[an error occurred while processing this directive]
Gene set: V$NFKAPPAB_01 (C3:TFAC:0025)
Standard nameV$NFKAPPAB_01
Systematic nameC3:TFAC:0025
Brief descriptionGenes with 3'UTR containing motif GGGAMTTYCC which matches annotation for NFKB
RELA: v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

Toggle abstract view

XX
 XX
 XX
 FA RelA
 XX
 SY NF-kappaB (p65); Rel-A;
p65.
 XX
 OS human, Homo sapiens
 OC eukaryota; animalia;
metazoa; chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria;
primates
 XX
 XX
 CL C0020; Rel; 4.1.1.0.3.1.
 XX

SZ 551 AA; 60.2 kDa (cDNA), 65 kDa (SDS)
 XX
 XX
 SC
SwissProt #Q04206
 XX
 FT 18 186 PF00554; RHD.
 FT 19
304 Rel homology region.
 FT 168 189 proline-rich region (7/22).

FT 193 289 SM00429; IPT.
 FT 194 289 PF01833; TIG.
 FT 216
216 cysteine important for homodimerization [13].
 FT 222 231
important for multimerization and for DNA-binding, missing in

FT p65delta.
 FT 273 276 potential PKA site important for homodimerization
[13].
 FT 286 551 binding to CBP/p300 [1].
 FT 301 304 nuclear
localization signal [20].
 FT 317 350 proline-rich region (12/34).

FT 381 428 proline-rich region (18/48).
 FT 415 550 transcription
activation domain [19].
 FT 428 521 trans-activation domain
2 (TA2) [2].
 FT 458 483 trans-activation domain 1' (TA1')
[2].
 FT 521 551 trans-activation domain 1 (TA1) [2].
 XX

SF four AA residues in the DNA-binding Rel domain mediate a distinct

SF DNA-binding specificity of the RelA (p65) homodimer compared
to
 SF heterodimers [14];
 SF cytoplasmic inhibitors (IkappaB-alpha
and -beta) bind to the Rel domain of
 SF RelA [31] [30] thus
masking the nuclear localization signal [20] [8];
 SF the splice
variant p65delta cannot dimerize with itself or with p50, but

SF with intact RelA [19], and interacts only weakly with IkappaB-alpha
since
 SF dimerization is important for inhibitor binding [20];

SF the Rel domain of RelA interacts with leucine zipper structures
of c-Fos,
 SF c-Jun [16], C/EBP-beta [11], and probably also
ATF-a and CRE-BP1 [10];
 SF it may also interact with the zinc
finger domain of Sp1 [7] and the
 SF DNA-binding domain of
the estrogen receptor (ER), independent of its
 SF ligand-bound
status [3];
 SF the potent trans-activating domain comprises
several subdomains, of which
 SF TA2 contains another TA1-homologous
region, both revealing a highly
 SF amphiphilic character when
alpha-helically folded, with one side
 SF exclusively comprising
serine residues [2];
 SF moreover, the trans-activating domain
contains several acidic modules with
 SF a critical core phenylalanine
and flanking bulky hydrophobic residues [2];
 XX
 CP ubiquitous

XX
 FF activator;
 FF contributes the major transcription
activation domain to the NF-kappaB
 FF  complex [26];

FF at some sequences, its homodimers may act as transcriptional
activators
 FF [25] [28];
 FF synergistic effects with AP-1
through AP-1 sites as well as through kappaB
 FF sites (c-Fos
and c-Jun, not JunB or JunD, also not found for NF-kappaB1)

FF [16];
 FF similar synergism with C/EBP family members [11]
and with Sp1, e. g. at the
 FF HIV-1 LTR [15];
 FF in T
cells, RelA is phosphorylated by a 43 kDa protein kinase associated

FF with the NF-kappaB/IkappaB complex [9];
 FF subsequent release
of RelA permits nuclear translocation [5];
 FF PKC-mediated
phosphorylation and trans-activation through TA2 [2];
 FF constitutive
phosphorylation of TA1 [2];
 FF PKA-mediated phosphorylation
decreases nuclear translocation of RelA,
 FF presumably by
decreasing the rate of IkappaB degradation [4];
 FF the splice
variant p65delta suppresses NF-kappaB activity and exhibits

FF transforming properties [22];
 XX
 IN T01795; AhR; human,
Homo sapiens.
 IN T00052; ATF-a; human, Homo sapiens.
 IN
T00123; c-Fos; human, Homo sapiens.
 IN T00133; c-Jun; human,
Homo sapiens.
 IN T00168; c-Rel; human, Homo sapiens.
 IN
T00581; C/EBPbeta; human, Homo sapiens.
 IN T02214; CBP; human,
Homo sapiens.
 IN T00167; CRE-BP1; human, Homo sapiens.

IN T00261; ER-alpha; human, Homo sapiens.
 IN T00950; IkappaB-alpha;
human, Homo sapiens.
 IN T00414; IkappaB-beta; human, Homo
sapiens.
 IN T00416; IkappaB-beta; chick, Gallus gallus.

IN T00971; IkappaB-beta; mouse, Mus musculus.
 IN T00593; NF-kappaB1;
human, Homo sapiens.
 IN T01930; NF-kappaB2 (p49); human, Homo
sapiens.
 IN T01927; NF-kappaB2 precursor; human, Homo sapiens.

IN T01929; NF-kappaB2 precursor; chick, Gallus gallus.
 IN
T00394; NF-kappaB2; human, Homo sapiens.
 IN T01427; p300;
human, Homo sapiens.
 IN T01523; p65delta; human, Homo sapiens.

IN T00594; RelA; human, Homo sapiens.
 IN T00897; v-Rel; REV-T,
reticuloendotheliosis virus (strain T).
 XX
 XX
 XX

XX
 RN [1]; RE0018223.
 RX MEDLINE; 97250467.
 RA Gerritsen
M. E., Williams A. J., Neish A. S., Moore S., Shi Y., Collins
T.
 RT CREB-binding protein/p300 are transcriptional coactivators
of p65.
 RL Proc. Natl. Acad. Sci. USA 94:2927-2932 (1997).

RN [2]; RE0003823.
 RX MEDLINE; 95318141.
 RA Schmitz M.
L., dos Santos Silva M. A., Baeuerle P. A.
 RT Transactivation
domain 2 (TA2) of p65 NF-kappaB
 RL J. Biol. Chem. 270:15576-15584
(1995).
 RN [3]; RE0004503.
 RX MEDLINE; 95379843.
 RA
Stein B., Yang M. X.
 RT Repression of the interleukin-6 promoter
by estrogen receptor is mediated
 RT by NF-kappaB and C/EBPbeta

RL Mol. Cell. Biol. 15:4971-4979 (1995).
 RN [4]; RE0004548.

RX MEDLINE; 95262639.
 RA Neumann M., Grieshammer T., Chuvpilo
S., Kneitz B., Lohoff M., Schimpl A.,
 RA Franza jr B. R.,
Serfling E.
 RT ReIA/p65 is a molecular target for the immunosuppressive
action of protein
 RT kinase A
 RL EMBO J. 14:1991-2004
(1995).
 RN [5]; RE0004507.
 RX MEDLINE; 95009960.
 RA
Naumann M., Scheidereit C.
 RT Activation of NF-6B in vivo
is regulated by multiple phosphorylations
 RL EMBO J. 13:4597-4607
(1994).
 RN [6]; RE0004546.
 RX MEDLINE; 95021251.
 RA
Blair W. S., Bogerd H. P., Madore S. J., Cullen B. R.
 RT Mutational
analysis of the transcription activation domain of RelA:
 RT
identification of a highly synergistic minimal acidic activation
module
 RL Mol. Cell. Biol. 14:7226-7234 (1994).
 RN [7];
RE0004557.
 RX MEDLINE; 95021185.
 RA Perkins N. D., Agranoff
A. B., Pascal E., Nabel G. J.
 RT An interaction the DNA-binding
domains of RelA(p65) and Sp1 mediates human
 RT immunodeficiency
virus gene activation
 RL Mol. Cell. Biol. 14:6570-6583 (1994).

RN [8]; RE0004487.
 RX MEDLINE; 93154322.
 RA Zabel U.,
Henkel T., dos Santos Silva M., Baeuerle P. A.
 RT Nuclear
uptake control of NF-kappaB by MAD-3, an IkappB protein present
in
 RT the nucleus
 RL EMBO J. 12:201-211 (1993).
 RN
[9]; RE0004496.
 RX MEDLINE; 94075380.
 RA Hayashi T., Sekine
T., Okamoto T.
 RT Identification of a new serine kinase that
activates NFkappaB by direct
 RT phosphorylation
 RL J.
Biol. Chem. 268:26790-26795 (1993).
 RN [10]; RE0004521.

RX MEDLINE; 94019389.
 RA Kaszubska W., Hooft van Huijsduijnen
R., Ghersa P., DeRaemy-Schenk A.-M.,
 RA Chen B. P. C., Hai
T., DeLamarter J. F., Whelan J.
 RT Cyclic AMP-independent
ATF family members interact with NF-kappaB and
 RT function
in the activation of the E-selectin promoter in response to

RT cytokines
 RL Mol. Cell. Biol. 13:7180-7190 (1993).

RN [11]; RE0004524.
 RX MEDLINE; 93309429.
 RA Stein B.,
Cogswell P. C., Baldwin jr A. S.
 RT Functional and physical
associations between NF-kappaB and C/EBP family
 RT members:
a Rel domain-bZIP interaction
 RL Mol. Cell. Biol. 13:3964-3974
(1993).
 RN [12]; RE0004541.
 RX MEDLINE; 93180775.

RA Duckett C. S., Perkins N. D., Kowalik T. F., Schmid R. M.,
Huang E.-S.,
 RA Baldwin jr A. S., Nabel G. J.
 RT Dimerization
of NF-KB2 with RelA(p65) regulates DNA binding,
 RT transcriptional
activation, and inhibition by an IkappaB-alpha (MAD-3)
 RL
Mol. Cell. Biol. 13:1315-1322 (1993).
 RN [13]; RE0004543.

RX MEDLINE; 94067143.
 RA Ganchi P. A., Sun S. C., Greene W.
C., Ballard D. W.
 RT A novel NF-kappaB complex containing
p65 homodimers: implications for
 RT transcriptional control
at the level of subunit dimerization
 RL Mol. Cell. Biol. 13:7826-7835
(1993).
 RN [14]; RE0004544.
 RX MEDLINE; 93309418.

RA Coleman T. A., Kunsch C., Maher M., Ruben S. M., Rosen C. A.

RT Acquisition of NFKB1-selective DNA binding by substitution
of four amino
 RT acid residues from NFKB1 into RelA
 RL
Mol. Cell. Biol. 13:3850-3859 (1993).
 RN [15]; RE0004545.

RX MEDLINE; 94074554.
 RA Perkins N. D., Edwards N. L., Duckett
C. S., Agranoff A. B., Schmid R. M.,
 RA Nabel G. J.
 RT
A cooperative interaction between NF-kappaB and Sp1 is required
for HIV-1
 RT enhancer activation
 RL EMBO J. 12:3551-3558
(1993).
 RN [16]; RE0004555.
 RX MEDLINE; 94008995.

RA Stein B., Baldwin jr A. S., Ballard D. W., Greene W. C., Angel
P., Herrlich
 RA P.
 RT Cross-coupling of the NF-kappaB
p65 and Fos/Jun transcription factors
 RT produces potentiated
biological function
 RL EMBO J. 12:3879-3891 (1993).
 RN
[17]; RE0004556.
 RX MEDLINE; 94052200.
 RA Higgins K. A.,
Perez J. R., Coleman T. A., Dorshkind K., McComas W. A.,
 RA
Sarmiento U. M., Rosen C. A., Narayanan R.
 RT Antisense inhibition
of the p65 subunit of NF-kappaB blocks tumorigenicity
 RT and
causes tumor regression
 RL Proc. Natl. Acad. Sci. USA 90:9901-9905
(1993).
 RN [18]; RE0002922.
 RX MEDLINE; 93024383.

RA Kunsch C., Ruben S. M., Rosen C. A.
 RT Selection of optimal
kappaB/Rel DNA-binding motifs: interaction of both
 RT subunits
of NF-kappaB with DNA is required for transcriptional activation

RL Mol. Cell. Biol. 12:4412-4421 (1992).
 RN [19]; RE0003105.

RX MEDLINE; 92123171.
 RA Ruben S. M., Narayanan R., Klement
J. F., Chen C.-H., Rosen C. A.
 RT Functional characterization
of the NF-kappaB p65 transcriptional activator
 RT and an alternatively
spliced derivate
 RL Mol. Cell. Biol. 12:444-454 (1992).

RN [20]; RE0004549.
 RX MEDLINE; 93012946.
 RA Beg A. A.,
Ruben S. M., Scheinman R. I., Rosen C. A., Baldwin jr A. S.

RT IkappaB interacts with the nuclear localization sequences of
the subunits
 RT of the NF-kappaB: a mechanism for cytoplasmic
retention
 RL Genes Dev. 6:1899-1913 (1992).
 RN [21]; RE0004552.

RX MEDLINE; 92355588.
 RA Duyao M. P., Kessler D. J., Spicer
D. B., Bartholomew C., Cleveland J. L.,
 RA Siekevitz M., Sonenshein
G. E.
 RT Transactivation of the c-myc promoter by human T
cell leukemia virus type I
 RT tax is mediated by NFkappaB

RL J. Biol. Chem. 267:16288-16291 (1992).
 RN [22]; RE0004554.

RX MEDLINE; 92229466.
 RA Narayanan R., Klement J. F., Ruben
S. M., Higgins K. A., Rosen C. A.
 RT Identification of a naturally
occurring transforming variant of the p65
 RT subunit of NF-kappaB

RL Science 256:367-370 (1992).
 RN [23]; RE0004558.
 RX
MEDLINE; 92179285.
 RA Ballard D. W., Dixon E. P., Peffer N.
J., Bogerd H., Doerre S., Stein B.,
 RA Greene W. C.
 RT
The 65-kDa subunit of human NF-kappaB functions as a potent transcriptional

RT activator and a target for v-Rel-mediated repression
 RL
Proc. Natl. Acad. Sci. USA 89:1875-1879 (1992).
 RN [24]; RE0004559.

RX MEDLINE; 92155160.
 RA Hansen S. K., Nerlov C., Zabel U.,
Verde P., Johnsen M., Baeuerle P., Blasi
 RA F.
 RT A novel
complex between the p65 subunit of NF-kappaB and c-Rel binds to
a
 RT DNA element involved in the phorbol ester induction of
the human urokinase
 RT gene
 RL EMBO J. 11:205-213 (1992).

RN [25]; RE0000458.
 RX MEDLINE; 91266911.
 RA Urban M.
B., Schreck R., Baeuerle P. A.
 RT NF-kappaB contacts DNA by
a heterodimer of the p50 and p65 subunit
 RL EMBO J. 10:1817-1825
(1991).
 RN [26]; RE0000506.
 RX MEDLINE; 92037544.

RA Schmitz M. L., Baeuerle P. A.
 RT The p65 subunit is responsible
for the strong transcription activating
 RT potential of NF-kappaB

RL EMBO J. 10:3805-3817 (1991).
 RN [27]; RE0001632.
 RX
MEDLINE; 89343960.
 RA Shirakawa F., Mizel S. B.
 RT In
vitro activation and nuclear translocation of NF-kappaB catalyzed
by
 RT cyclic AMP-dependent protein kinase and protein kinase
C
 RL Mol. Cell. Biol. 9:2424-2430 (1991).
 RN [28]; RE0002682.

RX MEDLINE; 91173312.
 RA Ruben S. M., Dillon P. J., Schreck
R., Henkel T., Chen C.-H., Maher M.,
 RA Baeuerle P. A., Rosen
C. A.
 RT Isolation of a rel-related human cDNA that potentially
encodes the p65-kD
 RT subunit of NF-kappaB
 RL Science
251:1490-1493 (1991).
 RN [29]; RE0000091.
 RX MEDLINE;
90235275.
 RA Zabel U., Bauerle P. A.
 RT Purified human
IkappaB can rapidly dissociate the complex of the NF-kappaB

RT transcription factor with its cognate DNA
 RL Cell 61:255-265
(1990).
 RN [30]; RE0000726.
 RX MEDLINE; 91115086.

RA Urban M. B., Baeuerle P. A.
 RT The 65-kD subunit of NF-kappaB
is a receptor for IkappaB and a modulator of
 RT DNA-binding
specificity
 RL Genes Dev. 4:1975-1984 (1990).
 RN [31];
RE0000609.
 RX MEDLINE; 90108665.
 RA Baeuerle P., Baltimore
D.
 RT A 65-kD subunit of active NF-kappaB is required for
inhibition of NF-kappaB
 RT by IkappaB
 RL Genes Dev. 3:1689-1698
(1989).
 RN [32]; RE0000629.
 RX MEDLINE; 90108684.

RA Errede B., Ammerer G.
 RT STE12, a protein involved in cell-type-specific
transcription and signal
 RT transduction in yeast, is part
of protein-DNA complexes
 RL Genes Dev. 3:1349-1361 (1989).

RN [33]; RE0000285.
 RX MEDLINE; 89337543.
 RA Baeuerle
P. A., Lenardo M., Pierce J. W., Baltimore D.
 RT Phorbol-ester-induced
activation of the NF-kappaB transcription factor
 RT involves
dissociation of an apparently cytoplasmic NF-kappaB/inhibitor

RT complex
 RL Cold Spring Harbor Symp. Quant. Biol. 53:789-798
(1988).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

256 genes, 256 accessions (Toggle view)

AccessionGeneTitleLinks
CXCL16CXCL16chemokine (C-X-C motif) ligand 16Source|GeneCards
GRIN2DGRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2DSource|GeneCards
TA-NFKBHTA-NFKBHT-cell activation NFKB-like proteinSource|GeneCards
CDK6CDK6cyclin-dependent kinase 6Source|GeneCards
PP1665GDPD5glycerophosphodiester phosphodiesterase domain containing 5Source|GeneCards
MGC46719LIX1LLix1 homolog (mouse) likeSource|GeneCards
SAMSN1SAMSN1SAM domain, SH3 domain and nuclear localisation signals, 1Source|GeneCards
MAP3K8MAP3K8mitogen-activated protein kinase kinase kinase 8Source|GeneCards
FLJ14466FLJ14466hypothetical protein FLJ14466Source|GeneCards
MAML2MAML2Mastermind-like 2 (Drosophila)Source|GeneCards
BDNFBDNFbrain-derived neurotrophic factorSource|GeneCards
MGC31967MGC31967hypothetical protein MGC31967Source|GeneCards
ARHGAP5ARHGAP5Rho GTPase activating protein 5Source|GeneCards
ASH1LASH1Lash1 (absent, small, or homeotic)-like (Drosophila)Source|GeneCards
P2RY10P2RY10purinergic receptor P2Y, G-protein coupled, 10Source|GeneCards
COL16A1COL16A1collagen, type XVI, alpha 1Source|GeneCards
SHOX2SHOX2short stature homeobox 2Source|GeneCards
CTAGE4CTAGE4CTAGE family, member 4Source|GeneCards
NLKNLKnemo like kinaseSource|GeneCards
PLAUPLAUplasminogen activator, urokinaseSource|GeneCards
EGFEGFepidermal growth factor (beta-urogastrone)Source|GeneCards
PCSK2PCSK2proprotein convertase subtilisin/kexin type 2Source|GeneCards
IL27RAIL27RAinterleukin 27 receptor, alphaSource|GeneCards
MR-1MR-1myofibrillogenesis regulator 1Source|GeneCards
UBE2HUBE2Hubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)Source|GeneCards
HCFC1HCFC1host cell factor C1 (VP16-accessory protein)Source|GeneCards
LNKLNKlymphocyte adaptor proteinSource|GeneCards
KRTAP13-1KRTAP13-1keratin associated protein 13-1Source|GeneCards
MSCMSCmusculin (activated B-cell factor-1)Source|GeneCards
TRA1TRA1tumor rejection antigen (gp96) 1Source|GeneCards
IRF1IRF1interferon regulatory factor 1Source|GeneCards
ETV6ETV6ets variant gene 6 (TEL oncogene)Source|GeneCards
LRCH1LRCH1leucine-rich repeats and calponin homology (CH) domain containing 1Source|GeneCards
CXCL10CXCL10chemokine (C-X-C motif) ligand 10Source|GeneCards
PPARBPPPARBPPPAR binding proteinSource|GeneCards
RND1RND1Rho family GTPase 1Source|GeneCards
CXCL11CXCL11chemokine (C-X-C motif) ligand 11Source|GeneCards
COL11A2COL11A2collagen, type XI, alpha 2Source|GeneCards
UBE2D3UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)Source|GeneCards
NOL4NOL4nucleolar protein 4Source|GeneCards
EDG5EDG5endothelial differentiation, sphingolipid G-protein-coupled receptor, 5Source|GeneCards
ASCL3ASCL3achaete-scute complex (Drosophila) homolog-like 3Source|GeneCards
AGPAT1AGPAT11-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)Source|GeneCards
MOBKL2CMOBKL2CMOB1, Mps One Binder kinase activator-like 2C (yeast)Source|GeneCards
FKHL18FKHL18forkhead-like 18 (Drosophila)Source|GeneCards
ZMYND15ZMYND15zinc finger, MYND domain containing 15Source|GeneCards
HSD3B7HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7Source|GeneCards
PRDM12PRDM12PR domain containing 12Source|GeneCards
KIAA1536CALCOCO1calcium binding and coiled-coil domain 1Source|GeneCards
GATA4GATA4GATA binding protein 4Source|GeneCards
FLJ35867ZNF690zinc finger protein 690Source|GeneCards
TLX1TLX1T-cell leukemia, homeobox 1Source|GeneCards
MSNMSNmoesinSource|GeneCards
GADD45BGADD45Bgrowth arrest and DNA-damage-inducible, betaSource|GeneCards
SESN2SESN2sestrin 2Source|GeneCards
USP52USP52ubiquitin specific protease 52Source|GeneCards
CHD4CHD4chromodomain helicase DNA binding protein 4Source|GeneCards
CPDCPDcarboxypeptidase DSource|GeneCards
TRAF4TRAF4TNF receptor-associated factor 4Source|GeneCards
MMP9MMP9matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Source|GeneCards
FGF1FGF1fibroblast growth factor 1 (acidic)Source|GeneCards
MGC15912MGC15912hypothetical protein MGC15912Source|GeneCards
FLRT1FLRT1fibronectin leucine rich transmembrane protein 1Source|GeneCards
NFKBIBNFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, betaSource|GeneCards
IL23AIL23Ainterleukin 23, alpha subunit p19Source|GeneCards
UBE4BUBE4Bubiquitination factor E4B (UFD2 homolog, yeast)Source|GeneCards
MSX1MSX1msh homeo box homolog 1 (Drosophila)Source|GeneCards
T2BPT2BPTRAF2 binding proteinSource|GeneCards
AGC1AGC1aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)Source|GeneCards
ZBTB11ZBTB11zinc finger and BTB domain containing 11Source|GeneCards
CTGFCTGFconnective tissue growth factorSource|GeneCards
KLK9KLK9Kallikrein 9Source|GeneCards
FUT7FUT7fucosyltransferase 7 (alpha (1,3) fucosyltransferase)Source|GeneCards
CYB5CYB5cytochrome b-5Source|GeneCards
STAT6STAT6signal transducer and activator of transcription 6, interleukin-4 inducedSource|GeneCards
ZNF161ZNF161zinc finger protein 161Source|GeneCards
JARID2JARID2Jumonji, AT rich interactive domain 2Source|GeneCards
IL1RNIL1RNinterleukin 1 receptor antagonistSource|GeneCards
TAZTAZtafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome)Source|GeneCards
TP73LTP73Ltumor protein p73-likeSource|GeneCards
CDC14ACDC14ACDC14 cell division cycle 14 homolog A (S. cerevisiae)Source|GeneCards
GNB1GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1Source|GeneCards
HBXAPHBXAPhepatitis B virus x associated proteinSource|GeneCards
C1ORF24C1ORF24chromosome 1 open reading frame 24Source|GeneCards
TRIB2TRIB2tribbles homolog 2 (Drosophila)Source|GeneCards
182-FIP182-FIP82-kD FMRP Interacting ProteinSource|GeneCards
MADCAM1MADCAM1mucosal vascular addressin cell adhesion molecule 1Source|GeneCards
GNAO1GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide OSource|GeneCards
IDN3NIPBLNipped-B homolog (Drosophila)Source|GeneCards
TCEA2TCEA2transcription elongation factor A (SII), 2Source|GeneCards
IL27IL27Interleukin 27Source|GeneCards
UNC84BUNC84Bunc-84 homolog B (C. elegans)Source|GeneCards
RBMS1RBMS1RNA binding motif, single stranded interacting protein 1Source|GeneCards
BFSP1BFSP1beaded filament structural protein 1, filensinSource|GeneCards
IL1AIL1Ainterleukin 1, alphaSource|GeneCards
GRK5GRK5G protein-coupled receptor kinase 5Source|GeneCards
HCSTHCSTHematopoietic cell signal transducerSource|GeneCards
TNFRSF5CD40CD40 antigen (TNF receptor superfamily member 5)Source|GeneCards
ENO3ENO3enolase 3, (beta, muscle)Source|GeneCards
KIAA0672KIAA0672KIAA0672 gene productSource|GeneCards
FLJ20309FLJ20309hypothetical protein FLJ20309Source|GeneCards
ERN1ERN1ER to nucleus signalling 1Source|GeneCards
NFKB2NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)Source|GeneCards
FBXL12FBXL12F-box and leucine-rich repeat protein 12Source|GeneCards
TSLPTSLPthymic stromal lymphopoietinSource|GeneCards
SOX5SOX5SRY (sex determining region Y)-box 5Source|GeneCards
C14ORF43C14ORF43chromosome 14 open reading frame 43Source|GeneCards
ZNF384ZNF384zinc finger protein 384Source|GeneCards
SMC6L1SMC6L1SMC6 structural maintenance of chromosomes 6-like 1 (yeast)Source|GeneCards
CHD6CHD6chromodomain helicase DNA binding protein 6Source|GeneCards
R-SPONDINR-SPONDINR-spondin homolog (Xenopus laevis)Source|GeneCards
C21ORF29C21ORF29chromosome 21 open reading frame 29Source|GeneCards
TRIM47TRIM47tripartite motif-containing 47Source|GeneCards
ARHGAP8ARHGAP8Rho GTPase activating protein 8Source|GeneCards
TNFRSF9TNFRSF9tumor necrosis factor receptor superfamily, member 9Source|GeneCards
HOXB9HOXB9homeo box B9Source|GeneCards
RIN2RIN2Ras and Rab interactor 2Source|GeneCards
RAP2CRAP2CRAP2C, member of RAS oncogene familySource|GeneCards
UBE2IUBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Source|GeneCards
CXCL9CXCL9chemokine (C-X-C motif) ligand 9Source|GeneCards
SMOC1SMOC1SPARC related modular calcium binding 1Source|GeneCards
WNT10AWNT10Awingless-type MMTV integration site family, member 10ASource|GeneCards
IL13IL13interleukin 13Source|GeneCards
FOXJ2FOXJ2forkhead box J2Source|GeneCards
GREM1GREM1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)Source|GeneCards
WNT10BWNT10Bwingless-type MMTV integration site family, member 10BSource|GeneCards
SLC12A2SLC12A2solute carrier family 12 (sodium/potassium/chloride transporters), member 2Source|GeneCards
CXCL5CXCL5chemokine (C-X-C motif) ligand 5Source|GeneCards
PRXPRXperiaxinSource|GeneCards
SDC4SDC4syndecan 4 (amphiglycan, ryudocan)Source|GeneCards
CDW92CDW92CDW92 antigenSource|GeneCards
TNFTNFtumor necrosis factor (TNF superfamily, member 2)Source|GeneCards
FLJ23861FLJ23861hypothetical protein FLJ23861Source|GeneCards
IL1RAPL1IL1RAPL1interleukin 1 receptor accessory protein-like 1Source|GeneCards
BIRC3BIRC3baculoviral IAP repeat-containing 3Source|GeneCards
ZNF232ZNF232zinc finger protein 232Source|GeneCards
BCKDKBCKDKbranched chain alpha-ketoacid dehydrogenase kinaseSource|GeneCards
PUNCPUNCputative neuronal cell adhesion moleculeSource|GeneCards
TNFSF15TNFSF15tumor necrosis factor (ligand) superfamily, member 15Source|GeneCards
LAMA1LAMA1laminin, alpha 1Source|GeneCards
JAK3JAK3Janus kinase 3 (a protein tyrosine kinase, leukocyte)Source|GeneCards
YAPYY1AP1YY1 associated protein 1Source|GeneCards
TP53TP53tumor protein p53 (Li-Fraumeni syndrome)Source|GeneCards
FLJ10307XKR8X Kell blood group precursor-related family, member 8Source|GeneCards
SP6SP6Sp6 transcription factorSource|GeneCards
LTBLTBlymphotoxin beta (TNF superfamily, member 3)Source|GeneCards
AP1S2AP1S2adaptor-related protein complex 1, sigma 2 subunitSource|GeneCards
SLAMF8SLAMF8SLAM family member 8Source|GeneCards
ALG6ALG6asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3-glucosyltransferase)Source|GeneCards
LTALTAlymphotoxin alpha (TNF superfamily, member 1)Source|GeneCards
G3BPG3BPRas-GTPase-activating protein SH3-domain-binding proteinSource|GeneCards
ZNF403ZNF403zinc finger protein 403Source|GeneCards
FLJ38335FLJ38335hypothetical protein FLJ38335Source|GeneCards
GNG4GNG4guanine nucleotide binding protein (G protein), gamma 4Source|GeneCards
SLICKKCNT2potassium channel, subfamily T, member 2Source|GeneCards
GPHNGPHNgephyrinSource|GeneCards
SOX10SOX10SRY (sex determining region Y)-box 10Source|GeneCards
UACAUACAuveal autoantigen with coiled-coil domains and ankyrin repeatsSource|GeneCards
RALGDSRALGDSral guanine nucleotide dissociation stimulatorSource|GeneCards
ITGB4ITGB4integrin, beta 4Source|GeneCards
PTMSPTMSparathymosinSource|GeneCards
BMFBMFBcl-2 modifying factorSource|GeneCards
HIVEP1HIVEP1human immunodeficiency virus type I enhancer binding protein 1Source|GeneCards
ACTN1ACTN1actinin, alpha 1Source|GeneCards
TNFRSF1BTNFRSF1Btumor necrosis factor receptor superfamily, member 1BSource|GeneCards
MGC10561MGC10561hypothetical protein MGC10561Source|GeneCards
NFAT5NFAT5nuclear factor of activated T-cells 5, tonicity-responsiveSource|GeneCards
C1QL1C1QL1complement component 1, q subcomponent-like 1Source|GeneCards
ZFP36L2ZFP36L2zinc finger protein 36, C3H type-like 2Source|GeneCards
VCAM1VCAM1vascular cell adhesion molecule 1Source|GeneCards
BCL6BBCL6BB-cell CLL/lymphoma 6, member B (zinc finger protein)Source|GeneCards
ZBTB5ZBTB5zinc finger and BTB domain containing 5Source|GeneCards
DAP3DAP3death associated protein 3Source|GeneCards
STC2STC2stanniocalcin 2Source|GeneCards
TJP4TJP4tight junction protein 4 (peripheral)Source|GeneCards
SALL1SALL1sal-like 1 (Drosophila)Source|GeneCards
FTHL17FTHL17ferritin, heavy polypeptide-like 17Source|GeneCards
ACTN3ACTN3actinin, alpha 3Source|GeneCards
MAP4K2MAP4K2mitogen-activated protein kinase kinase kinase kinase 2Source|GeneCards
OPCMLOPCMLopioid binding protein/cell adhesion molecule-likeSource|GeneCards
LIG1LIG1ligase I, DNA, ATP-dependentSource|GeneCards
KCNS3KCNS3potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3Source|GeneCards
CYLDCYLDcylindromatosis (turban tumor syndrome)Source|GeneCards
NR2F2NR2F2Nuclear receptor subfamily 2, group F, member 2Source|GeneCards
STN2STN2stonin 2Source|GeneCards
APPLAPPLadaptor protein containing pH domain, PTB domain and leucine zipper motifSource|GeneCards
DDR1DDR1discoidin domain receptor family, member 1Source|GeneCards
FLJ21062FLJ21062hypothetical protein FLJ21062Source|GeneCards
FLJ10159FLJ10159hypothetical protein FLJ10159Source|GeneCards
ICAM1ICAM1intercellular adhesion molecule 1 (CD54), human rhinovirus receptorSource|GeneCards
EHFEHFets homologous factorSource|GeneCards
CXCL6CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)Source|GeneCards
SMPD3SMPD3sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)Source|GeneCards
CARD15CARD15caspase recruitment domain family, member 15Source|GeneCards
RIMS2RIMS2regulating synaptic membrane exocytosis 2Source|GeneCards
EBI3EBI3Epstein-Barr virus induced gene 3Source|GeneCards
FGF17FGF17fibroblast growth factor 17Source|GeneCards
RPS6KA4RPS6KA4ribosomal protein S6 kinase, 90kDa, polypeptide 4Source|GeneCards
KCNN3KCNN3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3Source|GeneCards
BMP2KBMP2KBMP2 inducible kinaseSource|GeneCards
BCL3BCL3B-cell CLL/lymphoma 3Source|GeneCards
PFN1PFN1profilin 1Source|GeneCards
CLCN1CLCN1chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant)Source|GeneCards
LOC55565LOC55565hypothetical protein LOC55565Source|GeneCards
HSD11B2HSD11B2hydroxysteroid (11-beta) dehydrogenase 2Source|GeneCards
IL2RAIL2RAinterleukin 2 receptor, alphaSource|GeneCards
OAZINOAZINornithine decarboxylase antizyme inhibitorSource|GeneCards
EDN2EDN2endothelin 2Source|GeneCards
LOC81558LOC81558C/EBP-induced proteinSource|GeneCards
PCBP4PCBP4poly(rC) binding protein 4Source|GeneCards
SPTBSPTBspectrin, beta, erythrocytic (includes spherocytosis, clinical type I)Source|GeneCards
DCAMKL1DCAMKL1doublecortin and CaM kinase-like 1Source|GeneCards
FLJ10385WDR79WD repeat domain 79Source|GeneCards
NTN1NTN1netrin 1Source|GeneCards
FLJ39739FLJ39739FLJ39739 proteinSource|GeneCards
ZBTB9ZBTB9zinc finger and BTB domain containing 9Source|GeneCards
IFNB1IFNB1interferon, beta 1, fibroblastSource|GeneCards
DKFZP761C169GPBP1GC-rich promoter binding protein 1Source|GeneCards
UBDUBDubiquitin DSource|GeneCards
HOXA11HOXA11homeo box A11Source|GeneCards
TAL1TAL1T-cell acute lymphocytic leukemia 1Source|GeneCards
RRASRRASrelated RAS viral (r-ras) oncogene homologSource|GeneCards
BLR1BLR1Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)Source|GeneCards
CHX10CHX10ceh-10 homeo domain containing homolog (C. elegans)Source|GeneCards
RELBRELBv-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)Source|GeneCards
BAI2BAI2brain-specific angiogenesis inhibitor 2Source|GeneCards
TNFSF18TNFSF18tumor necrosis factor (ligand) superfamily, member 18Source|GeneCards
SEC14L2SEC14L2SEC14-like 2 (S. cerevisiae)Source|GeneCards
FLJ40869FLJ40869hypothetical protein FLJ40869Source|GeneCards
MAGMAGmyelin associated glycoproteinSource|GeneCards
ATOH1ATOH1atonal homolog 1 (Drosophila)Source|GeneCards
GABRB1GABRB1gamma-aminobutyric acid (GABA) A receptor, beta 1Source|GeneCards
C13ORF25C13ORF25chromosome 13 open reading frame 25Source|GeneCards
CD83CD83CD83 antigen (activated B lymphocytes, immunoglobulin superfamily)Source|GeneCards
CXORF21CXORF21Chromosome X open reading frame 21Source|GeneCards
SLC11A2SLC11A2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2Source|GeneCards
SIN3ASIN3ASIN3 homolog A, transcriptional regulator (yeast)Source|GeneCards
LOC374920LOC374920hypothetical protein LOC374920Source|GeneCards
SLC6A12SLC6A12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12Source|GeneCards
TNFSF7TNFSF7tumor necrosis factor (ligand) superfamily, member 7Source|GeneCards
TNIP1TNIP1TNFAIP3 interacting protein 1Source|GeneCards
IL4I1IL4I1interleukin 4 induced 1Source|GeneCards
EIF5AEIF5Aeukaryotic translation initiation factor 5ASource|GeneCards
BNC2BNC2basonuclin 2Source|GeneCards
CXCL2CXCL2chemokine (C-X-C motif) ligand 2Source|GeneCards
ABHD8ABHD8abhydrolase domain containing 8Source|GeneCards
KCNH3KCNH3potassium voltage-gated channel, subfamily H (eag-related), member 3Source|GeneCards
FLJ33207KYkyphoscoliosis peptidaseSource|GeneCards
76P76Pgamma tubulin ring complex protein (76p gene)Source|GeneCards
CCL5CCL5chemokine (C-C motif) ligand 5Source|GeneCards
ARPC2ARPC2actin related protein 2/3 complex, subunit 2, 34kDaSource|GeneCards
IER5IER5immediate early response 5Source|GeneCards
ATP1B1ATP1B1ATPase, Na+/K+ transporting, beta 1 polypeptideSource|GeneCards
CREB1CREB1cAMP responsive element binding protein 1Source|GeneCards
FLJ21308PARP8Poly (ADP-ribose) polymerase family, member 8Source|GeneCards
PTD015PTD015PTD015 proteinSource|GeneCards

[an error occurred while processing this directive]