XX
XX
XX
FA Sp1
XX
SY Sp1; simian-virus-40-protein-1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa;
chordata; vertebrata; tetrapoda; mammalia;
OC eutheria; primates
XX
XX
CL C0001; CH; 2.3.1.0.2.
XX
SZ >696 AA;
105+95 kDa (SDS)
XX
XX
SC translated from EMBL #J03133
XX
FT 57 162 Q-rich region (23/106), domain A [52], necessary
for
FT synergistic activation [4].
FT 67 124 PS50322;
GLN_RICH_1.
FT 263 405 Q-rich region (39/143), domain B, important
for
FT multimerization [52].
FT 263 391 PS50322; GLN_RICH_2.
FT 304 485 important for direct interaction with Oct-1 [3].
FT 471 537 charged region, domain C [52]; essential for synergistic
DNA
FT binding along with SREBP-1 [4].
FT 537 561 PF00096;
zf-C2H2.
FT 537 561 SM00355; ZnF_C2H2.
FT 539 561 zinc
finger 1.
FT 539 696 interaction with YY1 [9].
FT 567
591 PF00096; zf-C2H2.
FT 567 591 SM00355; ZnF_C2H2.
FT
569 591 zinc finger 2.
FT 597 619 SM00355; ZnF_C2H2.
FT
597 619 PF00096; zf-C2H2.
FT 599 619 zinc finger 3.
FT
620 696 domain D, required for synergism [20] [4].
XX
SF Q-rich activation domain may mediate self-aggregation [7];
SF S/T-rich stretch [6];
SF base contacts arise from the second
and the third zinc fingers [10];
SF Zn2+ can be substituted
for Cd2+, Co2+, less favourable: Mn2+, Ni2+;
SF thionein inhibits
DNA-binding;
SF Kd 0.41-0.53 nM;
SF t1/2 for binding to
and dissociation from DNA < 1 min;
SF phosphorylation (DNA-dependent
protein kinase);
SF homology to factors SP3 and SP4
[12];
SF possibly glycosylated [8];
SF interacts
with NF-kappaB by its trans-acting domain when bound to an
SF adjacent site [6];
SF interacts secies-specifically with
human, but not with Drosophila TFIID
SF complex [2];
XX
CP (HeLa); ubiquitous [14]
XX
FF multimerization leads
to superactivation;
FF effect of Sp1-sites depends on distance
to TATA-box [22];
FF synergistically cooperates with E2 at
BPV promoters [17];
FF highly specific cooperation with NF-kappaB
[6];
FF binding inhibited by formation of triple-stranded
structures [13];
FF binds to its site even when reconstituted
into nucleosome cores [7];
FF affinity for nucleosomal DNA
is reduced relative to naked DNA [7];
XX
IN T00205; E2;
BPV-1, bovine papilloma virus type 1.
IN T00590; NF-kappaB;
human, Homo sapiens.
IN T02375; NS-1; MVM(p), minute virus
of mice.
IN T01486; p107; human, Homo sapiens.
IN T00759;
Sp1; human, Homo sapiens.
IN T02121; TAF(II)110; fruit fly,
Drosophila melanogaster.
IN T02328; TAF(II)135; human, Homo
sapiens.
IN T00782; TAF(II)55; human, Homo sapiens.
IN
T00794; TBP; human, Homo sapiens.
IN T00795; TBP; fission
yeast, Schizosaccharomyces pombe.
IN T00796; TBP; mouse, Mus
musculus.
IN T00797; TBP; fruit fly, Drosophila melanogaster.
IN T00798; TBP; yeast, Saccharomyces cerevisiae.
IN T02399;
Vpr; HIV-1, human immunodeficiency virus type 1.
IN T00915;
YY1; human, Homo sapiens.
XX
XX
XX
XX
RN [1];
RE0006859.
RX MEDLINE; 98108022.
RA Emami K. H., Burke
T. W., Smale S. T.
RT Sp1 activation of a TATA-less promoter
requires a species-specific
RT interaction involving transcription
factor IID
RL Nucleic Acids Res. 26:839-846 (1998).
RN
[2]; RE0006858.
RX MEDLINE; 98088918.
RA Ton-That H.,
Kaestner K. H., Shields J. M., Mahatanankoon C. S., Yang V. W.
RT Expression of the gut-enriched Krueppel-like factor gene during
development
RT and intestinal tumorigenesis
RL FEBS Lett.
419:239-243 (1997).
RN [3]; RE0006546.
RX MEDLINE; 96251075.
RA Stroem A.-C., Forsberg M., Lillhager P., Westin G.
RT The
transcription factors Sp1 and Oct-1 interact physically to regulate
RT human U2 snRNA gene expression
RL Nucleic Acids Res. 24:1981-1986
(1996).
RN [4]; RE0006739.
RX MEDLINE; 95320223.
RA
Yieh L., Sanchez H. B., Osborne T. F.
RT Domains of transcription
factor Sp1 required for synergistic activation
RT with sterol
regulatory element binding protein 1 of low density lipoprotein
RT receptor promoter
RL Proc. Natl. Acad. Sci. USA 92:6102-6106
(1995).
RN [5]; RE0001710.
RX MEDLINE; 94158831.
RA
Emili A., Greenblatt J., Ingles C. J.
RT Species-specific
interaction of the glutamine-rich acitvation domains of
RT
Sp1 with the TATA box-binding protein
RL Mol. Cell. Biol.
14:1582-1593 (1994).
RN [6]; RE0006654.
RX MEDLINE; 95098605.
RA Majello B., de Luca P., Hagen G., Suske G., Lania L.
RT
Different members of the Sp1 multigene family exert opposite
RT transcriptional regulation of the long terminal repeat of HIV-1
RL Nucleic Acids Res. 22:4914-4921 (1994).
RN [7]; RE0006663.
RX MEDLINE; 94171813.
RA Li B., Adams C. C., Workman J. L.
RT Nucleosome binding by the constitutive transcription factor
Sp1
RL J. Biol. Chem. 269:7756-7763 (1994).
RN [8]; RE0006574.
RX MEDLINE; 93314966.
RA Geiser A. G., Busam K. J., Kim S.-J.,
Lafyatis R., O'Reilly M. A., Webbink
RA R., Roberts A. B.,
Sporn M. B.
RT Regulation of the transforming growth factor-beta1
and -beta3 promoters by
RT transcription factor Sp1
RL
Gene 129:223-228 (1993).
RN [9]; RE0006591.
RX MEDLINE;
93317640.
RA Lee J.-S., Galvin K. M., Shi Y.
RT Evidence
for physical interaction between the zinc-finger transcription
RT factors YY1 and Sp1
RL Proc. Natl. Acad. Sci. USA 90:6145-6149
(1993).
RN [10]; RE0006637.
RX MEDLINE; 93356835.
RA Nagaoka M., Kuwahara J., Sugiura Y.
RT Alteration of DNA
binding specificity by nickel (II) substitution in three
RT
zinc (II) fingers of transcription factor Sp1.
RL Biochem.
Biophys. Res. Commun. 194:1515-1520 (1993).
RN [11]; RE0002242.
RX MEDLINE; 92366166.
RA Chen X., Azizkhan J. C., Lee D. C.
RT The binding of transcription factor SP1 to multiple sites is
required for
RT maximal expression from the rat transforming
growth factor alpha promoter
RL Oncogene 7:1805-1815 (1992).
RN [12]; RE0006538.
RX MEDLINE; 93087156.
RA Hagen G.,
Muller S., Beato M., Suske G.
RT Cloning by recognition site
screening of two novel GT box binding proteins:
RT a familiy
of Sp1 related genes
RL Nucleic Acids Res. 20:5519-5525 (1992).
RN [13]; RE0006549.
RX MEDLINE; 92283818.
RA Gee J. E.,
Blume S., Snyder R. C., Ray R., Miller D. M.
RT Triplex formation
prevents Sp1 binding to the dihydrofolate resuctase
RT promoter
RL J. Biol. Chem. 267:11163-11167 (1992).
RN [14]; RE0006565.
RX MEDLINE; 92307657.
RA Avraham K. B., Prezioso V. R., Chen
W. S., Lai E., Sladek F. M., Zhong W.,
RA Darnell jr J. E.,
Jenkins N. A., Copeland N. G.
RT Murine Chromosomal Location
of Four Hepatocyte-Enriched Transcription
RT Factors: HNF-3alpha,
HNF-3beta, HNF-3gamma, and HNF-4
RL Genomics 13:264-268 (1992).
RN [15]; RE0000010.
RX MEDLINE; 91151370.
RA Thiesen H.-J.,
Schroeder B.
RT Amino acid substitutions in the Sp1 zinc finger
domain alter the DNA
RT binding affinity to cognate Sp1 target
site
RL Biochem. Biophys. Res. Commun. 175:333-338 (1991).
RN [16]; RE0000011.
RX MEDLINE; 91222214.
RA Thiesen H.-J.,
Bach C.
RT Transition metals modulate DNA-protein interactions
of Sp1 zinc finger
RT domains with its cognate target site
RL Biochem. Biophys. Res. Commun. 176:551-557 (1991).
RN [17];
RE0000237.
RX MEDLINE; 91208686.
RA Li R., Knight J. D.,
Jackson S. P., Tijan R., Botchan M. R.
RT Direct interaction
between Sp1 and the BPV Enhancer E2 protein mediates
RT synergistic
activation of transcription
RL Cell 65:493-505 (1991).
RN [18]; RE0000581.
RX MEDLINE; 91160740.
RA Zeng J.,
Heuchel R., Schaffner W., Kaegi J. H. R.
RT Thionein (apometallothionein)
can modulate DNA binding and transcription
RT activation by
zinc finger containing factor Sp1
RL FEBS Lett. 279:310-312
(1991).
RN [19]; RE0000693.
RX MEDLINE; 91224491.
RA Su W., Jackson S., Tjian R., Echols H.
RT DNA looping between
site for transcriptional activation: self-association
RT of
DNA-bound Sp1
RL Genes Dev. 5:820-826 (1991).
RN [20];
RE0000707.
RX MEDLINE; 91357479.
RA Pascal E., Tjian R.
RT Different activation domains of Sp1 govern formation of multimers
and
RT mediate transcriptional synergism
RL Genes Dev.
5:1646-1656 (1991).
RN [21]; RE0000708.
RX MEDLINE; 91224491.
RA Su W., Jackson S., Tjian R., Echols H.
RT DNA looping between
site for transcriptional activation: self-association
RT of
DNA-bound Sp1
RL Genes Dev. 5:820-826 (1991).
RN [22];
RE0000929.
RX MEDLINE; 92041874.
RA Segal R., Berk A.
J.
RT Promoter activity and distance constraints of one versus
two Sp1 binding
RT sites
RL J. Biol. Chem. 266:20406-20411
(1991).
RN [23]; RE0001001.
RX MEDLINE; 91250433.
RA Kagawa N., Waterman M. R.
RT Evidence that an adrenal-specific
nuclear protein regulates the cAMP
RT responsiveness of the
human CYP21B (P450C21) gene
RL J. Biol. Chem. 266:11199-11204
(1991).
RN [24]; RE0001013.
RX MEDLINE; 91139695.
RA Araki E., Murakami T., Shirotani T., Kanai F., Shinohara Y.,
Shimada F.,
RA Mori M., Shichiri M., Ebina Y.
RT A cluster
of four Sp1 binding sites required for efficient expression of
RT the human insulin receptor gene
RL J. Biol. Chem. 266:3944-3948
(1991).
RN [25]; RE0001022.
RX MEDLINE; 91224987.
RA Yu C.-Y., Motamed K., Chen J., Bailey A. D., Shen C.-K. J.
RT The CACC box upstream of human embryonic epsilon globin gene
binds Sp1 and
RT is a functional promoter element in vitro
and in vivo
RL J. Biol. Chem. 266:8907-8915 (1991).
RN
[26]; RE0001495.
RX MEDLINE; 91172208.
RA Saffer J. D.,
Jackson S. P., Annarella M. B.
RT Developmental expression
of Sp1 in the mouse
RL Mol. Cell. Biol. 11:2189-2199 (1991).
RN [27]; RE0001611.
RX MEDLINE; 91172211.
RA Spanopoulou
E., Giguere V., Grosveld F.
RT The functional domains of the
murine Thy-1 gene promoter
RL Mol. Cell. Biol. 11:2216-2228
(1991).
RN [28]; RE0001615.
RX MEDLINE; 91172179.
RA Anderson G. M., Freytag S. O.
RT Synergistic activation
of a human promoter in vivo by transcription factor
RT Sp1
RL Mol. Cell. Biol. 11:1935-1943 (1991).
RN [29]; RE0001890.
RX MEDLINE; 91095025.
RA Nardelli J., Gibson T. J., Vesque
C., Charnay P.
RT Base sequence discrimination by zinc-finger
DNA-binding domains
RL Nature 349:175-178 (1991).
RN [30];
RE0002428.
RX MEDLINE; 91288526.
RA Mastrangelo I. A.,
Courey A. J., Wall J. S., Jackson S. P., Hough P. V. C.
RT
DNA looping and Sp1 multimer links: a mechanism for transcriptional
RT synergism and enhancement
RL Proc. Natl. Acad. Sci. USA
88:5670-5674 (1991).
RN [31]; RE0002466.
RX MEDLINE; 91142131.
RA Dou Q.-P., Fridovich-Keil J. L., Pardee A. B.
RT Inducible
proteins binding to the murine thymidine kinase promoter in late
RT G1/S phase
RL Proc. Natl. Acad. Sci. USA 88:1157-1161 (1991).
RN [32]; RE0000182.
RX MEDLINE; 91004214.
RA Jackson S.
P., MacDonald J. J., Lees-Miller S., Tjian R.
RT GC box binding
induces phosphorylation by a DNA-dependent protein kinase
RL Cell 63:155-165 (1990).
RN [33]; RE0000197.
RX MEDLINE;
91004214.
RA Jackson S. P., MacDonald J. J., Lees-Miller S.,
Tjian R.
RT GC box binding induces phosphorylation by a DNA-dependent
protein kinase
RL Cell 63:155-165 (1990).
RN [34]; RE0000691.
RX MEDLINE; 91065526.
RA Sartorelli V., Webster K. A., Kedes
L.
RT Muscle-specific expression of the cardiac alpha-actin
gene requires MyoD1,
RT CArG-box binding factor, and Sp1
RL Genes Dev. 4:1811-1822 (1990).
RN [35]; RE0000692.
RX MEDLINE; 90299136.
RA Saffer J. D., Jackson S. P., Thurston
S. J.
RT SV40 stimulates expression of the trans-acting factor
Sp1 at the mRNA level
RL Genes Dev. 4:659-666 (1990).
RN [36]; RE0000988.
RX MEDLINE; 91056103.
RA Boyer T.
G., Maquat L. E.
RT Minimal sequence and factor requirements
for the initiation of
RT transcription from an atypical, TATATAA
box-containing housekeeping promoter
RL J. Biol. Chem. 265:20524-20532
(1990).
RN [37]; RE0001271.
RX MEDLINE; 90205866.
RA Lemaigre F. P., Lafontaine D. A., Courtois S. J., Durviaux
S. M., Rousseau
RA G. G.
RT Sp1 can displace GHF-1 from
its distal binding site and stimulate
RT transcription from
the growth hormone gene promoter
RL Mol. Cell. Biol. 10:1811-1814
(1990).
RN [38]; RE0001437.
RX MEDLINE; 90097868.
RA Sykes K., Kaufman R.
RT A Naturally Occurring Gamma Globin
Gene Mutation Enhances SP1 Binding
RT Activity
RL Mol.
Cell. Biol. 10:95-102 (1990).
RN [39]; RE0002113.
RX MEDLINE;
90287694.
RA Thiesen H.-J., Bach C.
RT Target detection
assay (TDA): a versatile procedure to determine DNA
RT binding
sites as demonstrated on SP1 protein
RL Nucleic Acids Res.
18:3202-3209 (1990).
RN [40]; RE0000196.
RX MEDLINE; 90075227.
RA Courey A. J., Holtzman D. A., Jackson S. P., Tjian R.
RT
Synergistic activation by the glutamine-rich domains of human
transcription
RT factor Sp1
RL Cell 59:827-836 (1989).
RN [41]; RE0000883.
RX MEDLINE; 90037078.
RA Kim S.-J.,
Denhez F., Kim K. Y., Holt J. T., Sporn M. B., Roberts A. B.
RT Activation of the Second Promoter of the Transforming Growth
Factor-beta1
RT Gene by Transforming Growth Factor-beta1 and
Phorbol Ester Occurs through
RT the Same Target Sequences
RL J. Biol. Chem. 264:19373-19378 (1989).
RN [42]; RE0000899.
RX MEDLINE; 89340553.
RA Evans M. J., Scarpulla R. C.
RT Interaction of Nuclear Factors with Multiple Sites in the Somatic
RT Cytochrome c Promoter
RL J. Biol. Chem. 264:14361-14368
(1989).
RN [43]; RE0001025.
RX MEDLINE; 89278150.
RA Miralles V. J., Cortes P., Stone N., Reinberg D.
RT The
adenovirus inverted terminal repeat functions as an enhancer in
a
RT cell-free system
RL J. Biol. Chem. 264:10763-10772
(1989).
RN [44]; RE0001374.
RX MEDLINE; 90014780.
RA Gustafson T. A., Kedes L.
RT Identification of Multiple
Proteins That Interact with Functional Regions
RT of the Human
Cardiac alpha-Actin Promoter
RL Mol. Cell. Biol. 9:3269-3283
(1989).
RN [45]; RE0001375.
RX MEDLINE; 90014783.
RA Schmidt M. C., Zhou Q., Berk A. J.
RT Sp1 Activates Transcription
without Enhancing DNA-Binding Activity of the
RT TATA Box
Factor
RL Mol. Cell. Biol. 9:3299-3307 (1989).
RN [46];
RE0001383.
RX MEDLINE; 89384647.
RA Morgan W. D.
RT
Transcriptional Factor Sp1 Binds to and Activates a Human hsp70
Gene
RT Promoter
RL Mol. Cell. Biol. 9:4099-4104 (1989).
RN [47]; RE0002041.
RX MEDLINE; 89240024.
RA Letovsky
J., Dynan W. S.
RT Measurement of the binding of transcription
factor Sp1 to a single GC box
RT recognition sequence
RL Nucleic Acids Res. 17:2639-2653 (1989).
RN [48]; RE0002053.
RX MEDLINE; 90067825.
RA Hughes M. J., Jost J.-P.
RT The
ubiquitous nuclear protein, NHP1, binds with high affinity to
different
RT sequences of the chicken vitellogenin II gene
RL Nucleic Acids Res. 17:8511-8520 (1989).
RN [49]; RE0002066.
RX MEDLINE; 90098860.
RA Ben-Hattar J., Beard P., Jiricny
J.
RT Cytosine methylation in CTF and Sp1 recognition sites
of an HSV tk
RT promoter: effects on transcription in vivo
and on factor binding in vitro
RL Nucleic Acids Res. 17:10179-10190
(1989).
RN [50]; RE0002067.
RX MEDLINE; 90098865.
RA Ronchi A., Nicolis S., Santoro C., Ottolenghi S.
RT Increased
Sp1 binding mediates erythroid-specific overexpression of a
RT mutated (HPFH) gamma-globulin promoter
RL Nucleic Acids
Res. 17:10231-10241 (1989).
RN [51]; RE0000101.
RX MEDLINE;
89051877.
RA Angel P., Hattori K., Smeal T., Karin M.
RT The jun proto-oncogene is positively autoregulated by its product,
Jun/AP-1
RL Cell 55:875-885 (1988).
RN [52]; RE0000121.
RX MEDLINE; 89051878.
RA Courey A. J., Tjian R.
RT Analysis
of Sp1 in vivo reveals multiple transcriptional domains, including
RT a novel glutamine-rich activation motif
RL Cell 55:887-898
(1988).
RN [53]; RE0000380.
RX MEDLINE; 89091123.
RA Westin G., Schaffner W.
RT A zinc-responsive factor interacts
with a metal-regulated enhancer element
RT (MRE) of the mouse
metallothionein-I gene
RL EMBO J. 7:3763-3770 (1988).
RN [54]; RE0000817.
RX MEDLINE; 88228059.
RA Smith J.
D., Melian A., Leff T., Breslow J. L.
RT Expression of the
Human Apolipoprotein E Gene is Regulated by Multiple
RT Positive
and Negative Elements
RL J. Biol. Chem. 263:8300-8308 (1988).
RN [55]; RE0000818.
RX MEDLINE; 88330840.
RA Paik Y.-K.,
Chang D. J., Reardon C. A., Walker M. D., Taxman E., Taylor J.
RA M.
RT Identification and Characterization of Transcriptional
Regulatory Regions
RT Associated with Expression of the Human
Apolipoprotein E Gene
RL J. Biol. Chem. 263:13340-13349 (1988).
RN [56]; RE0001242.
RX MEDLINE; 89039842.
RA Johnson A.
C., Jinno Y., Merlino G. T.
RT Modulation of Epidermal Growth
Factor Receptor Proto-Oncogene Transcription
RT by a promoter
Site Sensitive to S1 Nuclease
RL Mol. Cell. Biol. 8:4174-4184
(1988).
RN [57]; RE0001953.
RX MEDLINE; 88335604.
RA Dush M. K., Briggs M. R., Royce M. E., Schaff D. A., Khan S.
A., Tischfeld
RA J. A., Stambrook P. J.
RT Identification
of DNA sequences required for mouse APRT gene expression
RL
Nucleic Acids Res. 16:8509-8524 (1988).
RN [58]; RE0002025.
RX MEDLINE; 88289333.
RA Westin G., Schaffner W.
RT Heavy
metal ions in transcription factors from HeLa cells: Sp1, but
not
RT octamer transcription factor requires zinc for DNA
binding and for
RT activator functions
RL Nucleic Acids
Res. 16:5771-5781 (1988).
RN [59]; RE0002324.
RX MEDLINE;
88176887.
RA Harrington M., Jones P. A., Imagawa M., Karin
M.
RT Cytosine methylation does not affect binding of transcription
factor Sp1
RL Proc. Natl. Acad. Sci. USA 85:2066-2070 (1988).
RN [60]; RE0000105.
RX MEDLINE; 87301729.
RA Mitchell
P., Wang C., Tjian R.
RT Positive and Negative Regulation
of Transcription In Vitro:
RT Enhancer-Binding Protein AP-2
Is Inhibited by SV40 T Antigen
RL Cell 50:847-861 (1987).
RN [61]; RE0000138.
RX MEDLINE; 88080466.
RA Kadonaga
J. T., Carner K. R., Masiarz F. R., Tjian R.
RT Isolation
of cDNA encoding transcription factor Sp1 and functional analysis
RT of the DNA binding domain
RL Cell 51:1079-1090 (1987).
RN [62]; RE0000354.
RX MEDLINE; 88111565.
RA Garcia J.
A., Wu F. K., Mitsuyasu R., Gaynor R. B.
RT Interaction of
cellular proteins involved in the transcriptional regulation
RT of the human immunodeficiency virus
RL EMBO J. 6:3761-3770
(1987).
RN [63]; RE0001283.
RX MEDLINE; 88065503.
RA Greene J. M., Larin Z., Taylor I. C. A., Prentice H., Gwinn
K. A., Kingston
RA R. E.
RT Multiple Basal Elements of
a Human hsp70 Promoter Function Differently in
RT Human and
Rodent Cell Lines
RL Mol. Cell. Biol. 7:3646-3655 (1987).
RN [64]; RE0001813.
RX MEDLINE; 87115798.
RA Lee W., Haslinger
A., Karin M., Tjian R.
RT Activation of transcription by two
factors that bind promoter and enhancer
RT sequences of the
human metallothionein gene and SV40
RL Nature 325:368-372
(1987).
RN [65]; RE0002028.
RX MEDLINE; 87259982.
RA Janson L., Bark C., Petterson U.
RT Identification of proteins
interacting with the enhancer of human U2 small
RT nuclear
RNA genes
RL Nucleic Acids Res. 15:4997-5016 (1987).
RN
[66]; RE0001774.
RX MEDLINE; 86118666.
RA Dynan W. S.,
Sazer S., Tjian R., Schimke R. T.
RT Transcription factor
Sp1 recognizes a DNA sequence in the mouse
RT dihydrofolate
reductase promoter
RL Nature 319:246-248 (1986).
RN [67];
RE0002361.
RX MEDLINE; 86205850.
RA Das G. C., Piatigorsky
J.
RT The chicken delta1-crystallin gene promoter: binding
of transcription
RT factor(s) to the upstream G+C-rich region
is necessary for promoter
RT function invitro
RL Proc.
Natl. Acad. Sci. USA 83:3131-3135 (1986).
RN [68]; RE0002606.
RX MEDLINE; 86179897.
RA Jones K. A., Kadonaga J. T., Luciw
P. A., Tjian R.
RT Activation of the AIDS retrovirus promoter
by the cellular transcription
RT factor, Sp1
RL Science
232:755-759 (1986).
RN [69]; RE0002626.
RX MEDLINE; 86235432.
RA Ishii S., Kadonaga J. T., Tjian R., Brady J. N., Merlin G.
T., Pastan I.
RT Binding of the Sp1 Transcription Factor by
the Human Harvey ras1
RT Proto-oncogene Promoter
RL Science
232:1410-1413 (1986).
RN [70]; RE0000126.
RX MEDLINE;
85282613.
RA Jones K. A., Yamamoto K. R., Tjian R.
RT
Two distinct transcription factors that bind to the HSV thymidine
kinase
RT promoter in vitro
RL Cell 42:559-572 (1985).
RN [71]; RE0001798.
RX MEDLINE; 85296380.
RA Jones K.
A., Tjian R.
RT Sp1 binds to promoter sequences and activates
herpes simplex virus
RT 'immediate-early' gene transcription
in vitro
RL Nature 317:179-182 (1985).
RN [72]; RE0002349.
RX MEDLINE; 85270437.
RA Dynan W. S., Safer J. D., Lee W.
S., Tjian R.
RT Transcription factor Sp1 recognizes promoter
sequences from the monkey
RT genome that are similiar to the
simian virus 40 promoter
RL Proc. Natl. Acad. Sci. USA 82:4915-4919
(1985).
RN [73]; RE0002628.
RX MEDLINE; 86018849.
RA Gidoni D., Kadonaga J. T., Barrera-Saldana H., Takahashi K.,
Chambon P.,
RA Tjian R.
RT Bidirectional SV40 transcription
mediated by tandem Sp1 binding interactions
RL Science 230:511-517
(1985).
RN [74]; RE0001823.
RX MEDLINE; 85061571.
RA Gidoni D., Dynan W. S., Tjian R.
RT Multiple specific contacts
between a mammalian transcription factor and its
RT cognate
promoters
RL Nature 312:409-413 (1984).
RN [75]; RE0000122.
RX MEDLINE; 84026540.
RA Dynan W. S., Tjian R.
RT The
Promoter-Specific transcription Factor Sp1 Binds to Upstream Sequences
RT in the Sv40 Early Promoter
RL Cell 35:79-87 (1983).
XX