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Gene set: V$MYC_Q2 (C3:TFAC:0391)
Standard nameV$MYC_Q2
Systematic nameC3:TFAC:0391
Brief descriptionGenes with 3'UTR containing motif CACGTGS which matches annotation for MYC: V-myc myelocytomatosis viral oncogene homolog (avian)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA Max
 XX
 SY Myn; Myc-binding novel
HLH/LZ protein.
 XX
 OS mouse, Mus musculus
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; rodentia; myomorpha; muridae; murinae
 XX

XX
 CL C0012; bHLH-ZIP; 1.3.2.2.1.
 XX
 SZ 160 AA; 18.3
kDa (cDNA), 20 kDa, 22 kDa (SDS)
 XX
 XX
 SC SwissProt
#P28574
 XX
 FT 2 2 Ser-phosphorylation by CKII [6].

FT 3 14 acidic region (8/12).
 FT 11 11 Ser-phosphorylation
by CKII [6].
 FT 13 21 missing in Max1.
 FT 24 35 basic
region.
 FT 24 75 PF00010; HLH.
 FT 29 80 SM00353; HLH.

FT 36 75 helix-loop-helix domain.
 FT 74 102 leucine zipper
(MHL3).
 XX
 SF solution of the crystal structure revealed
that the HLH motifs form a
 SF four-helix-bundle with all helices
in parallel orientation [5];
 SF helix 2 is prolonged by the
alpha-helically folded leucine zipper;
 SF heterodimers with
c-Myc or Mad have higher DNA-binding affinity [9];
 SF the
leucine zipper is specifically required for heterodimerization
[9];
 SF belongs to group B HLH-proteins that bind to CACGTG
motif in DNA [2] which
 SF is due to certain residues in DNA-binding
domain (His at pos. 28, Glu at
 SF pos. 32, Arg at pos. 36)
[1];
 XX
 CP newborn: intestine, weak in brain, liver, lung;
adult: very strong in
 CP intestine, weak in brain, kidney,
lung [3]
 CN newborn: kidney; adult: liver [3]
 XX
 FF
enhances c-Myc DNA-binding, perturbation of homodimer-binding
after CKII
 FF phosphorylation, but not of Myc/Max-heterodimer
[6];
 FF in complexes with either Mxi1 or Mad, it represses
c-Myc or N-Myc effects
 FF [4];
 FF murine homolog of MAX
[9];
 XX
 IN T00140; c-Myc; human, Homo sapiens.
 IN
T00141; c-Myc; chick, Gallus gallus.
 IN T00142; c-Myc; rat,
Rattus norvegicus.
 IN T00143; c-Myc; mouse, Mus musculus.

IN T00523; Max; mouse, Mus musculus.
 IN T01445; N-Myc; mouse,
Mus musculus.
 IN T02379; N-Myc; human, Homo sapiens.
 XX

XX
 XX
 XX
 RN [1]; RE0017817.
 RX MEDLINE; 20528627.

RA Billin A. N., Eilers A. L., Coulter K. L., Logan J. S., Ayer
D. E.
 RT MondoA, a novel basic helix-loop-helix-leucine zipper
transcriptional
 RT activator that constitutes a positive branch
of a max-like network
 RL Mol. Cell. Biol. 20:8845-8854 (2000).

RN [2]; RE0017805.
 RX MEDLINE; 99075645.
 RA Meng X., Lu
X., Li Z., Green E. D., Massa H., Trask B. J., Morris C. A.,

RA Keating M. T.
 RT Complete physical map of the common deletion
region in Williams syndrome
 RT and identification and characterization
of three novel genes
 RL Hum. Genet. 103:590-599 (1998).

RN [3]; RE0005851.
 RX MEDLINE; 95396821.
 RA Chin L., Schreiber-Agus
N., Pellicer I., Chen K., Lee H.-W., Dudast M.,
 RA Cordon-Cardo
C., DePinho R. A.
 RT Contrasting roles for Myc and Mad proteins
in cellular growth and
 RT differentiation
 RL Proc. Natl.
Acad. Sci. USA 92:8488-8492 (1995).
 RN [4]; RE0003363.

RX MEDLINE; 94261614.
 RA Lahoz E. G., Xu L., Schreiber-Agus
N., DePinho R. A.
 RT Suppression of Myc, but not E1a, transformation
activity by Max-associated
 RT proteins, Mad and Mxi1
 RL
Proc. Natl. Acad. Sci. USA 91:5503-5507 (1994).
 RN [5]; RE0003393.

RX MEDLINE; 93241312.
 RA Ferre-D'Amare A. E., Prendergast
G. C., Ziff E. B., Burley S. K.
 RT Recognition by Max of its
cognate DNA through a dimeric b/HLH/Z domain
 RL Nature 363:38-45
(1993).
 RN [6]; RE0000705.
 RX MEDLINE; 92146952.
 RA
Berberich S. J., Cole M. D.
 RT Casein kinase II inhibits the
DNA-binding activity of Max homodimers but
 RT not Myc/Max
heterodimers
 RL Genes Dev. 6:166-176 (1992).
 RN [7]; RE0003351.

RX MEDLINE; 92354910.
 RA Mukherjee B., Morgenbesser S. D.,
DePinho R. A.
 RT Myc family oncoproteins function through
a common pathway to transform
 RT normal cells in culture:
cross-interference by Max and trans-acting
 RT dominant mutants

RL Genes Dev. 6:1480-1492 (1992).
 RN [8]; RE0003395.
 RX
MEDLINE; 93093476.
 RA Prendergast G. C., Hopewell R., Gorham
B. J., Ziff E. B.
 RT Biphasic effect of Max and Myc cotransformation
activity and dependence on
 RT amino- and carboxy-terminal
Max functions
 RL Genes Dev. 6:2429-2439 (1992).
 RN [9];
RE0000173.
 RX MEDLINE; 91208676.
 RA Prendergast G. C.,
Lawe D., Ziff E. B.
 RT Association of Myn, the murine homolog
of Max, with c-Myc stimulates
 RT methylation-sensitive DNA
binding and ras cotransformation
 RL Cell 65:395-407 (1991).

XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

189 genes, 189 accessions (Toggle view)

AccessionGeneTitleLinks
ADSSADSSadenylosuccinate synthaseSource|GeneCards
PITX3PITX3paired-like homeodomain transcription factor 3Source|GeneCards
CSDACSDAcold shock domain protein ASource|GeneCards
TDRD1TDRD1tudor domain containing 1Source|GeneCards
GTF2H1GTF2H1general transcription factor IIH, polypeptide 1, 62kDaSource|GeneCards
PSEN2PSEN2presenilin 2 (Alzheimer disease 4)Source|GeneCards
H3F3AH3F3AH3 histone, family 3ASource|GeneCards
CCDC6CCDC6coiled-coil domain containing 6Source|GeneCards
MGC20410MGC20410hypothetical protein BC012330Source|GeneCards
SLC16A1SLC16A1solute carrier family 16 (monocarboxylic acid transporters), member 1Source|GeneCards
POGKPOGKpogo transposable element with KRAB domainSource|GeneCards
FOXD3FOXD3forkhead box D3Source|GeneCards
ILKILKintegrin-linked kinaseSource|GeneCards
ZFP91ZFP91zinc finger protein 91 homolog (mouse)Source|GeneCards
SC5DLSC5DLsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-likeSource|GeneCards
LRP16LRP16LRP16 proteinSource|GeneCards
SIRT1SIRT1sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)Source|GeneCards
PA2G4PA2G4proliferation-associated 2G4, 38kDaSource|GeneCards
NR0B2NR0B2nuclear receptor subfamily 0, group B, member 2Source|GeneCards
TRIM46TRIM46tripartite motif-containing 46Source|GeneCards
FLJ10774FLJ10774N-acetyltransferase-like proteinSource|GeneCards
PFKFB3PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3Source|GeneCards
TMEM24TMEM24transmembrane protein 24Source|GeneCards
PCDH16DCHS1dachsous 1 (Drosophila)Source|GeneCards
IVNS1ABPIVNS1ABPinfluenza virus NS1A binding proteinSource|GeneCards
RPC155POLR3APolymerase (RNA) III (DNA directed) polypeptide A, 155kDaSource|GeneCards
FADS3FADS3fatty acid desaturase 3Source|GeneCards
USP15USP15ubiquitin specific protease 15Source|GeneCards
FLJ14904MAELmaelstrom homolog (Drosophila)Source|GeneCards
CHRM1CHRM1cholinergic receptor, muscarinic 1Source|GeneCards
AMPD2AMPD2adenosine monophosphate deaminase 2 (isoform L)Source|GeneCards
MYCL1MYCL1v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)Source|GeneCards
COL2A1COL2A1collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)Source|GeneCards
ZNF593ZNF593zinc finger protein 593Source|GeneCards
NUDCNUDCnuclear distribution gene C homolog (A. nidulans)Source|GeneCards
HPS5HPS5Hermansky-Pudlak syndrome 5Source|GeneCards
PLA2G4APLA2G4Aphospholipase A2, group IVA (cytosolic, calcium-dependent)Source|GeneCards
EIF3S10EIF3S10eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDaSource|GeneCards
B3GALT6B3GALT6UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6Source|GeneCards
STK22CSTK22Cserine/threonine kinase 22C (spermiogenesis associated)Source|GeneCards
AK3AK3Adenylate kinase 3-like 1Source|GeneCards
SLC26A10SLC26A10solute carrier family 26, member 10Source|GeneCards
SCYL1SCYL1SCY1-like 1 (S. cerevisiae)Source|GeneCards
MBC2FAM62Afamily with sequence similarity 62 (C2 domain containing), member ASource|GeneCards
NKX2-3NKX2-3NK2 transcription factor related, locus 3 (Drosophila)Source|GeneCards
HOXC13HOXC13homeo box C13Source|GeneCards
LOC51035LOC51035ORFSource|GeneCards
EPB41EPB41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)Source|GeneCards
PTPRFPTPRFprotein tyrosine phosphatase, receptor type, FSource|GeneCards
KIAA0409KIAA0409KIAA0409 proteinSource|GeneCards
ARL3ARL3ADP-ribosylation factor-like 3Source|GeneCards
RLFRLFRearranged L-myc fusionSource|GeneCards
NSEP1NSEP1nuclease sensitive element binding protein 1Source|GeneCards
MGC26598C12ORF12chromosome 12 open reading frame 12Source|GeneCards
POLR2LPOLR2Lpolymerase (RNA) II (DNA directed) polypeptide L, 7.6kDaSource|GeneCards
TESK2TESK2testis-specific kinase 2Source|GeneCards
CTBP2CTBP2C-terminal binding protein 2Source|GeneCards
UBXD3UBXD3UBX domain containing 3Source|GeneCards
LIN28LIN28lin-28 homolog (C. elegans)Source|GeneCards
SLC6A15SLC6A15solute carrier family 6 (neurotransmitter transporter), member 15Source|GeneCards
PYCSALDH18A1aldehyde dehydrogenase 18 family, member A1Source|GeneCards
ZZZ3ZZZ3zinc finger, ZZ-type containing 3Source|GeneCards
ERBPERBPestrogen receptor binding proteinSource|GeneCards
D1S155ECSDE1cold shock domain containing E1, RNA-bindingSource|GeneCards
COMMD3COMMD3COMM domain containing 3Source|GeneCards
RUSC1RUSC1RUN and SH3 domain containing 1Source|GeneCards
B4GALT2B4GALT2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2Source|GeneCards
COPS7ACOPS7ACOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)Source|GeneCards
FLJ32001C1ORF71chromosome 1 open reading frame 71Source|GeneCards
HNRPFHNRPFheterogeneous nuclear ribonucleoprotein FSource|GeneCards
FKBP11FKBP11FK506 binding protein 11, 19 kDaSource|GeneCards
TIAL1TIAL1TIA1 cytotoxic granule-associated RNA binding protein-like 1Source|GeneCards
FLJ14494RPUSD4RNA pseudouridylate synthase domain containing 4Source|GeneCards
HOXC12HOXC12homeo box C12Source|GeneCards
SLC1A7SLC1A7solute carrier family 1 (glutamate transporter), member 7Source|GeneCards
ALDH3B1ALDH3B1aldehyde dehydrogenase 3 family, member B1Source|GeneCards
PPRC1PPRC1peroxisome proliferative activated receptor, gamma, coactivator-related 1Source|GeneCards
TAGLN2TAGLN2transgelin 2Source|GeneCards
FCHSD2FCHSD2FCH and double SH3 domains 2Source|GeneCards
C10ORF69SPFH1SPFH domain family, member 1Source|GeneCards
CAB45SDF4stromal cell derived factor 4Source|GeneCards
TAF6LTAF6LTAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDaSource|GeneCards
CBX5CBX5chromobox homolog 5 (HP1 alpha homolog, Drosophila)Source|GeneCards
MEP50WDR77WD repeat domain 77Source|GeneCards
TIMM10TIMM10translocase of inner mitochondrial membrane 10 homolog (yeast)Source|GeneCards
CTSFCTSFcathepsin FSource|GeneCards
NIT1NIT1nitrilase 1Source|GeneCards
AMACOAMACOA-domain containing protein similar to matrilin and collagenSource|GeneCards
TFB2MTFB2Mtranscription factor B2, mitochondrialSource|GeneCards
CNNM1CNNM1cyclin M1Source|GeneCards
RBAF600RBAF600retinoblastoma-associated factor 600Source|GeneCards
LHX9LHX9LIM homeobox 9Source|GeneCards
LOC148523LOC148523hypothetical protein BC017397Source|GeneCards
FLJ32000WDR65WD repeat domain 65Source|GeneCards
KIAA0090KIAA0090KIAA0090 proteinSource|GeneCards
AGMATAGMATagmatine ureohydrolase (agmatinase)Source|GeneCards
AK2AK2adenylate kinase 2Source|GeneCards
SNFTSNFTJun dimerization protein p21SNFTSource|GeneCards
ALX4ALX4aristaless-like homeobox 4Source|GeneCards
FLJ22662FLJ22662hypothetical protein FLJ22662Source|GeneCards
LTBRLTBRlymphotoxin beta receptor (TNFR superfamily, member 3)Source|GeneCards
UVRAGUVRAGUV radiation resistance associated geneSource|GeneCards
OPRD1OPRD1opioid receptor, delta 1Source|GeneCards
FOSL1FOSL1FOS-like antigen 1Source|GeneCards
PAI-RBP1SERBP1SERPINE1 mRNA binding protein 1Source|GeneCards
TGFB2TGFB2transforming growth factor, beta 2Source|GeneCards
PAX6PAX6paired box gene 6 (aniridia, keratitis)Source|GeneCards
FLJ32549FLJ32549hypothetical protein FLJ32549Source|GeneCards
FXYD2FXYD2FXYD domain containing ion transport regulator 2Source|GeneCards
PABPC4PABPC4poly(A) binding protein, cytoplasmic 4 (inducible form)Source|GeneCards
LMX1ALMX1ALIM homeobox transcription factor 1, alphaSource|GeneCards
CHD4CHD4chromodomain helicase DNA binding protein 4Source|GeneCards
POU3F1POU3F1POU domain, class 3, transcription factor 1Source|GeneCards
CGI-01KIAA0859KIAA0859Source|GeneCards
ERCC6ERCC6excision repair cross-complementing rodent repair deficiency, complementation group 6Source|GeneCards
LRP8LRP8low density lipoprotein receptor-related protein 8, apolipoprotein e receptorSource|GeneCards
IPO13IPO13importin 13Source|GeneCards
PEPP3PLEKHA6pleckstrin homology domain containing, family A member 6Source|GeneCards
CA14CA14carbonic anhydrase XIVSource|GeneCards
MLLMLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)Source|GeneCards
RHEBL1RHEBL1Ras homolog enriched in brain like 1Source|GeneCards
MICAL2MICAL2flavoprotein oxidoreductase MICAL2Source|GeneCards
RFX5RFX5regulatory factor X, 5 (influences HLA class II expression)Source|GeneCards
GPD1GPD1glycerol-3-phosphate dehydrogenase 1 (soluble)Source|GeneCards
FLJ37794FLJ37794hypothetical protein FLJ37794Source|GeneCards
ATF7IPATF7IPactivating transcription factor 7 interacting proteinSource|GeneCards
ESRRAESRRAestrogen-related receptor alphaSource|GeneCards
LDHALDHAlactate dehydrogenase ASource|GeneCards
ARHGAP20ARHGAP20Rho GTPase activating protein 20Source|GeneCards
HOXC11HOXC11homeo box C11Source|GeneCards
RCOR2RCOR2REST corepressor 2Source|GeneCards
NRASNRASneuroblastoma RAS viral (v-ras) oncogene homologSource|GeneCards
USP2USP2ubiquitin specific protease 2Source|GeneCards
TM4SF7TM4SF7transmembrane 4 superfamily member 7Source|GeneCards
DKFZP566E144REXO2REX2, RNA exonuclease 2 homolog (S. cerevisiae)Source|GeneCards
TERE1UBIAD1UbiA prenyltransferase domain containing 1Source|GeneCards
ADKADKadenosine kinaseSource|GeneCards
IPO7IPO7importin 7Source|GeneCards
BCL9LBCL9LB-cell CLL/lymphoma 9-likeSource|GeneCards
SLC43A1SLC43A1solute carrier family 43, member 1Source|GeneCards
RTN4RL2RTN4RL2reticulon 4 receptor-like 2Source|GeneCards
C10ORF46C10ORF46chromosome 10 open reading frame 46Source|GeneCards
CDC14ACDC14ACDC14 cell division cycle 14 homolog A (S. cerevisiae)Source|GeneCards
HPCAHPCAhippocalcinSource|GeneCards
ATP5F1ATP5F1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1Source|GeneCards
AP3M1AP3M1adaptor-related protein complex 3, mu 1 subunitSource|GeneCards
RRAGCRRAGCRas-related GTP binding CSource|GeneCards
ATAD3AATAD3AATPase family, AAA domain containing 3ASource|GeneCards
FABP3FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)Source|GeneCards
B3GALT2B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2Source|GeneCards
TEBPTITF1thyroid transcription factor 1Source|GeneCards
APOA5APOA5apolipoprotein A-VSource|GeneCards
ATAD3BATAD3BATPase family, AAA domain containing 3BSource|GeneCards
C1ORF33C1ORF33chromosome 1 open reading frame 33Source|GeneCards
HNRPA1HNRPA1heterogeneous nuclear ribonucleoprotein A1Source|GeneCards
EIF4BEIF4Beukaryotic translation initiation factor 4BSource|GeneCards
HNRPH3HNRPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)Source|GeneCards
SHMT2SHMT2serine hydroxymethyltransferase 2 (mitochondrial)Source|GeneCards
FLJ23311E2F8E2F transcription factor 8Source|GeneCards
RORCRORCRAR-related orphan receptor CSource|GeneCards
HMGN2HMGN2high-mobility group nucleosomal binding domain 2Source|GeneCards
ATP6V0BATP6V0BATPase, H+ transporting, lysosomal 21kDa, V0 subunit c''Source|GeneCards
WEE1WEE1WEE1 homolog (S. pombe)Source|GeneCards
NIDNIDnidogen (enactin)Source|GeneCards
HPCAL4HPCAL4hippocalcin like 4Source|GeneCards
SYT6SYT6synaptotagmin VISource|GeneCards
FOXJ3FOXJ3forkhead box J3Source|GeneCards
BHLHB3BHLHB3basic helix-loop-helix domain containing, class B, 3Source|GeneCards
ZNF258ZNF258zinc finger protein 258Source|GeneCards
E2IG4LRRC54leucine rich repeat containing 54Source|GeneCards
MGC46534ATXN7L2ataxin 7-like 2Source|GeneCards
SFXN2SFXN2sideroflexin 2Source|GeneCards
FLJ90119FLJ90119hypothetical protein FLJ90119Source|GeneCards
RAB3IL1RAB3IL1RAB3A interacting protein (rabin3)-like 1Source|GeneCards
RPL22RPL22ribosomal protein L22Source|GeneCards
IL15RAIL15RAinterleukin 15 receptor, alphaSource|GeneCards
NRIP3NRIP3nuclear receptor interacting protein 3Source|GeneCards
TLP19TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum)Source|GeneCards
FXYD6FXYD6FXYD domain containing ion transport regulator 6Source|GeneCards
EBNA1BP2EBNA1BP2EBNA1 binding protein 2Source|GeneCards
CFL1CFL1cofilin 1 (non-muscle)Source|GeneCards
CENTB5CENTB5centaurin, beta 5Source|GeneCards
PFDN2PFDN2prefoldin 2Source|GeneCards
STMN1STMN1stathmin 1/oncoprotein 18Source|GeneCards
CGNCGNcingulinSource|GeneCards
MGC13053MGC13053hypothetical protein MGC13053Source|GeneCards
MGC4399MGC4399mitochondrial carrier proteinSource|GeneCards
KRTCAP2KRTCAP2keratinocyte associated protein 2Source|GeneCards
FGF6FGF6fibroblast growth factor 6Source|GeneCards

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