XX
XX
XX
FA STAT1
XX
SY STAT91; ISGF3alpha
p91; signal transducer and activator of transcription 1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata;
vertebrata; tetrapoda; mammalia;
OC eutheria; rodentia; myomorpha;
muridae; murinae
XX
XX
CL C0039; STAT; 4.2.1.0.1.1.
XX
SZ 749 AA; 87.2 kDa (cDNA), 91 kDa (SDS)
XX
XX
SC SwissProt #P42225
XX
FT 2 122 PF02865; STAT_prot.
FT 136 315 PF01017; STAT.
FT 199 227 leucine zipper-like motif
(LLVLT).
FT 317 567 PF02864; STAT_bind.
FT 505 559 SH3
domain.
FT 573 674 SH2 domain.
FT 573 668 PF00017; SH2.
FT 634 701 conserved tyrosine residues.
XX
SF tyrosine-phosphorylation;
SF subunit of ISGF-3alpha;
SF forms homodimers;
SF forms
heterodimers with STAT3;
XX
FF activator of a number of
genes;
FF homodimer may act as a repressor [1];
FF mediates
transduction of tyrosine phosphorylation signals to induction
of
FF interferon-stimulated gene expression [10];
FF most
likely identical with SIF (c-sis-inducible factor) [11];
FF
inducible by IFN-alpha and IFN-gamma [9] and also by CSF-1 [4],
other
FF cytokines except IL-6 [8], growth factors and hormones
[10] [5];
FF Tyr-phosphorylation promotes formation of ISGF3
complex, nuclear
FF translocation [9], enables DNA-binding
and trans-activation [9];
FF Stat1 Tyr-phosphorylation depends
on phosphorylation of Stat2 [2];
FF modifying protein kinases
are Jak1 (triggered by IFN-alpha and -gamma) and
FF Jak2 (responding
to IFN-gamma) [9];
FF is activated by IL-10 and IFNgamma [3];
XX
IN T01575; STAT1; mouse, Mus musculus.
IN T01492; STAT1alpha;
human, Homo sapiens.
IN T01573; STAT1beta; human, Homo sapiens.
IN T01494; STAT2; human, Homo sapiens.
IN T01574; STAT3; mouse,
Mus musculus.
IN T00824; TFII-I; human, Homo sapiens.
XX
XX
XX
XX
RN [1]; RE0018204.
RX MEDLINE;
21438987.
RA Hogan J. C., Stephens J. M.
RT The identification
and characterization of a STAT 1 binding site in the
RT PPARgamma2
promoter.
RL Biochem. Biophys. Res. Commun. 287:484-492 (2001).
RN [2]; RE0003816.
RX MEDLINE; 96104578.
RA Qureshi S.
A., Leung S., Kerr I. M., Stark G. R., Darnell jr J. E.
RT
Function of Stat2 protein in transcriptional activation by alpha
interferon
RL Mol. Cell. Biol. 16:288-293 (1996).
RN [3];
RE0023360.
RX MEDLINE; 8830676.
RA Wehinger J., Gouilleux
F., Groner B., Finke J., Mertelsmann R., Weber-Nordt
RA R.
M.
RT IL-10 induces DNA binding activity of three STAT proteins
(Stat1, Stat3,
RT and Stat5) and their distinct combinatorial
assembly in the promoters of
RT selected genes.
RL FEBS
Lett. 394:365-370 (1996).
RN [4]; RE0011175.
RX MEDLINE;
96067132.
RA Hill C. S., Treisman R.
RT Differential activation
of c-fos promoter elements by serum,
RT lysophosphatidic acid,
G proteins and polypeptide growth factors
RL EMBO J. 14:5037-5047
(1995).
RN [5]; RE0003501.
RX MEDLINE; 94316659.
RA
David M., Petricoin III E. F., Igarashi K.-I., Feldman G. M.,
Finbloom D.
RA S., Larner A. C.
RT Prolactin activates
the interferon-regulated p91 transcription factor and
RT the
Jak2 kinase by tyrosine phosphorylation
RL Proc. Natl. Acad.
Sci. USA 91:7174-7178 (1994).
RN [6]; RE0003503.
RX MEDLINE;
94188718.
RA Zhong Z., Wen Z., Darnell J. E.
RT Stat3:
a STAT family member activated by tyrosine phosphorylation in
RT response to epidermal growth factor and interleukin-6
RL
Science 264:95-98 (1994).
RN [7]; RE0003504.
RX MEDLINE;
94255416.
RA Zhong Z., Wen Z., Darnell J. E.
RT Stat3
and Stat4: members of the family of signal transducers and activators
RT of transcription
RL Proc. Natl. Acad. Sci. USA 91:4806-4810
(1994).
RN [8]; RE0003506.
RX MEDLINE; 94208062.
RA
Akira S., Nishio Y., Inoue M., Wang X. J., Shi W., Matsusaka T.,
Yoshida
RA K., Sudo T., Naruto M., Kishimoto T.
RT Molecular
cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related
RT transcription factor involved in the gp130-mediated signaling
pathway
RL Cell 77:63-71 (1994).
RN [9]; RE0003494.
RX MEDLINE; 94077184.
RA Silvennoinen O., Ihle J. N., Schlessinger
J., Levy D. E.
RT Interferon-induced nuclear signalling by
Jak protein tyrosine kinases
RL Nature 366:583-585 (1993).
RN [10]; RE0003498.
RX MEDLINE; 93391973.
RA Silvennoinen
O., Schindler C., Schlessinger J., Levy D. E.
RT Ras-independent
growth factor signaling by transcription factor tyrosine
RT
phosphorylation
RL Science 261:1736-1744 (1993).
RN [11];
RE0003500.
RX MEDLINE; 93391972.
RA Ruff-Jamison S., Chen
K., Cohen S.
RT Induction by EGF and interferon-gamma of tyrosine
phosphorylated DNA
RT binding proteins in mouse liver
RL Science 261:1733-1736 (1993).
RN [12]; RE0003523.
RX
MEDLINE; 93309428.
RA Kanno Y., Kozak C. A., Schindler C.,
Driggers P. H., Ennist D. L., Gleason
RA S. L., Darnell J.
E., Ozato K.
RT The genomic structure of the murine ICSBP
gene reveals the presence of the
RT gamma-interferon-responsive
element, to which an ISGF3alpha subunit (or
RT similar) molecule
binds
RL Mol. Cell. Biol. 13:3951-3963 (1993).
XX