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Gene set: V$SREBP1_02 (C3:TFAC:0141)
Standard nameV$SREBP1_02
Systematic nameC3:TFAC:0141
Brief descriptionGenes with 3'UTR containing motif KATCACCCCAC which matches annotation for SREBF1: sterol regulatory element binding transcription factor 1
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA SREBP-1
 XX
 SY ADD1.
 XX

OS rat, Rattus norvegicus
 OC eukaryota; animalia; metazoa;
chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria; rodentia;
myomorpha; muridae; murinae
 XX
 CL C0012; bHLH-ZIP; 1.3.1.3.1.

XX
 SZ 927 AA; 98.5 kDa (cDNA)
 XX
 XX
 SC translated
from EMBL #L16995
 XX
 FT 294 305 basic region.
 FT 294
344 PF00010; HLH.
 FT 299 349 SM00353; HLH.
 FT 306 344
helix-loop-helix domain.
 FT 343 357 leucine zipper (L3) (positions
refer to the first Met codon of
 FT [2]).
 XX
 SF the
dual DNA-binding specificity is due to Tyr-305 [1]
 XX

CP highest expression in brown adipose tissue, low levels in intestine,

CP spleen, skeletal muscle, thymus; nearly undetectable in brain,
heart,
 CP testis [2]
 CN white fat, liver, kidney [2]

XX
 FF transcriptional activator, acting through some E-box
elements (carbohydrate
 FF response element) [2] [1], but also
through sterol-regulatory element-1
 FF (SRE-1) [1];
 FF
may play an important role in controlling determination- and

FF differentiation-linked gene expression in adipocytes;
 FF
5-fold higher expression in preadipocytes than in undetermined

FF fibroblast-like cells, another 5-fold stimulation upon adipocytic

FF differentiation [2];
 XX
 XX
 XX
 XX
 RN [1];
RE0003451.
 RX MEDLINE; 95257939.
 RA Kim J. B., Spotts
G. D., Halvorsen Y.-D., Shih H.-M., Ellenberger T., Towle

RA H. C., Spiegelman B. M.
 RT Dual DNA binding specificity
of ADD1/SREBP1 controlled by a single amino
 RT acid in the
basic helix-loop-helix domain
 RL Mol. Cell. Biol. 15:2582-2588
(1995).
 RN [2]; RE0003438.
 RX MEDLINE; 93330269.
 RA
Kim J., Tontonoz P., Spiegelman B.
 RT ADD: a novel helix-loop-helix
protein associated with adipocyte
 RT determination and differentiation

RL Mol. Cell. Biol. 13:4753-4759 (1993).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

89 genes, 89 accessions (Toggle view)

AccessionGeneTitleLinks
NRGNNRGNneurogranin (protein kinase C substrate, RC3)Source|GeneCards
CD3ZCD3ZCD3Z antigen, zeta polypeptide (TiT3 complex)Source|GeneCards
KIAA1361TAOK1TAO kinase 1Source|GeneCards
GREM1GREM1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)Source|GeneCards
MLL4MLL4myeloid/lymphoid or mixed-lineage leukemia 4Source|GeneCards
HT008HT008uncharacterized hypothalamus protein HT008Source|GeneCards
WDR13WDR13WD repeat domain 13Source|GeneCards
NDRG2NDRG2NDRG family member 2Source|GeneCards
CORO1ACORO1Acoronin, actin binding protein, 1ASource|GeneCards
RARARARAretinoic acid receptor, alphaSource|GeneCards
KIAA0999KIAA0999KIAA0999 proteinSource|GeneCards
FLJ45455FLJ45455FLJ45455 proteinSource|GeneCards
N2NNOTCH2NLNotch homolog 2 (Drosophila) N-terminal likeSource|GeneCards
RAB33ARAB33ARAB33A, member RAS oncogene familySource|GeneCards
CHRM3CHRM3cholinergic receptor, muscarinic 3Source|GeneCards
FGF12FGF12fibroblast growth factor 12Source|GeneCards
KIAA1374WDR56WD repeat domain 56Source|GeneCards
KIF1CKIF1Ckinesin family member 1CSource|GeneCards
ZNF532ZNF532zinc finger protein 532Source|GeneCards
KTN1KTN1kinectin 1 (kinesin receptor)Source|GeneCards
FLJ39779FLJ39779FLJ39779 proteinSource|GeneCards
SREBF2SREBF2sterol regulatory element binding transcription factor 2Source|GeneCards
TOM1L1TOM1L1target of myb1-like 1 (chicken)Source|GeneCards
MGC33190ATXN7L4ataxin 7-like 4Source|GeneCards
HYAL1HYAL1Hyaluronoglucosaminidase 1Source|GeneCards
GNB2GNB2guanine nucleotide binding protein (G protein), beta polypeptide 2Source|GeneCards
UBE2BUBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)Source|GeneCards
ELOVL5ELOVL5ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)Source|GeneCards
PHOX2BPHOX2Bpaired-like homeobox 2bSource|GeneCards
PTMAPTMAprothymosin, alpha (gene sequence 28)Source|GeneCards
RCOR2RCOR2REST corepressor 2Source|GeneCards
JUNDJUNDjun D proto-oncogeneSource|GeneCards
SEC13LSEH1LSEH1-like (S. cerevisiae)Source|GeneCards
G22P1G22P1thyroid autoantigen 70kDa (Ku antigen)Source|GeneCards
MLL5MLL5myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)Source|GeneCards
NTN4NTN4netrin 4Source|GeneCards
UNC13DUNC13Dunc-13 homolog D (C. elegans)Source|GeneCards
LOXL1LOXL1lysyl oxidase-like 1Source|GeneCards
FLJ30296PTCHD1Patched domain containing 1Source|GeneCards
NF1NF1neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)Source|GeneCards
HS6ST2HS6ST2heparan sulfate 6-O-sulfotransferase 2Source|GeneCards
SPI1SPI1spleen focus forming virus (SFFV) proviral integration oncogene spi1Source|GeneCards
LOC375616LOC375616Cysteine rich BMP regulator 2 (chordin-like)Source|GeneCards
GFAPGFAPglial fibrillary acidic proteinSource|GeneCards
OSBPL7OSBPL7oxysterol binding protein-like 7Source|GeneCards
SSTR3SSTR3somatostatin receptor 3Source|GeneCards
DLGAP4DLGAP4discs, large (Drosophila) homolog-associated protein 4Source|GeneCards
MGC45441CCDC23coiled-coil domain containing 23Source|GeneCards
SEZ6SEZ6seizure related 6 homolog (mouse)Source|GeneCards
DHRS3DHRS3dehydrogenase/reductase (SDR family) member 3Source|GeneCards
BAI3BAI3brain-specific angiogenesis inhibitor 3Source|GeneCards
YWHAEYWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideSource|GeneCards
PACSIN3PACSIN3protein kinase C and casein kinase substrate in neurons 3Source|GeneCards
ZFP36L1ZFP36L1zinc finger protein 36, C3H type-like 1Source|GeneCards
STX4ASTX4Asyntaxin 4A (placental)Source|GeneCards
BCL6BBCL6BB-cell CLL/lymphoma 6, member B (zinc finger protein)Source|GeneCards
DPYSL2DPYSL2dihydropyrimidinase-like 2Source|GeneCards
MORF4L2MORF4L2mortality factor 4 like 2Source|GeneCards
PLA2G3PLA2G3phospholipase A2, group IIISource|GeneCards
SMC4L1SMC4L1SMC4 structural maintenance of chromosomes 4-like 1 (yeast)Source|GeneCards
C14ORF37C14ORF37chromosome 14 open reading frame 37Source|GeneCards
ZFYVE1ZFYVE1zinc finger, FYVE domain containing 1Source|GeneCards
NOL4NOL4nucleolar protein 4Source|GeneCards
PDP2PDP2pyruvate dehydrogenase phosphatase isoenzyme 2Source|GeneCards
PRKD2PRKD2protein kinase D2Source|GeneCards
CEBPBCEBPBCCAAT/enhancer binding protein (C/EBP), betaSource|GeneCards
EIF5AEIF5Aeukaryotic translation initiation factor 5ASource|GeneCards
FBS1FBS1Fibrosin 1Source|GeneCards
MEF2CMEF2CMADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)Source|GeneCards
BAZ2ABAZ2Abromodomain adjacent to zinc finger domain, 2ASource|GeneCards
INPP4AINPP4Ainositol polyphosphate-4-phosphatase, type I, 107kDaSource|GeneCards
NOTCH2NOTCH2Notch homolog 2 (Drosophila)Source|GeneCards
HOXB8HOXB8homeo box B8Source|GeneCards
MGC45491MGC45491hypothetical protein MGC45491Source|GeneCards
HOXB1HOXB1homeo box B1Source|GeneCards
INCA1INCA1Inhibitor of CDK interacting with cyclin A1Source|GeneCards
CACNA2D3CACNA2D3calcium channel, voltage-dependent, alpha 2/delta 3 subunitSource|GeneCards
ATP2B2ATP2B2ATPase, Ca++ transporting, plasma membrane 2Source|GeneCards
POU2AF1POU2AF1POU domain, class 2, associating factor 1Source|GeneCards
DDR1DDR1discoidin domain receptor family, member 1Source|GeneCards
CPA4CPA4carboxypeptidase A4Source|GeneCards
FOXP2FOXP2forkhead box P2Source|GeneCards
RHOGRHOGras homolog gene family, member G (rho G)Source|GeneCards
GNASGNASGNAS complex locusSource|GeneCards
FLJ36874FLJ36874hypothetical protein FLJ36874Source|GeneCards
RBP3RBP3retinol binding protein 3, interstitialSource|GeneCards
CD2APCD2APCD2-associated proteinSource|GeneCards
POU4F2POU4F2POU domain, class 4, transcription factor 2Source|GeneCards
PLAG1PLAG1pleiomorphic adenoma gene 1Source|GeneCards

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