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Gene set: V$SREBP1_01 (C3:TFAC:0140)
Standard nameV$SREBP1_01
Systematic nameC3:TFAC:0140
Brief descriptionGenes with 3'UTR containing motif NATCACGTGAY which matches annotation for SREBF1: sterol regulatory element binding transcription factor 1
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
XX
XX
FA SREBP-1
XX
SY ADD1.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;
OC eutheria; rodentia; myomorpha; muridae; murinae
XX
CL C0012; bHLH-ZIP; 1.3.1.3.1.
XX
SZ 927 AA; 98.5 kDa (cDNA)
XX
XX
SC translated from EMBL #L16995
XX
FT 294 305 basic region.
FT 294 344 PF00010; HLH.
FT 299 349 SM00353; HLH.
FT 306 344 helix-loop-helix domain.
FT 343 357 leucine zipper (L3) (positions refer to the first Met codon of
FT [2]).
XX
SF the dual DNA-binding specificity is due to Tyr-305 [1]
XX
CP highest expression in brown adipose tissue, low levels in intestine,
CP spleen, skeletal muscle, thymus; nearly undetectable in brain, heart,
CP testis [2]
CN white fat, liver, kidney [2]
XX
FF transcriptional activator, acting through some E-box elements (carbohydrate
FF response element) [2] [1], but also through sterol-regulatory element-1
FF (SRE-1) [1];
FF may play an important role in controlling determination- and
FF differentiation-linked gene expression in adipocytes;
FF 5-fold higher expression in preadipocytes than in undetermined
FF fibroblast-like cells, another 5-fold stimulation upon adipocytic
FF differentiation [2];
XX
XX
XX
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RN [1]; RE0003451.
RX MEDLINE; 95257939.
RA Kim J. B., Spotts G. D., Halvorsen Y.-D., Shih H.-M., Ellenberger T., Towle
RA H. C., Spiegelman B. M.
RT Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino
RT acid in the basic helix-loop-helix domain
RL Mol. Cell. Biol. 15:2582-2588 (1995).
RN [2]; RE0003438.
RX MEDLINE; 93330269.
RA Kim J., Tontonoz P., Spiegelman B.
RT ADD: a novel helix-loop-helix protein associated with adipocyte
RT determination and differentiation
RL Mol. Cell. Biol. 13:4753-4759 (1993).
XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

176 genes, 176 accessions (Toggle view)

AccessionGeneTitleLinks
HSPBAP1HSPBAP1HSPB (heat shock 27kDa) associated protein 1Source|GeneCards
MGC45714MGC45714hypothetical protein MGC45714Source|GeneCards
ATF4ATF4activating transcription factor 4 (tax-responsive enhancer element B67)Source|GeneCards
FEN1FEN1flap structure-specific endonuclease 1Source|GeneCards
TOP3ATOP3Atopoisomerase (DNA) III alphaSource|GeneCards
GTF2H1GTF2H1general transcription factor IIH, polypeptide 1, 62kDaSource|GeneCards
MGC11308MGC11308hypothetical protein MGC11308Source|GeneCards
NIP30NIP30NEFA-interacting nuclear protein NIP30Source|GeneCards
ATP7AATP7AATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)Source|GeneCards
ABRABRactive BCR-related geneSource|GeneCards
HOXB5HOXB5homeo box B5Source|GeneCards
PRKCL1PKN1protein kinase N1Source|GeneCards
ALG1ALG1asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase)Source|GeneCards
HPS3HPS3Hermansky-Pudlak syndrome 3Source|GeneCards
TOPORSTOPORStopoisomerase I binding, arginine/serine-richSource|GeneCards
APEX1APEX1APEX nuclease (multifunctional DNA repair enzyme) 1Source|GeneCards
EME1EME1essential meiotic endonuclease 1 homolog 1 (S. pombe)Source|GeneCards
SIRT1SIRT1sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)Source|GeneCards
FLJ13386FLJ13386hypothetical protein FLJ13386Source|GeneCards
HK2HK2hexokinase 2Source|GeneCards
BDNFBDNFbrain-derived neurotrophic factorSource|GeneCards
GLAGLAgalactosidase, alphaSource|GeneCards
CANXCANXcalnexinSource|GeneCards
HNRNPA3HNRNPA3heterogeneous nuclear ribonucleoprotein A3Source|GeneCards
GSK3BGSK3Bglycogen synthase kinase 3 betaSource|GeneCards
ARPC5ARPC5actin related protein 2/3 complex, subunit 5, 16kDaSource|GeneCards
KIAA1715KIAA1715KIAA1715Source|GeneCards
NGFRAP1NGFRAP1nerve growth factor receptor (TNFRSF16) associated protein 1Source|GeneCards
HPS5HPS5Hermansky-Pudlak syndrome 5Source|GeneCards
KRTAP9-2KRTAP9-2keratin associated protein 9-2Source|GeneCards
C11ORF10C11ORF10chromosome 11 open reading frame 10Source|GeneCards
DRE1KLHL24kelch-like 24 (Drosophila)Source|GeneCards
MGC45400TCEAL8transcription elongation factor A (SII)-like 8Source|GeneCards
DCTN4DCTN4dynactin 4 (p62)Source|GeneCards
ATP6V0D1ATP6V0D1ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1Source|GeneCards
OTOP2OTOP2otopetrin 2Source|GeneCards
KIAA1012KIAA1012KIAA1012 proteinSource|GeneCards
SUPT16HSUPT16Hsuppressor of Ty 16 homolog (S. cerevisiae)Source|GeneCards
SOCS2SOCS2suppressor of cytokine signaling 2Source|GeneCards
ZFYVE26ZFYVE26zinc finger, FYVE domain containing 26Source|GeneCards
MCM2MCM2MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)Source|GeneCards
KIAA1972KIAA1972KIAA1972 proteinSource|GeneCards
RNF146RNF146ring finger protein 146Source|GeneCards
CSRP2BPCSRP2BPCSRP2 binding proteinSource|GeneCards
DUSP8DUSP8dual specificity phosphatase 8Source|GeneCards
MTCH2MTCH2mitochondrial carrier homolog 2 (C. elegans)Source|GeneCards
CHD2CHD2chromodomain helicase DNA binding protein 2Source|GeneCards
SNAI1SNAI1snail homolog 1 (Drosophila)Source|GeneCards
SNX16SNX16sorting nexin 16Source|GeneCards
FLJ20618FLJ20618hypothetical protein FLJ20618Source|GeneCards
SOX10SOX10SRY (sex determining region Y)-box 10Source|GeneCards
COMMD3COMMD3COMM domain containing 3Source|GeneCards
U2AF2U2AF2U2 (RNU2) small nuclear RNA auxiliary factor 2Source|GeneCards
HIVEP1HIVEP1human immunodeficiency virus type I enhancer binding protein 1Source|GeneCards
SLC35A5SLC35A5solute carrier family 35, member A5Source|GeneCards
ZNF364ZNF364zinc finger protein 364Source|GeneCards
SNX2SNX2sorting nexin 2Source|GeneCards
FLJ34278FLJ34278hypothetical protein FLJ34278Source|GeneCards
FLJ41131FLJ41131FLJ41131 proteinSource|GeneCards
RAB3ARAB3ARAB3A, member RAS oncogene familySource|GeneCards
SNRPASNRPAsmall nuclear ribonucleoprotein polypeptide ASource|GeneCards
WHSC1L1WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 1Source|GeneCards
SMCR8SMCR8Smith-Magenis syndrome chromosome region, candidate 8Source|GeneCards
C6ORF82C6ORF82chromosome 6 open reading frame 82Source|GeneCards
ATP6V1AATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit ASource|GeneCards
BEX1BEX1brain expressed, X-linked 1Source|GeneCards
OSGEPOSGEPO-sialoglycoprotein endopeptidaseSource|GeneCards
MYST2MYST2MYST histone acetyltransferase 2Source|GeneCards
KIAA0063KIAA0063KIAA0063 gene productSource|GeneCards
CBARA1CBARA1calcium binding atopy-related autoantigen 1Source|GeneCards
XPO1XPO1exportin 1 (CRM1 homolog, yeast)Source|GeneCards
QTRT1QTRT1queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase)Source|GeneCards
ALDH6A1ALDH6A1aldehyde dehydrogenase 6 family, member A1Source|GeneCards
FMR1FMR1fragile X mental retardation 1Source|GeneCards
C20ORF104PHF20PHD finger protein 20Source|GeneCards
ZIC3ZIC3Zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)Source|GeneCards
HTATIPHTATIPHIV-1 Tat interactive protein, 60kDaSource|GeneCards
EIF4G1EIF4G1eukaryotic translation initiation factor 4 gamma, 1Source|GeneCards
C2ORF24C2ORF24chromosome 2 open reading frame 24 /// chromosome 2 open reading frame 24Source|GeneCards
SAE1SAE1SUMO-1 activating enzyme subunit 1Source|GeneCards
MGC23947TCEAL7transcription elongation factor A (SII)-like 7Source|GeneCards
MGC15737TCEAL3transcription elongation factor A (SII)-like 3Source|GeneCards
MRPL27MRPL27mitochondrial ribosomal protein L27Source|GeneCards
ADCY2ADCY2adenylate cyclase 2 (brain)Source|GeneCards
SETSETSET translocation (myeloid leukemia-associated)Source|GeneCards
KIAA0423KIAA0423KIAA0423Source|GeneCards
TCEAL1TCEAL1transcription elongation factor A (SII)-like 1Source|GeneCards
C13ORF7C13ORF7chromosome 13 open reading frame 7Source|GeneCards
IGF2RIGF2Rinsulin-like growth factor 2 receptorSource|GeneCards
HOXC5HOXC5homeo box C5Source|GeneCards
AARSAARSalanyl-tRNA synthetaseSource|GeneCards
BLOC1S1BLOC1S1biogenesis of lysosome-related organelles complex-1, subunit 1Source|GeneCards
SPPL3SPPL3signal peptide peptidase 3Source|GeneCards
STAF42TADA1Ltranscriptional adaptor 1 (HFI1 homolog, yeast)-likeSource|GeneCards
ACCN1ACCN1amiloride-sensitive cation channel 1, neuronal (degenerin)Source|GeneCards
EPC1EPC1enhancer of polycomb homolog 1, (Drosophila)Source|GeneCards
SUPT6HSUPT6Hsuppressor of Ty 6 homolog (S. cerevisiae)Source|GeneCards
UBE4BUBE4Bubiquitination factor E4B (UFD2 homolog, yeast)Source|GeneCards
RAB22ARAB22ARAB22A, member RAS oncogene familySource|GeneCards
LAMP1LAMP1lysosomal-associated membrane protein 1Source|GeneCards
PRKCEPRKCEprotein kinase C, epsilonSource|GeneCards
VPS26VPS26vacuolar protein sorting 26 (yeast)Source|GeneCards
ATF7IPATF7IPactivating transcription factor 7 interacting proteinSource|GeneCards
BLNKBLNKB-cell linkerSource|GeneCards
RAD9ARAD9ARAD9 homolog A (S. pombe)Source|GeneCards
DLX2DLX2distal-less homeo box 2Source|GeneCards
DSCAMDSCAMDown syndrome cell adhesion moleculeSource|GeneCards
ORF1-FL49ORF1-FL49putative nuclear protein ORF1-FL49Source|GeneCards
ZDHHC13ZDHHC13zinc finger, DHHC-type containing 13Source|GeneCards
HOXA2HOXA2homeo box A2Source|GeneCards
GNB2GNB2guanine nucleotide binding protein (G protein), beta polypeptide 2Source|GeneCards
ARMCX3ARMCX3armadillo repeat containing, X-linked 3Source|GeneCards
SEPT3SEPT3septin 3Source|GeneCards
HOXC11HOXC11homeo box C11Source|GeneCards
UBE2BUBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)Source|GeneCards
ZMYND12ZMYND12zinc finger, MYND domain containing 12Source|GeneCards
AF5Q31AFF4AF4/FMR2 family, member 4Source|GeneCards
GRNGRNgranulinSource|GeneCards
PIP5K1APIP5K1Aphosphatidylinositol-4-phosphate 5-kinase, type I, alphaSource|GeneCards
HOXA11HOXA11homeo box A11Source|GeneCards
FLJ11838PPCSphosphopantothenoylcysteine synthetaseSource|GeneCards
C5ORF5C5ORF5chromosome 5 open reading frame 5Source|GeneCards
USH1GUSH1GUsher syndrome 1G (autosomal recessive)Source|GeneCards
POLDIP2POLDIP2polymerase (DNA-directed), delta interacting protein 2Source|GeneCards
AKAP12AKAP12A kinase (PRKA) anchor protein (gravin) 12Source|GeneCards
SLC36A1SLC36A1solute carrier family 36 (proton/amino acid symporter), member 1Source|GeneCards
CBX6CBX6chromobox homolog 6Source|GeneCards
RRAGCRRAGCRas-related GTP binding CSource|GeneCards
RRM2BRRM2Bribonucleotide reductase M2 B (TP53 inducible)Source|GeneCards
CLN3CLN3ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)Source|GeneCards
LCP1LCP1lymphocyte cytosolic protein 1 (L-plastin)Source|GeneCards
CAMK2DCAMK2Dcalcium/calmodulin-dependent protein kinase (CaM kinase) II deltaSource|GeneCards
OGDHLOGDHLoxoglutarate dehydrogenase-likeSource|GeneCards
TNRC15TNRC15trinucleotide repeat containing 15Source|GeneCards
EIF4BEIF4Beukaryotic translation initiation factor 4BSource|GeneCards
FLJ23235FLJ23235hypothetical protein FLJ23235Source|GeneCards
CUL5CUL5cullin 5Source|GeneCards
HNRPH2HNRPH2heterogeneous nuclear ribonucleoprotein H2 (H')Source|GeneCards
TMEM15TMEM15transmembrane protein 15Source|GeneCards
DAZAP2DAZAP2DAZ associated protein 2Source|GeneCards
APG3APG3autophagy Apg3p/Aut1p-likeSource|GeneCards
CCAR1CCAR1cell division cycle and apoptosis regulator 1Source|GeneCards
TRPM7TRPM7transient receptor potential cation channel, subfamily M, member 7Source|GeneCards
BAXBAXBCL2-associated X proteinSource|GeneCards
CD164CD164CD164 antigen, sialomucinSource|GeneCards
MAK3MAK3Mak3 homolog (S. cerevisiae)Source|GeneCards
GGNGGNgametogenetinSource|GeneCards
PICALMPICALMphosphatidylinositol binding clathrin assembly proteinSource|GeneCards
SDF2SDF2stromal cell-derived factor 2Source|GeneCards
NICE-3C1ORF43chromosome 1 open reading frame 43Source|GeneCards
DVL2DVL2dishevelled, dsh homolog 2 (Drosophila)Source|GeneCards
HOXB7HOXB7homeo box B7Source|GeneCards
FLJ20811ARMCX6armadillo repeat containing, X-linked 6Source|GeneCards
C2ORF17C2ORF17Chromosome 2 open reading frame 17Source|GeneCards
C9ORF156C9ORF156chromosome 9 open reading frame 156Source|GeneCards
KLF12KLF12Kruppel-like factor 12Source|GeneCards
STX6STX6syntaxin 6Source|GeneCards
GPNMBGPNMBglycoprotein (transmembrane) nmbSource|GeneCards
HYPBHYPBhuntingtin interacting protein BSource|GeneCards
HOXA7HOXA7homeo box A7Source|GeneCards
IRS4IRS4insulin receptor substrate 4Source|GeneCards
NR1D1NR1D1nuclear receptor subfamily 1, group D, member 1Source|GeneCards
USP31USP31Ubiquitin specific peptidase 31Source|GeneCards
ANAPC13ANAPC13anaphase promoting complex subunit 13Source|GeneCards
PDCD6IPPDCD6IPprogrammed cell death 6 interacting proteinSource|GeneCards
STMN1STMN1stathmin 1/oncoprotein 18Source|GeneCards
BTBD5BTBD5BTB (POZ) domain containing 5Source|GeneCards
MY048TCEAL2transcription elongation factor A (SII)-like 2Source|GeneCards
RGL1RGL1Ral guanine nucleotide dissociation stimulator-like 1Source|GeneCards
PIAS4PIAS4protein inhibitor of activated STAT, 4Source|GeneCards
ASNA1ASNA1arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)Source|GeneCards
ASPSCR1ASPSCR1alveolar soft part sarcoma chromosome region, candidate 1Source|GeneCards
LOC51255LOC51255hypothetical protein LOC51255Source|GeneCards
POLR3CPOLR3Cpolymerase (RNA) III (DNA directed) polypeptide C (62kD)Source|GeneCards
MIRMYLIPmyosin regulatory light chain interacting proteinSource|GeneCards
DIRC2DIRC2disrupted in renal carcinoma 2Source|GeneCards


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