTRDNtriadinSource|GeneCards
AGTPBP1AGTPBP1ATP/GTP binding protein 1Source|GeneCards
SOX14SOX14SRY (sex determining region Y)-box 14Source|GeneCards
FGF6FGF6fibroblast growth factor 6Source|GeneCards
GTF3C3GTF3C3general transcription factor IIIC, polypeptide 3, 102kDaSource|GeneCards
HS3ST5HS3ST5heparan sulfate (glucosamine) 3-O-sulfotransferase 5Source|GeneCards

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