XX
XX
XX
FA Pax-5
XX
SY BSAP; Pax-5; B-cell
specific activator protein; PAX5; mPax5; mPax-5.
XX
OS
mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata;
vertebrata; tetrapoda; mammalia;
OC eutheria; rodentia; myomorpha;
muridae; murinae
XX
XX
HO TSAP (sea urchin)
XX
CL C0017; paired; 3.2.2.0.3.
XX
SZ 391 AA; 42.2 kDa (cDNA),
50 kDa (SDS) [8]
XX
XX
SC SwissProt #Q02650
XX
FT 16 141 paired domain.
FT 16 140 PF00292; PAX.
FT 16
140 SM00351; PAX.
FT 179 186 conserved octapeptide.
XX
SF a few differences within the paired domains determine different
DNA-binding
SF sequence specificities between Pax-5 and Pax-6
[2]
XX
CP (pro-, pre-, mature B cells)
XX
FF required
for B-cell development [5];
FF represses Ig 3'alpha enhancer
by preventing binding of an activator [3];
FF also required
for correct early development of posterior midbrain [5];
FF
expression positively regulated by E2A genes [4];
FF Pax-2,
Pax-5 and Pax-8 show overlapping expression with the engrailed
genes
FF and bind as activators to the En-2 5' enhancer [1];
XX
XX
XX
XX
RN [1]; RE0014313.
RX MEDLINE;
96189352.
RA Song D. L., Chalepakis G., Gruss P., Joyner A.
L.
RT Two Pax-binding sites are required for early embryonic
brain expression of
RT an Engrailed-2 transgene
RL Development
122:627-635 (1996).
RN [2]; RE0004263.
RX MEDLINE; 95257968.
RA Czerny T., Busslinger M.
RT DNA-binding and transactivation
properties of Pax-6: three amino acids in
RT the paired domain
are responsible for the different sequence recognition of
RT Pax-6 and BSAP (Pax-5)
RL Mol. Cell. Biol. 15:2858-2871
(1995).
RN [3]; RE0004295.
RX MEDLINE; 95296305.
RA
Neurath M. F., Max E. E., Strober W.
RT Pax5 (BSAP) regulates
the mrine immunoglobulin 3'a enhancer by suppressing
RT binding
of NF-aP, a protein that controls heavy chain transcription
RL Proc. Natl. Acad. Sci. USA 92:5336-5340 (1995).
RN [4];
RE0004022.
RX MEDLINE; 95094259.
RA Bain G., Maandag E.
C. R., Izon D. J., Amsen D., Kruisbeek A. M., Weintraub
RA
B. C., Krop I., Schlissel M. S., Feeney A. J., van Roon M., van
der Falk
RA M., te Riele H. P. J., Berns A., Murre C.
RT E2A proteins are required for proper B cell development and
initiation of
RT immunoglobulin gene rearrangements
RL
Cell 79:885-892 (1994).
RN [5]; RE0004294.
RX MEDLINE;
95094261.
RA Urbanek P., Wang Z.-Q., Fetka I., Wagner E. F.,
Busslinger M.
RT Complete block of early B cell differentiation
and altered patterning of
RT the posterior midbrain in mice
lacking Pax5/BSAP
RL Cell 79:901-912 (1994).
RN [6]; RE0004279.
RX MEDLINE; 92387536.
RA Adams B., Doerfler P., Aguzzi A.,
Kozmik Z., Urbanek P., Maurer-Fogy I.,
RA Busslinger M.
RT Pax-5 encodes the transcription factor BSAP and is expressed
in B
RT lymphocytes, the developing CNS, and adult testis
RL Genes Dev. 6:1589-1607 (1992).
RN [7]; RE0004257.
RX
MEDLINE; 92120664.
RA Walther C., Guenet J. L., Simon D.,
Deutsch U., Jostes B., Goulding M. D.,
RA Plachov D., Balling
R., Gruss P.
RT Pax: a murine multigene family of paired box-containing
genes
RL Genomics 11:424-434 (1991).
RN [8]; RE0002744.
RX MEDLINE; 90337320.
RA Barberis A., Widenhorn K., Vitelli
L., Busslinger M.
RT A novel B-cell lineage-specific transcription
factor present at early but
RT not late stages of differentiation
RL Genes Dev. 4:849-859 (1990).
XX