XX
XX
XX
FA STAT3
XX
SY signal transducer
and activator of transcription 3; APRF; acute-phase
SY response
factor.
XX
OS mouse, Mus musculus
OC eukaryota; animalia;
metazoa; chordata; vertebrata; tetrapoda; mammalia;
OC eutheria;
rodentia; myomorpha; muridae; murinae
XX
XX
CL C0039;
STAT; 4.2.1.0.3.
XX
SZ 770 AA; 88.0 kDa (cDNA), 92 kDa
(SDS) [7], 95 kDa (SDS) [9]
XX
XX
SC SwissProt #P42227
XX
FT 2 122 PF02865; STAT_prot.
FT 138 319 PF01017; STAT.
FT 203 231 leucine zipper-like motif (LLILV).
FT 321 574 PF02864;
STAT_bind.
FT 406 514 DNA-binding specificity determining
domain [4].
FT 512 566 SH3 domain.
FT 580 681 SH2 domain.
FT 584 674 PF00017; SH2.
FT 705 705 conserved tyrosine residue.
XX
SF tyrosine-phosphorylation [7] [9]
XX
FF activator;
FF functionally related to SIF (c-sis-inducible element-binding
factor) [7];
FF activated by EGF and IL-6, not by IFN-gamma,
by tyrosine phosphorylation
FF [7] [9];
FF also modified
by other cytokines whose receptors share the gp130 component
FF [9];
FF maximal transcriptional activation after additional
phosphorylation of
FF Ser-727, possibly by MAP kinase [5];
FF activation induced by IFN-alpha and CSF-1 [6] and IL-10 [3];
FF positive autoregulation of the stat3 gene by the STAT3 factor
[2];
XX
IN T01575; STAT1; mouse, Mus musculus.
IN
T01574; STAT3; mouse, Mus musculus.
XX
XX
XX
XX
RN [1]; RE0023482.
RX MEDLINE; 12244095.
RA Schreiner
S. J., Schiavone A. P., Smithgall T. E.
RT Activation of STAT3
by the Src family kinase Hck requires a functional SH3
RT
domain.
RL J. Biol. Chem. 277:45680-45687 (2002).
RN [2];
RE0023186.
RX MEDLINE; 9497331.
RA Ichiba M., Nakajima
K., Yamanaka Y., Kiuchi N., Hirano T.
RT Autoregulation of
the Stat3 gene through cooperation with a cAMP-responsive
RT element-binding protein.
RL J. Biol. Chem. 273:6132-6138
(1998).
RN [3]; RE0023360.
RX MEDLINE; 8830676.
RA
Wehinger J., Gouilleux F., Groner B., Finke J., Mertelsmann R.,
Weber-Nordt
RA R. M.
RT IL-10 induces DNA binding activity
of three STAT proteins (Stat1, Stat3,
RT and Stat5) and their
distinct combinatorial assembly in the promoters of
RT selected
genes.
RL FEBS Lett. 394:365-370 (1996).
RN [4]; RE0003481.
RX MEDLINE; 95293230.
RA Horvath C. M., Wen Z., Darnell jr
J. E.
RT A STAT protein domain that determines DNA sequence
recognition suggests a
RT novel DNA-binding domain
RL
Genes Dev. 9:984-994 (1995).
RN [5]; RE0003507.
RX MEDLINE;
95354205.
RA Wen Z., Zhong Z., Darnell J. E.
RT Maximal
activation of transcription by Stat1 and Stat3 requires both
RT tyrosine and serine phosophorylation
RL Cell 82:241-250
(1995).
RN [6]; RE0011175.
RX MEDLINE; 96067132.
RA
Hill C. S., Treisman R.
RT Differential activation of c-fos
promoter elements by serum,
RT lysophosphatidic acid, G proteins
and polypeptide growth factors
RL EMBO J. 14:5037-5047 (1995).
RN [7]; RE0003503.
RX MEDLINE; 94188718.
RA Zhong Z.,
Wen Z., Darnell J. E.
RT Stat3: a STAT family member activated
by tyrosine phosphorylation in
RT response to epidermal growth
factor and interleukin-6
RL Science 264:95-98 (1994).
RN [8]; RE0003504.
RX MEDLINE; 94255416.
RA Zhong Z.,
Wen Z., Darnell J. E.
RT Stat3 and Stat4: members of the family
of signal transducers and activators
RT of transcription
RL Proc. Natl. Acad. Sci. USA 91:4806-4810 (1994).
RN [9];
RE0003506.
RX MEDLINE; 94208062.
RA Akira S., Nishio Y.,
Inoue M., Wang X. J., Shi W., Matsusaka T., Yoshida
RA K.,
Sudo T., Naruto M., Kishimoto T.
RT Molecular cloning of APRF,
a novel IFN-stimulated gene factor 3 p91-related
RT transcription
factor involved in the gp130-mediated signaling pathway
RL
Cell 77:63-71 (1994).
XX