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Gene set: V$ARP1_01 (C3:TFAC:0098)
Standard nameV$ARP1_01
Systematic nameC3:TFAC:0098
Brief descriptionGenes with 3'UTR containing motif TGARCCYTTGAMCCCW which matches annotation for PITX2: paired-like homeodomain transcription factor 2
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA ARP-1
 XX
 SY ARP-1; COUP-beta;
apolipoprotein AI regulatory protein; NR2F2; COUP-TF II.
 XX

OS human, Homo sapiens
 OC eukaryota; animalia; metazoa; chordata;
vertebrata; tetrapoda; mammalia;
 OC eutheria; primates

XX
 XX
 CL C0002; CC (rec); 2.1.2.10.6.
 XX
 SZ 414
AA; 47 kDa (SDS), 45.6 kDa (cDNA)
 XX
 XX
 SC SwissProt
#P24468
 XX
 FT 1 78 proline-, glutamine-, glycine-rich
region A/B.
 FT 76 147 SM00399; ZnF_C4.
 FT 77 152 PF00105;
zf-C4.
 FT 79 149 region C.
 FT 150 176 region D.
 FT
176 401 ligand-binding region E.
 FT 214 374 SM00430; HOLI.

FT 217 400 PF00104; hormone_rec.
 FT 337 414 dimerization domain.

FT 401 414 region F.
 XX
 SF forms homodimers, can bind
as monomer or homodimer [6];
 SF loss of dimerization function
leads to a loss of DNA-binding unless it is
 SF C-terminally
truncated to AA 171;
 SF can bind to DR0, DR4 elements [2];

XX
 CP widespread
 XX
 FF repressor of apolipoprotein
AI and CIII genes [11], of the human
 FF erythropoietin promoter
[7];
 FF activator of the mouse LPL promoter [4], FABPI promoter
[8], rat CYP7A
 FF [2], salmon HNF-1 promoter [1];
 FF participates
in regulation of lipid metabolism and cholesterol synthesis;

FF regulates cholesterol metabolism and bile acid synthesis [2];

FF acts as an antagonistic regulator of myogenesis via directly
effecting the
 FF myoD gene family [6];
 FF can activate
transcription synergystically with HNF-4 [5] [1] [2];
 FF can
act antagonistically to HNF-4 [11] [7];
 XX
 IN T00045;
ARP-1; human, Homo sapiens.
 IN T01345; RXR-alpha; human, Homo
sapiens.
 XX
 XX
 XX
 XX
 RN [1]; RE0016834.

RX MEDLINE; 20539843.
 RA McNair A., Cereghini S., Brand H.,
Smith T., Breillat C., Gannon F.
 RT Synergistic activation
of the Atlantic salmon hepatocyte nuclear factor
 RT (HNF)
1 promoter by the orphan nuclear receptors HNF4 and chicken ovalbumin

RT upstream promoter transcription factor I (COUP-TFI).
 RL
Biochem. J. 352:557-564 (2000).
 RN [2]; RE0016841.
 RX
MEDLINE; 20094868.
 RA Stroup D., Chiang J. Y.
 RT HNF4
and COUP-TFII interact to modulate transcription of the cholesterol

RT 7alpha-hydroxylase gene (CYP7A1).
 RL J. Lipid. Res. 41:1-11
(2000).
 RN [3]; RE0013625.
 RX MEDLINE; 99235977.
 RA
Nuclear Receptors Nomenclature Committee.
 RT A unified nomenclature
system for the nuclear receptor superfamily
 RL Cell 97:161-163
(1999).
 RN [4]; RE0018030.
 RX MEDLINE; 99196128.
 RA
Robinson C. E., Wu X., Nawaz Z., Onate S. A., Gimble J. M.

RT A corepressor and chicken ovalbumin upstream promoter transcriptional

RT factor proteins modulate peroxisome proliferator-activated

RT receptor-gamma2/retinoid X receptor alpha-activated transcription
from the
 RT murine lipoprotein lipase promoter.
 RL Endocrinology
140:1586-1593 (1999).
 RN [5]; RE0016808.
 RX MEDLINE; 98129834.

RA Vorgia P., Zannis V. I., Kardassis D.
 RT A short proximal
promoter and the distal hepatic control region-1 (HCR-1)
 RT
contribute to the liver specificity of the human apolipoprotein
C-II gene.
 RT Hepatic enhancement by HCR-1 requires two proximal
hormone response
 RT elements which have different binding
specificities for orphan receptors
 RT HNF-4, ARP-1, and EAR-2.

RL J. Biol. Chem. 273:4188-4196 (1998).
 RN [6]; RE0010425.

RX MEDLINE; 95273166.
 RA Muscat G. E. O., Rea S., Downes M.

RT Identification of a regulatory function for an orphan receptor
in muscle:
 RT COUP-TF II affects the expression of the myoD
gene family during myogenesis
 RL Nucleic Acids Res. 23:1311-1318
(1995).
 RN [7]; RE0010509.
 RX MEDLINE; 7891708.
 RA
Galson D. L., Tsuchiya T., Tendler D. S., Huang L. E., Ren Y.,
Ogura T.,
 RA Bunn H. F.
 RT The orphan receptor hepatic
nuclear factor 4 functions as a transcriptional
 RT activator
for tissue-specific and hypoxia-specific erythropoietin gene

RT expression and is antagonized by EAR3/COUP-TF1
 RL Mol.
Cell. Biol. 15:2135-2144 (1995).
 RN [8]; RE0014411.
 RX
MEDLINE; 93280171.
 RA Rottman J. N., Gordon J. I.
 RT Comparison
of the patterns of expression of rat intestinal fatty acid

RT binding protein/human growth hormone fusion genes in cultured
intestinal
 RT epithelial cell lines and in the gut epithelium
of transgenic mice
 RL J. Biol. Chem. 268:11994-12002 (1993).

RN [9]; RE0002994.
 RX MEDLINE; 93024411.
 RA Tran P., Zhang
X.-K., Salbert G., Hermann T., Lehmann J. M., Pfahl M.
 RT
COUP orphan receptors are negative regulators of retinoic acid
response
 RT pathways
 RL Mol. Cell. Biol. 12:4666-4676
(1992).
 RN [10]; RE0003068.
 RX MEDLINE; 92334336.

RA Widom R. L., Rhee M., Karathanasis S. K.
 RT Repression
by ARP-1 sensitizes apolipoprotein AI gene responsiveness to

RT RXRalpha and retinoic acid
 RL Mol. Cell. Biol. 12:3380-3389
(1992).
 RN [11]; RE0003072.
 RX MEDLINE; 92195317.

RA Mietus-Snyder M., Sladek F. M., Ginsburg G. S., Kuo C. F.,
Ladias J. A. A.,
 RA Darnell jr J. E., Karathanasis S. K.

RT Antagonism between apolipoprotein AI regulatory protein 1,
Ear3/COUP-TF,
 RT and hepatocyte nuclear factor 4 modulates
apolipoprotein CIII gene
 RT expression in liver and intestinal
cells
 RL Mol. Cell. Biol. 12:1708-1718 (1992).
 RN [12];
RE0002714.
 RX MEDLINE; 91118002.
 RA Ladias J. A. A., Karathanasis
S. K.
 RT Regulation of the apolipoprotein A1 gene by ARP-1,
a novel member of the
 RT steroid receptor superfamily

RL Science 251:561-565 (1991).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

168 genes, 168 accessions (Toggle view)

AccessionGeneTitleLinks
PPFIA3PPFIA3protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3Source|GeneCards
C1ORF21C1ORF21chromosome 1 open reading frame 21Source|GeneCards
FLJ34588FLJ34588Smhs2 homolog (rat)Source|GeneCards
CCDC6CCDC6coiled-coil domain containing 6Source|GeneCards
ZNF288ZBTB20zinc finger and BTB domain containing 20Source|GeneCards
SPARCSPARCsecreted protein, acidic, cysteine-rich (osteonectin)Source|GeneCards
MED8MED8mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)Source|GeneCards
CYP2E1CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 1Source|GeneCards
CPNE1CPNE1RNA binding motif protein 12Source|GeneCards
ARR3ARR3arrestin 3, retinal (X-arrestin)Source|GeneCards
IRAK1IRAK1interleukin-1 receptor-associated kinase 1Source|GeneCards
KIAA1221ZNF644Zinc finger protein 644Source|GeneCards
LOC93343LOC93343hypothetical protein BC011840Source|GeneCards
ZNF532ZNF532zinc finger protein 532Source|GeneCards
C6ORF32C6ORF32chromosome 6 open reading frame 32Source|GeneCards
COL16A1COL16A1collagen, type XVI, alpha 1Source|GeneCards
NLKNLKnemo like kinaseSource|GeneCards
FLJ37266FLJ37266hypothetical protein FLJ37266Source|GeneCards
MLPCSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)Source|GeneCards
FBXL20FBXL20F-box and leucine-rich repeat protein 20Source|GeneCards
MGC8407CAMKVCaM kinase-like vesicle-associatedSource|GeneCards
AP1B1AP1B1adaptor-related protein complex 1, beta 1 subunitSource|GeneCards
TGIF2TGIF2TGFB-induced factor 2 (TALE family homeobox)Source|GeneCards
FLJ20509PARP16Poly (ADP-ribose) polymerase family, member 16Source|GeneCards
ZHX2ZHX2transcription factor ZHX2Source|GeneCards
GATA1GATA1GATA binding protein 1 (globin transcription factor 1)Source|GeneCards
LOC57149LOC57149hypothetical protein A-211C6.1Source|GeneCards
C14ORF20TSSK4testis-specific serine kinase 4Source|GeneCards
ATBF1ATBF1AT-binding transcription factor 1Source|GeneCards
POLD4POLD4polymerase (DNA-directed), delta 4Source|GeneCards
NDST2NDST2N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2Source|GeneCards
MYOCDMYOCDMyocardinSource|GeneCards
LOC149469LOC149469hypothetical protein LOC149469Source|GeneCards
CBFA2T1RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
SLITRK6SLITRK6SLIT and NTRK-like family, member 6Source|GeneCards
MAB21L2MAB21L2mab-21-like 2 (C. elegans)Source|GeneCards
CHD2CHD2chromodomain helicase DNA binding protein 2Source|GeneCards
TRERF1TRERF1transcriptional regulating factor 1Source|GeneCards
HOXA3HOXA3homeo box A3Source|GeneCards
ARHGEF15ARHGEF15Rho guanine nucleotide exchange factor (GEF) 15Source|GeneCards
RASIP1RASIP1Ras interacting protein 1Source|GeneCards
MRPS18BMRPS18Bmitochondrial ribosomal protein S18BSource|GeneCards
APOMAPOMapolipoprotein MSource|GeneCards
OMDOMDosteomodulinSource|GeneCards
AQP7AQP7aquaporin 7Source|GeneCards
CDX1CDX1caudal type homeo box transcription factor 1Source|GeneCards
LOC283849LOC283849hypothetical protein LOC283849Source|GeneCards
DNAJC5BDNAJC5BDnaJ (Hsp40) homolog, subfamily C, member 5 betaSource|GeneCards
MYL1MYL1myosin, light polypeptide 1, alkali; skeletal, fastSource|GeneCards
SLC12A5SLC12A5solute carrier family 12, (potassium-chloride transporter) member 5Source|GeneCards
PMF1PMF1polyamine-modulated factor 1Source|GeneCards
C1QTNF7C1QTNF7C1q and tumor necrosis factor related protein 7Source|GeneCards
PPM1EPPM1Eprotein phosphatase 1E (PP2C domain containing)Source|GeneCards
FCHSD2FCHSD2FCH and double SH3 domains 2Source|GeneCards
TREML2TREML2Triggering receptor expressed on myeloid cells-like 2Source|GeneCards
CLDN15CLDN15claudin 15Source|GeneCards
MNAT1MNAT1menage a trois 1 (CAK assembly factor)Source|GeneCards
JADE1PHF17PHD finger protein 17Source|GeneCards
GPR124GPR124G protein-coupled receptor 124Source|GeneCards
TNRC4TNRC4trinucleotide repeat containing 4Source|GeneCards
ZFXZFXzinc finger protein, X-linkedSource|GeneCards
RALYRALYRNA binding protein (autoantigenic, hnRNP-associated with lethal yellow)Source|GeneCards
MGC40107MGC40107hypothetical protein MGC40107Source|GeneCards
HSPB8HSPB8heat shock 22kDa protein 8Source|GeneCards
CRYGCCRYGCcrystallin, gamma CSource|GeneCards
CDK5R1CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)Source|GeneCards
SIPA1SIPA1signal-induced proliferation-associated gene 1Source|GeneCards
SLC7A8SLC7A8solute carrier family 7 (cationic amino acid transporter, y+ system), member 8Source|GeneCards
KIRREL2KIRREL2kin of IRRE like 2 (Drosophila)Source|GeneCards
FLJ22679FLJ22679hypothetical protein FLJ22679Source|GeneCards
FLJ44313FLJ44313FLJ44313 proteinSource|GeneCards
EMP1EMP1epithelial membrane protein 1Source|GeneCards
NFIXNFIXnuclear factor I/X (CCAAT-binding transcription factor)Source|GeneCards
KIAA0423KIAA0423KIAA0423Source|GeneCards
FCHSD1FCHSD1FCH and double SH3 domains 1Source|GeneCards
HRBLHRBLHIV-1 Rev binding protein-likeSource|GeneCards
ESRRGESRRGestrogen-related receptor gammaSource|GeneCards
ELF4ELF4E74-like factor 4 (ets domain transcription factor)Source|GeneCards
PITPNC1PITPNC1phosphatidylinositol transfer protein, cytoplasmic 1Source|GeneCards
PIK3CGPIK3CGphosphoinositide-3-kinase, catalytic, gamma polypeptideSource|GeneCards
SERPINC1SERPINC1serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1Source|GeneCards
GLIGLI1glioma-associated oncogene homolog 1 (zinc finger protein)Source|GeneCards
SLITRK1SLITRK1SLIT and NTRK-like family, member 1Source|GeneCards
LTBP3LTBP3Latent transforming growth factor beta binding protein 3Source|GeneCards
TRAF4TRAF4TNF receptor-associated factor 4Source|GeneCards
DLX5DLX5distal-less homeo box 5Source|GeneCards
CASKCASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)Source|GeneCards
C1QTNF5C1QTNF5C1q and tumor necrosis factor related protein 5Source|GeneCards
FLJ25530FLJ25530hypothetical protein FLJ25530Source|GeneCards
CROC4C1ORF61chromosome 1 open reading frame 61Source|GeneCards
DMDDMDdystrophin (muscular dystrophy, Duchenne and Becker types)Source|GeneCards
FLJ90024FLJ90024fasting-inducible integral membrane protein TM6P1Source|GeneCards
RIN1RIN1Ras and Rab interactor 1Source|GeneCards
SMARCC2SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2Source|GeneCards
ATF7IPATF7IPactivating transcription factor 7 interacting proteinSource|GeneCards
MLLT6MLLT6myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6Source|GeneCards
RNF34RNF34ring finger protein 34Source|GeneCards
KIF13AKIF13Akinesin family member 13ASource|GeneCards
OAZINOAZINornithine decarboxylase antizyme inhibitorSource|GeneCards
FLJ20716FAM70Afamily with sequence similarity 70, member ASource|GeneCards
DBPDBPD site of albumin promoter (albumin D-box) binding proteinSource|GeneCards
ASB12ASB12ankyrin repeat and SOCS box-containing 12Source|GeneCards
ZNF205ZNF205zinc finger protein 205Source|GeneCards
CTGFCTGFconnective tissue growth factorSource|GeneCards
ACFACFapobec-1 complementation factorSource|GeneCards
FLJ39739FLJ39739FLJ39739 proteinSource|GeneCards
CFL2CFL2cofilin 2 (muscle)Source|GeneCards
SARGC1ORF116chromosome 1 open reading frame 116Source|GeneCards
SORBS1SORBS1sorbin and SH3 domain containing 1Source|GeneCards
TGFB3TGFB3transforming growth factor, beta 3Source|GeneCards
NR6A1NR6A1nuclear receptor subfamily 6, group A, member 1Source|GeneCards
UNQ9372UNQ9372AWKS9372Source|GeneCards
CMKOR1CMKOR1chemokine orphan receptor 1Source|GeneCards
FLJ40217SLC25A35solute carrier family 25, member 35Source|GeneCards
FLJ39630FAM77Dfamily with sequence similarity 77, member DSource|GeneCards
RNF36RNF36ring finger protein 36Source|GeneCards
DLX1DLX1distal-less homeo box 1Source|GeneCards
ENSAENSAendosulfine alphaSource|GeneCards
HOXA1HOXA1homeo box A1Source|GeneCards
HPCAHPCAhippocalcinSource|GeneCards
FGF20FGF20fibroblast growth factor 20Source|GeneCards
MGC14376MGC14376hypothetical protein MGC14376Source|GeneCards
B3GALT2B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2Source|GeneCards
FLJ10490FLJ10490hypothetical protein FLJ10490Source|GeneCards
POU3F4POU3F4POU domain, class 3, transcription factor 4Source|GeneCards
RUNX3RUNX3runt-related transcription factor 3Source|GeneCards
MMP28MMP28matrix metalloproteinase 28Source|GeneCards
NR5A2NR5A2nuclear receptor subfamily 5, group A, member 2Source|GeneCards
PKP3PKP3plakophilin 3Source|GeneCards
NFE2NFE2nuclear factor (erythroid-derived 2), 45kDaSource|GeneCards
CTLA4CTLA4cytotoxic T-lymphocyte-associated protein 4Source|GeneCards
BAHD1BAHD1bromo adjacent homology domain containing 1Source|GeneCards
ATP2C1ATP2C1ATPase, Ca++ transporting, type 2C, member 1Source|GeneCards
KIAA0913KIAA0913KIAA0913 proteinSource|GeneCards
ALDOAALDOAaldolase A, fructose-bisphosphateSource|GeneCards
HTR1BHTR1B5-hydroxytryptamine (serotonin) receptor 1BSource|GeneCards
RBBP6RBBP6retinoblastoma binding protein 6Source|GeneCards
ARL7ARL7ADP-ribosylation factor-like 7Source|GeneCards
E2F4E2F4E2F transcription factor 4, p107/p130-bindingSource|GeneCards
CDC37L1CDC37L1Cell division cycle 37 homolog (S. cerevisiae)-like 1Source|GeneCards
BMP5BMP5bone morphogenetic protein 5Source|GeneCards
FLJ33817FLJ33817hypothetical protein FLJ33817Source|GeneCards
JPH1JPH1junctophilin 1Source|GeneCards
PROSAPIP1PROSAPIP1ProSAPiP1 proteinSource|GeneCards
PDGFBPDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)Source|GeneCards
HOXD4HOXD4homeo box D4Source|GeneCards
MORF4MORF4mortality factor 4Source|GeneCards
IL21IL21Interleukin 21Source|GeneCards
SKILSKILSKI-likeSource|GeneCards
HAPLN1HAPLN1hyaluronan and proteoglycan link protein 1Source|GeneCards
C14ORF43C14ORF43chromosome 14 open reading frame 43Source|GeneCards
CACNA1GCACNA1Gcalcium channel, voltage-dependent, alpha 1G subunitSource|GeneCards
TMEM28TMEM28transmembrane protein 28Source|GeneCards
PLK3PLK3polo-like kinase 3 (Drosophila)Source|GeneCards
PDZRN4PDZRN4PDZ domain containing RING finger 4Source|GeneCards
C13ORF12C13ORF12chromosome 13 open reading frame 12Source|GeneCards
OTX2OTX2orthodenticle homolog 2 (Drosophila)Source|GeneCards
TLP19TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum)Source|GeneCards
IFIFI factor (complement)Source|GeneCards
PROP1PROP1prophet of Pit1, paired-like homeodomain transcription factorSource|GeneCards
ZNF6ZNF6zinc finger protein 6 (CMPX1)Source|GeneCards
GPR3GPR3G protein-coupled receptor 3Source|GeneCards
NXPH1NXPH1neurexophilin 1Source|GeneCards
IL11RAIL11RAinterleukin 11 receptor, alphaSource|GeneCards
BTBD5BTBD5BTB (POZ) domain containing 5Source|GeneCards
STARSTARsteroidogenic acute regulatorSource|GeneCards
FOXP2FOXP2forkhead box P2Source|GeneCards
RRAGDRRAGDRas-related GTP binding DSource|GeneCards

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