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Gene set: V$SREBP1_Q6 (C3:TFAC:0362)
Standard nameV$SREBP1_Q6
Systematic nameC3:TFAC:0362
Brief descriptionGenes with 3'UTR containing motif CACSCCA which matches annotation for SREBF1: sterol regulatory element binding transcription factor 1
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA SREBP-1
 XX
 SY ADD1.
 XX

OS rat, Rattus norvegicus
 OC eukaryota; animalia; metazoa;
chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria; rodentia;
myomorpha; muridae; murinae
 XX
 CL C0012; bHLH-ZIP; 1.3.1.3.1.

XX
 SZ 927 AA; 98.5 kDa (cDNA)
 XX
 XX
 SC translated
from EMBL #L16995
 XX
 FT 294 305 basic region.
 FT 294
344 PF00010; HLH.
 FT 299 349 SM00353; HLH.
 FT 306 344
helix-loop-helix domain.
 FT 343 357 leucine zipper (L3) (positions
refer to the first Met codon of
 FT [2]).
 XX
 SF the
dual DNA-binding specificity is due to Tyr-305 [1]
 XX

CP highest expression in brown adipose tissue, low levels in intestine,

CP spleen, skeletal muscle, thymus; nearly undetectable in brain,
heart,
 CP testis [2]
 CN white fat, liver, kidney [2]

XX
 FF transcriptional activator, acting through some E-box
elements (carbohydrate
 FF response element) [2] [1], but also
through sterol-regulatory element-1
 FF (SRE-1) [1];
 FF
may play an important role in controlling determination- and

FF differentiation-linked gene expression in adipocytes;
 FF
5-fold higher expression in preadipocytes than in undetermined

FF fibroblast-like cells, another 5-fold stimulation upon adipocytic

FF differentiation [2];
 XX
 XX
 XX
 XX
 RN [1];
RE0003451.
 RX MEDLINE; 95257939.
 RA Kim J. B., Spotts
G. D., Halvorsen Y.-D., Shih H.-M., Ellenberger T., Towle

RA H. C., Spiegelman B. M.
 RT Dual DNA binding specificity
of ADD1/SREBP1 controlled by a single amino
 RT acid in the
basic helix-loop-helix domain
 RL Mol. Cell. Biol. 15:2582-2588
(1995).
 RN [2]; RE0003438.
 RX MEDLINE; 93330269.
 RA
Kim J., Tontonoz P., Spiegelman B.
 RT ADD: a novel helix-loop-helix
protein associated with adipocyte
 RT determination and differentiation

RL Mol. Cell. Biol. 13:4753-4759 (1993).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

250 genes, 250 accessions (Toggle view)

AccessionGeneTitleLinks
KIAA1361TAOK1TAO kinase 1Source|GeneCards
AGERAGERadvanced glycosylation end product-specific receptorSource|GeneCards
MSI1MSI1musashi homolog 1 (Drosophila)Source|GeneCards
CORO1ACORO1Acoronin, actin binding protein, 1ASource|GeneCards
PEX16PEX16peroxisomal biogenesis factor 16Source|GeneCards
ZNF532ZNF532zinc finger protein 532Source|GeneCards
MAML3MAML3Mastermind-like 3 (Drosophila)Source|GeneCards
HYAL1HYAL1Hyaluronoglucosaminidase 1Source|GeneCards
FADS3FADS3fatty acid desaturase 3Source|GeneCards
DDX17DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17Source|GeneCards
ZNF593ZNF593zinc finger protein 593Source|GeneCards
FLJ22955FLJ22955hypothetical protein FLJ22955Source|GeneCards
LPHN1LPHN1latrophilin 1Source|GeneCards
CLDN5CLDN5claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)Source|GeneCards
MLL5MLL5myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)Source|GeneCards
PSDPSDpleckstrin and Sec7 domain proteinSource|GeneCards
ZFP67ZFP67zinc finger protein 67 homolog (mouse)Source|GeneCards
YWHAQYWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideSource|GeneCards
TNSTNStensinSource|GeneCards
SOX12SOX12SRY (sex determining region Y)-box 12Source|GeneCards
GAP43GAP43growth associated protein 43Source|GeneCards
ERFERFEts2 repressor factorSource|GeneCards
LOC144747LOC144747hypothetical protein LOC144747Source|GeneCards
PDXPPDXPpyridoxal (pyridoxine, vitamin B6) phosphataseSource|GeneCards
PPP1R10PPP1R10protein phosphatase 1, regulatory subunit 10Source|GeneCards
ACTCACTCactin, alpha, cardiac muscleSource|GeneCards
SPI1SPI1spleen focus forming virus (SFFV) proviral integration oncogene spi1Source|GeneCards
KCNMB1KCNMB1potassium large conductance calcium-activated channel, subfamily M, beta member 1Source|GeneCards
PLCB3PLCB3phospholipase C, beta 3 (phosphatidylinositol-specific)Source|GeneCards
FLNCFLNCfilamin C, gamma (actin binding protein 280)Source|GeneCards
FLJ32447FLJ32447hypothetical protein FLJ32447Source|GeneCards
DUSP8DUSP8dual specificity phosphatase 8Source|GeneCards
DLGAP4DLGAP4discs, large (Drosophila) homolog-associated protein 4Source|GeneCards
LIN28LIN28lin-28 homolog (C. elegans)Source|GeneCards
MYH10MYH10myosin, heavy polypeptide 10, non-muscleSource|GeneCards
HOXA3HOXA3homeo box A3Source|GeneCards
TRERF1TRERF1transcriptional regulating factor 1Source|GeneCards
FLJ12595FLJ12595hypothetical protein FLJ12595Source|GeneCards
MRPS18BMRPS18Bmitochondrial ribosomal protein S18BSource|GeneCards
SERPINI1SERPINI1serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1Source|GeneCards
H2AFYH2AFYH2A histone family, member YSource|GeneCards
B4GALT2B4GALT2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2Source|GeneCards
RHOARHOAras homolog gene family, member ASource|GeneCards
DPYSL2DPYSL2dihydropyrimidinase-like 2Source|GeneCards
ZFYVE1ZFYVE1zinc finger, FYVE domain containing 1Source|GeneCards
RAB10RAB10RAB10, member RAS oncogene familySource|GeneCards
MGC12458EFCAB2EF-hand calcium binding domain 2Source|GeneCards
EVX1EVX1eve, even-skipped homeo box homolog 1 (Drosophila)Source|GeneCards
LOC92799LOC92799hypothetical protein BC007653Source|GeneCards
BAZ2ABAZ2Abromodomain adjacent to zinc finger domain, 2ASource|GeneCards
MYL6MYL6myosin, light polypeptide 6, alkali, smooth muscle and non-muscleSource|GeneCards
TCF2TCF2transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factorSource|GeneCards
MGC45491MGC45491hypothetical protein MGC45491Source|GeneCards
KCNK7KCNK7potassium channel, subfamily K, member 7Source|GeneCards
NEUROD2NEUROD2neurogenic differentiation 2Source|GeneCards
MTMR3MTMR3myotubularin related protein 3Source|GeneCards
EPOEPOerythropoietinSource|GeneCards
EMP1EMP1epithelial membrane protein 1Source|GeneCards
RARGRARGretinoic acid receptor, gammaSource|GeneCards
SIPA1L2SIPA1L2signal-induced proliferation-associated 1 like 2Source|GeneCards
DOC1CDK2AP1CDK2-associated protein 1Source|GeneCards
HUMMLC2BHUMMLC2Bmyosin light chain 2Source|GeneCards
NRGNNRGNneurogranin (protein kinase C substrate, RC3)Source|GeneCards
SLCO3A1SLCO3A1solute carrier organic anion transporter family, member 3A1Source|GeneCards
RBX1RBX1ring-box 1Source|GeneCards
DKFZP564J0123DKFZP564J0123nuclear protein E3-3Source|GeneCards
RBP5RBP5Retinol binding protein 5, cellularSource|GeneCards
NDRG2NDRG2NDRG family member 2Source|GeneCards
HOXD10HOXD10homeo box D10Source|GeneCards
SIX4SIX4sine oculis homeobox homolog 4 (Drosophila)Source|GeneCards
ABCG4ABCG4ATP-binding cassette, sub-family G (WHITE), member 4Source|GeneCards
LRP8LRP8low density lipoprotein receptor-related protein 8, apolipoprotein e receptorSource|GeneCards
TRAF4TRAF4TNF receptor-associated factor 4Source|GeneCards
MEOX2MEOX2mesenchyme homeo box 2 (growth arrest-specific homeo box)Source|GeneCards
ZNF342ZNF342zinc finger protein 342Source|GeneCards
SSBP2SSBP2single-stranded DNA binding protein 2Source|GeneCards
ENO2ENO2enolase 2, (gamma, neuronal)Source|GeneCards
NTRK3NTRK3neurotrophic tyrosine kinase, receptor, type 3Source|GeneCards
CACNA1DCACNA1Dcalcium channel, voltage-dependent, L type, alpha 1D subunitSource|GeneCards
TGFB1I1TGFB1I1transforming growth factor beta 1 induced transcript 1Source|GeneCards
KCNK10KCNK10potassium channel, subfamily K, member 10Source|GeneCards
PIAS1PIAS1protein inhibitor of activated STAT, 1Source|GeneCards
ANP32AANP32Aacidic (leucine-rich) nuclear phosphoprotein 32 family, member ASource|GeneCards
STAT6STAT6signal transducer and activator of transcription 6, interleukin-4 inducedSource|GeneCards
SORBS1SORBS1sorbin and SH3 domain containing 1Source|GeneCards
KPNB1KPNB1karyopherin (importin) beta 1Source|GeneCards
HIF1AHIF1Ahypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Source|GeneCards
NF1NF1neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)Source|GeneCards
ETV5ETV5ets variant gene 5 (ets-related molecule)Source|GeneCards
HBXAPHBXAPhepatitis B virus x associated proteinSource|GeneCards
182-FIP182-FIP82-kD FMRP Interacting ProteinSource|GeneCards
GRWD1GRWD1glutamate-rich WD repeat containing 1Source|GeneCards
ESR1ESR1estrogen receptor 1Source|GeneCards
GNAO1GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide OSource|GeneCards
C20ORF112C20ORF112chromosome 20 open reading frame 112Source|GeneCards
DCTN1DCTN1dynactin 1 (p150, glued homolog, Drosophila)Source|GeneCards
PAX3PAX3paired box gene 3 (Waardenburg syndrome 1)Source|GeneCards
LOC374768LOC374768hypothetical protein LOC374768Source|GeneCards
CLIC1CLIC1chloride intracellular channel 1Source|GeneCards
STX4ASTX4Asyntaxin 4A (placental)Source|GeneCards
DHHDHHdesert hedgehog homolog (Drosophila)Source|GeneCards
GRIA1GRIA1glutamate receptor, ionotropic, AMPA 1Source|GeneCards
CDC42EP4CDC42EP4CDC42 effector protein (Rho GTPase binding) 4Source|GeneCards
RPS10RPS10ribosomal protein S10Source|GeneCards
PDP2PDP2pyruvate dehydrogenase phosphatase isoenzyme 2Source|GeneCards
KRT17KRT17keratin 17Source|GeneCards
PRKD2PRKD2protein kinase D2Source|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
MT4MT4metallothionein IVSource|GeneCards
ZNF179ZNF179zinc finger protein 179Source|GeneCards
LASP1LASP1LIM and SH3 protein 1Source|GeneCards
NFATC4NFATC4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4Source|GeneCards
MGC13053MGC13053hypothetical protein MGC13053Source|GeneCards
LRCH4LRCH4leucine-rich repeats and calponin homology (CH) domain containing 4Source|GeneCards
CLSTN3CLSTN3calsyntenin 3Source|GeneCards
FLJ10496DALRD3DALR anticodon binding domain containing 3Source|GeneCards
IMP-1IMP-1IGF-II mRNA-binding protein 1Source|GeneCards
TIMP4TIMP4tissue inhibitor of metalloproteinase 4Source|GeneCards
GREM1GREM1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)Source|GeneCards
SLC2A4SLC2A4solute carrier family 2 (facilitated glucose transporter), member 4Source|GeneCards
ZNF238ZNF238zinc finger protein 238Source|GeneCards
ARFIP2ARFIP2ADP-ribosylation factor interacting protein 2 (arfaptin 2)Source|GeneCards
EN1EN1engrailed homolog 1Source|GeneCards
MGC50896CNIH2cornichon homolog 2 (Drosophila)Source|GeneCards
SMTNSMTNsmoothelinSource|GeneCards
NSFNSFN-ethylmaleimide-sensitive factorSource|GeneCards
CRLF1CRLF1cytokine receptor-like factor 1Source|GeneCards
LPHN3LPHN3latrophilin 3Source|GeneCards
KIF1BKIF1Bkinesin family member 1BSource|GeneCards
CLASP1CLASP1cytoplasmic linker associated protein 1Source|GeneCards
EMX2EMX2empty spiracles homolog 2 (Drosophila)Source|GeneCards
FLJ37266FLJ37266hypothetical protein FLJ37266Source|GeneCards
JUPJUPjunction plakoglobinSource|GeneCards
LRRN1LRRN1leucine rich repeat neuronal 1Source|GeneCards
C6ORF81C6ORF81chromosome 6 open reading frame 81Source|GeneCards
ATP6V0CATP6V0CATPase, H+ transporting, lysosomal 16kDa, V0 subunit cSource|GeneCards
FOXP4FOXP4forkhead box P4Source|GeneCards
FBXO24FBXO24F-box only protein 24Source|GeneCards
NBEANBEAneurobeachinSource|GeneCards
PCF11PCF11pre-mRNA cleavage complex II protein Pcf11Source|GeneCards
CACNB1CACNB1calcium channel, voltage-dependent, beta 1 subunitSource|GeneCards
TBCCTBCCtubulin-specific chaperone cSource|GeneCards
KLK13KLK13kallikrein 13Source|GeneCards
ARHGDIBARHGDIBRho GDP dissociation inhibitor (GDI) betaSource|GeneCards
ZFP36L1ZFP36L1zinc finger protein 36, C3H type-like 1Source|GeneCards
PHF15PHF15PHD finger protein 15Source|GeneCards
NFAT5NFAT5nuclear factor of activated T-cells 5, tonicity-responsiveSource|GeneCards
BCL6BBCL6BB-cell CLL/lymphoma 6, member B (zinc finger protein)Source|GeneCards
ANXA9ANXA9annexin A9Source|GeneCards
PLA2G3PLA2G3phospholipase A2, group IIISource|GeneCards
TFAP2BTFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta)Source|GeneCards
HOXB2HOXB2homeo box B2Source|GeneCards
SALL1SALL1sal-like 1 (Drosophila)Source|GeneCards
GRID2GRID2glutamate receptor, ionotropic, delta 2Source|GeneCards
ATP6V1AATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit ASource|GeneCards
FCHSD2FCHSD2FCH and double SH3 domains 2Source|GeneCards
LOC112476LOC112476similar to lymphocyte antigen 6 complex, locus G5B; G5b protein; open reading frame 31Source|GeneCards
FLJ32796FAM71Afamily with sequence similarity 71, member ASource|GeneCards
SLC4A10SLC4A10solute carrier family 4, sodium bicarbonate transporter-like, member 10Source|GeneCards
MAP1AMAP1Amicrotubule-associated protein 1ASource|GeneCards
TYRO3TYRO3TYRO3 protein tyrosine kinaseSource|GeneCards
FBS1FBS1Fibrosin 1Source|GeneCards
DSG4DSG4desmoglein 4Source|GeneCards
ELKSRAB6IP2RAB6 interacting protein 2Source|GeneCards
DDR1DDR1discoidin domain receptor family, member 1Source|GeneCards
DYRK1ADYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1ASource|GeneCards
PTK2BPTK2BPTK2B protein tyrosine kinase 2 betaSource|GeneCards
RAB30RAB30RAB30, member RAS oncogene familySource|GeneCards
RHOGRHOGras homolog gene family, member G (rho G)Source|GeneCards
NFIXNFIXnuclear factor I/X (CCAAT-binding transcription factor)Source|GeneCards
PVRL1PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)Source|GeneCards
A2BP1A2BP1ataxin 2-binding protein 1Source|GeneCards
SYNPO2LSYNPO2Lsynaptopodin 2-likeSource|GeneCards
ATE1ATE1arginyltransferase 1Source|GeneCards
POU4F2POU4F2POU domain, class 4, transcription factor 2Source|GeneCards
GPR85GPR85G protein-coupled receptor 85Source|GeneCards
MSCPSLC25A37solute carrier family 25, member 37Source|GeneCards
P15RSP15RShypothetical protein FLJ10656Source|GeneCards
MACF1MACF1microtubule-actin crosslinking factor 1Source|GeneCards
LOC338773LOC338773hypothetical protein LOC338773Source|GeneCards
LMX1ALMX1ALIM homeobox transcription factor 1, alphaSource|GeneCards
SNIPSNIPSNAP25-interacting proteinSource|GeneCards
LBX1LBX1transcription factor similar to D. melanogaster homeodomain protein lady bird lateSource|GeneCards
KCNN3KCNN3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3Source|GeneCards
SLIT3SLIT3slit homolog 3 (Drosophila)Source|GeneCards
HSPA9BHSPA9Bheat shock 70kDa protein 9B (mortalin-2)Source|GeneCards
PDCD10PDCD10programmed cell death 10Source|GeneCards
MLLMLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)Source|GeneCards
DKFZP566B183NECAP1adaptin-ear-binding coat-associated protein 1Source|GeneCards
DKKL1-PENDINGDKKL1-PENDINGsoggy-1 geneSource|GeneCards
RHEBL1RHEBL1Ras homolog enriched in brain like 1Source|GeneCards
FLJ39779FLJ39779FLJ39779 proteinSource|GeneCards
GUCA2BGUCA2Bguanylate cyclase activator 2B (uroguanylin)Source|GeneCards
SREBF2SREBF2sterol regulatory element binding transcription factor 2Source|GeneCards
MGC33190ATXN7L4ataxin 7-like 4Source|GeneCards
HOXC11HOXC11homeo box C11Source|GeneCards
ZIC4ZIC4Zic family member 4Source|GeneCards
RCOR2RCOR2REST corepressor 2Source|GeneCards
AP1G2AP1G2adaptor-related protein complex 1, gamma 2 subunitSource|GeneCards
TCF1TCF1Transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factorSource|GeneCards
ZBTB9ZBTB9zinc finger and BTB domain containing 9Source|GeneCards
FLJ43654FLJ43654FLJ43654 proteinSource|GeneCards
SLC39A14SLC39A14solute carrier family 39 (zinc transporter), member 14Source|GeneCards
FXC1FXC1fracture callus 1 homolog (rat)Source|GeneCards
HOXA11HOXA11homeo box A11Source|GeneCards
LGP2LGP2likely ortholog of mouse D11lgp2Source|GeneCards
DTX1DTX1deltex homolog 1 (Drosophila)Source|GeneCards
SYTL2SYTL2synaptotagmin-like 2Source|GeneCards
TEAD2TEAD2TEA domain family member 2Source|GeneCards
HSPG2HSPG2heparan sulfate proteoglycan 2 (perlecan)Source|GeneCards
IMMTIMMTinner membrane protein, mitochondrial (mitofilin)Source|GeneCards
GFAPGFAPglial fibrillary acidic proteinSource|GeneCards
MMP14MMP14matrix metalloproteinase 14 (membrane-inserted)Source|GeneCards
EIF4G2EIF4G2eukaryotic translation initiation factor 4 gamma, 2Source|GeneCards
SIK2SNF1LK2SNF1-like kinase 2Source|GeneCards
PKP3PKP3plakophilin 3Source|GeneCards
FABP6FABP6fatty acid binding protein 6, ileal (gastrotropin)Source|GeneCards
PACSIN3PACSIN3protein kinase C and casein kinase substrate in neurons 3Source|GeneCards
PDE5APDE5Aphosphodiesterase 5A, cGMP-specificSource|GeneCards
SLC24A1SLC24A1solute carrier family 24 (sodium/potassium/calcium exchanger), member 1Source|GeneCards
SLC4A1SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)Source|GeneCards
STX1ASTX1Asyntaxin 1A (brain)Source|GeneCards
PDGFBPDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)Source|GeneCards
MAK3MAK3Mak3 homolog (S. cerevisiae)Source|GeneCards
DDX6DDX6DEAD (Asp-Glu-Ala-Asp) box polypeptide 6Source|GeneCards
MGC46534ATXN7L2ataxin 7-like 2Source|GeneCards
MGC20470MGC20470hypothetical protein MGC20470Source|GeneCards
DLK1DLK1delta-like 1 homolog (Drosophila)Source|GeneCards
C14ORF4C14ORF4chromosome 14 open reading frame 4Source|GeneCards
CEBPBCEBPBCCAAT/enhancer binding protein (C/EBP), betaSource|GeneCards
LOC257106LOC257106hypothetical protein LOC257106Source|GeneCards
KLF12KLF12Kruppel-like factor 12Source|GeneCards
LOC284345LOC284345similar to LL5 betaSource|GeneCards
FXYD1FXYD1FXYD domain containing ion transport regulator 1 (phospholemman)Source|GeneCards
INPP4AINPP4Ainositol polyphosphate-4-phosphatase, type I, 107kDaSource|GeneCards
NR1D1NR1D1nuclear receptor subfamily 1, group D, member 1Source|GeneCards
MAPKAPK3MAPKAPK3mitogen-activated protein kinase-activated protein kinase 3Source|GeneCards
DNMT3BDNMT3BDNA (cytosine-5-)-methyltransferase 3 betaSource|GeneCards
LEFTBLEFTY1left-right determination factor 1Source|GeneCards
RELRELv-rel reticuloendotheliosis viral oncogene homolog (avian)Source|GeneCards
RKHD3RKHD3ring finger and KH domain containing 3Source|GeneCards
NMT1NMT1N-myristoyltransferase 1Source|GeneCards
GNASGNASGNAS complex locusSource|GeneCards
FLJ20321CASZ1castor homolog 1, zinc finger (Drosophila)Source|GeneCards
FLJ10871FLJ10871hypothetical protein FLJ10871Source|GeneCards
ITPR3ITPR3inositol 1,4,5-triphosphate receptor, type 3Source|GeneCards
PTRFPTRFpolymerase I and transcript release factorSource|GeneCards
PTD015PTD015PTD015 proteinSource|GeneCards
LDLRLDLRlow density lipoprotein receptor (familial hypercholesterolemia)Source|GeneCards
IMPDH2IMPDH2IMP (inosine monophosphate) dehydrogenase 2Source|GeneCards

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