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Gene set: V$PAX5_01 (C3:TFAC:0091)
Standard nameV$PAX5_01
Systematic nameC3:TFAC:0091
Brief descriptionGenes with 3'UTR containing motif BCNNNRNGCANBGNTGNRTAGCSGCHNB which matches annotation for PAX5: paired box gene 5 (B-cell lineage specific activator protein)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA Pax-5
 XX
 SY BSAP; Pax-5; B-cell
specific activator protein; PAX5; mPax5; mPax-5.
 XX
 OS
mouse, Mus musculus
 OC eukaryota; animalia; metazoa; chordata;
vertebrata; tetrapoda; mammalia;
 OC eutheria; rodentia; myomorpha;
muridae; murinae
 XX
 XX
 HO TSAP (sea urchin)
 XX

CL C0017; paired; 3.2.2.0.3.
 XX
 SZ 391 AA; 42.2 kDa (cDNA),
50 kDa (SDS) [8]
 XX
 XX
 SC SwissProt #Q02650
 XX

FT 16 141 paired domain.
 FT 16 140 PF00292; PAX.
 FT 16
140 SM00351; PAX.
 FT 179 186 conserved octapeptide.
 XX

SF a few differences within the paired domains determine different
DNA-binding
 SF sequence specificities between Pax-5 and Pax-6
[2]
 XX
 CP (pro-, pre-, mature B cells)
 XX
 FF required
for B-cell development [5];
 FF represses Ig 3'alpha enhancer
by preventing binding of an activator [3];
 FF also required
for correct early development of posterior midbrain [5];
 FF
expression positively regulated by E2A genes [4];
 FF Pax-2,
Pax-5 and Pax-8 show overlapping expression with the engrailed
genes
 FF and bind as activators to the En-2 5' enhancer [1];

XX
 XX
 XX
 XX
 RN [1]; RE0014313.
 RX MEDLINE;
96189352.
 RA Song D. L., Chalepakis G., Gruss P., Joyner A.
L.
 RT Two Pax-binding sites are required for early embryonic
brain expression of
 RT an Engrailed-2 transgene
 RL Development
122:627-635 (1996).
 RN [2]; RE0004263.
 RX MEDLINE; 95257968.

RA Czerny T., Busslinger M.
 RT DNA-binding and transactivation
properties of Pax-6: three amino acids in
 RT the paired domain
are responsible for the different sequence recognition of

RT Pax-6 and BSAP (Pax-5)
 RL Mol. Cell. Biol. 15:2858-2871
(1995).
 RN [3]; RE0004295.
 RX MEDLINE; 95296305.
 RA
Neurath M. F., Max E. E., Strober W.
 RT Pax5 (BSAP) regulates
the mrine immunoglobulin 3'a enhancer by suppressing
 RT binding
of NF-aP, a protein that controls heavy chain transcription

RL Proc. Natl. Acad. Sci. USA 92:5336-5340 (1995).
 RN [4];
RE0004022.
 RX MEDLINE; 95094259.
 RA Bain G., Maandag E.
C. R., Izon D. J., Amsen D., Kruisbeek A. M., Weintraub
 RA
B. C., Krop I., Schlissel M. S., Feeney A. J., van Roon M., van
der Falk
 RA M., te Riele H. P. J., Berns A., Murre C.

RT E2A proteins are required for proper B cell development and
initiation of
 RT immunoglobulin gene rearrangements
 RL
Cell 79:885-892 (1994).
 RN [5]; RE0004294.
 RX MEDLINE;
95094261.
 RA Urbanek P., Wang Z.-Q., Fetka I., Wagner E. F.,
Busslinger M.
 RT Complete block of early B cell differentiation
and altered patterning of
 RT the posterior midbrain in mice
lacking Pax5/BSAP
 RL Cell 79:901-912 (1994).
 RN [6]; RE0004279.

RX MEDLINE; 92387536.
 RA Adams B., Doerfler P., Aguzzi A.,
Kozmik Z., Urbanek P., Maurer-Fogy I.,
 RA Busslinger M.

RT Pax-5 encodes the transcription factor BSAP and is expressed
in B
 RT lymphocytes, the developing CNS, and adult testis

RL Genes Dev. 6:1589-1607 (1992).
 RN [7]; RE0004257.
 RX
MEDLINE; 92120664.
 RA Walther C., Guenet J. L., Simon D.,
Deutsch U., Jostes B., Goulding M. D.,
 RA Plachov D., Balling
R., Gruss P.
 RT Pax: a murine multigene family of paired box-containing
genes
 RL Genomics 11:424-434 (1991).
 RN [8]; RE0002744.

RX MEDLINE; 90337320.
 RA Barberis A., Widenhorn K., Vitelli
L., Busslinger M.
 RT A novel B-cell lineage-specific transcription
factor present at early but
 RT not late stages of differentiation

RL Genes Dev. 4:849-859 (1990).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

158 genes, 158 accessions (Toggle view)

AccessionGeneTitleLinks
LOC57117LOC57117hypothetical nuclear factor SBBI22Source|GeneCards
ANGPTL2ANGPTL2angiopoietin-like 2Source|GeneCards
KCNIP1KCNIP1Kv channel interacting protein 1Source|GeneCards
FLJ10154FLJ10154hypothetical protein FLJ10154Source|GeneCards
ABCA2ABCA2ATP-binding cassette, sub-family A (ABC1), member 2Source|GeneCards
TIMP3TIMP3tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)Source|GeneCards
C11ORF31C11ORF31chromosome 11 open reading frame 31Source|GeneCards
FLJ23129WDR78WD repeat domain 78Source|GeneCards
ARFIP2ARFIP2ADP-ribosylation factor interacting protein 2 (arfaptin 2)Source|GeneCards
XPR1XPR1xenotropic and polytropic retrovirus receptorSource|GeneCards
LOC124842LOC124842hypothetical protein LOC124842Source|GeneCards
CTNNBIP1CTNNBIP1catenin, beta interacting protein 1Source|GeneCards
FLJ13236FLJ13236hypothetical protein FLJ13236Source|GeneCards
EML1EML1echinoderm microtubule associated protein like 1Source|GeneCards
KIAA1841KIAA1841KIAA1841 proteinSource|GeneCards
CBLN1CBLN1cerebellin 1 precursorSource|GeneCards
ARHGEF12ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12Source|GeneCards
PLAGL2PLAGL2pleiomorphic adenoma gene-like 2Source|GeneCards
CDK9CDK9cyclin-dependent kinase 9 (CDC2-related kinase)Source|GeneCards
FLJ10700FLJ10700hypothetical protein FLJ10700Source|GeneCards
FLJ32011FLJ32011hypothetical protein FLJ32011Source|GeneCards
UBTFUBTFupstream binding transcription factor, RNA polymerase ISource|GeneCards
NEUROD6NEUROD6neurogenic differentiation 6Source|GeneCards
C17ORF27C17ORF27chromosome 17 open reading frame 27Source|GeneCards
MAML3MAML3Mastermind-like 3 (Drosophila)Source|GeneCards
GPP34RGOLPH3Lgolgi phosphoprotein 3-likeSource|GeneCards
GSK3BGSK3Bglycogen synthase kinase 3 betaSource|GeneCards
RGS19IP1RGS19IP1regulator of G-protein signalling 19 interacting protein 1Source|GeneCards
MNTMNTMAX binding proteinSource|GeneCards
POLR1DPOLR1Dpolymerase (RNA) I polypeptide D, 16kDaSource|GeneCards
RORARORARAR-related orphan receptor ASource|GeneCards
PUNCPUNCputative neuronal cell adhesion moleculeSource|GeneCards
FGF5FGF5fibroblast growth factor 5Source|GeneCards
ACTA1ACTA1actin, alpha 1, skeletal muscleSource|GeneCards
LOC51057LOC51057hypothetical protein LOC51057Source|GeneCards
DNAL4DNAL4dynein, axonemal, light polypeptide 4Source|GeneCards
TNNC2TNNC2troponin C2, fastSource|GeneCards
CDC27CDC27cell division cycle 27Source|GeneCards
LNKLNKlymphocyte adaptor proteinSource|GeneCards
HOXC13HOXC13homeo box C13Source|GeneCards
CREB3L2CREB3L2cAMP responsive element binding protein 3-like 2Source|GeneCards
TLK1TLK1tousled-like kinase 1Source|GeneCards
CDC40CDC40cell division cycle 40 homolog (yeast)Source|GeneCards
ACTCACTCactin, alpha, cardiac muscleSource|GeneCards
FLJ10597C1ORF164chromosome 1 open reading frame 164Source|GeneCards
POLD4POLD4polymerase (DNA-directed), delta 4Source|GeneCards
ARL3ARL3ADP-ribosylation factor-like 3Source|GeneCards
KDELR2KDELR2KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2Source|GeneCards
SYNJ1SYNJ1synaptojanin 1Source|GeneCards
FBXO24FBXO24F-box only protein 24Source|GeneCards
FLNCFLNCfilamin C, gamma (actin binding protein 280)Source|GeneCards
SENP1SENP1sentrin/SUMO-specific proteaseSource|GeneCards
MYH10MYH10myosin, heavy polypeptide 10, non-muscleSource|GeneCards
SESN3SESN3sestrin 3Source|GeneCards
LOC128153LOC128153hypothetical protein BC014608Source|GeneCards
ICA1ICA1islet cell autoantigen 1, 69kDaSource|GeneCards
PTDSRPTDSRphosphatidylserine receptorSource|GeneCards
ERBB2ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)Source|GeneCards
PHF15PHF15PHD finger protein 15Source|GeneCards
BIRC4BIRC4baculoviral IAP repeat-containing 4Source|GeneCards
UBE2D3UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)Source|GeneCards
FXR2FXR2fragile X mental retardation, autosomal homolog 2Source|GeneCards
C10ORF69SPFH1SPFH domain family, member 1Source|GeneCards
C20ORF67C20ORF67chromosome 20 open reading frame 67Source|GeneCards
FLJ45187FLJ45187FLJ45187 proteinSource|GeneCards
SRFSRFserum response factor (c-fos serum response element-binding transcription factor)Source|GeneCards
STAG2STAG2stromal antigen 2Source|GeneCards
ZFXZFXzinc finger protein, X-linkedSource|GeneCards
CALCRCALCRcalcitonin receptorSource|GeneCards
LIG1LIG1ligase I, DNA, ATP-dependentSource|GeneCards
ZBTB4ZBTB4zinc finger and BTB domain containing 4Source|GeneCards
POLR2APOLR2Apolymerase (RNA) II (DNA directed) polypeptide A, 220kDaSource|GeneCards
VCIP135VCPIP1valosin containing protein (p97)/p47 complex interacting protein 1Source|GeneCards
GAB2GAB2GRB2-associated binding protein 2Source|GeneCards
EPHA1EPHA1EphA1Source|GeneCards
DET1DET1de-etiolated homolog 1 (Arabidopsis)Source|GeneCards
SH3GL3SH3GL3SH3-domain GRB2-like 3Source|GeneCards
ARID1AARID1AAT rich interactive domain 1A (SWI- like)Source|GeneCards
PTCH2PTCH2patched homolog 2 (Drosophila)Source|GeneCards
FLJ10330PRPF38BPRP38 pre-mRNA processing factor 38 (yeast) domain containing BSource|GeneCards
HIC2HIC2hypermethylated in cancer 2Source|GeneCards
CASKIN2CASKIN2CASK interacting protein 2Source|GeneCards
MGC9850MGC9850hypothetical protein MGC9850Source|GeneCards
BCORBCORBCL6 co-repressorSource|GeneCards
FLJ21870C2ORF26chromosome 2 open reading frame 26Source|GeneCards
ZA20D1ZA20D1zinc finger, A20 domain containing 1Source|GeneCards
NR2F1NR2F1nuclear receptor subfamily 2, group F, member 1Source|GeneCards
FLJ31951FLJ31951hypothetical protein FLJ31951Source|GeneCards
PRPF4BPRPF4BPRP4 pre-mRNA processing factor 4 homolog B (yeast)Source|GeneCards
ZNF143ZNF143zinc finger protein 143 (clone pHZ-1)Source|GeneCards
TRAF4TRAF4TNF receptor-associated factor 4Source|GeneCards
DKFZP566B183NECAP1adaptin-ear-binding coat-associated protein 1Source|GeneCards
RAB11ARAB11ARAB11A, member RAS oncogene familySource|GeneCards
CDH16CDH16cadherin 16, KSP-cadherinSource|GeneCards
POFUT1POFUT1protein O-fucosyltransferase 1Source|GeneCards
POU3F3POU3F3POU domain, class 3, transcription factor 3Source|GeneCards
CACNG3CACNG3calcium channel, voltage-dependent, gamma subunit 3Source|GeneCards
HMGN3HMGN3high mobility group nucleosomal binding domain 3Source|GeneCards
FLJ13273FLJ13273hypothetical protein FLJ13273Source|GeneCards
RAB33ARAB33ARAB33A, member RAS oncogene familySource|GeneCards
WNT2WNT2wingless-type MMTV integration site family member 2Source|GeneCards
DMDDMDdystrophin (muscular dystrophy, Duchenne and Becker types)Source|GeneCards
PAIP2PAIP2poly(A) binding protein interacting protein 2Source|GeneCards
RAPGEFL1RAPGEFL1Rap guanine nucleotide exchange factor (GEF)-like 1Source|GeneCards
PRKCEPRKCEprotein kinase C, epsilonSource|GeneCards
CKLFSF5CKLFSF5chemokine-like factor super family 5Source|GeneCards
FLJ36268FLJ36268FLJ36268 proteinSource|GeneCards
RNF12RNF12ring finger protein 12Source|GeneCards
BMPR2BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)Source|GeneCards
WASF1WASF1WAS protein family, member 1Source|GeneCards
CALD1CALD1caldesmon 1Source|GeneCards
RFX4RFX4regulatory factor X, 4 (influences HLA class II expression)Source|GeneCards
FXC1FXC1fracture callus 1 homolog (rat)Source|GeneCards
TCF7L2TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Source|GeneCards
SYTL2SYTL2synaptotagmin-like 2Source|GeneCards
LOC168850LOC168850hypothetical protein LOC168850Source|GeneCards
MAP3K5MAP3K5mitogen-activated protein kinase kinase kinase 5Source|GeneCards
DLX1DLX1distal-less homeo box 1Source|GeneCards
HPCAHPCAhippocalcinSource|GeneCards
ATP5G2ATP5G2ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 2Source|GeneCards
FLJ40125FLJ40125hypothetical protein FLJ40125Source|GeneCards
MMP23AMMP23Amatrix metalloproteinase 23ASource|GeneCards
EIF4G2EIF4G2eukaryotic translation initiation factor 4 gamma, 2Source|GeneCards
C20ORF112C20ORF112chromosome 20 open reading frame 112Source|GeneCards
BAHD1BAHD1bromo adjacent homology domain containing 1Source|GeneCards
CDK5R2CDK5R2cyclin-dependent kinase 5, regulatory subunit 2 (p39)Source|GeneCards
NRG1NRG1neuregulin 1Source|GeneCards
PACSIN3PACSIN3protein kinase C and casein kinase substrate in neurons 3Source|GeneCards
THRATHRAthyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)Source|GeneCards
RORCRORCRAR-related orphan receptor CSource|GeneCards
MAFMAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)Source|GeneCards
EIF4EEIF4Eeukaryotic translation initiation factor 4ESource|GeneCards
FLJ45950FLJ45950FLJ45950 proteinSource|GeneCards
FLJ38348FLJ38348hypothetical protein FLJ38348Source|GeneCards
HOXA10HOXA10homeo box A10Source|GeneCards
GPATC2GPATC2G patch domain containing 2Source|GeneCards
LNX2LNX2ligand of numb-protein X 2Source|GeneCards
DKFZP547K1113DKFZP547K1113hypothetical protein DKFZp547K1113Source|GeneCards
ARF6ARF6ADP-ribosylation factor 6Source|GeneCards
LOC374920LOC374920hypothetical protein LOC374920Source|GeneCards
RTN2RTN2reticulon 2Source|GeneCards
SFXN2SFXN2sideroflexin 2Source|GeneCards
SEN54LTSEN54tRNA splicing endonuclease 54 homolog (SEN54, S. cerevisiae)Source|GeneCards
BTBD1BTBD1BTB (POZ) domain containing 1Source|GeneCards
NRF1NRF1nuclear respiratory factor 1Source|GeneCards
PDZRN4PDZRN4PDZ domain containing RING finger 4Source|GeneCards
ASXL1ASXL1additional sex combs like 1 (Drosophila)Source|GeneCards
PGFPGFplacental growth factor, vascular endothelial growth factor-related proteinSource|GeneCards
IL11RAIL11RAinterleukin 11 receptor, alphaSource|GeneCards
SEPT10SEPT10septin 10Source|GeneCards
RKHD3RKHD3ring finger and KH domain containing 3Source|GeneCards
NCOA6NCOA6nuclear receptor coactivator 6Source|GeneCards
LRCH4LRCH4leucine-rich repeats and calponin homology (CH) domain containing 4Source|GeneCards
SCNN1ASCNN1Asodium channel, nonvoltage-gated 1 alphaSource|GeneCards
FLJ21308PARP8Poly (ADP-ribose) polymerase family, member 8Source|GeneCards
CCL20CCL20chemokine (C-C motif) ligand 20Source|GeneCards
TNFAIP8TNFAIP8tumor necrosis factor, alpha-induced protein 8Source|GeneCards
MMP23BMMP23Bmatrix metalloproteinase 23BSource|GeneCards

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