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Gene set: V$NKX25_01 (C3:TFAC:0152)
Standard nameV$NKX25_01
Systematic nameC3:TFAC:0152
Brief descriptionGenes with 3'UTR containing motif TYAAGTG which matches annotation for NKX2-5: NK2 transcription factor related, locus 5 (Drosophila)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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FA Nkx2-5
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SY Csx; Nkx-2.5; cardiac-specific homeobox protein.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;
OC eutheria; rodentia; myomorpha; muridae; murinae
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HO tinman (Drosophila)
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CL C0006; homeo; 3.1.1.15.5.
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SZ 318 AA; 34.2 kDa (cDNA)
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SC SwissProt #P42582
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FT 10 19 conserved decapeptide.
FT 46 121 trans-activating domain [7].
FT 98 135 charged region (10-,10+/39).
FT 136 196 homeo domain.
FT 137 199 SM00389; HOX.
FT 138 194 PF00046; homeobox.
FT 203 318 inhibitory domain [7].
FT 210 226 NK2-specific domain.
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SF at least two different consensus binding sequences [7];
SF the potent trans-activation domain is maked by the alanine- and
SF proline-rich C-terminus [7];
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CP (cell lines). Fibroblast: NIH3T3; Bone marrow stroma: BAd; Thymic stroma:
CP SCL-19; Lymph node stroma: TSL-1 [1]
CN (cell lines): Fibroblasts: Balb/c 3T3, STO; Myoblasts: 3H10T1/2, C2C12;
CN Myocytes: C3H10T1/2, C2C12; Bone marrow stroma: A6. BMS; Thymic stroma:
CN B6T-ea, SCL-5,SCL-13; Lymph node stroma: TSL-3 [1]
EX atrium of heart (right and left),,,Theiler Stage 21;detectable; RNA-in situ
EX hybridization (radioactive); RNA (undefined); [1].
EX bone marrow,,,adult;none; RNAse protection assay; total RNA; [1].
EX brain,,,Theiler Stage 28;none; RNAse protection assay; total RNA; [1].
EX brain,,,adult;none; RNAse protection assay; total RNA; [1].
EX brain,,,fetal;none; RNAse protection assay; total RNA; [1].
EX dorsal aorta,,,Theiler Stage 14;none; RNA-in situ hybridization
EX (radioactive); RNA (undefined); [1].
EX endocardial cushion tissue,,,Theiler Stage 21;none; RNA-in situ
EX hybridization (radioactive); RNA (undefined); [1].
EX endoderm of foregut,,,Theiler Stage 12;detectable; RNA-in situ
EX hybridization (radioactive); RNA (undefined); [1].
EX heart,,,Theiler Stage 19;detectable; RNA-in situ hybridization
EX (radioactive); RNA (undefined); [1].
EX heart,,,adult;high; RNAse protection assay; total RNA; [1].
EX heart,,,fetal;very high; RNAse protection assay; total RNA; [1].
EX heart,myogenic cell,,Theiler Stage 13;detectable; RNA-in situ hybridization
EX (radioactive); RNA (undefined); [1].
EX kidney (right and left),,,adult;none; RNAse protection assay; total RNA;
EX [1].
EX large intestine,,,adult;none; RNAse protection assay; total RNA; [1].
EX liver,,,adult;none; RNAse protection assay; total RNA; [1].
EX liver,,,fetal;none; RNAse protection assay; total RNA; [1].
EX lung,,,adult;none; RNAse protection assay; total RNA; [1].
EX lymph node,,,adult;none; RNAse protection assay; total RNA; [1].
EX muscles,,,adult;none; RNAse protection assay; total RNA; [1].
EX ovary,,,adult;none; RNAse protection assay; total RNA; [1].
EX pericardium,,,Theiler Stage 21;none; RNA-in situ hybridization
EX (radioactive); RNA (undefined); [1].
EX primitive heart tube,,,Theiler Stage 13;detectable; RNA-in situ
EX hybridization (radioactive); RNA (undefined); [1].
EX roof of pharynx,,,Theiler Stage 15;none; RNA-in situ hybridization
EX (radioactive); RNA (undefined); [1].
EX small intestine,,,adult;none; RNAse protection assay; total RNA; [1].
EX splanchnopleure,,,Theiler Stage 12;detectable; RNA-in situ hybridization
EX (radioactive); RNA (undefined); [1].
EX spleen,,,adult;low; RNAse protection assay; total RNA; [1].
EX stomach,,,adult;none; RNAse protection assay; total RNA; [1].
EX testis (right and left),,,adult;none; RNAse protection assay; total RNA;
EX [1].
EX thymus,,,adult;none; RNAse protection assay; total RNA; [1].
EX thyroid gland,,,Theiler Stage 19;detectable; RNA-in situ hybridization
EX (radioactive); RNA (undefined); [1].
EX tongue,,,adult;low; RNAse protection assay; total RNA; [1].
EX uterus,,,adult;none; RNAse protection assay; total RNA; [1].
EX venous sinus of primitive heart,,,Theiler Stage 14;high; RNA-in situ
EX hybridization (radioactive); RNA (undefined); [1].
EX venous sinus of primitive heart,,,Theiler Stage 15;detectable; RNA-in situ
EX hybridization (radioactive); RNA (undefined); [1].
EX ventricle of heart (right and left),,,Theiler Stage 21;detectable; RNA-in
EX situ hybridization (radioactive); RNA (undefined); [1].
XX
FF modest activator [7];
FF probably important for myocard development [1];
FF expression first detected in myocardiogenic progenitor cells during early
FF headfold stages, then maintained in cardiomyocytes of embryonic, fetal and
FF adult heart [1];
FF also expressed in pharyngeal endoderm precursors, later in pharyngeal floor;
FF finally, expression is restricted to the thyroid primordium [1];
FF activates with SRF cardiac alpha-actin transcription [6];
FF induces left-sided expression of Hand1 but not Hand2 [5];
FF directly or indirectly autoregulated by negative feedback [3];
FF transcriptional activator, Nkx2-5 and HMX1 act as transcriptional
FF antagonists [4];
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RN [1]; RE0003810.
RX MEDLINE; 94116443.
RA Lints T. J., Parsons L. M., Hartley L., Lyons I., Harvey R. P.
RT Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor
RT cells and their myogenic descendants
RL Development 119:419-431 (1993).
RN [2]; RE0015782.
RX MEDLINE; 11042197.
RA Kasahara H., Usheva A., Ueyama T., Aoki H., Horikoshi N., Izumo S.
RT Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5
RT homeoprotein
RL J. Biol. Chem. 276:4570-4580 (2001).
RN [3]; RE0015753.
RX MEDLINE; 99169087.
RA Tanaka M., Wechsler S. B., Lee I. W., Yamasaki N., Lawitts J. A., Izumo S.
RT Complex modular cis-acting elements regulate expression of the cardiac
RT specifying homeobox gene Csx/Nkx2.5
RL Development 126:1439-1450 (1999).
RN [4]; RE0016078.
RX MEDLINE; 99223479.
RA Amendt B. A., Sutherland L. B., Russo A. F.
RT Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding
RT site
RL J. Biol. Chem. 274:11635-11642 (1999).
RN [5]; RE0006047.
RX MEDLINE; 97336070.
RA Biben C., Harvey R. P.
RT Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH
RT gene eHand during murine heart development
RL Genes Dev. 11:1357-1369 (1997).
RN [6]; RE0015484.
RX MEDLINE; 97042466.
RA Chen C.Y., Schwartz R.J.
RT Recruitment of the tinman homolog Nkx-2.5 by serum response factor
RT activates cardiac alpha-actin gene transcription
RL Mol. Cell. Biol. 16:6372-6384 (1996).
RN [7]; RE0003808.
RX MEDLINE; 95318148.
RA Chen C. Y., Schwartz R. J.
RT Identification of novel DNA binding targets and regulatory domains of a
RT murine tinman homeodomain factor, nkx-2.5
RL J. Biol. Chem. 270:15628-15633 (1995).
RN [8]; RE0003811.
RX MEDLINE; 94244488.
RA Lints T. J., Parsons L. M., Hartley L., Lyons I., Harvey R. P.
RT Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor
RT cells and their myogenic descendants (erratum)
RL Development 119:969-969 (1993).
RN [9]; RE0003812.
RX MEDLINE; 93376760.
RA Komuro I., Izumo S.
RT Csx: A murine homeobox-containing gene specifically expressed in the
RT developing heart
RL Proc. Natl. Acad. Sci. USA 90:8145-8149 (1993).
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Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

128 genes, 128 accessions (Toggle view)

AccessionGeneTitleLinks
C11ORF30C11ORF30chromosome 11 open reading frame 30Source|GeneCards
HOXB4HOXB4homeo box B4Source|GeneCards
PGM2L1PGM2L1phosphoglucomutase 2-like 1Source|GeneCards
PDK2PDK2pyruvate dehydrogenase kinase, isoenzyme 2Source|GeneCards
FLJ90637C1ORF118chromosome 1 open reading frame 118Source|GeneCards
BCL11BBCL11BB-cell CLL/lymphoma 11B (zinc finger protein)Source|GeneCards
RASL11BRASL11BRAS-like, family 11, member BSource|GeneCards
IRAK1IRAK1interleukin-1 receptor-associated kinase 1Source|GeneCards
AQP6AQP6aquaporin 6, kidney specificSource|GeneCards
CREB5CREB5cAMP responsive element binding protein 5Source|GeneCards
SMYD1SMYD1SET and MYND domain containing 1Source|GeneCards
NR0B2NR0B2nuclear receptor subfamily 0, group B, member 2Source|GeneCards
MAML3MAML3Mastermind-like 3 (Drosophila)Source|GeneCards
GSK3BGSK3Bglycogen synthase kinase 3 betaSource|GeneCards
EGFEGFepidermal growth factor (beta-urogastrone)Source|GeneCards
LHFPL1LHFPL1lipoma HMGIC fusion partner-like 1Source|GeneCards
GPM6AGPM6Aglycoprotein M6ASource|GeneCards
GDF3GDF3growth differentiation factor 3Source|GeneCards
UCP3UCP3uncoupling protein 3 (mitochondrial, proton carrier)Source|GeneCards
C20ORF17C20ORF17chromosome 20 open reading frame 17Source|GeneCards
NEDD4NEDD4neural precursor cell expressed, developmentally down-regulated 4Source|GeneCards
FLJ32786FLJ32786hypothetical protein FLJ32786Source|GeneCards
HOXD1HOXD1homeo box D1Source|GeneCards
MCF2MCF2MCF.2 cell line derived transforming sequenceSource|GeneCards
CLST11240HIGD1BHIG1 domain family, member 1BSource|GeneCards
MAB21L2MAB21L2mab-21-like 2 (C. elegans)Source|GeneCards
RAB27ARAB27ARAB27A, member RAS oncogene familySource|GeneCards
TITF1TITF1thyroid transcription factor 1Source|GeneCards
CRABP2CRABP2cellular retinoic acid binding protein 2Source|GeneCards
RINT-1FLJ11785Rad50-interacting protein 1Source|GeneCards
TGIFTGIFTGFB-induced factor (TALE family homeobox)Source|GeneCards
WNT8BWNT8Bwingless-type MMTV integration site family, member 8BSource|GeneCards
GGTL3GGTL3gamma-glutamyltransferase-like 3Source|GeneCards
LRRC4LRRC4leucine rich repeat containing 4Source|GeneCards
LY6G6DLY6G6Dlymphocyte antigen 6 complex, locus G6DSource|GeneCards
MYL1MYL1myosin, light polypeptide 1, alkali; skeletal, fastSource|GeneCards
STC2STC2stanniocalcin 2Source|GeneCards
FLJ46020FLJ46020FLJ46020 proteinSource|GeneCards
PCDH17PCDH17protocadherin 17Source|GeneCards
EIF2C2EIF2C2eukaryotic translation initiation factor 2C, 2Source|GeneCards
STAG2STAG2stromal antigen 2Source|GeneCards
CLPXCLPXClpX caseinolytic protease X homolog (E. coli)Source|GeneCards
RNF29TRIM55tripartite motif-containing 55Source|GeneCards
CTNNA3CTNNA3catenin (cadherin-associated protein), alpha 3Source|GeneCards
CUEDC1CUEDC1CUE domain containing 1Source|GeneCards
FGF16FGF16fibroblast growth factor 16Source|GeneCards
CACNA2D3CACNA2D3calcium channel, voltage-dependent, alpha 2/delta 3 subunitSource|GeneCards
TLX1TLX1T-cell leukemia, homeobox 1Source|GeneCards
DDR1DDR1discoidin domain receptor family, member 1Source|GeneCards
TAIP-2TAIP-2TGF-beta induced apotosis protein 2Source|GeneCards
MYH2MYH2myosin, heavy polypeptide 2, skeletal muscle, adultSource|GeneCards
SPAS1SPATA19spermatogenesis associated 19Source|GeneCards
MGC29649TTC9Ctetratricopeptide repeat domain 9CSource|GeneCards
TCF4TCF4Transcription factor 4Source|GeneCards
PCDHAC2PCDHAC2protocadherin alpha subfamily C, 2Source|GeneCards
LEMD1LEMD1LEM domain containing 1Source|GeneCards
SDF2L1SDF2L1stromal cell-derived factor 2-like 1Source|GeneCards
CRTAC1CRTAC1cartilage acidic protein 1Source|GeneCards
HTR4HTR45-hydroxytryptamine (serotonin) receptor 4Source|GeneCards
FLJ34503FLJ34503hypothetical protein FLJ34503Source|GeneCards
PAX6PAX6paired box gene 6 (aniridia, keratitis)Source|GeneCards
MGC13168MGC13168hypothetical protein MGC13168Source|GeneCards
LMX1ALMX1ALIM homeobox transcription factor 1, alphaSource|GeneCards
PAX7PAX7paired box gene 7Source|GeneCards
HT007HT007uncharacterized hypothalamus protein HT007Source|GeneCards
EBFEBFearly B-cell factorSource|GeneCards
PDGFCPDGFCplatelet derived growth factor CSource|GeneCards
RGS1RGS1regulator of G-protein signalling 1Source|GeneCards
CROC4C1ORF61chromosome 1 open reading frame 61Source|GeneCards
MBPMBPmyelin basic proteinSource|GeneCards
WNT3WNT3wingless-type MMTV integration site family, member 3Source|GeneCards
SCNN1GSCNN1Gsodium channel, nonvoltage-gated 1, gammaSource|GeneCards
LOC115811IQCDIQ motif containing DSource|GeneCards
PCBP4PCBP4poly(rC) binding protein 4Source|GeneCards
ZIC4ZIC4Zic family member 4Source|GeneCards
BCL2BCL2B-cell CLL/lymphoma 2Source|GeneCards
ZNF41ZNF41zinc finger protein 41Source|GeneCards
NRASNRASneuroblastoma RAS viral (v-ras) oncogene homologSource|GeneCards
CFL2CFL2cofilin 2 (muscle)Source|GeneCards
FLJ10997ZNF654zinc finger protein 654Source|GeneCards
RAM2CDCA7Lcell division cycle associated 7-likeSource|GeneCards
NKX2-2NKX2-2NK2 transcription factor related, locus 2 (Drosophila)Source|GeneCards
TEAD1TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor)Source|GeneCards
GPR27GPR27G protein-coupled receptor 27Source|GeneCards
CDC42EP3CDC42EP3CDC42 effector protein (Rho GTPase binding) 3Source|GeneCards
DLX1DLX1distal-less homeo box 1Source|GeneCards
TTT, brachyury homolog (mouse)Source|GeneCards
C6ORF15C6ORF15chromosome 6 open reading frame 15Source|GeneCards
LOC375616LOC375616Cysteine rich BMP regulator 2 (chordin-like)Source|GeneCards
CKLFSF4CKLFSF4chemokine-like factor super family 4Source|GeneCards
BCL9BCL9B-cell CLL/lymphoma 9Source|GeneCards
FGF10FGF10fibroblast growth factor 10Source|GeneCards
EGFREGFRepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Source|GeneCards
KCTD4KCTD4potassium channel tetramerisation domain containing 4Source|GeneCards
SMARCA1SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1Source|GeneCards
LUC7LLUC7LLUC7-like (S. cerevisiae)Source|GeneCards
PPP3CCPPP3CCprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)Source|GeneCards
DCTN1DCTN1dynactin 1 (p150, glued homolog, Drosophila)Source|GeneCards
LRRTM1LRRTM1leucine-rich repeat transmembrane neuronal 1 proteinSource|GeneCards
KLF5KLF5Kruppel-like factor 5 (intestinal)Source|GeneCards
JPH1JPH1junctophilin 1Source|GeneCards
MAP4K4MAP4K4mitogen-activated protein kinase kinase kinase kinase 4Source|GeneCards
PRDM8PRDM8PR domain containing 8Source|GeneCards
STARD3NLSTARD3NLSTARD3 N-terminal likeSource|GeneCards
C18ORF25C18ORF25chromosome 18 open reading frame 25Source|GeneCards
STATIP1STATIP1signal transducer and activator of transcription 3 interacting protein 1Source|GeneCards
ADAMTS5ADAMTS5a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)Source|GeneCards
FOXO1AFOXO1Aforkhead box O1A (rhabdomyosarcoma)Source|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
BNC2BNC2basonuclin 2Source|GeneCards
MEF2CMEF2CMADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)Source|GeneCards
PDZK1PDZK1PDZ domain containing 1Source|GeneCards
SLC39A6SLC39A6solute carrier family 39 (zinc transporter), member 6Source|GeneCards
EGLN2EGLN2egl nine homolog 2 (C. elegans)Source|GeneCards
BCL11ABCL11AB-cell CLL/lymphoma 11A (zinc finger protein)Source|GeneCards
MYO3BMYO3Bmyosin IIIBSource|GeneCards
CTCFCTCFCCCTC-binding factor (zinc finger protein)Source|GeneCards
ACCN2ACCN2amiloride-sensitive cation channel 2, neuronalSource|GeneCards
RGS8RGS8regulator of G-protein signalling 8Source|GeneCards
SLC22A2SLC22A2solute carrier family 22 (organic cation transporter), member 2Source|GeneCards
TPD52TPD52tumor protein D52Source|GeneCards
RAFTLINRAFTLINraft-linking proteinSource|GeneCards
PHOX2APHOX2Apaired-like (aristaless) homeobox 2aSource|GeneCards
PSMA3PSMA3proteasome (prosome, macropain) subunit, alpha type, 3Source|GeneCards
USP32USP32ubiquitin specific protease 32Source|GeneCards
LOC51255LOC51255hypothetical protein LOC51255Source|GeneCards
MAP2K5MAP2K5mitogen-activated protein kinase kinase 5Source|GeneCards
FEZLZNF312zinc finger protein 312Source|GeneCards


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