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Gene set: V$PAX2_01 (C3:TFAC:0057)
Standard nameV$PAX2_01
Systematic nameC3:TFAC:0057
Brief descriptionGenes with 3'UTR containing motif NNNNGTCANGNRTKANNNN which matches annotation for PAX2: paired box gene 2
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA Pax-2
 XX
 SY PAX2; hPax2; hPax-2.

XX
 OS human, Homo sapiens
 OC eukaryota; animalia; metazoa;
chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria; primates

XX
 XX
 CL C0017; paired.
 XX
 SZ 416 AA; 44.7 kDa
(cDNA)
 XX
 XX
 SC SwissProt #Q02962
 XX
 FT 16
141 paired domain.
 FT 16 140 PF00292; PAX.
 FT 16 140 SM00351;
PAX.
 FT 185 192 conserved octapeptide.
 XX
 SF comprises
a remnant of a homeo domain;
 SF similar sequence specificity
as Pax-6 [3];
 SF as in murine cells, there may be two human
splice variants as well [6];
 XX
 FF active during mesenchamy-to
epithelium transition in early kidney
 FF development [6];

FF overexpressed in Wilms tumor [6];
 FF tumor initiation by
inhibiting the p53 transcription [2];
 XX
 XX
 XX

XX
 RN [1]; RE0004276.
 RX MEDLINE; 95315985.
 RA Sanyanusin
P., Schimmenti L. A., McNoe L. A., Ward T. A., Pierpont M. E.,

RA Sullivan M. J., Dobyns W. B., Eccles M. R.
 RT Mutation
of the PAX2 gene in a family with optic nerve colobomas, renal

RT anomalies and vesicoureteral reflux
 RL Nat. Genet. 9:358-364
(1995).
 RN [2]; RE0011183.
 RX MEDLINE; 96091136.
 RA
Stuart E. T., Haffner R., Oren M., Gruss P.
 RT Loss of p53
function through PAX-mediated transcriptional repression
 RL
EMBO J. 14:5638-5645 (1995).
 RN [3]; RE0002969.
 RX MEDLINE;
94179217.
 RA Epstein J., Cai J., Glaser T., Jepeal L., Maas
R.
 RT Identification of a Pax paired domain recognition sequence
and evidence for
 RT DNA-dependent conformational changes

RL J. Biol. Chem. 269:8355-8361 (1994).
 RN [4]; RE0004275.

RX MEDLINE; 95118905.
 RA Ward T. A., Nebel A., Reeve A. E.,
Eccles M. R.
 RT Alternative messenger RNA forms and open reading
frames within an
 RT additional conserved region of the human
PAX-2 gene
 RL Cell Growth Differ. 5:1015-1021 (1994).

RN [5]; RE0004273.
 RX MEDLINE; 95072651.
 RA Stapleton
P., Weith A., Urbanek P., Kozmik Z., Busslinger M.
 RT Chromosomal
localization of seven PAX genes and cloning of a novel member,

RT PAX-9
 RL Nat. Genet. 3:292-298 (1993).
 RN [6]; RE0002828.

RX MEDLINE; 92159012.
 RA Dressler G. R., Douglass E. C.

RT Pax-2 is a DNA-binding protein expressed in embryonic kidney
and Wilms tumor
 RL Proc. Natl. Acad. Sci. USA 89:1179-1183
(1992).
 RN [7]; RE0004274.
 RX MEDLINE; 92338102.
 RA
Eccles M. R., Wallis L. J., Fidler A. E., Spurr N. K., Goodfellow
P. J.,
 RA Reeve A. E.
 RT Expression of the pax2 gene in
human fetal kidney and Wilms tumor
 RL Cell Growth Differ.
3:279-289 (1992).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

61 genes, 61 accessions (Toggle view)

AccessionGeneTitleLinks
CXORF12CXORF12chromosome X open reading frame 12Source|GeneCards
PDE10APDE10Aphosphodiesterase 10ASource|GeneCards
MGC40047MGC40047hypothetical protein MGC40047Source|GeneCards
HPSE2HPSE2heparanase 2Source|GeneCards
FLJ36119TTLL10tubulin tyrosine ligase-like family, member 10Source|GeneCards
CBX8CBX8chromobox homolog 8 (Pc class homolog, Drosophila)Source|GeneCards
PRDM13PRDM13PR domain containing 13Source|GeneCards
POU3F2POU3F2POU domain, class 3, transcription factor 2Source|GeneCards
KRTAP17-1KRTAP17-1keratin associated protein 17-1Source|GeneCards
FLRT1FLRT1fibronectin leucine rich transmembrane protein 1Source|GeneCards
CDH16CDH16cadherin 16, KSP-cadherinSource|GeneCards
FLJ11783FLJ11783hypothetical protein FLJ11783Source|GeneCards
DMDDMDdystrophin (muscular dystrophy, Duchenne and Becker types)Source|GeneCards
HDAC9HDAC9histone deacetylase 9Source|GeneCards
TAF11TAF11TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDaSource|GeneCards
GLAGLAgalactosidase, alphaSource|GeneCards
ED1EDAectodysplasin ASource|GeneCards
NKX2-8NKX2-8NK2 transcription factor related, locus 8 (Drosophila)Source|GeneCards
ACTN4ACTN4actinin, alpha 4Source|GeneCards
MBNL1MBNL1muscleblind-like (Drosophila)Source|GeneCards
VCLVCLvinculinSource|GeneCards
SPRR1ASPRR1Asmall proline-rich protein 1ASource|GeneCards
RAM2CDCA7Lcell division cycle associated 7-likeSource|GeneCards
KCNE4KCNE4potassium voltage-gated channel, Isk-related family, member 4Source|GeneCards
FLJ43965CCDC4coiled-coil domain containing 4Source|GeneCards
ANKS1ANKS1ankyrin repeat and sterile alpha motif domain containing 1Source|GeneCards
HIST1H4CHIST1H4Chistone 1, H4cSource|GeneCards
NPAS2NPAS2neuronal PAS domain protein 2Source|GeneCards
CAM-KIINCAMK2N2calcium/calmodulin-dependent protein kinase II inhibitor 2Source|GeneCards
FOXG1BFOXG1Bforkhead box G1BSource|GeneCards
BA108L7.2BA108L7.2similar to rat tricarboxylate carrier-like proteinSource|GeneCards
ALDRL6ALDRL6aldehyde reductase (aldose reductase) like 6Source|GeneCards
LRRFIP2LRRFIP2leucine rich repeat (in FLII) interacting protein 2Source|GeneCards
IDN3NIPBLNipped-B homolog (Drosophila)Source|GeneCards
ITGB3BPITGB3BPintegrin beta 3 binding protein (beta3-endonexin)Source|GeneCards
BDG29ZCCHC14zinc finger, CCHC domain containing 14Source|GeneCards
HNRPH2HNRPH2heterogeneous nuclear ribonucleoprotein H2 (H')Source|GeneCards
KIAA1959KIAA1959nm23-phosphorylated unknown substrateSource|GeneCards
ZNF263ZNF263zinc finger protein 263Source|GeneCards
C14ORF116CHES1checkpoint suppressor 1Source|GeneCards
HOXA10HOXA10homeo box A10Source|GeneCards
PDZK7PDZK7PDZ domain containing 7Source|GeneCards
ACADSBACADSBacyl-Coenzyme A dehydrogenase, short/branched chainSource|GeneCards
FLJ20668MARCH1membrane-associated ring finger (C3HC4) 1Source|GeneCards
ADRB2ADRB2adrenergic, beta-2-, receptor, surfaceSource|GeneCards
KIAA0063KIAA0063KIAA0063 gene productSource|GeneCards
JADE1PHF17PHD finger protein 17Source|GeneCards
MAP1AMAP1Amicrotubule-associated protein 1ASource|GeneCards
LOC90799LOC90799hypothetical protein BC009518Source|GeneCards
RBM3RBM3RNA binding motif protein 3Source|GeneCards
ACCN2ACCN2amiloride-sensitive cation channel 2, neuronalSource|GeneCards
BRUNOL6BRUNOL6bruno-like 6, RNA binding protein (Drosophila)Source|GeneCards
JMJD1CJMJD1Cjumonji domain containing 1CSource|GeneCards
ZNFN1A5ZNFN1A5zinc finger protein, subfamily 1A, 5Source|GeneCards
FOXP2FOXP2forkhead box P2Source|GeneCards
RNF128RNF128ring finger protein 128Source|GeneCards
TAF5TAF5TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDaSource|GeneCards
PCYT1BPCYT1Bphosphate cytidylyltransferase 1, choline, beta isoformSource|GeneCards
MAP2K5MAP2K5mitogen-activated protein kinase kinase 5Source|GeneCards
SEC14L1SEC14L1SEC14-like 1 (S. cerevisiae)Source|GeneCards
EB-1EB-1E2a-Pbx1-associated proteinSource|GeneCards

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