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Gene set: V$SRY_01 (C3:TFAC:0096)
Standard nameV$SRY_01
Systematic nameC3:TFAC:0096
Brief descriptionGenes with 3'UTR containing motif AAACWAM which matches annotation for SRY: sex determining region Y
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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FA SRY
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SY sex-determining region Y gene product; TDF; testis-determining factor.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;
OC eutheria; primates
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CL C0015; HMG; 4.7.1.0.1.
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SZ 204 AA; 23.9 kDa (cDNA)
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XX
SC SwissProt #Q05066
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FT 57 137 HMG domain.
FT 59 129 SM00398; HMG.
FT 60 128 PF00505; HMG_box.
FT 65 81 alpha-helix 1 [1].
FT 88 100 alpha-helix 2 [1].
FT 102 123 alpha-helix 3 [1].
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FF testis-determining factor;
FF isolated mutants causing XY females: V60L, M64I, G95R, K106I;
FF recognizes sharp angles in DNA (60-120 deg) irrespective of sequence;
FF when binding to AACAAAG consensus, it produces a sharp bend;
FF mutants with different DNA-binding properties (affinity or induction of
FF structural deformations) have been found in patients with gonadal
FF dysgenesis [2];
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RN [1]; RE0005081.
RX MEDLINE; 95292338.
RA Werner M. H., Huth J. R., Gronenborn A. M., Clore G. M.
RT Molecular basis of human 46X,Y sex reversal revealed from the
RT three-dimensional solution structure of the human SRY-DNA complex
RL Cell 81:705-714 (1995).
RN [2]; RE0003119.
RX MEDLINE; 95112822.
RA Pontiggia A., Rimini R., Harley V. R., Goodfellow P. N., Lovell-Badge R.,
RA Bianchi M. E.
RT Sex-reversing mutations affect the architecture of SRY--DNA complexes
RL EMBO J. 13:6115-6124 (1994).
RN [3]; RE0000305.
RX MEDLINE; 93049201.
RA Ferrari S., Harley V. R., Pontiggia A., Goodfellow P. N., Lovell-Badge R.,
RA Bianchi M. E.
RT SRY, like HMG1, recognizes sharp angles in DNA
RL EMBO J. 11:4497-4506 (1992).
RN [4]; RE0002703.
RX MEDLINE; 92132550.
RA Harley V. R., Jackson D. I., Hextall P. J., Hawkins J. R., Berkovitz G. D.,
RA Sockanathan S., Lovell-Badge R., Goodfellow P. N.
RT DNA binding activity of recombinant SRY from normal males and XY females
RL Science 255:453-456 (1992).
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Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

235 genes, 235 accessions (Toggle view)

AccessionGeneTitleLinks
PLXDC2PLXDC2plexin domain containing 2Source|GeneCards
MAGI-3MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 3Source|GeneCards
MPZMPZmyelin protein zero (Charcot-Marie-Tooth neuropathy 1B)Source|GeneCards
CRY2CRY2cryptochrome 2 (photolyase-like)Source|GeneCards
THBS3THBS3thrombospondin 3Source|GeneCards
H3F3AH3F3AH3 histone, family 3ASource|GeneCards
FLJ11783FLJ11783hypothetical protein FLJ11783Source|GeneCards
RALGPS2RALGPS2Ral GEF with PH domain and SH3 binding motif 2Source|GeneCards
FKBP2FKBP2FK506 binding protein 2, 13kDaSource|GeneCards
MAML2MAML2Mastermind-like 2 (Drosophila)Source|GeneCards
LMO3LMO3LIM domain only 3 (rhombotin-like 2)Source|GeneCards
PCDH16DCHS1dachsous 1 (Drosophila)Source|GeneCards
BHC80PHF21APHD finger protein 21ASource|GeneCards
GABARAPL1GABARAPL1GABA(A) receptor-associated protein like 1Source|GeneCards
MLPCSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)Source|GeneCards
RBM4RBM4RNA binding motif protein 4Source|GeneCards
GGPS1GGPS1geranylgeranyl diphosphate synthase 1Source|GeneCards
PIK3C2APIK3C2Aphosphoinositide-3-kinase, class 2, alpha polypeptideSource|GeneCards
ASCL2ASCL2achaete-scute complex-like 2 (Drosophila)Source|GeneCards
CKAP4CKAP4cytoskeleton-associated protein 4Source|GeneCards
SSB1SSB1SPRY domain-containing SOCS box protein SSB-1Source|GeneCards
NTSNTSneurotensinSource|GeneCards
LIMRLIMRlipocalin-interacting membrane receptorSource|GeneCards
SEMA4GSEMA4Gsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4GSource|GeneCards
PDE3BPDE3Bphosphodiesterase 3B, cGMP-inhibitedSource|GeneCards
TTS-2.2PNPLA2patatin-like phospholipase domain containing 2Source|GeneCards
DUSP6DUSP6dual specificity phosphatase 6Source|GeneCards
LOC149469LOC149469hypothetical protein LOC149469Source|GeneCards
RAB6ARAB6ARAB6A, member RAS oncogene familySource|GeneCards
C1ORF19C1ORF19chromosome 1 open reading frame 19Source|GeneCards
CYR61CYR61cysteine-rich, angiogenic inducer, 61Source|GeneCards
HRMT1L3HRMT1L3HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae)Source|GeneCards
ZZZ3ZZZ3zinc finger, ZZ-type containing 3Source|GeneCards
AKR1CL2AKR1CL2aldo-keto reductase family 1, member C-like 2Source|GeneCards
D1S155ECSDE1cold shock domain containing E1, RNA-bindingSource|GeneCards
LAMC2LAMC2laminin, gamma 2Source|GeneCards
FLJ25476FLJ25476FLJ25476 proteinSource|GeneCards
PCTK2PCTK2PCTAIRE protein kinase 2Source|GeneCards
ANK3ANK3ankyrin 3, node of Ranvier (ankyrin G)Source|GeneCards
FLJ14494RPUSD4RNA pseudouridylate synthase domain containing 4Source|GeneCards
CLCCLCCharcot-Leyden crystal proteinSource|GeneCards
ELAVL4ELAVL4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)Source|GeneCards
SMBPSMBPSM-11044 binding proteinSource|GeneCards
C10ORF26C10ORF26chromosome 10 open reading frame 26Source|GeneCards
LOC90806LOC90806similar to RIKEN cDNA 2610307I21Source|GeneCards
DAB1DAB1disabled homolog 1 (Drosophila)Source|GeneCards
FLJ35821FLJ35821hypothetical protein FLJ35821Source|GeneCards
GAB2GAB2GRB2-associated binding protein 2Source|GeneCards
FLJ38159FLJ38159hypothetical protein FLJ38159Source|GeneCards
EFNA4EFNA4ephrin-A4Source|GeneCards
SH3GLB1SH3GLB1SH3-domain GRB2-like endophilin B1Source|GeneCards
HABP2HABP2hyaluronan binding protein 2Source|GeneCards
SESN2SESN2sestrin 2Source|GeneCards
LDB1LDB1LIM domain binding 1Source|GeneCards
TPH2TPH2tryptophan hydroxylase 2Source|GeneCards
ARID4BARID4BAT rich interactive domain 4B (RBP1- like) /// AT rich interactive domain 4B (RBP1- like)Source|GeneCards
CAPONNOS1APnitric oxide synthase 1 (neuronal) adaptor proteinSource|GeneCards
NBL1NBL1neuroblastoma, suppression of tumorigenicity 1Source|GeneCards
EB-1EB-1E2a-Pbx1-associated proteinSource|GeneCards
ABLIM1ABLIM1actin binding LIM protein 1Source|GeneCards
FLJ10706C1ORF112chromosome 1 open reading frame 112Source|GeneCards
DKFZP547E1010C1ORF77chromosome 1 open reading frame 77Source|GeneCards
SIAT7ESIAT7Esialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) ESource|GeneCards
ZA20D1ZA20D1zinc finger, A20 domain containing 1Source|GeneCards
HLX1HLX1H2.0-like homeo box 1 (Drosophila)Source|GeneCards
C10ORF45C10ORF45chromosome 10 open reading frame 45Source|GeneCards
HOXC6HOXC6homeo box C6Source|GeneCards
DKFZP547C195DKFZP547C195hypothetical protein DKFZp547C195Source|GeneCards
CACNA1ECACNA1Ecalcium channel, voltage-dependent, alpha 1E subunitSource|GeneCards
NCAM1NCAM1neural cell adhesion molecule 1Source|GeneCards
ELF5ELF5E74-like factor 5 (ets domain transcription factor)Source|GeneCards
PNLIPRP2PNLIPRP2pancreatic lipase-related protein 2Source|GeneCards
NOX4NOX4NADPH oxidase 4Source|GeneCards
VDRVDRVitamin D (1,25- dihydroxyvitamin D3) receptorSource|GeneCards
ZNF436ZNF436zinc finger protein 436Source|GeneCards
CSADCSADcysteine sulfinic acid decarboxylaseSource|GeneCards
C12ORF2C12ORF22chromosome 12 open reading frame 22Source|GeneCards
TRIM8TRIM8tripartite motif-containing 8Source|GeneCards
NRASNRASneuroblastoma RAS viral (v-ras) oncogene homologSource|GeneCards
PDCD4PDCD4programmed cell death 4 (neoplastic transformation inhibitor)Source|GeneCards
CLECSF8CLECSF8C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8Source|GeneCards
SORBS1SORBS1sorbin and SH3 domain containing 1Source|GeneCards
SELENBP1SELENBP1selenium binding protein 1Source|GeneCards
CTSKCTSKcathepsin K (pycnodysostosis)Source|GeneCards
EVA1EVA1epithelial V-like antigen 1Source|GeneCards
RBM8ARBM8ARNA binding motif protein 8ASource|GeneCards
HECTD2HECTD2HECT domain containing 2Source|GeneCards
HGNT-IV-HHGNT-IV-HUDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologSource|GeneCards
TORC2TORC2transducer of regulated cAMP response element-binding protein (CREB) 2Source|GeneCards
B3GALT2B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2Source|GeneCards
MGC2629ZBTB37zinc finger and BTB domain containing 37Source|GeneCards
SMP1TMEM50Atransmembrane protein 50ASource|GeneCards
BCL9BCL9B-cell CLL/lymphoma 9Source|GeneCards
NAV3NAV3neuron navigator 3Source|GeneCards
SP1SP1Sp1 transcription factorSource|GeneCards
ATP1A4ATP1A4ATPase, Na+/K+ transporting, alpha 4 polypeptideSource|GeneCards
LOC91614LOC91614novel 58.3 KDA proteinSource|GeneCards
GRK5GRK5G protein-coupled receptor kinase 5Source|GeneCards
HMGN2HMGN2high-mobility group nucleosomal binding domain 2Source|GeneCards
LOC144097LOC144097hypothetical protein BC007540Source|GeneCards
CPEB3CPEB3cytoplasmic polyadenylation element binding protein 3Source|GeneCards
LALBALALBAlactalbumin, alpha-Source|GeneCards
FLJ30213YPEL4yippee-like 4 (Drosophila)Source|GeneCards
SOX5SOX5SRY (sex determining region Y)-box 5Source|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
F11RF11RF11 receptorSource|GeneCards
R-SPONDINR-SPONDINR-spondin homolog (Xenopus laevis)Source|GeneCards
PDZRN4PDZRN4PDZ domain containing RING finger 4Source|GeneCards
SLC26A9SLC26A9solute carrier family 26, member 9Source|GeneCards
KCNQ1DNKCNQ1DNKCNQ1 downstream neighborSource|GeneCards
DFFBDFFBDNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)Source|GeneCards
EDG1EDG1endothelial differentiation, sphingolipid G-protein-coupled receptor, 1Source|GeneCards
LOC163590TOR1AIP2torsin A interacting protein 2Source|GeneCards
HUMAUANTIGGNL2guanine nucleotide binding protein-like 2 (nucleolar)Source|GeneCards
FLJ11588C1ORF165chromosome 1 open reading frame 165Source|GeneCards
EGR2EGR2early growth response 2 (Krox-20 homolog, Drosophila)Source|GeneCards
FLJ90231FLJ90231hypothetical protein FLJ90231Source|GeneCards
C11ORF30C11ORF30chromosome 11 open reading frame 30Source|GeneCards
DLG2DLG2Discs, large homolog 2, chapsyn-110 (Drosophila)Source|GeneCards
C1ORF21C1ORF21chromosome 1 open reading frame 21Source|GeneCards
ZNF238ZNF238zinc finger protein 238Source|GeneCards
KCNA1KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)Source|GeneCards
LOC148898LOC148898hypothetical protein BC007899Source|GeneCards
FLJ13236FLJ13236hypothetical protein FLJ13236Source|GeneCards
MED8MED8mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)Source|GeneCards
LOC253827LOC253827hypothetical protein LOC253827Source|GeneCards
ING4ING4inhibitor of growth family, member 4Source|GeneCards
KIAA1221ZNF644Zinc finger protein 644Source|GeneCards
SOX6SOX6SRY (sex determining region Y)-box 6Source|GeneCards
EMX2EMX2empty spiracles homolog 2 (Drosophila)Source|GeneCards
FLJ37266FLJ37266hypothetical protein FLJ37266Source|GeneCards
SLC38A4SLC38A4solute carrier family 38, member 4Source|GeneCards
LGI1LGI1leucine-rich, glioma inactivated 1Source|GeneCards
TBX5TBX5T-box 5Source|GeneCards
UNQ5782UNQ5782macrophage antigen hSource|GeneCards
AKR1A1AKR1A1aldo-keto reductase family 1, member A1 (aldehyde reductase)Source|GeneCards
FLJ10597C1ORF164chromosome 1 open reading frame 164Source|GeneCards
PRKAG1PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunitSource|GeneCards
PCF11PCF11pre-mRNA cleavage complex II protein Pcf11Source|GeneCards
NSEP1NSEP1nuclease sensitive element binding protein 1Source|GeneCards
RNF153MARCH5membrane-associated ring finger (C3HC4) 5Source|GeneCards
KIAA0140FAM53Bfamily with sequence similarity 53, member BSource|GeneCards
CREBL2CREBL2cAMP responsive element binding protein-like 2Source|GeneCards
CLSTN1CLSTN1calsyntenin 1Source|GeneCards
PDE6CPDE6Cphosphodiesterase 6C, cGMP-specific, cone, alpha primeSource|GeneCards
CYP26A1CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 1Source|GeneCards
PRRX1PRRX1paired related homeobox 1Source|GeneCards
DKFZP586H2123DKFZP586H2123DKFZP586H2123 proteinSource|GeneCards
LRP5LRP5low density lipoprotein receptor-related protein 5Source|GeneCards
KIRRELKIRRELkin of IRRE like (Drosophila)Source|GeneCards
FLJ25590FLJ25590hypothetical protein FLJ25590Source|GeneCards
FCHSD2FCHSD2FCH and double SH3 domains 2Source|GeneCards
FLJ45187FLJ45187FLJ45187 proteinSource|GeneCards
OPCMLOPCMLopioid binding protein/cell adhesion molecule-likeSource|GeneCards
CDKN1CCDKN1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2)Source|GeneCards
ENTPD1ENTPD1ectonucleoside triphosphate diphosphohydrolase 1Source|GeneCards
PALMDPALMDpalmdelphinSource|GeneCards
CTNNA3CTNNA3catenin (cadherin-associated protein), alpha 3Source|GeneCards
MGC3047MGC3047hypothetical protein MGC3047Source|GeneCards
DEDDDEDDdeath effector domain containingSource|GeneCards
CLEC2CLEC1BC-type lectin domain family 1, member BSource|GeneCards
LHX9LHX9LIM homeobox 9Source|GeneCards
JMJD1CJMJD1Cjumonji domain containing 1CSource|GeneCards
ATP2A2ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2Source|GeneCards
SORT1SORT1sortilin 1Source|GeneCards
EHFEHFets homologous factorSource|GeneCards
PVRL1PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)Source|GeneCards
LOC284723LOC284723Solute carrier family 25, member 34Source|GeneCards
FLJ10747TMEM57transmembrane protein 57Source|GeneCards
IGSF4IGSF4immunoglobulin superfamily, member 4Source|GeneCards
ESRRGESRRGestrogen-related receptor gammaSource|GeneCards
LEMD1LEMD1LEM domain containing 1Source|GeneCards
LRP6LRP6low density lipoprotein receptor-related protein 6Source|GeneCards
HTR3BHTR3B5-hydroxytryptamine (serotonin) receptor 3BSource|GeneCards
HOXC8HOXC8homeo box C8Source|GeneCards
CHS1VPS13Bvacuolar protein sorting 13B (yeast)Source|GeneCards
PAX6PAX6paired box gene 6 (aniridia, keratitis)Source|GeneCards
LOC58486LOC58486transposon-derived Buster1 transposase-like proteinSource|GeneCards
MGC34648FAM76Afamily with sequence similarity 76, member ASource|GeneCards
GRIN2BGRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2BSource|GeneCards
HRMT1L6HRMT1L6HMT1 hnRNP methyltransferase-like 6 (S. cerevisiae)Source|GeneCards
TNKS2TNKS2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2Source|GeneCards
LBX1LBX1transcription factor similar to D. melanogaster homeodomain protein lady bird lateSource|GeneCards
USP44USP44ubiquitin specific protease 44Source|GeneCards
AMICAAMICA1adhesion molecule that interacts with CXADR antigen 1Source|GeneCards
CA14CA14carbonic anhydrase XIVSource|GeneCards
MLLMLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)Source|GeneCards
SORL1SORL1sortilin-related receptor, L(DLR class) A repeats-containingSource|GeneCards
BAMBIBAMBIBMP and activin membrane-bound inhibitor homolog (Xenopus laevis)Source|GeneCards
PPAP2BPPAP2Bphosphatidic acid phosphatase type 2BSource|GeneCards
BARHL2BARHL2BarH-like 2 (Drosophila)Source|GeneCards
ATF7IPATF7IPactivating transcription factor 7 interacting proteinSource|GeneCards
EFNA1EFNA1ephrin-A1Source|GeneCards
MXI1MXI1MAX interacting protein 1Source|GeneCards
KIAA1747LOC57795hypothetical protein from clone 24828Source|GeneCards
SPON1SPON1spondin 1, (f-spondin) extracellular matrix proteinSource|GeneCards
PEPP2PLEKHA5Pleckstrin homology domain containing, family A member 5Source|GeneCards
RFX4RFX4regulatory factor X, 4 (influences HLA class II expression)Source|GeneCards
TCF7L2TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Source|GeneCards
TEAD1TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor)Source|GeneCards
MGC9084C1ORF156chromosome 1 open reading frame 156Source|GeneCards
INSRRINSRRinsulin receptor-related receptorSource|GeneCards
MTX1MTX1metaxin 1Source|GeneCards
DDIT4DDIT4DNA-damage-inducible transcript 4Source|GeneCards
TAL1TAL1T-cell acute lymphocytic leukemia 1Source|GeneCards
DPYSL4DPYSL4dihydropyrimidinase-like 4Source|GeneCards
PRG1PRG1proteoglycan 1, secretory granuleSource|GeneCards
GFRA1GFRA1GDNF family receptor alpha 1Source|GeneCards
EIF4G2EIF4G2eukaryotic translation initiation factor 4 gamma, 2Source|GeneCards
FLJ38716C1ORF161chromosome 1 open reading frame 161Source|GeneCards
USF1USF1upstream transcription factor 1Source|GeneCards
FLJ22938C1ORF113chromosome 1 open reading frame 113Source|GeneCards
DHRS3DHRS3dehydrogenase/reductase (SDR family) member 3Source|GeneCards
C10ORF81C10ORF81chromosome 10 open reading frame 81Source|GeneCards
FLJ30634FLJ30634hypothetical protein FLJ30634Source|GeneCards
PIK3CDPIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptideSource|GeneCards
DDX6DDX6DEAD (Asp-Glu-Ala-Asp) box polypeptide 6Source|GeneCards
PRDCGREM2gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)Source|GeneCards
MGC46534ATXN7L2ataxin 7-like 2Source|GeneCards
DKFZP547A023CTTNBP2NLCTTNBP2 N-terminal likeSource|GeneCards
NICE-3C1ORF43chromosome 1 open reading frame 43Source|GeneCards
CDKN2CCDKN2Ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)Source|GeneCards
DKFZP564M082DKFZP564M082DKFZP564M082 proteinSource|GeneCards
TEAD4TEAD4TEA domain family member 4Source|GeneCards
LOC221091LOC221091similar to hypothetical proteinSource|GeneCards
DKFZP761D221SGIP1SH3-domain GRB2-like (endophilin) interacting protein 1Source|GeneCards
MGC40368TCP11L2t-complex 11 (mouse) like 2Source|GeneCards
NFIANFIAnuclear factor I/ASource|GeneCards
NMNAT2NMNAT2nicotinamide nucleotide adenylyltransferase 2Source|GeneCards
ATF7ATF7activating transcription factor 7Source|GeneCards
SIAT8ASIAT8Asialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase)Source|GeneCards
STMN1STMN1stathmin 1/oncoprotein 18Source|GeneCards
RBP3RBP3retinol binding protein 3, interstitialSource|GeneCards
C10ORF83C10ORF83chromosome 10 open reading frame 83Source|GeneCards
TDRD5TDRD5tudor domain containing 5Source|GeneCards


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